Ribozymes in the age of molecular therapeutics

Current Molecular Medicine

Volumn 4, Issue 5, 2004, Pages 489-506

  Bagheri, Sepideh ^a   Kashani Sabet, Mohammed ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti viral therapy; Cancer; Gene repair; Gene therapy; Molecular therapeutics; Repair of heritable diseases; Ribozymes; RNA catalysis

Indexed keywords

ANGIOZYME; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; BCR ABL PROTEIN; HEPTAZYME; HERBZYME; HERZYME; INTERFERON; LAMIVUDINE; PLEIOTROPHIN; PROTEIN MDM2; RIBONUCLEASE P; RIBOZYME; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; BREAST CANCER; CLINICAL TRIAL; COLORECTAL CANCER; DRUG EFFICACY; ENZYME ACTIVE SITE; ENZYME MECHANISM; GENE EXPRESSION; GENE IDENTIFICATION; GENE TARGETING; HEPATITIS B; HEPATITIS C; HUMAN; LUNG CANCER; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; REVIEW; RNA SEQUENCE; SIDE EFFECT; SPLICEOSOME; TRANS SPLICING; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; GENE THERAPY; GENETIC DISEASES, INBORN; HUMANS; INTRONS; NEOPLASMS; NUCLEIC ACID CONFORMATION; RIBONUCLEASE P; RNA SPLICING; RNA, CATALYTIC; RNA, MESSENGER; VIRUS DISEASES;

EID: 3242670633     PISSN: 15665240     EISSN: None     Source Type: Journal    
DOI: 10.2174/1566524043360410     Document Type: Review

References (215)

