AIDS vaccine: Intranasal immunization using inactivated HIV-1-capturing core-corona type polymeric nanospheres

Journal of Controlled Release

Volumn 109, Issue 1-3, 2005, Pages 49-61

  Akagi, Takami ^a,d   Ueno, Masamichi ^b   Hiraishi, Katsuya ^b   Baba, Masanori ^c,d   Akashi, Mitsuru ^a,d  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN IMMUNORESEARCH LABORATORIES   (Japan)

^c KAGOSHIMA UNIVERSITY   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

HIV; IgA; Mucosal immunization; Nanospheres; Vaccine

Indexed keywords

CELLS; DISEASE CONTROL; DRUG PRODUCTS; GENES; IMMUNOLOGY; NANOSTRUCTURED MATERIALS; POLYSTYRENES; VIRUSES;

HIV; IGA; MUCOSAL IMMUNIZATION; NANOSPHERES;

VACCINES;

CONCANAVALIN A; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INACTIVATED VIRUS VACCINE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FEMALE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; VACCINATION; VAGINA MUCOSA; VIRUS CORE; VIRUS PARTICLE;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, INTRAVAGINAL; AIDS VACCINES; ANIMALS; CONCANAVALIN A; FEMALE; HIV ANTIBODIES; HIV-1; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MICROSPHERES; PARTICLE SIZE; VACCINES, INACTIVATED;

EID: 28444444447     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.09.014     Document Type: Conference Paper

References (49)

