JP-8 jet fuel exposure and divided attention test performance in 1991 Gulf War veterans

Aviation Space and Environmental Medicine

Volumn 76, Issue 12, 2005, Pages 1136-1144

  Bell, Iris R ^a,b,c,d   Brooks, Audrey J ^c   Baldwin, Carol M ^a,b,c,e   Fernandez, Mercedes ^a,f   Figueredo, Aurelio J ^c   Witten, Mark L ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c University of Arizona   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e ARIZONA STATE UNIVERSITY   (United States)

^f Carlos Albizu University   (United States)

Author keywords

Divided attention; Dopamine; Environmental illness; Jet fuel; Persian Gulf syndrome; Sensitization

Indexed keywords

DOPAMINE; FUEL; GALAXOLIDE; PROPYLENE GLYCOL;

ADULT; ARTICLE; ATTENTION; CLINICAL ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; ENVIRONMENTAL EXPOSURE; FEMALE; HUMAN; MALE; PERSIAN GULF SYNDROME; PSYCHOLOGIC TEST; RESPONSE TIME; SENSITIZATION; SOLDIER; TASK PERFORMANCE;

ADULT; ANALYSIS OF VARIANCE; ATTENTION; CHI-SQUARE DISTRIBUTION; DOUBLE-BLIND METHOD; ENVIRONMENTAL EXPOSURE; FEMALE; HUMANS; HYDROCARBONS; LINEAR MODELS; MALE; PERSIAN GULF SYNDROME; REACTION TIME; TIME FACTORS; VETERANS;

EID: 28844432946     PISSN: 00956562     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (75)

