Hippocampal dysfunction in Gulf War Syndrome. A proton MR spectroscopy study

Brain Research

Volumn 1009, Issue 1-2, 2004, Pages 189-194

  Menon, P Mohanakrishnan ^a,b   Nasrallah, Henry A ^c   Reeves, Roy R ^a,b   Ali, Jeffrey A ^a  

^a UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF CINCINNATI MEDICAL CENTER   (United States)

Author keywords

Axonal neuronal impairment; Gulf War Syndrome; Hippocampus; N Acetyl aspartate; Neurotoxicity; Proton MRS

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID;

ADULT; ARTICLE; BRAIN DYSFUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; FEMALE; HEMISPHERIC DOMINANCE; HIPPOCAMPUS; HUMAN; MALE; NEUROPATHOLOGY; NEUROTOXICITY; PERSIAN GULF SYNDROME; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SOLDIER;

ADULT; ANALYSIS OF VARIANCE; ASPARTIC ACID; BRAIN CHEMISTRY; CHOLINE; CREATINE; DOMINANCE, CEREBRAL; FEMALE; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PERSIAN GULF SYNDROME; VETERANS;

EID: 2142762959     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.02.063     Document Type: Article

References (29)

1. Abdel-Rehman A., Shetty A.K., Abou-Donia M.B. Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, thalamus and hypothalamus in rat model of Gulf-War syndrome. Neurobiol. Dis. 10:2002;306-326
2. Abou-Donia M.B., Wilmarth K.R., Jensen K.F., Oehme F.W., Kurt T.L. Neurotoxicity resulting from coexposure to pyridostigmine bromide, DEET, and permethrin: implications of Gulf War chemical exposures. J. Toxicol. Environ. Health. 48:1996;35-56
3. Amato A.A., McVey A., Cha C., Mathews E.C., Jackson C.E., Kleingunther R., Worley L., Cornman E., Kagan-Hallet K. Evaluation of neuromuscular symptoms in veterans of the Persian Gulf War. Neurology. 48:1997;4-12
4. P.A. Bottomley, Spatial localization in NMR spectroscopy in vivo. Ann N.Y. Acad. Sci. 508 (1987) 333-348. U.S. Patent. 4 480 228 (1984).
5. P.A. Bottomley, Spatial localization in NMR spectroscopy in vivo. Ann N.Y. Acad. Sci. 508 (1987) 333-348. U.S. Patent. 4 480 228 (1984).
6. Frost S.D. Gulf War syndrome: proposed causes. Clevel. Clin. J. Med. 67:2000;17-20. (and references 5-8)
7. Haley R.W., Kurt T.M. Self-reported exposure to neurotoxic chemical combinations in the Gulf War. A cross-sectional epidemiologic study. JAMA. 277:1997;231-238
8. Haley R.W., Kurt T.L., Hom J. Is there a Gulf War Syndrome? Searching for syndromes by factor analysis by symptoms. JAMA. 277:1997;215-222
9. Haley R.W., Hom J., Roland P.S., Bryan W.W., Van Ness P.C., Bonte F.J., Devous M.D. Sr., Mathews D., Fleckenstein J.D., Wians F.H. Jr., Wolfe G.I., Kurt T.L. Evaluation of neurologic function in Gulf War veterans: a blinded case-control study. JAMA. 277:1997;223-230
10. Haley R.W., Billecke S., La Du B.N. Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans. Toxicol. Appl. Pharmacol. 157:1999;227-233
11. 1H MR spectroscopy. Radiology. 215:2000;807-817
12. Hoffman L., Slotboom J., Jung B., Maloca P., Boesch C., Kreis R. Quantitative 1H-magnetic resonance spectroscopy of human brain: influence of composition and parameterization of the basis set in linear combination model-fitting. Magn. Reson. Med. 40:2002;440-453
13. Huang Y.P., Okudera T. Arterial supply to the hippocampal formation. Neuroimaging Clin. N. Am. 7:1997;31-50
14. The Iowa Persian Gulf Study Group Self-reported illness and health status among Gulf War veterans. JAMA. 277:1997;238-245
15. Kipen H.M., Hallman W., Kang H., Natelson B.H. Prevalence of chronic fatigue and chemical sensitivities in Gulf Registry veterans. Arch. Environ. Health. 54:1999;313-318. (See also, W.J. Meggs, Gulf War syndrome, chronic fatigue syndrome, and the multiple chemical sensitivity syndrome: Stirring the cauldron of confusion. Am. J. Epidemiol. 54 (1999) 309-311)
16. Kurt T.L. Epidemiological association in US veterans between Gulf War illness and exposures to anticholinesterases. Toxicol. Lett. 102-103:1998;523-526
17. La Du B.N., Billecke S., Hsu C., Haley R.W., Broomfield C.A. Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals. Drug Metab. Dispos. 29:2001;566-569
18. Loscher C.E., Donnelly S., Mills K.H., Lynch M.A. Interlwukin-1 beta-dependent changes in the hippocampus following parenteral immunizations with a whole cell pertussis vaccine. J. Neuroimmunol. 111:2000;68-76
19. Nicolson G.L., Nicolson N.L. Chronic fatigue illness and operation desert storm. J. Occup. Environ. Med. 38:1996;14-16
20. Nicolson G.L., Nasralla M., Haier J., Nicolson N.L. Gulf War illnesses: role of chemical, biological and radiological exposures. Tapamainen H. War and Health. 2002;431-446 Zed Press, Helsinki
21. Parker A.J.R., Wessely S., Cleare A.J. The neuroendochrinology of chronic fatigue syndrome and fibromyalgia. Psychol. Med. 31:2001;1331-1345
22. Plapp F.W. Jr. Permethrin and the Gulf War Syndrome. Arch. Environ. Health. 54:1999;312
23. Provencher S.W. Estimation of metabolite concentration from localized in vivo proton NMR spectra. Magn. Reson. Med. 30:1993;672-679
24. Spencer P.S., McCauley L.A., Joos S.K., Lasarev M.R., Schuell T., Bourdette D., Barkhuisen A., Johnston W., Storabach D., Wynn M., Grewenow R. other members of the Portland Environmental Hazards Research Centre U.S. Gulf War veterans: service period in theater, differential exposures and persistent unexplained illness. Toxicol. Lett. 102-103:1998;515-521
25. Steele L. Prevalence and Patterns of Gulf War Illness in Kansas Veterans: association of symptoms with characteristics of person, place, and time of military service. Am. J. Epidemiol. 152:2000;992-1002
26. Tournie J.N., Jouan A., Mathieu J., Drouet E. Gulf War syndrome: could it be triggered by biological warfare-vaccines using pertussis as an adjuvant. Med. Hypotheses. 58:2002;291-292
27. van der Hart M.G.C., Czeh B., de Biurrun G., Watanabe T., Natt O., Frahm J., Fuchs E. Substance P receptor and clomipramine prevent stress-induced alterations in cerebral metabolites, cytpgenesis in dentate gyrus and hippocampal volume. Mol. Psychiatry. 7:2002;933-941
28. Van Haaren F., De Jongh R., Hoy J.B., Karix J.L., Schmidt C.J., Tebbett I.R., Wielbo D. The effects of acute and repeated pyridostigmine bromide administration on response acquisition with immediate and delayed reinforcement. Pharmacol. Biochem. Behav. 62:1999;389-394
29. Webb P.G., Sailasuta N., Kohler S.J., Raidy T., Moats R.A. Automated single-voxel proton MRS: technical development and multi-site verification. Magn. Reson. Med. 31:1994;363-373