Differing patterns of cognitive dysfunction and heart rate reactivity in chemically-intolerant individuals with and without lifestyle changes

Journal of Chronic Fatigue Syndrome

Volumn 5, Issue 2, 1999, Pages 3-25

  Bell, Iris R ^a,b   Bootzin, Richard R ^a   Schwartz, Gary E R ^a   Baldwin, Carol M ^a   Ballesteros, Faith ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b SOUTHERN ARIZONA VA HEALTH CARE SYSTEM   (United States)

Author keywords

Chemical intolerance; Divided attention; Family alcoholism; Heart rate; Hypertension; Multiple chemical sensitivity; Neural sensitization; Visual memory

Indexed keywords

ARTICLE; CARDIOVASCULAR RESPONSE; COGNITIVE DEFECT; FAMILY HISTORY; HEART RATE VARIABILITY; HUMAN; HYPERTENSION; LIFESTYLE; MULTIPLE CHEMICAL SENSITIVITY; PATTERN RECOGNITION; PSYCHOLOGICAL ASPECT; SENSITIZATION; VISUAL MEMORY;

EID: 0033023756     PISSN: 10573321     EISSN: None     Source Type: Journal    
DOI: 10.1300/J092v05n02_02     Document Type: Article

References (81)

1. Bell IR, Miller CS, Schwartz GE, Peterson JM, Amend D. Neuropsychiatric and somatic characteristics of young adults with and without self-reported chemical odor intolerance and chemical sensitivity. Arch Environ Health 1996; 51:9-21.
2. Ryan CM, Morrow LA, Hodgson M. Cacosmia and neurobehavioral dysfunction associated with occupational exposure to mixtures of organic solvents. Am J Psychiatry 1988; 145:1442-1445.
3. Fiedler N, Kipen HM, DeLuca J, Kelly-McNeil K, Natelson B. A controlled comparison of multiple chemical sensitivities and chronic fatigue syndrome. Psychosom Med 1996; 58:38-49.
4. Buchwald D, Garrity D. Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities. Arch Internal Med 1994; 154: 2049-2053.
5. Slotkoff AT, Radulovic DA, Clauw DJ. The relationship between fibromyalgia and the multiple chemical sensitivity syndrome. Scand J Rheumatol 1997; 26:364-367.
6. Miller CS. Chemical sensitivity: symptom, syndrome, or mechanism for disease? Toxicology 1996; 111:69-86.
7. Fiedler N, Kipen H, Natelson B, Ottenweller J. Chemical sensitivities and the Gulf War: Department of Veterans Affairs Research Center in basic and clinical science studies of environmental hazards. Regulat Toxicol Pharmacol 1996; 24:S129-S138.
8. Bell IR, Warg-Damiani L, Baldwin CM, Walsh M, Schwartz GE. Self-reported chemical sensitivity and wartime chemical exposures in Gulf War veterans with and without decreased global health ratings. Military Medicine 1998; in press.
9. Meggs WJ, Dunn KA, Bloch RM, Goodman PE, Davidoff AL. Prevalence and nature of allergy and chemical sensitivity in a general population. Arch Environ Health 1996; 51:275-282.
10. Bell IR, Schwartz GE, Amend D, Peterson JM, Stini WA. Sensitization to early life stress and response to chemical odors in older adults. Biol Psychiatry 1994; 35:857-863.
11. Kreutzer R, Neutra RR, Lashuay N. The prevalence of people reporting sensitivities to chemicals in a population based survey. Am J Epidemiology 1998; in press.
12. Bell IR, Baldwin CM, Schwartz GE. Illness from low levels of environmental chemicals: relevance to chronic fatigue syndrome and fibromyalgia. Am J Med (Suppl) 1998: 105(3A):74S-82S.
13. Wallace L, Nelson CJ, Kollander M, Leaderer B, Bascom R, Dunteman G. Indoor air quality and work environment study. Multivariate Statistical analysis of health, comfort, and odor perceptions as related to personal and workplace characteristics. US Environmental Protection Agency vol. 4, EPA Headquarters Buildings. Atmospheric Research and Exposure Assessment Laboratory, June 1991 (21M-3004).
14. Morrow LA, Ryan CM, Hodgson MJ, Robin N. Alterations in cognitive and psychological functioning after organic solvent exposure. J Occup Med 1990; 32: 444-450.
15. Fiedler N, Kipen H. Chemical sensitivity: the scientific literature. Env Health Perspect 1997; 105(suppl 2):409-415.