1. Uhlenbeck, O.C. (1987) Nature, 328, 596-600.
2. Kruger, K., Grabowski, P.J., Zaug, A.J., Sands, J., Gottschling, D.E. and Cech, T.R. (1982) Cell, 31, 147-157.
3. Forster, A.C. and Symons, R.H. (1987) Cell, 49, 211-220.
4. Forster, A.C. and Symons, R.H. (1987) Cell, 50, 9-16.
5. Haseloff, J. and Gerlach, W.L. (1992) Biotechnology, 24, 264-269.
6. Symons, R.H. (1992) Annu. Rev. Biochem., 61, 641-671.
7. Phylactou, L.A., Kilpatrick, M.W. and Wood, M.J. (1998) Hum. Mol. Genet, 7, 1649-1653.
8. Pley, H.W., Flaherty, K.M. and McKay, D.B. (1994) Nature, 372, 68-74.
9. Scott, W.G., Finch, J.T. and Klug, A. (1995) Cell, 81, 991-1002.
10. Kore, A.R., Vaish, N.K., Kutzke, U. and Eckstein, F. (1998) Nucleic Acids Res., 26, 4116-4120.
11. Peracchi, A., Beigelman, L., Scott, E.C., Uhlenbeck, O.C. and Herschlag, D. (1997) J. Biol. Chem., 272, 26822-26826.
12. Wang, S., Karbstein, K., Peracchi, A., Beigelman, L. and Herschlag, D. (1999) Biochemistry, 38, 14363-14378.
13. Scott, E.C. and Uhlenbeck, O.C. (1999) Nucleic Acids Res., 27, 479-484.
14. Takagi, Y., Warashina, M., Stec, W.J., Yoshinari, K. and Taira, K. (2001) Nucleic Acids Res., 29, 1815-1834.
15. Doudna, J.A. and Cech, T.R. (2002) Nature, 418, 222-228.]
16. Dahm, S.C., Derrick, W.B. and Uhlenbeck, O.C. (1993) Biochemistry, 32, 13040-13045.
17. Scott, W.G., Murray, J.B., Arnold, J.R., Stoddard, B.L. and Klug, A. (1996) Science, 274, 2065-2069.
18. Pontius, B.W., Lott, W.B. and von Hippel, P.H. (1997) Proc. Natl. Acad. Sci. U.S.A., 94, 2290-2294.
19. Zhou, D.M., Zhang, L.H. and Taira, K. (1997) Proc. Natl. Acad. Sci. U.S.A., 94, 14343-14348.
20. Lott, W.B., Pontius, B.W. and von Hippel, P.H. (1998) Proc. Natl. Acad. Sci. U.S.A., 95, 542-547.
21. Murray, J.B., Seyhan, A.A., Walter, N.G., Burke, J.M. and Scott, W. G. (1998) Chem. Biol., 5, 587-595.
22. O'Rear, J.L., Wang, S., Feig, A.L., Beigelman, L., Uhlenbeck, O.C. and Herschlag D. (2001) RNA, 7, 537-545.
23. Fedor, M.J. and Westhof, E. (2002) Mol. Cell, 10, 703-704.
24. Lewin, A.S. and Hauswirth, W.W. (2001) Trends Mol. Med., 7, 221-228.
25. Ferre-D'amare, A.R. and Rupert, P.B. (2002) Biochem. Soc. Trans., 30, 1105-1109.
26. Rupert, P.B., Massey, A.P., Sigurdsson, S.T. and Ferré-D'Amaré, A.R. (2002) Science, 298, 1421-1424.
27. Lai, M.M. (1995) Annu. Rev. Biochem., 64, 259-286.
28. Levesque, D., Choufani, S. and Perreault, J.P. (2002) RNA, 8, 4644-4677.
29. Shih, I.H. and Been, M.D. (2002) Annu. Rev. Biochem., 71, 887-917.
30. Roy, G., Ananvoranich, S. and Perreault, J.P. (1999) Nucleic Acids Res., 27, 942-948.
31. Ananvoranich, S., Lafontaine, D.A. and Perreault, J.P. (1999) Nucleic Acids Res., 27, 1473-1479.
32. Deschenes, P., Lafontaine, D.A., Charland, S. and Perreault, J.P. (2000) Antisense Nucleic Acid Drug Dev., 10, 53-61.
33. Shih, I.H. and Been, M.D. (2001) EMBO J., 20, 4884-4891.
34. Bergeron, L.J. and Perreault, J.P. (2002) Nucleic Acids Res., 30, 4682-4691.
35. Collins, R.A. and Saville, B.J. (1990) Nature, 345, 177-179.
36. Saville, B.J. and Collins, R.A. (1991) Proc. Natl. Acad. Sci. U.S.A., 88, 8826-8830.
37. Jones, F.D., Ryder, S.P. and Strobel, S.A. (2001) Nucleic Acids Res., 29, 5115-5120.
38. Collins, R.A. and Olive, J.E. (1993) Biochemistry, 32, 2795-2799.
39. Guo, H.C. and Collins, R.A. (1995) EMBO J., 14, 368-376.
40. Collins, R.A. (2002) Biochem. Soc. Trans., 30, 1122-1126.
41. Cech, T.R. (1990) Annu. Rev. Biochem., 59, 543-568.
42. Sullenger, B.A. and Cech, T.R. (1994) Nature, 371, 619-622.
43. Shan, S., Yoshida, A., Sun, S., Piccirilli, J.A. and Herschlag, D. (1999) Proc. Natl. Acad. Sci. U.S.A., 96, 12299-12304.
44. Michel, F. and Ferat, J.L. (1995) Annu. Rev. Biochem., 64, 435-461.
45. Zimmerly, S., Guo, H., Eskes, R., Yang, J., Perlman, P.S. and Lambowitz, A.M. (1995) Cell, 83, 529-538.
