메뉴 건너뛰기




Volumn 37, Issue 2, 2000, Pages 398-409

Identification and characterization of SarH1, a new global regulator of virulence gene expression in Staphylococcus aureus

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOXIN; DNA BINDING PROTEIN; DNA FRAGMENT; MUTANT PROTEIN; PROTEIN A;

EID: 0033913836     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.02003.x     Document Type: Article
Times cited : (135)

References (48)
  • 1
    • 0027169704 scopus 로고
    • The accessory regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model
    • Abdelnour, A., Arvidson, S., Bremell, T., Ryden, C., and Tarkowski, A. (1993) The accessory regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect Immun 61: 3879-3885.
    • (1993) Infect Immun , vol.61 , pp. 3879-3885
    • Abdelnour, A.1    Arvidson, S.2    Bremell, T.3    Ryden, C.4    Tarkowski, A.5
  • 3
    • 0032540422 scopus 로고    scopus 로고
    • Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus
    • Balaban, N., Goldkorn, T., Nhan, R.T., Dang, L.B., Scott, S., Ridgley, R., et al. (1998) Autoinducer of virulence as a target for vaccine and therapy against Staphylococcus aureus. Science 280: 438-440.
    • (1998) Science , vol.280 , pp. 438-440
    • Balaban, N.1    Goldkorn, T.2    Nhan, R.T.3    Dang, L.B.4    Scott, S.5    Ridgley, R.6
  • 4
    • 0029785913 scopus 로고    scopus 로고
    • The molecular architecture of the sar locus in Staphylococcus aureus
    • Bayer, M.G., Heinrichs, J.H., and Cheung, A.L. (1996) The molecular architecture of the sar locus in Staphylococcus aureus. J Bacteriol 178: 4563-4570.
    • (1996) J Bacteriol , vol.178 , pp. 4563-4570
    • Bayer, M.G.1    Heinrichs, J.H.2    Cheung, A.L.3
  • 5
    • 0033035830 scopus 로고    scopus 로고
    • The Staphylococcal accessory regulator (sar) represses transcription of the Staphylococcus aureus collagen adhesin gene (cna) in an agr-independent manner
    • Blevins, J., Gillaspy, A., Rechtin, T., Hurlburt, B., and Smeltzer, M. (1999) The Staphylococcal accessory regulator (sar) represses transcription of the Staphylococcus aureus collagen adhesin gene (cna) in an agr-independent manner. Mol Microbiol 33: 317-326.
    • (1999) Mol Microbiol , vol.33 , pp. 317-326
    • Blevins, J.1    Gillaspy, A.2    Rechtin, T.3    Hurlburt, B.4    Smeltzer, M.5
  • 6
    • 0023664778 scopus 로고
    • Nucleotide sequence of the serine protease gene of Staphylococcus aureus strain V8
    • Carmona, C., and Gray, G.L. (1987) Nucleotide sequence of the serine protease gene of Staphylococcus aureus strain V8. Nucleic Acids Res 15: 6757-6757.
    • (1987) Nucleic Acids Res , vol.15 , pp. 6757-6757
    • Carmona, C.1    Gray, G.L.2
  • 7
    • 0031786412 scopus 로고    scopus 로고
    • Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus
    • Chan, P.F., and Foster, S.J. (1998) Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus. J Bacteriol 180: 6232-6241.
    • (1998) J Bacteriol , vol.180 , pp. 6232-6241
    • Chan, P.F.1    Foster, S.J.2
  • 8
    • 0028318256 scopus 로고
    • Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr
    • Cheung, A.L., and Projan, S.J. (1994) Cloning and sequencing of sarA of Staphylococcus aureus, a gene required for the expression of agr. J Bacteriol 176: 4168-4172.
    • (1994) J Bacteriol , vol.176 , pp. 4168-4172
    • Cheung, A.L.1    Projan, S.J.2
  • 9
    • 0028173022 scopus 로고
    • Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis
    • Cheung, A.L., Eberhardt, K.J., Chung, E., Yeaman, M.R., Sullam, P.M., Ramos, M., and Bayer, A.S. (1994) Diminished virulence of a sar-/agr- mutant of Staphylococcus aureus in the rabbit model of endocarditis. J Clin Invest 94: 1815-1822.