1. T.W. Baba, V. Liska, R.H. Lehmann, J. Vlasak, W. Xu, S. Ayehunie, L.A. Cavacini, M.R. Posner, H. Katinger, G. Stiegler, B.J. Bernacky, T.A. Rizvi, R. Schmidt, L.R. Hill, M.E. Keeling, Y. Lu, J.E. Wright, T.C. Chou, and R.M. Ruprecht Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection Nat. Med. 6 2000 200 206
2. I.M. Belyakov, J.D. Ahlers, B.Y. Brandwein, P. Earl, B.L. Kelsall, B. Moss, W. Strober, and J.A. Berzofsky The importance of local mucosal HIV-specific CD8(+) cytotoxic T lymphocytes for resistance to mucosal viral transmission in mice and enhancement of resistance by local administration of IL-12 J. Clin. Invest. 102 1998 2072 2081
3. S. Mazzoli, L. Lopalco, A. Salvi, D. Trabattoni, S.L. Caputo, F. Semplici, M. Biasin, C. Ble, A. Cosma, C. Pastori, F. Meacci, F. Mazzotta, M.L. Villa, A.G. Siccardi, and M. Clerici Human immunodeficiency virus (HIV)-specific IgA and HIV neutralizing activity in the serum of exposed seronegative partners of HIV-seropositive persons J. Infect. Dis. 180 1999 871 875
4. S.L. Caputo, D. Trabattoni, F. Vichi, S. Piconi, L. Lopalco, M.L. Villa, F. Mazzotta, and M. Clerici Mucosal and systemic HIV-1-specific immunity in HIV-1-exposed but uninfected heterosexual men AIDS 17 2003 531 539
5. H.F. Staats, W.G. Nichols, and T.J. Palker Mucosal immunity to HIV-1: systemic and vaginal antibody responses after intranasal immunization with the HIV-1 C4/V3 peptide T1SP10 MN(A) J. Immunol. 157 1996 462 472
6. T.C. VanCott, R.W. Kaminski, J.R. Mascola, V.S. Kalyanaraman, N.M. Wassef, C.R. Alving, J.T. Ulrich, G.H. Lowell, and D.L. Birx HIV-1 neutralizing antibodies in the genital and respiratory tracts of mice intranasally immunized with oligomeric gp160 J. Immunol. 160 1998 2000 2012
7. I.M. Belyakov, Z. Hel, B. Kelsall, V.A. Kuznetsov, J.D. Ahlers, J. Nacsa, D.I. Watkins, T.M. Allen, A. Sette, J. Altman, R. Woodward, P.D. Markham, J.D. Clements, G. Franchini, W. Strober, and J.A. Berzofsky Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques Nat. Med. 7 2001 1320 1326
8. I.M. Belyakov, and J.A. Berzofsky Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines Immunity 20 2004 247 253
9. S. Sutjipto, N.C. Pedersen, C.J. Miller, M.B. Gardner, C.V. Hanson, A. Gettie, M. Jennings, J. Higgins, and P.A. Marx Inactivated simian immunodeficiency virus vaccine failed to protect rhesus macaques from intravenous or genital mucosal infection but delayed disease in intravenously exposed animals J. Virol. 64 1990 2290 2297
10. K. Imaoka, C.J. Miller, M. Kubota, M.B. McChesney, B. Lohman, M. Yamamoto, K. Fujihashi, K. Someya, M. Honda, J.R. McGhee, and H. Kiyono Nasal immunization of nonhuman primates with simian immunodeficiency virus p55gag and cholera toxin adjuvant induces Th1/Th2 help for virus-specific immune responses in reproductive tissues J. Immunol. 161 1998 5952 5958
11. C.B. Morris, E. Cheng, A. Thanawastien, L. Cardenas-Freytag, and J.D. Clements Effectiveness of intranasal immunization with HIV-gp160 and an HIV-1 env CTL epitope peptide (E7) in combination with the mucosal adjuvant LT(R192G) Vaccine 18 2000 1944 1951
12. H.F. Staats, C.P. Bradney, W.M. Gwinn, S.S. Jackson, G.D. Sempowski, H.X. Liao, N.L. Letvin, and B.F. Haynes Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization J. Immunol. 167 2001 5386 5394
13. C.P. Bradney, G.D. Sempowski, H.X. Liao, B.F. Haynes, and H.F. Staats Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization J. Virol. 76 2002 517 524
14. N. Dumais, A. Patrick, R.B. Moss, H.L. Davis, and K.L. Rosenthal Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge J. Infect. Dis. 186 2002 1098 1105
15. N. Yoshino, F.X. Lu, K. Fujihashi, Y. Hagiwara, K. Kataoka, D. Lu, L. Hirst, M. Honda, F.W. van Ginkel, Y. Takeda, C.J. Miller, H. Kiyono, and J.R. McGhee A novel adjuvant for mucosal immunity to HIV-1 gp120 in nonhuman primates J. Immunol. 173 2004 6850 6857
16. J.Q. Jiang, A. Patrick, R.B. Moss, and K.L. Rosenthal CD8+T-cell-mediated cross-clade protection in the genital tract following intranasal immunization with inactivated human immunodeficiency virus antigen plus CpG oligodeoxynucleotides J. Virol. 79 2005 393 400
17. D.T. O'Hagan, and E. Lavelle Novel adjuvants and delivery systems for HIV vaccines AIDS 16 2002 115 124
18. J. Banchereau, and R.M. Steinman Dendritic cells and the control of immunity Nature 392 1998 245 252
19. J.R. Mascola, S.S. Frankel, and K. Broliden HIV-1 entry at the mucosal surface: role of antibodies in protection AIDS 14 2000 167 174
20. J.C. Reece, N.J. Vardaxis, J.A. Marshall, S.M. Crowe, and P.U. Cameron Uptake of HIV and latex particles by fresh and cultured dendritic cells and monocytes Immunol. Cell Biol. 79 2001 255 263
21. L. Thiele, J.E. Diederichs, R. Reszka, H.P. Merkle, and E. Walter Competitive adsorption of serum proteins at microparticles affects phagocytosis by dendritic cells Biomaterials 24 2003 1409 1418
22. M.E. Lutsiak, D.R. Robinson, C. Coester, G.S. Kwon, and J. Samuel Analysis of poly(d,l-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro Pharm. Res. 19 2002 1480 1487
23. M. Yoshida, and J.E. Babensee Poly (lactic-co-glycolic acid) enhances maturation of human monocyte-derived dendritic cells J. Biomed. Mater. Res. 71 2004 45 54
