Inhibition of phosphatidylinositol 3-kinase/protein kinase B signaling is not sufficient to account for indole-3-carbinol-induced apoptosis in some breast and prostate tumor cells

Clinical Cancer Research

Volumn 11, Issue 23, 2005, Pages 8521-8527

  Howells, Lynne M ^a   Hudson, E Ann ^a   Manson, Margaret M ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 3 INDOLEMETHANOL; EPIDERMAL GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL VIABILITY; DRUG EFFECT; ENZYME INHIBITION; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROSTATE TUMOR; TARGET CELL; TUMOR CELL CULTURE; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CHROMONES; DRUG COMBINATIONS; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOPRECIPITATION; INDOLES; MALE; MORPHOLINES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 28544449453     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-05-0348     Document Type: Article

References (39)

1. IARC, editor. Cruciferous vegetables, isothiocyanates and indoles. Vol. 9. IARC handbooks of cancer chemoprevention. Lyon: IARC Press; 2004.
2. Rosen CA, Woodson GE, Thompson JW, Hengesteg AP, Bradlow HL. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118: 810-5.
3. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynaecol Oncol 2000;78:123-9.
4. de Bilderling G, Bodart E, Lawson G, et al. Successful use of intralesional and intravenous cidofovir in association with indole-3-carbinol in and 8-year old girl with pulmonary papillomatosis. J Med Virol 2005;75: 332-5.
5. Yoshida M, Katashima S, Ando J, et al. Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism. Carcinogenesis 2004;25: 2257-64.
6. Howells LM, Gallacher-Horley B, Houghton CE, Manson MM, Hudson EA. Indole-3-carbinol inhibits protein kinase B/Akt and induces apoptosis in the human breast tumor cell line MDA MB468 but not in the nontumorigenic HBL100 line. Mol Cancer Ther 2002;1: 1161-72.
7. Chinni SR, Sarkar FH. Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells. Clin Cancer Res 2002;8:1228-36.
8. Rahman KMW, Li Y, Sarkar FH. Inactivation of Akt and NF-κB play important roles during indole-3-carbinol-induced apoptosis in breast cancer cells. Nutrition Cancer 2004;48:84-94.
9. Madrid LV, Wang C-Y, Guttridge DC, Schottelius AJG, Baldwin AS, Jr., Mayo MW. Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-κB. Mol Cell Biol 2000;20: 1626-38.
10. Pugazhenthi S, Nesterova A, Sable C, et al. Akt/protein kinase B upregulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 2000;275:10761-6.
11. Tang Y, Zhou H, Chen A, Pittman RN, Field J. The Akt proto-oncogene links Ras to Pak and cell survival signals. J Biol Chem 2000;275:9106-9.
12. Burow ME, Weldon CB, Melnik LI, et al. PI3-K/AKT regulation of NF-κB signaling events in suppression of TNF-induced apoptosis. Biochem Biophys Res Commun 2000;271:342-5.
13. Cross TG, Scheel-Toeller D, Henriquez NV, Deacon E, Salmon M, Lord JM. Serine/threonine protein kinases and apoptosis. Exp Cell Res 2000;256:34-41.
14. Toker A. Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol 2000;57: 652-8.
15. Datta SR, Brunet A, Greenberg ME. Cellular survival: a play in three Akts. Genes Development 1999;13: 2905-27.
16. Datta SR, Dudek H, Jao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231-41.
17. Stambolic V, Mak TW, Woodgett JR. Modulation of cellular apoptotic potential: contributions to oncogenesis. Oncogene 1999;18:6094-103.
18. Nakatani K, Thompson DA, Barthel, et al. Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines. J Biol Chem 1999;274:21528-32.
19. Sheng HM, Shao JY, DuBois RN. Akt/PKB activity is required for Ha-Ras-mediated transformation of intestinal epithelial cells. J Biol Chem 2001;276: 14498-504.
20. Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase-Akt pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
21. Moiseeva EP, Howells LM, Fox LH, Hudson EA, Manson MM. Transient activation of Src and EGFR may contribute to indole-3 carbinol-induced cell death in MDA-MB-468 breast cells. In: Seattle, Washington: Frontiers in Cancer Prevention Research; October 16-20. 2004. p. 123; B157.
22. Nachshon-Kedmi M, Yannai S, Haj A, Fares FA. Indole-3-carbinol and 3,3′-diindolylmethane induce apoptosis in human prostate cancer cells. Food Chem Toxicol 2003;41:745-52.
23. Rahman A, Aranha O, Sarkar FH. Indole-3-carbinol (I3C) induces apoptosis in tumorigenic but not in non-tumorigenic breast epithelial cells. Nutrition Cancer 2003;45:101-12.
24. Hudson EA, Dinh PA, Kokubun T, Simmonds MSJ, Gescher A. Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit the growth of human breast and colon cancer cells. Cancer Epidemiol Biomarkers Prev 2000;9:1163-70.
25. Squires MS, Hudson EA, Howelis L, et al. Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells. Biochem Pharmacol 2003; 65:361-76.
26. Hawkins PT, Anderson KE, Stephens LR. Signaling via phosphoinositide-3- kinases. Society for Endocrinology; 1998. Available from: http://www. endocrinology.org/sfe/training/mew99/mew_haw.htm.
27. Andjelkovic M, Alessi DR, Meier R, et al. Role of translocation in the activation and function of protein kinase B. J Biol Chem 1997;272:31515-24.
28. Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000;351: 95-105.
29. Pervin S, Singh R, Gau C-L, Edamatsu H, Tamanoi F, Chaudhuri G. Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer. Cancer Res 2001;61:4701-6.
30. Gibson S, Tu S, Oyer R, Anderson SM, Johnson GL. Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. J Biol Chem 1999; 274:17612-8.
31. Gibson EM, Henson ES, Haney N, Villanueva J, Gibson SB. Epidermal growth factor protects epithelial-derived cells from tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by inhibiting cytochrome c release. Cancer Res 2002; 62:488-96.
32. Leu C-M, Chang C, Hu C-P. Epidermal growth factor (EGF) suppresses staurosporine-induced apoptosis by inducing mcl-1 via the mitogen-activated protein kinase pathway. Oncogene 2000; 19:1665-75.
33. Fabregat I, Herrera B, Fernandez M, et al. Epidermal growth factor impairs the cytochrome c/caspase-3 apoptotic pathway induced by transforming growth factor à in rat fetal hepatocytes via a phosphoinositide 3-kinase dependent pathway. Hepatology 2000;32: 523-35.
34. Armstrong DK, Kaufmann SH, Ottaviano Y, et al. Epidermal growth factor-mediated apoptosis of MDA-MB-468 human breast cancer cells. Cancer Res 1994;54:5280-3.
35. Kottke TJ, Blajeski AL, Martins LM, et al. Comparison of paclitaxel-, 5-fluoro-2′-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. J Biol Chem 1999;274:15927-36.
36. Thomas T, Balabhadrapathruni S, Gardner CR, Hong J, Faaland CA, Thomas TJ. Effects of epidermal growth factor on MDA-MB-468 breast cancer cells: alterations in polyamine biosynthesis and the expression of p21/CIP1/WAF-1. J Cell Physiol 1999;179: 257-66.
37. 1 cell cycle arrest and inhibits prostate-specific antigen production in human LNCaP prostate carcinoma cells. Cancer 2003;98:2511-20.
38. Lin J, Adam RM, Santiestevan E, Freeman MR. The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 1999;59:2891-7.
39. Howells LM. Mechanisms of action of the chemopreventive agent indole-3-carbinol. PhD Thesis; University of Leicester: 2003.