Erectile dysfunction is a signal of risk for cardiovascular disease: A primary care view

Primary Care - Clinics in Office Practice

Volumn 32, Issue 4, 2005, Pages 977-993

  Sadovsky, Richard ^a   Miner, Martin ^b,c  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b Swansea Family Practice   (United States)

^c BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; COMORBIDITY; ENDOCRINE DISEASE; ENDOTHELIUM; ERECTILE DYSFUNCTION; HEART MUSCLE ISCHEMIA; HUMAN; MALE; NEUROLOGIC DISEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PSYCHOSOCIAL DISORDER; REVIEW; VASCULAR DISEASE;

CARDIOVASCULAR DISEASES; ENDOTHELIUM; HUMANS; IMPOTENCE; IMPOTENCE, VASCULOGENIC; MALE; PRIMARY HEALTH CARE; RISK ASSESSMENT; RISK FACTORS;

EID: 28444441554     PISSN: 00954543     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pop.2005.09.010     Document Type: Review

References (103)

1. R. Sadovsky, and J.P. Mulhall The potential value of erectile dysfunction inquiry and management Int J Clin Pract 57 7 2003 601 608
2. T. Lue Erectile dysfunction N Engl J Med 342 2000 1802 1813
3. M.E. Sullivan, S.R. Keoghane, and M.A. Miller Vascular risk factors and erectile dysfunction BJU Int 87 9 2002 838 845
4. E.J. Meuleman Prevalence of erectile dysfunction: need for treatment? Int J Impot Res 14 Suppl 2002 122 128
5. K.K. Chew, C.M. Earle, and B.G. Stuckey Erectile dysfunction in general medicine practice: prevalence and clinical correlates Int J Impot Res 12 2000 41 45
6. H.A. Feldman, J.B. McKinlay, and I. Goldstein Erectile dysfunction, cardiovascular disease and cardiovascular risk factors: prospective results in a large random sample of Massachusetts men J Urol 159 Suppl 5 1998 91
7. R.C. Rosen, W.A. Fisher, and I. Eardley The multinational Men's Attitudes to Life Events and Sexuality (MALES) study: I. Prevalence of erectile dysfunction and related health concerns in the general population Curr Med Res Opin 25 5 2004 607 617
8. H.A. Feldman, C.B. Johannes, and C.A. Derby Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study Prev Med 30 2000 328 338
9. K. Billups, and S. Fiedrich Assessment of fasting lipid panels and Doppler ultrasound testing in men presenting with erectile dysfunction and n other medical problems J Urol 163 4 2000 147
10. M.E. Sullivan, S.R. Keoghane, and M.A. Miller Vascular risk factors and erectile dysfunction BJU Int 87 9 2001 838 845
11. M. Burchardt, T. Burchhardt, and L. Baer Hypertension is associated with severe erectile dysfunction J Urol 164 4 2000 1188 1191
12. C.A. Derby, B.A. Mohr, and I. Goldstein Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk? Urology 56 2000 302 306
13. W.S. Chung, J.H. Sohn, and Y.Y. Park Is obesity an underlying factor in erectile dysfunction? Eur Urol 36 1999 68 70
14. A.B. Aruajo, R. Durnante, and H.A. Feldman The relationship between depressive symptoms and male erectile dysfunction: cross sectional results form the Massachusetts Male Aging Study Psychosom Med 60 1998 458 465
15. H.A. Feldman, I. Goldstein, and D.G. Hatzichristou Impotence and its medicla and psychosocial correlates: results of the Massachusetts Male Aging Study J Urol 151 1 1994 54 61
16. E.O. Lauman, A. Nicolosi, and D.B. Glasser Sexual problems among women and men aged 40-80y: prevalence and correlates identified in the global study of sexual atttitudes and behaviors Int J Impot Res 17 1 2005 39 57
17. T.H. Roumeguere, E. Wespes, and Y. Carpentier Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk Eur Urol 44 2003 355 359
18. D.M. DeWire Evaluation and treatment of ED Am Fam Physician 53 1996 2102 2107
19. Curkendall SM, Jones JK, Glasser D, et al. Incidence of medically detected erectile dysfunction and related diseases before and after Viagra (sildenafil citrate). Eur Urol ;37(Suppl 2):81.
20. C. Foresta, N. Caretta, and A. Aversa Erectile dysfunction: symptom or disease? J Endocrinol Invest 27 2004 80 95
21. T. Heitzer, T. Schlinzig, and K. Krohn Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease Circulation 108 2001 500