16. Fiedler N, Kipen H, DeLuca J, Kelly-McNeil K, Natelson B. Neuropsychology and psychology of MCS. Toxicol Industr Health 1994; 10:545-554.
17. Bell IR, Wyatt JK, Bootzin RR, Schwartz GE. Slowed reaction time performance on a divided attention task in elderly with environmental chemical odor intolerance. Int J Neurosci 1995; 84:127-134.
18. Simon GE, Daniell W, Stockbridge H, Claypoole K, Rosenstock L. Immunologic, psychological, and neuropsychological factors In multiple chemical sensitivity. A controlled study. Ann Internal Med 1993; 19:97-103.
19. Bell IR, Bootzin RR, Ritenbaugh C, Wyatt JK, DeGiovanni G, Kulinovich T, Anthony JL, Kuo TF, Rider SP, Peterson JM, Schwartz GE, Johnson KA. A polysomnographic study of sleep disturbance in community elderly with self-reported environmental chemical odor intolerance. Biol Psychiatry 1996; 40:123-133.
20. Bell IR, Bootzin RR, Davis T, Hau V, Ritenbaugh C, Johnson KA, Schwartz GE, Time-dependent sensitization of plasma beta-endorphin in community elderly with self-reported environmental chemical odor intolerance. Biol Psychiatry 1996; 40:134-143.
21. Bell IR, Schwartz GE, Bootzin RR, Wyatt JK. Time-dependent sensitization of heart rate and blood pressure over multiple laboratory sessions in elderly individuals with chemical odor intolerance. Arch Environ Health 1997; 52:6-17.
22. Bell IR, Schwartz GE, Baldwin CM, Hardin EE, Kline JP. Differential resting qEEG alpha patterns in women with environmental chemical intolerance, depressives, and normals. Biological Psychiatry 1998; 43(5):376-388.
23. Bell IR, Kline, JP, Schwartz GE, Peterson JM. Quantitative EEG patterns during nose versus mouth inhalation of filtered room air in young adults with and without self-reported chemical odor intolerance. Int J Psychophysiol 1998; 28:23-35.
24. Bell IR, Patarca R, Baldwin CM, Klimas NG, Schwartz GE, Hardin EE. Serum neopterin and somatization in women with chemical intolerance, depressives, and normals. Neuropsychobiology 1998; 38:13-18.
25. Doty RL, Deems DA, Frye RE, Pelberg R, Shapiro A. Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities. Arch Otolaryngol Head Neck Surg 1988; 114:1422-1427.
26. Meggs WJ, Elsheik T, Metzger WJ, Albernaz M, Bloch RM. Nasal pathology and ultrastructure in patients with chronic airway inflammation (RADS and RUDS) following an irritant exposure. J Toxicol Clin Toxicol 1996; 34:383-396.
27. Bell IR, Walsh ME, Goss A, Gersmeyer J, Schwartz GE, Kanof P. Cognitive dysfunction and disability in geriatric veterans with self-reported intolerance to environmental chemicals. J Chronic Fatigue Syndrome 1997; 3:15-42.
28. Ashford NA, Miller CS. Chemical Exposures. Low Levels and High Stakes, 2nd ed. NY: Van Nostrand Reinhold, 1998.
29. Miller CS. Chemical sensitivity: history and phenomenology. Toxicol Industr Health 1994; 10:253-276.
30. Sparks PJ, Daniell W, Black DW, Kipen HM, Altman LC, Simon GE, Terr AI. Multiple chemical sensitivity syndrome: a clinical perspective. I. Case definition, theories of pathogenesis, and research needs, J Occup Med 1994; 36:718-730.
31. Miller CS, Mitzel HC. Chemical sensitivity attributed to pesticide exposure versus remodeling. Arch Environ Health 1995; 50:119-129.
32. Cullen MR. The worker with multiple chemical sensitivities: an overview. In MR Cullen (ed): Occupational Medicine: State of the Art Reviews, Philadelphia: Hanley and Belfus, 1987; 655-662.
33. Simon GE, Katon WJ, Sparks PJ. Allergic to life: psychological factors in environmental illness. Am J Psychiatry 1990; 147:901-906.
34. Bell IR, Peterson JM, Schwartz GE. Medical histories and psychological profiles of middle-aged women with and without self-reported illness from environmental chemicals. J Clin Psychiatry 1995; 56: 151-160.