    • (1994) J Clin Invest , vol.94 , pp. 1815-1822
    • Cheung, A.L.1    Eberhardt, K.J.2    Chung, E.3    Yeaman, M.R.4    Sullam, P.M.5    Ramos, M.6    Bayer, A.S.7
  • 10
    • 0030926455 scopus 로고    scopus 로고
    • sar genetic determinants necessary for transcription of RNAII and RNAIII in the agr locus of Staphylococcus aureus
    • Cheung, A.L., Bayer, M.G., and Heinrichs, J.H. (1997a) sar genetic determinants necessary for transcription of RNAII and RNAIII in the agr locus of Staphylococcus aureus. J Bacteriol 179: 3963-3971.
    • (1997) J Bacteriol , vol.179 , pp. 3963-3971
    • Cheung, A.L.1    Bayer, M.G.2    Heinrichs, J.H.3
  • 11
    • 0030976395 scopus 로고    scopus 로고
    • Regulation of protein A synthesis by the sar and agr loci of Staphylococcus aureus
    • Cheung, A.L., Eberhardt, K., and Heinrichs, J.H. (1997b) Regulation of protein A synthesis by the sar and agr loci of Staphylococcus aureus. Infect Immun 65: 2243-2249.
    • (1997) Infect Immun , vol.65 , pp. 2243-2249
    • Cheung, A.L.1    Eberhardt, K.2    Heinrichs, J.H.3
  • 12
    • 0033012331 scopus 로고    scopus 로고
    • Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus
    • Cheung, A.L., Chien and Bayer, A.S. (1999) Hyperproduction of alpha-hemolysin in a sigB mutant is associated with elevated SarA expression in Staphylococcus aureus. Infect Immun 67: 1331-1337.
    • (1999) Infect Immun , vol.67 , pp. 1331-1337
    • Cheung, A.L.1    Chien2    Bayer, A.S.3
  • 13
    • 0033601339 scopus 로고    scopus 로고
    • SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation
    • Chien, Y.-T., Manna, A.C., Projan, S.J., and Cheung, A.L. (1999) SarA, a global regulator of virulence determinants in Staphylococcus aureus, binds to a conserved motif essential for sar-dependent gene regulation. J Biol Chem 274: 37169-37176.
    • (1999) J Biol Chem , vol.274 , pp. 37169-37176
    • Chien, Y.-T.1    Manna, A.C.2    Projan, S.J.3    Cheung, A.L.4
  • 14
    • 0030809034 scopus 로고    scopus 로고
    • Alternative transcription factor σB of Staphylococcus aureus: Characterization and role in transcription of the global regulatory locus sar
    • Deora, R., Tseng, T., and Misra, T.K. (1997) Alternative transcription factor σB of Staphylococcus aureus: characterization and role in transcription of the global regulatory locus sar. J Bacteriol 179: 6355-6359.
    • (1997) J Bacteriol , vol.179 , pp. 6355-6359
    • Deora, R.1    Tseng, T.2    Misra, T.K.3
  • 15
    • 0028106958 scopus 로고
    • Characterization of a Tn551-mutant of Staphylococcus aureus defective in the production of several exoproteins
    • Giraudo, A.T., Raspanti, C.G., Calzolari, A., and Nagel, R. (1994) Characterization of a Tn551-mutant of Staphylococcus aureus defective in the production of several exoproteins. Can J Microbiol 40: 677-681.
    • (1994) Can J Microbiol , vol.40 , pp. 677-681
    • Giraudo, A.T.1    Raspanti, C.G.2    Calzolari, A.3    Nagel, R.4
  • 16
    • 0029879516 scopus 로고    scopus 로고
    • Phenotypic characterization and virulence of sae- agr- mutant of Staphylococcus aureus
    • Giraudo, A.T., Rampone, H., Calzolari, A., and Nagel, R. (1996) Phenotypic characterization and virulence of sae- agr- mutant of Staphylococcus aureus. Can J Microbiol 42: 120-123.
    • (1996) Can J Microbiol , vol.42 , pp. 120-123
    • Giraudo, A.T.1    Rampone, H.2    Calzolari, A.3    Nagel, R.4
  • 17
    • 0021747672 scopus 로고
    • Primary sequence of the alpha-toxin gene from Staphylococcus aureus Wood 46
    • Gray, G.S., and Kehoe, M. (1984) Primary sequence of the alpha-toxin gene from Staphylococcus aureus Wood 46. Infect Immun 46: 615-618.
    • (1984) Infect Immun , vol.46 , pp. 615-618
    • Gray, G.S.1    Kehoe, M.2
  • 18
    • 0021988172 scopus 로고
    • Simplified method for silver staining of protein in polyacrylamide gels and the mechanism of silver staining
    • Heukshoven, J., and Dernick, R. (1985) Simplified method for silver staining of protein in polyacrylamide gels and the mechanism of silver staining. Electrophoresis 6: 103-112.