22. J.P. Halcox, W.H. Schenjke, and G. Zalos Prognostic value of coronary vascular endothelial dysfunction Circulation 106 2002 653 658
23. M. Burchardt, T. Burchardt, and A.G. Anastasiadis Erectile dysfunction is a marker for cardiovascular complications and psychological functioning in men with hypertension Int J Impot Res 13 2001 276 281
24. J.E. Morley, S.G. Korenman, and F.E. Kaiser Relationship of penile brachial pressure index to myocardial infarction and cerebrovascular accidents in older men Am J Med 84 1988 445 448
25. R.A. Kloner, S.H. Mullin, and T. Shook Erectile dysfunction in the cardiac patient: how common and should we treat? J Urol 170 2003 S46 S50
26. A. Greenstein, J. Chen, and H. Miller Does severity of ischemic coronary disease correlate with erectile function? Int J Impot Res 9 1997 123 126
27. R. Maas, E. Schwedhelm, and J. Albsmeier The pathophysiology of erectile dysfunction related to endothelial dysfunction and mediators of vascular function Vasc Med 7 2002 213 225
28. H. Solomon, J.W. Man, and G. Jackson Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator Heart 89 2003 251 253
29. M.A. Gonzalez, and A.P. Selwyn Endothelial function, inflammation, and prognosis in cardiovascular disease Am J Med 115 8A 2003 99S 106S
30. T.J. Bivalacqua, M.F. Usta, and H.C. Champion Enothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease J Androl 24 6 2003 S17 S37
31. H. Cai, and D.G. Harrison Endothelial dysfunction in cardiovascular diseases: the role of oxidative stress Circ Res 87 2000 840 844
32. D. Behrendt, and P. Ganz Endothelial function. From vascular biology to clinical applications Am J Cardiol 90 2002 40L 48L
33. A.J. Maxwell Mechanisms of dysfunction of the nitric oxide pathway in vascular diseases Nitric Oxide 6 2002 101 124
34. P. Libby, P.M. Ridker, and A. Maseri Inflammation and atherosclerosis Circulation 105 2002 1135 1143
35. R.A. Kloner, and M. Speakman Erectile dysfunction and atherosclerosis Curr Atheroscler Rep 4 5 2002 397 401
36. M. Pritzker The penile stress test: a window to the hearts of man? Circulation 100 Suppl 1 1999
37. D.S. Celermajer, K.E. Sorensen, and C. Bull Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction J Am Coll Cardiol 24 1994 1468 1474
38. R.G. Brindis, and R.A. Kloner Sildenafil in patients with cardiovascular disease Am J Cardiol 93 Suppl 2003 26M 36M
39. D.G. Edwards, R.S. Schofield, and S.L. Lennon Effect of exercise training on endothelial function in men with coronary artery disease Am J Cardiol 93 2004 617 620
40. M.E. Sullivan, C.S. Thompson, and M.R. Dashwood Nitric oxide and penile erection: is erectile dysfunction another manifestation of vascular disease? Cardiovasc Res 43 1999 658 665
41. D. Kaiser, K. Billups, and C. Mason Impaired brachial artery endothelium-dependent and-independent vasodilation in men with erectile dysfunction and no other clinical cardiovascular disease J Am Coll Cardiol 43 2004 179 184
42. A. Benet, and S. Melman The epidemiology of erectile dysfunction Urol Clin North Am 22 1995 699 709
43. P. Montorsi, F. Montorsi, and C.C. Schulman Is erectile dysfunction the "tip of the iceberg" of a systemic vascular disorder? Eur Urol 44 3 2003 352 354
44. M. Anderson, B. Nicholson, and E. Louie An analysis of vasculogenic erectile dysfunction as a potential predictor of occult cardiovascular disease J Urol 159 Suppl 5 1998 118
45. M.L. Zoler Erectile dysfunction may presage vascular dysfunction Fam Pract News 2004 40
46. F. Montorsi, A. Salonia, and P. Montorsi May erectile dysfunction predict heart disease? Int J Impot Res 14 Suppl 3 2002 S51
47. C. Gazzaruso, S. Giordanetti, and E. DeAmici Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients Circulation 110 2004 22 26
48. M. Bocchio, G. Desideri, and P. Scarpelli Endothelial cell activation in men with erectile dysfunction without cardiovascular risk factors and overt vascular damage J Urol 171 2004 1601 1604