35. Aaron LA, Bradley LA, Alarcon GS, Alexander RW, Triana-Alexander M, Martin MY, Alberts KR. Psychiatric diagnoses in patients with fibromyalgia are related to health care-seeking behavior rather than to illness. Arth Rheum 1996; 39:436-445.
36. DeLuca J, Johnson SK, Ellis SP, Natelson BH. Cognitive functioning is impaired in patients with chronic fatigue syndrome devoid of psychiatric disease. J Neurol Neurosurg Psychiatry 1997; 62:151-155.
37. Bell IR, Miller CS, Schwartz GE. An olfactory-limbic model of multiple chemical sensitivity syndrome: possible relationship to kindling and affective spectrum disorders. Biol Psychiatry 1992; 32:218-242.
38. Bell IR. Neuropsychiatric aspects of sensitivity to low level chemicals: a neural sensitization model. Toxicol Indust Health 1994; 10:277-312.
39. Antelman SM. Time-dependent sensitization in animals: a possible model of multiple chemical sensitivity in humans. Toxicol Industr Health 1994; 10:335-342.
40. Antelman SM. Time-dependent sensitization as the cornerstone for a new approach to pharmacotherapy: drugs as foreign/stressful stimuli. Drug Devel Res 1988; 14:1-30.
41. Kalivas PW, Sorg BA, Hooks MS. The pharmacology and neural circuitry of sensitization to psychostimulants. Behav Pharmacol 1993; 4:315-334.
42. Antelman SM, Kocan D, Knopf S. One brief exposure to a psychological Stressor induces long-lasting, time-dependent sensitization of both the cataleptic and neurochemical responses to haloperidol. Life Sci 1992; 51:261-266.
43. Bell IR, Hardin E, Baldwin CM, Schwartz GE. Increased limbic system symptomatology and sensitizability of young adults with chemical and noise sensitivities. Environ Res 1995; 70:84-97.
44. Bell IR, Baldwin CM, Fernandez M, Schwartz GER. Paternal alcoholism in multiple chemical sensitivity: a genetic link with the biology of neural sensitization? Submitted for publication.
45. Bell IR, Szarek MJ, DiCenso DR, Baldwin CM, Schwartz GE, Bootzin RR. Patterns of waking EEG spectral power in chemically intolerant individuals during repeated chemical exposures. Submitted for publication.
46. Fernandez M. EEG Measures of Subjects with Idiopathic Chemical Sensitivity: A Test of the Sensitization Model. Ph.D. dissertation in the Dept. of Psychology, The University of Arizona, 1998.
47. Szarek MJ, Bell IR, Schwartz GE. Validation of a brief screening measure of environmental chemical sensitivity: the chemical odor intolerance index. J Environ Psychol 1997; 17(4):345-351.
48. Ewing JA. Detecting alcoholism: the CAGE questionnaire. JAMA 1984; 252:1905-1907.
49. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23:56-62.
50. Maier W, Buller R, Philipp M, Heuser I. The Hamilton Anxiety Scale: reliability, validity, and sensitivity to change in anxiety and depressive disorders. J Affective Disord 1988; 14:61-68.
51. Cain WS, Gent JF, Goodspeed RB, Leonard G. Evaluation of olfactory dysfunction in the Connecticut Chemosensory Clinical Research Center. Laryngoscope 1988; 98:83-88.
52. Teicher MH, Glod CA, Surrey J, Swett C. Early childhood abuse and limbic system ratings in adult psychiatric outpatients. J Neuropsychiatry Clin Neurosci 1993; 5:301-306.
53. Cheek JM, Buss AH. Shyness and sociability. J Personality Soc Psychol 1981; 41:330-339.
54. Barsky AJ, Goodson JD, Lane RS, Cleary PD. The amplification of somatic symptoms. Psychosom Med 1988; 50:510-519.
55. Reiss S, Peterson RA, Gursky DM, McNally RJ. Anxiety sensitivity, anxiety frequency, and the predictions of fearfulness. Behav Res Ther 1986; 24:1-8.
56. Heller RF, Heller RF. The Carbohydrate Addict's Diet. NY: Signet, 1991.
57. Bell IR, Bootzin RR, DiCenso DR, Szarek MJ, Baldwin CM, Schwartz GE. Objective sleep disturbance in chemically-intolerant individuals with associated lifestyle changes. Submitted for publication.
58. Retzlaff PD, Morris GL. Event-related potentials during the Continuous Visual Memory Test. J Clin Psychol 1996; 52:43-47.
