BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene

Cancer Research

Volumn 65, Issue 22, 2005, Pages 10265-10272

  Kennedy, Richard D ^a   Gorski, Julia J ^a   Quinn, Jennifer E ^a   Stewart, Gail E ^a   James, Colin R ^a   Moore, Stephen ^d   Mulligan, Karl ^d   Emberley, Ethan D ^c   Lioe, Tong F ^b   Morrison, Patrick J ^b   Mullan, Paul B ^a   Reid, George ^e   Johnston, Patrick G ^a,b   Watson, Peter H ^c   Harkin, D Paul ^a,d  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b BELFAST CITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF MANITOBA   (Canada)

^d Arradx Ltd   (United Kingdom)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BRCA1 PROTEIN; CALCIUM BINDING PROTEIN; DNA; DNA TOPOISOMERASE (ATP HYDROLYSING); ETOPOSIDE; MYC PROTEIN; POISON; PSORIASIN; S100 A8 PROTEIN; S100 A9 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA DAMAGE; DRUG MECHANISM; ENZYME INDUCTION; GENE INDUCTION; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN TARGETING; TRANSCRIPTION REGULATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRCA1 PROTEIN; BREAST NEOPLASMS; CALCIUM-BINDING PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BRCA1; HUMANS; PROTO-ONCOGENE PROTEINS C-MYC; RNA, SMALL INTERFERING; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 28544447228     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1841     Document Type: Article

References (36)

1. Miki Y, Swensen J, Shattuck-Eidens D, et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994;266:66-71.
2. King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 2003;302:643-6.
3. Tutt A, Ashworth A. The relationship between the roles of BRCA genes in DNA repair and cancer predisposition. Trends Mol Med 2002;8:571-6.
4. Xu B, Kim S, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation. Mol Cell Biol 2001;21:3445-50.
5. Xu B, O'Donnell AH, Kim ST, Kastan MB. Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation. Cancer Res 2002;62:4588-91.
6. 2/M cell cycle arrest in response to antimicrotubule agents. Oncogene 2001;20:6123-31.
7. Welcsh PL, Lee MK, Gonzalez-Hernandez RM, et al. BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci U S A 2002;99:7560-5.
8. Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ. Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. J Biol Chem 2002;277:22085-92.
9. Anderson SF, Schlegel BP, Nakajima T, Wolpin ES, Parvin JD. BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet 1998;19:254-6.
10. Ouchi T, Monteiro AN, August A, Aaronson SA, Hanafusa H. BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci U S A 1998;95:2302-6.
11. Li H, Lee TH, Avraham H. A novel tricomplex of BRCA1, Nmi, and c-Myc inhibits c-Myc-induced human telomerase reverse transcriptase gene (hTERT) promoter activity in breast cancer. J Biol Chem 2002;277:20965-73.
12. Houvras Y, Benezra M, Zhang H, Manfredi JJ, Weber BL, Licht JD. BRCA1 physically and functionally interacts with ATF1. J Biol Chem 2000;275:36230-7.
13. Ouchi T, Lee SW, Ouchi M, Aaronson SA, Horvath CM. Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-γ target genes. Proc Natl Acad Sci U S A 2000;97:5208-13.
14. Yarden RI, Brody LC. BRCA1 interacts with components of the histone deacetylase complex. Proc Natl Acad Sci U S A 1999;96:4983-8.
15. Bochar DA, Wang L, Beniya H, et al. BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell 2000;102:257-65.
16. Kennedy RD, Quinn JE, Mullan PB, Johnston PG, Harkin DP. The role of BRCA1 in the cellular response to chemotherapy. J Natl Cancer Inst 2004;96:1659-68.
17. Quinn JE, Kennedy RD, Mullan PB, et al. BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis. Cancer Res 2003;63:6221-8.
18. Andrews HN, Mullan PB, McWilliams S, et al. BRCA1 regulates the interferon γ-mediated apoptotic response. J Biol Chem 2002;277:26225-32.
19. Emberley ED, Mu Y, Leygue E, et al. Psoriasin interacts with Jab1 and influences breast cancer progression. Cancer Res 2003;63:1954-61.
20. Lee KA, Bindereif A, Green MR. A small-scale procedure for preparation of nuclear extracts that support efficient transcription and pre-mRNA splicing. Gene Anal Tech 1988;5:22-31.
21. Emberley ED, Niu Y, Njue C, Kliewer EV, Murphy LC, Watson PH. Psoriasin (S100A7) expression is associated with poor outcome in estrogen receptor-negative invasive breast cancer. Clin Cancer Res 2003;9:2627-31.
22. Emberley E, Alowami S, Snell L, Murphy L, Watson P. S100A7 (psoriasin) expression is associated with aggressive features and alteration of Jab1 in ductal carcinoma in situ of the breast. Breast Cancer Res 2004;6:R308-15.
23. Annab LA, Hawkins RE, Solomon G, Barrett JC, Afshari CA. Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line. Breast Cancer Res 2000;2:139-48.
24. Wang Q, Zhang H, Kajino K, Greene MI. BRCA1 binds c-Myc and inhibits its transcriptional and transforming activity in cells. Oncogene 1998;17:1939-48.
25. Halazonetis TD, Kandil AN. Determination of the c-MYC DNA-binding site. Proc Natl Acad Sci U S A 1991;88:6162-6.
26. Heizmann CW, Fritz G, Schafer BW. S100 proteins: structure, functions and pathology. Front Biosci 2002;7: d1356-68.
27. Celis JE, Cruger D, Kiil J, et al. Identification of a group of proteins that are strongly up-regulated in total epidermal keratinocytes from psoriatic skin. FEBS Lett 1990;262:159-64.
28. Madsen P, Rasmussen HH, Leffers H, et al. Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin. J Invest Dermatol 1991;97:701-12.
29. Leygue E, Snell L, Hiller T, et al. Differential expression of psoriasin messenger RNA between in situ and invasive human breast carcinoma Cancer Res 1996;56:4606-9.
30. Enerback C, Porter DA, Seth P, et al. Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res 2002;62:43-7.
31. Jiang WG, Watkins G, Douglas-Jones A, Mansel RE. Psoriasin is aberrantly expressed in human breast cancer and is related to clinical outcomes. Int J Oncol 2004;25:81-5.
32. Grushko TA, Dignam JJ, Das S, et al. MYC is amplified in BRCA1-associated breast cancers. Clin Cancer Res 2004;10:499-507.
33. Jones C, Mackay A, Grigoriadis A, et al. Expression profiling of purified normal human luminal and myoepithelial breast cells: identification of novel prognostic markers for breast cancer. Cancer Res 2004;64:3037-45.
34. Foulkes WD. BRCA1 functions as a breast stem cell regulator. J Med Genet 2004;41:1-5.
35. Sorlie T, Tibshirani R, Parker J, et al. Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 2003;100:8418-23.
36. Chiarle R, Pagano M, Inghirami G. The cyclin dependent kinase inhibitor p27 and its prognostic role in breast cancer. Breast Cancer Res 2001;3:91-4.