46. Zimmerly, S., Guo, H., Perlman, P.S. and Lambowitz, A.M. (1995) Cell, 82, 545-554.
47. Matsuura, M., Saldanha, R., Ma, H., Wank, H., Yang, J., Mohr, G., Cavanagh, S., Dunny, G.M., Belfort, M. and Lambowitz, A.M. (1997) Genes Dev., 11, 2910-2924.
48. Guo, H., Zimmerly, S., Perlman, P.S. and Lambowitz, A.M. (1997) EMBO J., 16, 6835-6848.
49. Eskes, R., Yang, J., Lambowitz, A.M. and Perlman P.S. (1997) Cell, 88, 865-874.
50. Cousineau, B., Smith, D., Lawrence-Cavanagh, S., Mueller, J.E., Yang, J., Mills, D., Manias, D., Dunny, G., Lambowitz, A.M. and Belfort, M. (1998) Cell, 94, 451-462.
51. Guo, H., Karberg, M., Long, M., Jones, J.P. 3rd, Sullenger, B. and Lambowitz, A.M. (2000) Science, 289, 452-457.
52. Bhattacharya, D., Simon, D., Huang, J., Cannone, J.J. and Gutell, R.R. (2003) BMC Evol. Biol., 3, 7.
53. Sullenger, B.A. and Gilboa, E. (2002) Nature, 418, 252-258.
54. Kikumori, T., Cote, G.J. and Gagel, R.F. (2001) Hum. Gene Ther., 12, 1429-1441.
55. Dallinger, G., Puttaraju, M., Mitchell, L.G., Yancey, K.B., Yee, C., Klausegger, A., Hintner, H. and Bauer, J.W. (2003) Exp. Dermatol., 12, 37-46.
56. Frank, D.N. and Pace, N.R. (1998) Annu. Rev. Biochem., 67, 153-180.
57. Vioque, A., Arnez, J. and Altman, S. (1988) J. Mol. Biol., 202, 835-848.
58. Altman, S. and Kirsebom, L.A. (1999) The RNA World. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
59. Fang, X. W., Yang, X.J., Littrell, K., Niranjanakumari, S., Thiyagarajan, P., Fierke, C.A., Sosnick, T.R. and Pan, T. (2001) RNA, 7, 233-241.
60. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N. and Altman, S. (1983) Cell, 35, 849-857.
61. Pannucci, J.A., Haas, E.S., Hall, T.A., Harris, J.K., and Brown, J.W. (1999) Proc. Natl. Acad. Sci. U.S.A., 96, 7803-7808.
62. Guerrier-Takada, C., Haydock, K., Allen, L. and Altman, S. (1986) Biochemistry, 25, 1509-1515.
63. Smith, D. and Pace, N.R. (1993) Biochemistry, 32, 5273-5281.
64. Kirsebom, L.A. (2002) Biochem. Soc. Trans., 30, 1153-1158.
65. Trang, P., Lee, J., Kilani, A.F., Kim, J. and Liu, F. (2001) Nucleic Acids Res., 29, 5071-5078.
66. Forster, A.C. and Altman, S. (1990) Science, 249, 783-786.
67. Cobaleda, C. and Sanchez-Garcia, I. (2000) Blood, 95, 731-737.
68. Trang, P., Lee, M., Nepomuceno, E., Kim, J., Zhu, H. and Liu, F. (2000) Proc. Natl. Acad. Sci. U.S.A., 97, 5812-5817.
69. Trang, P., Kilani, A., Lee, J., Hsu, A., Liou, K., Kim, J., Nassi, A., Kim, K. and Liu, F. (2002) J. Clin. Virol., 25, S63-S74.
70. Kilani, A.F., Trang, P., Jo, S., Hsu, A., Kim, J., Nepomuceno, E., Liou, K. and Liu, F. (2000) J. Biol. Chem., 275, 10611-10622.
71. Trang, P., Hsu, A., Zhou, T., Lee, J., Kilani, A.F., Nepomuceno, E. and Liu, F. (2002) J. Mol. Biol., 315, 573-586.
72. Jaschke, A., Stuhlmann, F., Bebenroth, D., Keiper, S. and Wombacher, R. (2001) Biochem. Soc. Trans., 30, 1137-1140.
73. Jaschke, A. (2001) Biol. Chem., 382, 1321-1325.
74. Zhang, B. and Cech, T.R. (1997) Nature, 390, 96-100.
75. Sun, L., Cui, Z., Gottlieb, R.L. and Zhang, B. (2002) Chem. Biol., 9, 619-628.
76. Wiegand, T.W., Janssen, R.C. and Eaton, B.E. (1997) Chem. Biol., 4, 675-683.
77. Eisenfuhr, A., Arora, P.S., Sengle, G., Takaoka, L.R., Nowick, J.S., and Famulok, M. (2003) Bioorg. Med. Chem., 11, 235-249.
78. Sengle, G., Eisenfuhr, A., Arora, P.S., Nowick, J.S. and Famulok, M. (2001) Biol. Chem., 8, 459-473.
79. Jenne, A. and Famulok, M. (1998) Chem. Biol., 5, 23-24.
80. Suga, H., Lohse, P.A. and Szostak, J.W. (1998) J. Am. Chem. Soc., 120, 1151-1156.
81. Vaidya, A. and Suga, H. (2001) Biochemistry, 40, 7200-7210.
82. Lohse, P.A. and Szostak, J.W. (1996) Nature, 381, 442-444.
83. Flynn-Charlebois, A., Lee, N. and Suga, H. (2001) Biochemistry, 40, 13623-13632.
84. Moore, P.B. and Steitz, T.A. (2003) RNA, 9, 155-159.
