Solid-phase syntheses of olefin-containing inhibitors for HTLV-1 protease using the Horner-Emmons reaction

Journal of Organic Chemistry

Volumn 70, Issue 25, 2005, Pages 10596-10599

  Bang, Jeong Kyu ^a   Naka, Hiromi ^a   Teruya, Kenta ^a   Aimoto, Saburo ^a   Konno, Hiroyuki ^b   Nosaka, Kazuto ^b   Tatsumi, Tadashi ^a   Akaji, Kenichi ^b  

^a OSAKA UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; OPTIMIZATION; REACTION KINETICS; SYNTHESIS (CHEMICAL);

HORNER-EMMONS REACTION; INHIBITORS; SCISSILE SITE; SOLID-PHASE SYNTHESIS;

OLEFINS;

2 (4 AMINO 6 METHYLHEPT 2 ENOYLAMINO) 3 INDOL 3 YLPROPANOIC ACID; 4 [(TERT BUTOXY)CARBONYLAMINO] 6 METHYLHEPT 2 ENOIC ACID; ALKENE DERIVATIVE; AMINO ACID DERIVATIVE; BASE; GAMMA AMINO ACID; GLUTAMINE; ISOLEUCINE; LEUCINE; LYSYLGLYCYLPROLYLPROLYLVALYLISOLEUCYLLEUCYLPROLYLISOLEUCINE; PEPTIDE DERIVATIVE; PEPTIDE LIBRARY; PROP 2 ENYL 2 [4 [(TERT BUTOXY)CARBONYLAMINO] 6 METHYLHEPT 2 ENOYLAMINO] 3 [1 [(TERT BUTYL)OXYCARBONYL]INDOL 3 YL]PROPANOATE; PROP 2 ENYL 4 [(TERT BUTOXY)CARBONYLAMINO] 6 METHYLHEPT 2 ENOATE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; DEPROTECTION REACTION; DRUG CONFORMATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORNER WADSWORTH EMMONS REACTION; HUMAN T CELL LEUKEMIA VIRUS 1; HYDROPHOBICITY; IC 50; ISOMER; ISOMERIZATION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; REPRODUCIBILITY; SOLID PHASE SYNTHESIS; STRUCTURE ANALYSIS; TECHNIQUE;

ALKENES; AMINO ACID SEQUENCE; COMBINATORIAL CHEMISTRY TECHNIQUES; HIV PROTEASE INHIBITORS; INHIBITORY CONCENTRATION 50; OLIGOPEPTIDES;

EID: 28744436883     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo051872s     Document Type: Article

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