1. Abdel-Rahman A, Abou-Donia S, El-Masry E, et al. Stress and combined exposure to low doses of pyridostigmine bromide, DEET, and permethrin produce neurochemical and neuropathological alterations in cerebral cortex, hippocampus, and cerebellum. J Toxicol Environ Health A 2004; 67:163-92.
2. Antelman SM. Time-dependent sensitization in animals: a possible model of multiple chemical sensitivity in humans. Toxicol Industr Health 1994; 10:335-42.
3. Antelman SM, Caggiula AR. Oscillation follows drug sensitization: implications. Crit Rev Neurobiol 1996; 10:101-17.
4. Antelman SM, Caggiula AR, Kocan D, et al. One experience with 'lower' or 'higher' intensity Stressors respectively enhances or diminishes responsiveness to haloperidol weeks later: implications for understanding drug variability. Brain Res 1991; 566:276-83.
5. Axelrod BN, Milner IB. Neuropsychological findings in a sample of Operation Desert Storm veterans. J Neuropsychiatry Clin Neurosci 1997; 9:23-8.
6. Baldwin CM, Houston FP, Podgornik MN, et al. Effects of aerosol-vapor JP-8 jet fuel on the functional observational battery, and learning and memory in the rat. Arch Environ Health 2001; 56:216-26.
7. Bell IR, Baldwin CM, Russek LG, et al. Early life stress, negative paternal relationships, and chemical intolerance in middle-aged women: support for a neural sensitization model. J Women's Health 1998; 7:1135-47.
8. Bell IR, Baldwin CM, Stoltz E, et al. Concomitant environmental chemical intolerance modifies the neurobehavioral presentation of women with fibromyalgia. J Chron Fatigue Syndr 2001; 9:3-19.
9. Bell IR, Bootzin RR, Schwartz GE, et al. Differing patterns of cognitive dysfunction and heart rate reactivity in chemically-intolerant individuals with and without lifestyle changes. J Chron Fatigue Syndr 1999; 5:3-25.
10. Bell IR, Markley EJ, King DS, et al. Polysymptomatic syndromes and autonomic reactivity to nonfood stressors in individuals with self-reported adverse food reactions. J Am Coll Nutrition 1993; 12:227-38.
11. Bell IR, Miller CS, Schwartz GE, et al. Neuropsychiatric and somatic characteristics of young adults with and without self-reported chemical odor intolerance and chemical sensitivity. Arch Environ Health 1996; 51:9-21.
12. Bell IR, Schwartz GE, Hardin EE, et al. Differential resting qEEG alpha patterns in women with environmental chemical intolerance, depressives, and normals. Biol Psychiatry 1998; 43:376-88.
13. Bell IR, Schwartz GE, Peterson JM, Amend D. Self-reported illness from chemical odors in young adults without clinical syndromes or occupational exposures. Arch Environ Health 1993; 48:6-13.
14. Bell IR, Schwartz GE, Peterson JM, et al. Possible time-dependent sensitization to xenobiotics: self-reported illness from chemical odors, foods, and opiate drugs in an older adult population. Arch Environ Health 1993; 48:315-27.
15. Bell IR, Warg-Damiani L, Baldwin CM, et al. Self-reported chemical sensitivity and wartime chemical exposures in Gulf War veterans with and without decreased global health ratings. Mil Med 1998; 163:725-32.
16. Bell IR, Wyatt JK, Bootzin RR, Schwartz GE. Slowed reaction time performance on a divided attention task in elderly with environmental chemical odor intolerance. Int J Neurosci 1996; 84:127-34.
17. Binder LM, Storzbach D, Campbell KA, et al. Neurobehavioral deficits associated with chronic fatigue syndrome in veterans with Gulf War unexplained illnesses. J Int Neuropsychol Soc 2001; 7:835-9.
18. Black DW, Doebbeling BN, Voelker MD, et al. Quality of life and health-services utilization in a population-based sample of military personnel reporting multiple chemical sensitivities. J Occup Environ Med 1999; 41:928-33.
19. Black DW, Doebbeling BN, Voelker MD, et al. Multiple chemical sensitivity syndrome: symptom prevalence and risk factors in a military population. Arch Intern Med 2000; 160:1169-76.
20. Bourdette DN, McCauley LA, Barkhuizen A, et al. Symptom factor analysis, clinical findings, and functional status in a population-based case control study of Gulf War unexplained illness. J Occup Environ Med 2001; 43:1026-40.
21. Brantley PJ, Dietz LS, McKnight GT, et al. Convergence between the Daily Stress Inventory and endocrine measures of stress. J Consult Clin Psychol 1988; 56:549-51.
22. Brantley PJ, Waggoner CD, Jones GN, Rappaport NB. A Daily Stress Inventory: development, reliability, and validity. J Behav Med 1987; 10:61-74.
23. Bryk AS, Raudenbush SW. Hierarchichal linear models: applications and data analysis. Newbury Park, CA: Sage; 1992.