24. M.J. Copland, M.A. Baird, T. Rades, J.L. McKenzie, B. Becker, F. Reck, P.C. Tyler, and N.M. Davies Liposomal delivery of antigen to human dendritic cells Vaccine 21 2003 883 890
25. C.V. Harding, and R. Song Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules J. Immunol. 153 1994 4925 4933
26. M.P. Desai, V. Labhasetwar, E. Walter, R.J. Levy, and G.L. Amidon The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent Pharm. Res. 14 1997 1568 1573
27. M. Akashi, T. Niikawa, T. Serizawa, T. Hayakawa, and M. Baba Capture of HIV-1 gp120 and virions by lectin-immobilized polystyrene nanospheres Bioconjug. Chem. 9 1998 50 53
28. T. Hayakawa, M. Kawamura, M. Okamoto, M. Baba, T. Niikawa, S. Takehara, T. Serizawa, and M. Akashi Concanavalin A-immobilized polystyrene nanospheres capture HIV-1 virions and gp120: potential approach towards prevention of viral transmission J. Med. Virol. 56 1998 327 331
29. M. Kawamura, T. Naitou, M. Ueno, T. Akagi, K. Hiraishi, I. Takai, M. Makino, T. Serizawa, K. Sugimura, M. Akashi, and M. Baba Induction of mucosal IgA following intravaginal administration of inactivated HIV-1-capturing nanospheres in mice J. Med. Virol. 66 2002 291 298
30. T. Akagi, M. Kawamura, M. Ueno, K. Hiraishi, M. Adachi, T. Serizawa, M. Akashi, and M. Baba Mucosal immunization with inactivated HIV-1-capturing nanospheres induced a significant HIV-1-specific vaginal antibody response in mice J. Med. Virol. 69 2003 163 172
31. A. Miyake, T. Akagi, Y. Enose, M. Ueno, M. Kawamura, R. Horiuchi, K. Hiraishi, M. Adachi, T. Serizawa, M. Akashi, M. Baba, and M. Hayami Induction of HIV-specific antibody response and protection against vaginal SHIV transmission by intranasal immunization with inactivated SHIV-capturing nanospheres in macaques J. Med. Virol. 73 2004 368 377
32. E.L. Johansson, C. Rask, M. Fredriksson, K. Eriksson, C. Czerkinsky, and J. Holmgren Antibodies and antibody-secreting cells in the female genital tract after vaginal or intranasal immunization with cholera toxin B subunit or conjugates Infect. Immun. 66 1998 514 520
33. S.A. Cetinus, and H.N. Oztop Immobilization of catalase into chemically crosslinked chitosan beads Enzyme Microb. Technol. 32 2003 889 894
34. K. Kang, C. Kan, A. Yeung, and D. Liu The properties of covalently immobilized trypsin on soap-free P(MMA-EA-AA) latex particles Macromol. Biosci. 5 2005 344 351
35. A.D. Tommaso, G. Saletti, M. Pizza, R. Rappuoli, G. Dougan, S. Abrignani, G. Douce, and M.T.D.D. Magistris Induction of antigen-specific antibodies in vaginal secretions by using a nontoxic mutant of heat-labile enterotoxin as a mucosal adjuvant Infect. Immun. 64 1996 974 979
36. H.F. Staats, S.P. Montgomery, and T.J. Palker Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses AIDS Res. Hum. Retrovir. 13 1997 945 952
37. C. Czerkinsky, S.J. Prince, S.M. Michalek, S. Jackson, M.W. Russell, Z. Moldoveanu, J.R. McGhee, and J. Mestecky IgA antibody-producing cells in peripheral blood after antigen ingestion: evidence for a common mucosal immune system in humans Proc. Natl. Acad. Sci. U. S. A. 84 1987 2449 2453
38. M. van Egmond, C.A. Damen, A.B. van Spriel, G. Vidarsson, E. van Garderen, and J.G. van de Winkel IgA and the IgA Fc receptor Trends Immunol. 22 2001 205 211
39. M.P. Desai, V. Labhasetwar, G.L. Amidon, and R.J. Levy Gastrointestinal uptake of biodegradable microparticles: effect of particle size Pharm. Res. 13 1996 1838 1845
40. C.O. Elson, J.A. Heck, and W. Strober T-cell regulation of murine IgA synthesis J. Exp. Med. 149 1979 632 643
41. N. Foster, M.A. Clark, M.A. Jepson, and B.H. Hirst Ulex europaeus 1 lectin targets microspheres to mouse Peyer's patch M-cells in vivo Vaccine 16 1998 536 541
42. R. Nakaoka, Y. Inoue, Y. Tabata, and Y. Ikada Size effect on the antibody production induced by biodegradable microspheres containing antigen Vaccine 14 1996 1251 1256
43. Y. Tabata, Y. Inoue, and Y. Ikada Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres Vaccine 14 1996 1677 1685
44. Y. Matsunaga, Y. Wakatsuki, Y. Tabata, H. Kawasaki, T. Usui, M. Yoshida, T. Itoh, S. Habu, and T. Kita Oral immunization with size-purified microsphere beads as a vehicle selectively induces systemic tolerance and sensitization Vaccine 19 2000 579 588
45. T. Jung, W. Kamm, A. Breitenbach, K.D. Hungerer, E. Hundt, and T. Kissel Tetanus toxoid loaded nanoparticles from sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide): evaluation of antibody response after oral and nasal application in mice Pharm. Res. 18 2001 352 360
46. I. Gutierro, R.M. Hernandez, M. Igartua, A.R. Gascon, and J.L. Pedraz Size dependent immune response after subcutaneous, oral and intranasal administration of BSA loaded nanospheres Vaccine 21 2002 67 77
47. X. Wang, T. Uto, K. Sato, K. Ide, T. Akagi, M. Okamoto, T. Kaneko, M. Akashi, and M. Baba Potent activation of antigen-specific T cells by antigen-loaded nanospheres Immunol. Lett. 98 2005 123 130
48. M. Matsusaki, K. Larsson, T. Akagi, M. Lindstedt, M. Akashi1, C. AK Borrebaeck, Nanosphere induced gene expression in human dendritic cells, Nano Lett. in press.
49. M. Kawamura, X. Wang, T. Uto, K. Sato, M. Ueno, T. Akagi, K. Hiraishi, T. Matsuyama, M. Akashi, and M. Baba Induction of dendritic cell-mediated immune responses against HIV-1 by antigen-capturing nanospheres in mice J. Med. Virol. 76 2005 7 15