59. Roehrs T, Zwyhuizen-Doorenbos A, Roth T. Sedative effects and plasma concentrations following single doses of triazolam, diphenhydramine, ethanol, and placebo. Sleep 1993; 16:301-305.
60. Yehuda R, Antelman SM. Criteria for rationally evaluating animal models of posttraumatic stress disorder. Biol Psychiatry 1993; 33:479-486.
61. Bell IR, Baldwin CM, Russek LG, Schwartz GE, Hardin EE. Early life stress, negative paternal relationships, and current chemical odor intolerance in middle-aged women: support for a neural sensitization model. J Women's Health 1998; in press.
62. Rueckert L, Grafman J. Sustained attention deficits in patients with right frontal lesions. Neuropsychologia 1996; 34:953-963.
63. Lezak MD. Neuropsychological Assessment. 3rd edition. NY: Oxford; 1995.
64. Fink GR, Halligan PW, Marshall JC, Frith CD, Frackowiak RSJ, Dolan RJ. Where in the brain does visual attention select the forest and the trees? Nature 1996; 382:626-628.
65. Chen HC, Schultz AB, Ashton-Miller JA, Giordani B, Alexander NB, Guire KE. Stepping over obstacles: dividing attention impairs performance of old more than young adults. J Gerontology (Med Sci) 1996; 51A:M116-M122.
66. Baldwin CM, Bell IR. Increased cardiopulmonary disease risk in a community-based sample with chemical odor intolerance: implications for women's health and health care utilization. Arch Environ Health 1998; 53: 347-353.
67. Harden PW, Pihl RO. Cognitive function, cardiovascular reactivity, and behavior in boys at high risk for alcoholism. J Abn Psychology 1995; 104:94-103.
68. Peterson JB, Finn PR, Pihl RO. Cognitive dysfunction and the inherited predisposition to alcoholism. J Stud Alcohol 1992; 53:154-160.
69. Russell V, de Villiers A, Sagvolden T, Lamm M, Taljaard J. Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of Attention-Deficit Hyperactivity Disorder-the spontaneously hypertensive rat. Brain Res 1995; 676:343-351.
70. Johnson SK, DeLuca J, Natelson BH. Assessing somatization disorder in the chronic fatigue syndrome. Psychosom Med 1996; 58:50-57.
71. Bell IR. Somatization disorder: health care costs in the decade of the brain. Biol Psychiatry 1994; 35:81-83.
72. Morrison JR, Stewart MA. A family study of the hyperactive child syndrome. Biol Psychiatry 1971; 3:189-195.
73. Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism. Science 1987; 236:410-416.
74. Bohman M, Cloninger CR, von Knorring AL, Sigvardsson S. An adoption study of somatoform disorders. III. Cross-fostering analysis and genetic relationship to alcoholism and criminality. Arch Gen Psychiatry 1984; 41(9):872-8.
75. Hill SY, Smith TR. Evidence for genetic mediation of alcoholism in women. J Substance Abuse 1991; 3:159-174.
76. Ito Y, Teicher MH, Glod CA, Harper D, Magnus E, Gelbard HA. Increased prevalence of electrophysiological abnormalities in children with psychological, physical, and sexual abuse. J Neuropsychiatry Clin Neurosci 1993; 5:401-408.
77. Robinson TE, Berridge KC. The neural basis of drug craving: an incentivesensitization theory of addiction. Brain Res Rev 1993; 18:247-291.
78. Newlin DB, Thomson JB. Chronic tolerance and sensitization to alcohol in sons of alcoholics. Alc Clin Exp Res 1991; 15:399-405.
79. Ferger B, Stahl D, Kuschinsky K. Effects of cocaine on the EEG power spectrum of rats are significantly altered after its repeated administration: do they reflect sensitization phenomena? Naunyn-Schmied Arch Pharmaco. 1996; 353:545-551.
80. Ehlers C, Phillips E, Parry BL. Electrophysiological findings during the menstrual cycle in women with and without late luteal phase dysphoric disorder: relationship to risk for alcoholism? Biol Psychiatry 1996; 39:720-732.
81. Ehlers CL, Schuckit MA. Evaluation of EEG alpha activity in sons of alcoholics. Neuropsychopharmacology 1991; 4:199-205.