Artepillin C in Brazilian propolis induces G0/G1 arrest via stimulation of Cip1/p21 expression in human colon cancer cells

Molecular Carcinogenesis

Volumn 44, Issue 4, 2005, Pages 293-299

  Shimizu, Kazuo ^a   Das, Swadesh K ^a   Hashimoto, Takashi ^a   Sowa, Yoshihiro ^b   Yoshida, Tatsushi ^b   Sakai, Toshiyuki ^b   Matsuura, Yukinaga ^c   Kanazawa, Kazuki ^a  

^a KOBE UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c Yamada Apiculture Center Inc   (Japan)

Author keywords

Artepillin C; Cell cycle arrest; Cip1 p21; Colon cancer; Propolis

Indexed keywords

ANTINEOPLASTIC AGENT; ARTEPILLIN C; BRAZILIAN PROPOLIS; CYCLIN D; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MESSENGER RNA; PHENOL DERIVATIVE; PROPOLIS; RETINOBLASTOMA PROTEIN; SERINE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BACCHARIS; BACCHARIS DRACUNCULIFOLIA; CANCER CELL CULTURE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL STRAIN HCT116; CHEMOPROPHYLAXIS; COLON CANCER; COLON CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

BLOTTING, NORTHERN; CELL PROLIFERATION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; FLOW CYTOMETRY; G0 PHASE; G1 PHASE; HCT116 CELLS; HUMANS; IMMUNOPRECIPITATION; NUCLEIC ACID SYNTHESIS INHIBITORS; PHENYLPROPIONATES; PHOSPHORYLATION; PROPOLIS; RETINOBLASTOMA PROTEIN; RNA, MESSENGER;

BACCHARIS; BACCHARIS DRACUNCULIFOLIA;

EID: 28844452880     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.20148     Document Type: Article

References (42)