    • (1985) Electrophoresis , vol.6 , pp. 103-112
    • Heukshoven, J.1    Dernick, R.2
  • 19
    • 0025238943 scopus 로고
    • The role of the delta-lysin gene (hld) in regulation of virulence genes by the accessory gene regulator (agr) in Staphylococcus aureus
    • Janzon, L., and Arvidson, S. (1990) The role of the delta-lysin gene (hld) in regulation of virulence genes by the accessory gene regulator (agr) in Staphylococcus aureus. EMBO J 9: 1391-1399.
    • (1990) EMBO J , vol.9 , pp. 1391-1399
    • Janzon, L.1    Arvidson, S.2
  • 20
    • 0022599284 scopus 로고
    • Evidence for a coordinate transcriptional control of alpha-toxin and protein A in Staphylococcus aureus
    • Janzon, L., Löfdahl, S., and Arvidson, S. (1986) Evidence for a coordinate transcriptional control of alpha-toxin and protein A in Staphylococcus aureus. FEMS Microbiol Lett 33: 193-198.
    • (1986) FEMS Microbiol Lett , vol.33 , pp. 193-198
    • Janzon, L.1    Löfdahl, S.2    Arvidson, S.3
  • 21
    • 0024331951 scopus 로고
    • Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus
    • Janzon, L., Löfdahl, S., and Arvidson, S. (1989) Identification and nucleotide sequence of the delta-lysin gene, hld, adjacent to the accessory gene regulator (agr) of Staphylococcus aureus. Mol Gen Genet 219: 480-485.
    • (1989) Mol Gen Genet , vol.219 , pp. 480-485
    • Janzon, L.1    Löfdahl, S.2    Arvidson, S.3
  • 22
    • 0030838740 scopus 로고    scopus 로고
    • Bacterial interference caused by autoinducing peptide variants
    • Ji, G., Beavis, R.C., and Novick, R.P. (1997) Bacterial interference caused by autoinducing peptide variants. Science 276: 2027-2030.
    • (1997) Science , vol.276 , pp. 2027-2030
    • Ji, G.1    Beavis, R.C.2    Novick, R.P.3
  • 23
    • 0023225294 scopus 로고
    • A simple and exact two-point interpolation method for determination of haemolytic activity in micrometer plates
    • Kanclerski, K., and Mollby, R. (1987) A simple and exact two-point interpolation method for determination of haemolytic activity in micrometer plates. Acta Pathol Microbiol Immunol Scand Microbiol 95: 175-179.
    • (1987) Acta Pathol Microbiol Immunol Scand Microbiol , vol.95 , pp. 175-179
    • Kanclerski, K.1    Mollby, R.2
  • 24
    • 0002014616 scopus 로고
    • Agr: A polycistronic locus regulating exoprotein synthesis in Staphylococcus aureus
    • Novick, R.P. (ed.). New York: VCH Publishers
    • Kornblum, J., Kreiswirth, B.N., Projan, S.J., Ross, H., and Novick, R.P. (1990) Agr: a polycistronic locus regulating exoprotein synthesis in Staphylococcus aureus. In Molecular Biology of the Staphylococci, Novick, R.P. (ed.). New York: VCH Publishers, pp. 373-402.
    • (1990) Molecular Biology of the Staphylococci , pp. 373-402
    • Kornblum, J.1    Kreiswirth, B.N.2    Projan, S.J.3    Ross, H.4    Novick, R.P.5
  • 25
    • 0020610320 scopus 로고
    • The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage
    • Kreiswirth, B., Löfdahl, S., Betley, M.J., O'Reilly, M., Schleivert, M.P., Bergdoll, M.S., et al. (1983) The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature 305: 709-712.
    • (1983) Nature , vol.305 , pp. 709-712
    • Kreiswirth, B.1    Löfdahl, S.2    Betley, M.J.3    O'Reilly, M.4    Schleivert, M.P.5    Bergdoll, M.S.6
  • 26
    • 0030892308 scopus 로고    scopus 로고
    • The alternative sigma factor σB in Staphylococcus aureus: Regulation of the sigB operon in response to growth and heat shock
    • Kullik, I., and Giachino, P. (1997) The alternative sigma factor σB in Staphylococcus aureus: regulation of the sigB operon in response to growth and heat shock. Arch Microbiol 167: 151-159.
