Structural determinants of the partial agonist-inverse agonist properties of 6'-azidohex-2'-yne-Δ8-tetrahydrocannabinol at cannabinoid receptors

British Journal of Pharmacology

Volumn 128, Issue 3, 1999, Pages 735-743

  Ross, Ruth A ^a   Gibson, T Michael ^a   Stevenson, Lesley A ^a   Saha, Bijali ^b   Crocker, Peter ^b   Razdan, Raj K ^b   Pertwee, Roger G ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ORGANIX INC   (United States)

Author keywords

6' Azidohex 2' yne 8 tetrahydrocannabinol; Cannabinoid CB1 receptors; Cannabinoid CB2 receptors; Cannabinoids; Inverse agonism; Mouse vas deferens; O 1184

Indexed keywords

1 DEOXYOCTYL 2' YNE DELTA 8 TETRAHYDROCANNABINOL; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 6' AZIDOHEX 2' ENE DELTA 8 TETRAHYDROCANNABINOL; 6' AZIDOHEX 2' YNE DELTA 8 TETRAHYDROCANNABINOL; CANNABINOID RECEPTOR; CYCLIC AMP; FORSKOLIN; OCTYL 2' YNE DELTA 8 TETRAHYDROCANNABINOL; TETRAHYDROCANNABINOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CELL MEMBRANE; CHO CELL; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROSTIMULATION; GENETIC TRANSFECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SMOOTH MUSCLE CONTRACTION; VAS DEFERENS;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; CYCLOHEXANOLS; ELECTRIC STIMULATION; FORSKOLIN; MALE; MICE; MUSCLE CONTRACTION; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROCANNABINOL; VAS DEFERENS;

EID: 0032749404     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702836     Document Type: Article

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