1. Talbot SM, Neugut AI. Epidemiological trends in colorectal cancer. In: Saltz LB, editor. Colorectal cancer: Multimodality management. Totowa, NJ: Humana Press Inc; 2002. pp 23-46.
2. Potter JD, McMichael AJ. Diet and cancer of the colon and rectum: A case-control study. J Natl Cancer Inst 1986;76:557-569.
3. Block G, Patterson B, Subar A. Fruits, vegetables and cancer prevention: A review of the epidemiological evidence. Nutr Cancer 1992;18:1-29.
4. Husain SR, Cillard J, Cillard P. Hydroxyl radical scavenging activity of flavonoids. Phytochemistry 1987;26:2489-2492.
5. Boyer RF, Clark HM, LaRoche AP. Reduction and release of ferritin iron by plant phenolics. J Inorg Biochem 1988;32:171-181.
6. Kanazawa K, Yamashita T, Ashida H, Danno G. Antimutagenicity of flavones and flavonols to heterocyclic amines by specific and strong inhibition of the cytochrome P450 1A family. Biosci Biotechnol Biochem 1998;62:970-977.
7. 2/M and growth inhibition by apigenin in human colon carcinoma cell lines. Mol Carcinog 2000;28:102-110.
8. Pan MH, Chen WJ, Lin-Shiau SY, Ho CT, Lin JK. Tangeretin induces cell-cycle G, arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells. Carcinogenesis 2002;23:1677-1684.
9. Murota K, Terao J. Antioxidative flavonoid quercetin: Implication of its intestinal absorption and metabolism. Arch Biochem Biophys 2003;417:12-17.
10. Day AJ, Mellon F, Barron D, Sarrazin G, Morgan MR, Williamson G. Human metabolism of dietary flavonoids: Identification of plasma metabolites of quercetin. Free Radic Res 2001;35:941-952.
11. Burdock GA. Review of the biological properties and toxicity of bee propolis (propolis). Food Chem Toxicol 1988;36:347-363.
12. Banskota AH, Tezuka Y, Kadota S. Recent progress in pharmacological research of propolis. Phytother Res 2001;15:561-571.
13. Nomura M, Kaji A, Ma W-Y, Miyamoto K, Dong Z. Suppression of cell transformation and induction of apoptosis by caffeic acid phenethyl ester. Mol Carcinog 2001;3:183-189.
14. Wang D, Xiang D-B, He Y-J, et al. Effect of caffecic acid phenethyl ester on proliferation and apoptosis of colorectal cancer cells in vitro. World J Gastroenterol 2005;11:4008-4012.
15. Kimoto T, Koya S, Hino K, et al. Renal carcinogenesis induced by ferric nitrilotriacetate in mice, and protection from it by Brazilian propolis and artepillin C. Pathol Int 2000;50:679-689.
16. Kimoto T, Koya-Miyata S, Hino K, et al. Pulmonary carcinogenesis induced by ferric nitrilotriacetate in mice and protection from it by Brazilian propolis and artepillin C. Virchows Arch 2001;438:259-270.
17. Shimizu K, Ashida H, Matsuura Y, Kanazawa K. Antioxidative bioavailability of artepillin C in Brazilian propolis. Arch Biochem Biophys 2004;424:181-188.
18. Martin GS. Cell signaling and cancer. Cancer Cell 2003;4:167-174.
19. Hahn WC. Cancer: Surviving on the edge. Cancer Cell 2004;6:215-222.
20. Sherr CJ, McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2002;2:103-112.
21. Alley MC, Scudiero DA, Monks A, et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 1988;48:589-601.
22. Obaya AJ, Kotenko I, Cole MD, Sedivy JM. The proto-oncogene c-myc acts through the cyclin-dependent kinase (Cdk) inhibitor p27(Kip1) to facilitate the activation of Cdk4/6 and early G(1) phase progression. J Biol Chem 2002;277:31263-31269.
23. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951;193:265-275.
24. 1 phase arrest in A549 lung adenocarcinoma cells. FEBS Lett 1998;437:61-64.
25. Sambrook J, Russell DW. Cloning: A laboratory manual, 1st edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 2001. pp 7.42-7.44.
26. Weinstein IB. Disorders in cell circuitry during multistage carcinogenesis: The role of homeostasis. Carcinogenesis 2000;21:857-864.
27. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995;81:323-330.
28. Taya Y. RB kinases and RB-binding proteins: New points of view. Trends Biochem Sci 1997;22:14-17.
29. Kitagawa M, Higashi H, Jung HK, et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 1996;15:7060-7069.
30. Kato J, Matsushime H, Hiebert SW, Ewen ME, Sherr CJ. Direct binding of cyclin D to the retinoblastoma gene product (pRb) and pRb phosphorylation by the cyclin D-dependent kinase CDK4. Genes Dev 1993;7:331-342.
31. Hunter T, Pines J. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell 1994;79:573-582.
32. Morgan DO. Principles of CDK regulation. Nature 1995;374:131-134.
33. Nojima H. Cell cycle checkpoints, chromosome stability and the progression of cancer. Hum Cell 1997;10:221-230.
34. Eastwood GL. A review of gastrointestinal epithelial renewal and its relevance to the development of adenocarcinomas of the gastrointestinal tract. J Clin Gastroenterol 1995;21:S1-S11.
35. Kimoto T, Aga M, Hino K, et al. Apoptosis of human leukemia cells induced by Artepillin C, an active ingredient of Brazilian propolis. Anticancer Res 2001;21:221-228.
36. Kimoto T, Arai S, Kohguchi M, et al. Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis. Cancer Detect Prev 1998;22:506-515.
37. Matsuno T, Jung SK, Matsumoto Y, Saito M, Morikawa J. Preferential cytotoxicity to tumor cells of 3,5-diprenyl-4-hydroxycinnamic acid (artepillin C) isolated from propolis. Anticancer Res 1997;17:3565-3568.
38. Gryfe R, Swallow C, Bapat B, Redston M, Gallinger S, Couture J. Molecular biology of colorectal cancer. Curr Probl Cancer 1997;21:233-300.
39. Matsushime H, Quelle DE, Shurtleff SA, Shibuya M, Sherr CJ, Kato JY. D-type cyclin-dependent kinase activity in mammalian cells. Mol Cell Biol 1994;14:2066-2076.
40. Xiong Y, Menninger J, Beach D, Ward DC. Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins. Genomics 1992;13:575-584.
41. 1 phase progression: Cycling on cue. Cell 1994;79:551-555.
42. 1 control in mammalian cells. J Cell Sci Suppl 1994;18:69-73.