    • (1997) Arch Microbiol , vol.167 , pp. 151-159
    • Kullik, I.1    Giachino, P.2
  • 27
    • 0031659829 scopus 로고    scopus 로고
    • Deletion of the alternative sigma factor σB in Staphylococcus aureus reveals its function as a global regulator of virulence genes
    • Kullik, I., Giachino, P., and Fuchs, T. (1998) Deletion of the alternative sigma factor σB in Staphylococcus aureus reveals its function as a global regulator of virulence genes. J Bacteriol 180: 4814-4820.
    • (1998) J Bacteriol , vol.180 , pp. 4814-4820
    • Kullik, I.1    Giachino, P.2    Fuchs, T.3
  • 28
    • 0032843519 scopus 로고    scopus 로고
    • Interactive regulatory pathways control virulence determinant production and stability in response to environmental conditions in Staphylococcus aureus
    • Lindsay, J., and Foster, S. (1999) Interactive regulatory pathways control virulence determinant production and stability in response to environmental conditions in Staphylococcus aureus. Mol Gen Genet 262: 323-331.
    • (1999) Mol Gen Genet , vol.262 , pp. 323-331
    • Lindsay, J.1    Foster, S.2
  • 30
    • 0032551901 scopus 로고    scopus 로고
    • Staphylococcus aureus infections
    • Lowy, F. (1998) Staphylococcus aureus infections. N Engl J Med 339: 520-532.
    • (1998) N Engl J Med , vol.339 , pp. 520-532
    • Lowy, F.1
  • 31
    • 0031004994 scopus 로고    scopus 로고
    • Modification of the Staphylococcus aureus fibronectin binding phenotype by V8 protease
    • McGavin, M.J., Zahradka, C., Rice, K., and Scott, J.E. (1997) Modification of the Staphylococcus aureus fibronectin binding phenotype by V8 protease. Infect Immun 65: 2621-2628.
    • (1997) Infect Immun , vol.65 , pp. 2621-2628
    • McGavin, M.J.1    Zahradka, C.2    Rice, K.3    Scott, J.E.4
  • 32
    • 0031829309 scopus 로고    scopus 로고
    • Transcriptional analysis of different promoters in the sar locus in Staphylococcus aureus
    • Manna, A.C., Bayer, M.G., and Cheung, A.L. (1998) Transcriptional analysis of different promoters in the sar locus in Staphylococcus aureus. J Bacteriol 180: 3828-3836.
    • (1998) J Bacteriol , vol.180 , pp. 3828-3836
    • Manna, A.C.1    Bayer, M.G.2    Cheung, A.L.3
  • 33
    • 0032951950 scopus 로고    scopus 로고
    • The Staphylococcus aureus rsbW (orf159) gene encodes an anti-sigma factor of SigB
    • Miyazaki, E., Chen, J.M., Ko, C., and Bishai, W.R. (1999) The Staphylococcus aureus rsbW (orf159) gene encodes an anti-sigma factor of SigB. J Bacteriol 181: 2846-2851.
    • (1999) J Bacteriol , vol.181 , pp. 2846-2851
    • Miyazaki, E.1    Chen, J.M.2    Ko, C.3    Bishai, W.R.4
  • 34
    • 0001639009 scopus 로고
    • Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus
    • Morfeldt, E., Janzon, L., Arvidson, S., and Löfdahl, S. (1988) Cloning of a chromosomal locus (exp) which regulates the expression of several exoprotein genes in Staphylococcus aureus. Mol Gen Genet 211: 435-440.
    • (1988) Mol Gen Genet , vol.211 , pp. 435-440
    • Morfeldt, E.1    Janzon, L.2    Arvidson, S.3    Löfdahl, S.4
  • 35
    • 0029113833 scopus 로고
    • Activation of alpha-toxin translation in Staphylococcus aureus by the trans-encoded antisense RNA, RNAIII
    • Morfeldt, E., Taylor, D., von Gabain, A., and Arvidson, S. (1995) Activation of alpha-toxin translation in Staphylococcus aureus by the trans-encoded antisense RNA, RNAIII. EMBO J 14: 4569-4577.
    • (1995) EMBO J , vol.14 , pp. 4569-4577
    • Morfeldt, E.1    Taylor, D.2    Von Gabain, A.3    Arvidson, S.4
  • 36
    • 0029814352 scopus 로고    scopus 로고
    • Transcriptional control of the agr-dependent virulence gene regulator, RNAIII, in Staphylococcus aureus
    • Morfeldt, E., Tegmark, K., and Arvidson, S. (1996) Transcriptional control of the agr-dependent virulence gene regulator, RNAIII, in Staphylococcus aureus. Mol Microbiol 21: 1227-1237.