24. Bunegin L, Mitzel HC, Miller CS, et al. Cognitive performance and cerebrohemodynamics associated with the Persian Gulf Syndrome. Toxicol Industr Health 2001; 17:128-37.
25. Caggiula AR, Antelman SM, Kucinski BJ, et al. Oscillatory-sensitization model of repeated drug exposure: cocaine's effects on shock-induced hypoalgesia. Prog Neuro-Psychopharm Biol Psychiatry 1998; 22:511-21.
26. Caggiula AR, Antelman SM, Palmer AM, et al. The effects of ethanol on striatal dopamine and frontal cortical D-[3H]aspartate efflux oscillate with repeated treatment. Relevance to individual differences in drug responsiveness. Neuropsychopharmacol 1996; 15:125-32.
27. Coull JT. Neural correlates of attention and arousal: insights from electrophysiology, functional neuroimaging and psychopharmacology. Prog Neurobiol 1998; 55:343-61.
28. DeLuca J, Johnson SK, Ellis SP, Natelson BH. Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease. J Neurol Neurosurg Psychiatry 1997; 62:151-5.
29. Drake CL, Roehrs TA, Royer H, et al. Effects of an experimentally induced rhinovirus cold on sleep, performance and daytime alertness. Physiol Behav 2000; 71:75-81.
30. Eisen SA, Kang HK, Murphy FM, et al. Gulf War veterans' health: medical evaluation of a U.S. cohort. Ann Intern Med 2005; 142:881-90.
31. Ferger B, Kuschinsky K. Effects of cocaine on the EEG power spectrum of rats are significantly altered after its repeated administration: do they reflect sensitization phenomena? Naunyn-Schmeideberg's Arch Pharm 1996; 353:545-51.
32. Fernandez M, Bell IR, Schwartz GE. EEG sensitization during chemical exposure in women with and without chemical sensitivity of unknown etiology. Toxicol Ind Health 1999; 15:305-12.
33. Fiedler N, Giardino N, Natelson B, et al. Responses to controlled diesel vapor exposure among chemically sensitive Gulf War veterans. Psychosom Med 2004; 66:588-98.
34. Fiedler N, Kipen HM, DeLuca J, et al. A controlled comparison of multiple chemical sensitivities and chronic fatigue syndrome. Psychosom Med 1996; 58:38-49.
35. Fukuda K, Nisenbaum R, Stewart G, et al. Chrome multisymptom illness affecting Air Force veterans of the Gulf War. JAMA 1998; 280:981-8.
36. Granon S, Passetti F, Thomas KL, et al. Enhanced and impaired attentional performance after infusion of D1 dopaminergic receptor agents into rat prefrontal cortex. J Neurosci 2000; 20:1208-15.
37. Haley RW, Billecke S, La Du BN. Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans. Toxicol Appl Pharmacol 1999; 157:227-33.
38. Haley RW, Fleckenstein JL, Marshall WW, et al. Effect of basal ganglia injury on central dopamine activity in Gulf War syndrome: correlation of proton magnetic resonance spectroscopy and plasma homovanillic acid levels. Arch Neurol 2000; 57:1280-5.
39. Haley RW, Hom J, Roland PS, et al. Evaluation of neurologic function in Gulf War veterans. A blinded case-control study. JAMA 1997; 277:223-30.
40. Haley RW, Kurt TL. Self-reported exposure to neurotoxic chemical combinations in the Gulf War. A cross-sectional epidemiologic study. JAMA 1997; 277:231-7.
41. Iudice A, Bonanni E, Gelli A, et al. Effects of prolonged wakefulness combined with alcohol and hands-free cell phone divided attention tasks on simulated driving. Hum Psychopharmacol 2005; 20:125-32.
42. Kane RL, Gantz NM, DiPino RK. Neuropsychological and psychological functioning in chronic fatigue syndrome. Neuropsychiatry Neuropsychol Behav Neurol 1997; 10:25-31.
43. Kang HK, Bullman TA. Mortality among U.S. veterans of the Persian Gulf War. N Engl J Med 1996; 335:1498-504.
44. Kang HK, Natelson BH, Mahan CM, et al. Post-traumatic stress disorder and chronic fatigue syndrome-like illness among Gulf War veterans: a population-based survey of 30,000 veterans. Am J Epidemiol 2003; 157:141-8.
45. Kucinski BJ, Antelman SM, Caggiula AR, et al. Oscillatory effects of repeated morphine on shock-induced hypoalgesia and beta-endorphin. Synapse 1998; 30:30-7.
46. Lange G, Tiersky LA, Scharer JB, et al. Cognitive functioning in Gulf War Illness. J Clin Exp Neuropsychol 2001; 23:240-9.
47. Lezak MD. Neuropsychological assessment, 3rd ed. New York: Oxford University Press; 1995.
48. Malt EA, Olafsson S, Aakvaag A, et al. Altered dopamine D2 receptor function in fibromyalgia patients: a neuroendocrine study with buspirone in women with fibromyalgia compared to female population based controls. J Affect Disord 2003; 75:77-82.
49. Menon PM, Nasrallah HA, Reeves RR, Ali JA. Hippocampal dysfunction in Gulf War Syndrome. A proton MR spectroscopy study. Brain Res 2004; 1009:189-94.