49. A. Khan, A. Ledda, and D.P. Mikhalidis Second consensus conference on cardiovascular risk factors and erectile dysfunction Curr Med Res Opin 18 1 2002 33 35
50. M.D. Cheitlin Erectile dysfunction the earliest sign of generalized vascular disease J Am Coll Cardiol 43 2 2004 185 186
51. A. Lochmann, and J. Gallmetzer Erectile dysfunction of arterial origin as a possible manifestation of atherosclerosis Minerva Cardioangiol 44 1996 243 246
52. M. Kirby, and G. Jackson Is erectile dysfunction a marker for cardiovascular disease? Int J Clin Pract 55 2001 614 618
53. G. Jackson Sex, the heart and erectile dysfunction 2004 Taylor and Francis London p. 18
54. D.S. Celermajer Endothelial dysfunction: does it matter? Is it reversible? J Am Coll Cardiol 30 1997 325 333
55. D. Richardson, and A. Vinik Etiology and treatment of erectile failure in diabetes mellitus Curr Diab Rep 2 2002 501 509
56. Solomon H, Man JW, Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003;89:251-3.
57. R.D. Rakhit, and M.S. Marber Nitric oxide: an emerging role in cardioprotection? Heart 86 2001 368 372
58. US Preventive Services Task Force Screening for coronary heart disease. Recommendaiton statement Ann Intern Med 140 2004 569 572
59. E. Barrett-Connor Cardiovascular risk stratification and cardiovascular risk factors associated with erectile dysfunction Clin Cardiol 27 2004 I8 I13 4(Suppl)
60. P.W. Wilson, R.B. D'Agostino, and D. Levy Prediction of coronary heart disease using risk factor categories Circulation 97 1998 1837 1847
61. D.M. Lloyd-Jones, P.W. Wilson, and M.G. Larson Framingham risk score and prediction of lifetime risk for coronary heart disease Am J Cardiol 94 1 2004 20 24
62. D.G. Hackam, and S.S. Anand Emerging risk factors for atherosclerotic vascular disease JAMA 290 7 2003 932 940
63. P.M. Ridker, N. Rifai, and L. Rose Comparison of C-reactive protein and low density lipoprotein cholesterol levels in the prediction of first cardiovascular events N Engl J Med 347 2002 1557 1565
64. P. Greenland, L. LaBree, and S.P. Azen Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals JAMA 291 2004 210 215
65. S.W. Kim, J.S. Paick, and W. Park Potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction Urology 58 2001 441 445
66. P.D. O'Kane, and G. Jackson Erectile dysfunction: is there silent obstructive coronary artery disease? Int J Clin Pract 55 3 2001 219 220
67. B. Gazzaruso, S. Giordanetti, and E. De Amici Relationship between erectile dysfunction and silent myocardial ischemia in apparently uncomplicated type 2 diabetic patients Circulation 110 2004 22 26
68. R. Hambrecht, A. Wolf, and S. Gielen Effect of exercise on coronary endothelial function in patients with coronary artery disease New Engl J Med 342 2000 454 460
69. N. Gokce, J.A. Vita, and D.S. Bader Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease Am J Cardiol 90 2002 124 132
70. D.G. Edwards, R.S. Schofield, and S.L. Lennon Effect of exercise training on endothelial function in men with coronary artery disease Am J Cardiol 93 2004 617 620
71. K. Watts, P. Beye, and A. Siafarkas Effects of exercise training on vascular function in obese children J Pediatr 144 2004 620 625
72. G. Rose, and D.J.P. Barker Epidemiology for the uninitiated 2nd edition 1986 British Medical Journal London
73. I. Goldstein, M.B. Siroky, and D.S. Sax Neurologic abnormalities in multiple sclerosis J Urol 128 3 1982 541 545
74. H. Fujisawa, S. Igarashi, and T. Koyama Acute caudal equina syndrome secondary to lumbar disc herniation mimicking pure conus medullaris syndrome Neurol Med Chir (Tokyo) 38 7 1998 429 431
75. J. Zonszein Diagnosis and management of endocrine disorders of erectile dysfunction Urol Clin North Am 22 4 1995 789 802
76. E.D. Whitehead, and B.J. Klyde Diabetes-related impotence in the elderly Clin Geriatr Med 6 1990 771 795
77. G. DeBerardis, M. Franciosi, and Belfiglio Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked Diabetes Care 25 2002 284 291
78. S. Gaspar, M. Maytom, and L. Okamoto Comorbid conditions in patients with erectile dysfunction in a community setting Manag Care Interface 14 12 2001 36 42
