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28844473545
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note
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Four factors were considered when designing these receptors. (i) Anion size: as most anions of interest are not comparable in size to the large [n]polynorbornane framework, hence, only [3]polynorbornanes were employed in this study. (ii) Recognition unit: we chose to use substituted aromatic thioureas as these may be readily tuned to enhance binding affinity, (iii) Symmetry: to facilitate spectroscopic analysis, a highly symmetric framework based on endo-norborn-5-ene-2,3-anhydride 3 was chosen. (iv) Rigidity: to maximize the anion-receptor interaction without compromising preorganization, a flexible ethyl spacer was placed between the rigid [3]-polynorbornane backbone and the thiourea receptor units.
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