50. Miller CS, Prihoda TJ. The Environmental Exposure and Sensitivity Inventory (EESI): a standardized approach for measuring chemical intolerances for research and clinical applications. Toxicol Industr Health 1999; 15:370-85.
51. Miller CS, Prihoda TJ. A controlled comparison of symptoms and chemical intolerances reported by Gulf War veterans, implant recipients and persons with multiple chemical sensitivity. Toxicol Industr Health 1999; 15:386-97.
52. Mills KC, Spruill SE, Kanne RW, et al. The influence of stimulants, sedatives, and fatigue on tunnel vision: risk factors for driving and piloting. Hum Factors 2001; 43:310-27.
53. Nezlek JB. Multilevel random coefficient analyses of event- and interval-contingent data in social and personality psychology research. PSPB 2001; 27:771-85.
54. Nyenhuis DL, Yamamoto C, Luchetta T, et al. Adult and geriatric normative data and validation of the Profile of Mood States. J Clin Psychol 1999; 55:79-86.
55. Follet C, Natelson BH, Lange G, et al. Medical evaluation of Persian Gulf veterans with fatigue and/or chemical sensitivity. J Med 1998; 29:101-13.
56. Randolph T. Specific adaptation. Ann Allergy 1978; 40:333-45.
57. Research Advisory Committee on Gulf War Veterans' Illnesses. Scientific progress in understanding Gulf War veterans' illnesses: report and recommendations. Washington, DC: Department of Veterans Affairs; 2004.
58. Ritchie GD, Rossi J 3rd, Nordholm AF, et al. Effects of repeated exposure to JP-8 jet fuel vapor on learning of simple and difficult operant tasks by rats. J Toxicol Environ Health Part A 2001; 64:385-415.
59. Roehrs T, Burduvali E, Bonahoom A, et al. Ethanol and sleep loss: a "dose" comparison of impairing effects. Sleep 2003; 26:981-5.
60. Ross S, Fantie B, Straus SF, Grafman J. Divided attention deficits in patients with chronic fatigue syndrome. Appl Neuropsychol 2001; 8:4-11.
61. Rossi J 3rd, Nordholm AF, Carpenter RL, et al. Effects of repeated exposure of rats to JP-5 or JP-8 jet fuel vapor on neurobehavioral capacity and neurotransmitter levels. J Toxicol Environ Health Part A 2001; 63:397-428.
62. Servatius RJ, Tapp WN, Bergen MT, et al. Impaired associative learning in chronic fatigue syndrome. NeuroReport 1998; 9:1153-7.
63. Sillanpaa MC, Agar LM, Milner IB, et al. Gulf War veterans: a neuropsychological examination. J Clin Exp Neuropsychol 1997; 19:211-9.
64. Slotkoff AT, Radulovic DA, Clauw DJ. The relationship between fibromyalgia and the multiple chemical sensitivity syndrome. Scand J Rheumatol 1997; 26:364-7.
65. Sorg BA. Mesocorticolimbic dopamine systems: cross-sensitization between stress and cocaine. Ann NY Acad Sci 1992; 654:136-44.
66. Sorg B, Bailie T, Tschirgi M, et al. Exposure to repeated low-level formaldehyde in rats increases basal corticosterone levels and enhances the corticosterone response to subsequent formaldehyde. Brain Res 2001; 898:314-20.
67. Sorg B, Tschirgi M, Swindell S, et al. Repeated formaldehyde effects in an animal model for multiple chemical sensitivity. Ann N Y Acad Sci 2001; 933:57-67.
68. Sorg BA, Willis JR, See RE, et al. Repeated low-level formaldehyde exposure produces cross-sensitization to cocaine: possible relevance to chemical sensitivity in humans. Neuropsychopharmacol 1998; 18:385-94.
69. Stahl D, Ferger B, Kuschinsky K. Sensitization to d-amphetamine after its repeated administration: evidence in EEG and behaviour. Naunyn-Schmiedebergs Arch Pharmacol 1997; 356:335-40.
70. Steketee JD, Sorg BA, Kalivas PW. The role of the nucleus accumbens in sensitization to drugs of abuse. Prog Neuropsychopharmacol Biol Psychiatry 1992; 16:237-46.
71. Szarek MJ, Bell IR, Schwartz GE. Validation of a brief screening measure of environmental chemical sensitivity: the chemical odor intolerance index. J Environ Psychol 1997; 17:345-51.
72. Uttl B. North American Adult Reading Test: age norms, reliability, and validity. J Clin Exp Neuropsychol 2002; 24:1123-37.
73. Vanderschuren LJ, Kalivas PW. Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization: a critical review of preclinical studies. Psychopharmacology 2000; 151:99-120.
74. von Euler G, Ogren S, Eneroth P, et al. Persistent effects of 80 ppm toluene on dopamine-regulated locomotor activity and prolactin secretion in the male rat. Neurotoxicology 1994; 15:621-4.
75. von Euler G, Ogren SO, Li XM, et al. Persistent effects of subchronic toluene exposure on spatial learning and memory, dopamine-mediated locomotor activity, and dopamine D2 agonist binding in the rat. Toxicology 1993; 77:223-32.