79. J.H. Romero, A.D. Seftel, and Z.T. Madhun Sexual function in men with type 2 diabetes: association with glycemic control J Urol 163 2000 788 791
80. R. Klein, B.E. Klein, and K.E. Lee Prevalence of self-reported erectile dysfunction in people with long-term IDDM Diabetes Care 19 1996 135 141
81. W.J. Reiter, A. Pycha, and G. Schatzl Serum dehyproepiandosterone sulfate concentrations in men with erectile dysfunction Urology 55 5 2000 755 758
82. S.R. Fine Erectile dysfunction and comorbid diseases, androgen deficiency, and diminished libido in men J Am Osteopath Assoc 104 Suppl 1 2004 S9 S15
83. R. Rosen, J. Altwein, and P. Boyle Lower urinary tract symptoms and male sexual dysfunction. The Multinational Survey of the Aging Male (MSAM-7) Eur Urol 44 2003 637 649
84. P. Boyle, C. Robertson, and C. Mazzetta The association between lower urinary tract symptoms and erectile dysfunction in four centers. The UrEpik study BJU Int 92 2003 719 725
85. W.J. Hellstrom Benign prostatic hyperplasia, sexual function, and overall evaluation of the male patient J Am Osteopath Assoc 104 Suppl 2 2004 S5 S10
86. J.P. Mulhall, S.D. Creech, and S.A. Boorjian Subjective and objective analysis of the prevalence of Peyronie's disease in a population of men presenting for prostate cancer screening J Urol 171 2004 2350 2353
87. A. Kadioglu, T. Oktar, and E. Kandirali Incidentally diagnosed Peyronie's disease in men presenting with erectile dysfunction Int J Impot Res 16 6 2004 540 543
88. A.B. Aruajo, R. Durnante, and H.A. Feldman The relationship between depressive symptoms and male erectile dysfunction: cross sectional results form the Massachusetts Male Aging Study Psychosom Med 60 1998 458 465
89. S.P. Roose Depression: links with ischemic heart disease and erectile dysfunction J Clin Psychiatry 64 Suppl 10 2003 26 30
90. S.N. Seidman, and S.P. Roose The relationship between depression and erectile dysfunction Curr Psychiatry Rep 2 2000 201 205
91. R. Shabsigh, L.T. Klein, and S. Seidman Increased incidence of depressive symptoms in men with erectile dysfunction Urology 52 1998 848 852
92. R.J. Mathew, and M.I. Weinman Sexual dysfunctions in depression Arch Sex Behav 11 1982 323 328
93. S.H. Kennedy, S.E. Dickens, and B.S. Eisfeld Sexual dysfunction before antidepressant therapy in major depression J Affect Disord 56 1999 201 208
94. J.F. Todaro, B.J. Shen, and R. Niauru Effect of negative emotions on frequency of coronary heart disease (the Normative Aging Study) Am J Cardiol 92 2003 901 906
95. H. Hemingway, M. Shipley, and M.J. Mullen Social and psychosocial influences on inflammatory markers and vascular function in civil servants (the Whitehall II Study) Am J Cardiol 92 2003 984 987
96. B.G. Bokhourn, J.A. Clark, and T.S. Inui Sexuality after treatment for early prostate cancer; exploring the meanings of "erectile dysfunction." J Gen Intern Med 16 10 2001 649 655
97. F.E. Kaiser Erectiledysfunction in the aging man Med Clin N Am 83 1999 1267 1287
98. R. Sadovsky Asking the questions and offering solutions: the ongoing dialogue between the primary care physicians and the patient with erectile dysfunction Rev Urol 5 Suppl 7 2003 S35 S48
99. L.F. Berkman The role of social relations in health promotion Psychosom Med 57 1995 245 254
100. E. Freidman, and A.A. Thomas Pet ownership, social support, and one year survival after acute myocardial infarction in the Cardiac Arrhythmia Suppression Trial (CAST) Am J Cardiol 76 17 1995 1213 1217
101. W.L. Maurice Sexual medicine in primary care 1999 Mosby New York
102. K.M. Dunn, P.R. Croft, and G.I. Hackett Association of sexual problems with social, psychological, and physical problems in men and women; a cross-sectional population survey J Epidemiol Community Health 53 1999 144 148
103. L.F. Berkman Emotional support and survival after myocardial infarction: a prospective, population-based study of the elderly Ann Intern Med 117 12 1992 1003 1009