    • (1996) Mol Microbiol , vol.21 , pp. 1227-1237
    • Morfeldt, E.1    Tegmark, K.2    Arvidson, S.3
  • 37
    • 0014127769 scopus 로고
    • Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus
    • Novick, R.P. (1967) Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus. Virology 33: 155-166.
    • (1967) Virology , vol.33 , pp. 155-166
    • Novick, R.P.1
  • 38
    • 0025837196 scopus 로고
    • Genetic systems in staphylococci
    • Novick, R.P. (1991) Genetic systems in staphylococci. Methods Enzymol 204: 587-636.
    • (1991) Methods Enzymol , vol.204 , pp. 587-636
    • Novick, R.P.1
  • 39
    • 0027180031 scopus 로고
    • Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule
    • Novick, R.P., Ross, H.F., Projan, S.J., Kornblum, J., Kreiswirth, B., and Moghazeh, S. (1993) Synthesis of staphylococcal virulence factors is controlled by a regulatory RNA molecule. EMBO J 12: 3967-3975.
    • (1993) EMBO J , vol.12 , pp. 3967-3975
    • Novick, R.P.1    Ross, H.F.2    Projan, S.J.3    Kornblum, J.4    Kreiswirth, B.5    Moghazeh, S.6
  • 40
    • 0029085646 scopus 로고
    • The agr P2 operon: An autocatalytic sensory transduction system in Staphylococcus aureus
    • Novick, R.P., Projan, S.J., Kornblum, J., Ross, H.F., Ji, G., Kreiswirth, B., et al. (1995) The agr P2 operon: an autocatalytic sensory transduction system in Staphylococcus aureus. Mol Gen Genet 248: 446-458.
    • (1995) Mol Gen Genet , vol.248 , pp. 446-458
    • Novick, R.P.1    Projan, S.J.2    Kornblum, J.3    Ross, H.F.4    Ji, G.5    Kreiswirth, B.6
  • 44
    • 0026891517 scopus 로고
    • Improved methods for electroporation of Staphylococcus aureus
    • Schenk, S., and Laddaga, R.A. (1992) Improved methods for electroporation of Staphylococcus aureus. FEMS Microbiol Lett 94: 133-138.
    • (1992) FEMS Microbiol Lett , vol.94 , pp. 133-138
    • Schenk, S.1    Laddaga, R.A.2
  • 46
    • 0026010391 scopus 로고
    • A temporal signal, independent of agr, is required for hla but not spa transcription in Staphylococcus aureus
    • Vandenesch, F., Kornblum, J., and Novick, R.P. (1991) A temporal signal, independent of agr, is required for hla but not spa transcription in Staphylococcus aureus. J Bacteriol 173: 6313-6320.
    • (1991) J Bacteriol , vol.173 , pp. 6313-6320
    • Vandenesch, F.1    Kornblum, J.2    Novick, R.P.3
  • 47
    • 0034036997 scopus 로고    scopus 로고
    • Agr-independent regulation of fibronectin-binding protein(s) by the regulatory locus sar in Staphylococcus aureus
    • Wolz, C., Pöhlmann-Dietze, P., Steinhuber, A., Chien, Y.-T., Manna, A.W., van Wamell, W., et al. (2000) Agr-independent regulation of fibronectin-binding protein(s) by the regulatory locus sar in Staphylococcus aureus. Mol Microbiol 36: 230-243.
    • (2000) Mol Microbiol , vol.36 , pp. 230-243
    • Wolz, C.1    Pöhlmann-Dietze, P.2    Steinhuber, A.3    Chien, Y.-T.4    Manna, A.W.5    Van Wamell, W.6
  • 48
    • 0032952897 scopus 로고    scopus 로고
    • The Staphylococcus aureus transposon Tn551: Complete nucleotide sequence and transcriptional analysis of the expression of the erythromycin
    • Wu, S., de Lencastre, H., and Tomasz, A. (1999) The Staphylococcus aureus transposon Tn551: complete nucleotide sequence and transcriptional analysis of the expression of the erythromycin. Microb Drug Resists 5: 1-7.
    • (1999) Microb Drug Resists , vol.5 , pp. 1-7
    • Wu, S.1    De Lencastre, H.2    Tomasz, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.