85. Jadhav, V.R. and Yarus, M. (2002) Biochemistry, 41, 723-729.
86. Soukup, G.A. and Breaker, R.R. (1999) Proc. Natl. Acad. Sc. U.S.A i., 96, 3584-3589.
87. Soukup, G.A. and Breaker, R.R. (1999) Trends Biotechnol., 17, 469-476.
88. Breaker, R.R. (2002) Curr. Opin. Biotechnol., 13, 31-39.
89. Soukup, G.A. and Breaker, R.R. (1999) Structure Fold. Des., 7, 783-791.
90. Kuwabara, T., Tanabe, T., Warashina, M., Xiong, K.X., Tani, K., Taira, K. and Asana, S. (2001) Biomacromolecules, 2, 1220-1228.
91. Iyo, M., Kawasaki, H. and Taira, K. (2002) Curr. Opin. Mol. Ther., 4, 154-165.
92. Tanabe, T., Takata, I., Kuwabara, T., Warashina, M., Kawasaki, H., Tani, K., Ohta, S., Asano, S. and Taira, K. (2000) Biomacromolecules, 1, 108-117.
93. Suwanai, H., Matsushita, H., Kobayashi, H., Ikeda, Y. and Kizaki, M. (2002) Int. J. Oncol., 20, 127-130.
94. Piganeau, N., Jenne, A., Thuillier, V. and Famulok, M. (2001) Angew. Chem. Int. Ed. Engl., 40, 3503.
95. Hartig, J.S., Najafi-Shoushtari, S.H., Grune, I., Yan, A., Ellington, A.D. and Famulok, M. (2002) Nat. Biotechnol., 20, 717-722.
96. Jenne, A., Hartig, J.S., Piganeau, N., Tauer, A., Samarsky, D.A., Green, M.R., Davies, J. and Famulok, M. (2001) Nat. Biotechnol., 19, 56-61.
97. Hartig, J.S. and Famulok, M. (2002) Angew. Chem. Int. Ed. Engl., 41, 4263-4266.
98. Zinnen, S.P., Domenico, K., Wilson, M., Dickinson, B.A., Beaudry, A., Mokler, V., Daniher, A.T., Burgin, A. and Beigelman, L. (2002) RNA, 8, 214-228.
99. Parry, T.J., Cushman, C., Gallegos, A.M., Agrawal, A.B., Richardson, M., Andrews, L.E., Maloney, L., Mokler, V.R., Wincott, F. E. and Pavco, P.A. (1999) Nucleic Acids Res., 27, 2569-2577.
100. Beigelman, L., McSwiggen, J.A., Draper, K.G., Gonzalez, C., Jensen, K., Karpeisky, A.M., Modak, A.S., Matulic-Adamic, J., DiRenzo, A.B., Haeberli, P., Sweedler, D., Tracz, D., Grimm, S., Wincott, F.E., Thackray, V.G. and Usman, N. (1995) J. Biol. Chem., 270, 25702-25708.
101. Pieken, W.A., Olsen, D.B., Benseler, F., Aurup, H. and Eckstein, F. (1991) Science, 253, 314-317.
102. Jarvis, T.C., Wincott, F.E., Alby, L.J., McSwiggen, J.A., Beigelman, L., Gustofson, J., DiRenzo, A., Levy, K., Arthur, M., Matulic-Adamic, J., Karpeisky, A., Gonzalez, C., Woolf, T.M., Usman, N. and Stinchcomb, D.T. (1996) J. Biol. Chem., 271, 29107-29112.
103. Sandberg, J.A., Bouhana, K.S., Gallegos, A.M., Agrawal, A.B., Grimm, S.L., Wincott, F.E., Reynolds, M.A., Pavco, P.A. and Parry, T.J. (1999) Antisense Nucleic Acid Drug Dev., 9, 271-277.
104. Aigner, A., Fischer, D., Merdan, T., Brus, C., Kissel, T. and Czubayko, F. (2002) Gene Ther., 9, 1700-1707.
105. Felgner, P.L., Tsai, Y.J., Sukhu, L., Wheeler, C.J., Manthorpe, M., Marshall, J. and Cheng, S.H. (1995) Ann. N.Y. Acad. Sci., 772, 126-139.
106. Konopka, K., Rossi, J.J., Swiderski, P., Slepushkin, V.A. and Duzgunes, N. (1998) Biochim. Biophys. Acta., 1372, 55-68.
107. Duzgunes, N., Simoes, S., Slepushkin, V., Pretzer, E., Rossi, J.J., De Clercq, E., Antao, V.P., Collins, M.L. and de Lima, M.C. (2001) Nucleosides Nucleotides Nucleic Acids, 20, 515-523.
108. Chirmule, N., Propert, K., Magosin, S., Qian, Y., Qian, R. and Wilson, J. (1999) Gene Ther., 6, 1574-1583.
109. Li, H.O., Zhu, Y.F., Asakawa, M., Kuma, H., Hirata, T., Ueda, Y., Lee, Y.S., Fukumura, M., Iida, A., Kato, A., Nagai, Y. and Hasegawa, M. (2000) J. Virol., 74, 6564-6569.
110. Armeanu, S., Ungerechts, G., Bernloehr, C., Bossow, S., Gregor, M., Neubert, W.J., Lauer, U.M. and Bitzer, M. (2003) J. Virol. Methods, 108, 229-233.
111. Sakai, Y., Kiyotani, K., Fukumura, M., Asakawa, M., Kato, A., Shioda, T., Yoshida, T., Tanaka, A., Hasegawa, M. and Nagai, Y. (1999) FEBS Lett., 456, 221-226.
112. Khromykh, A.A. (2000) Curr. Opin. Mol. Ther., 2, 555-569.
113. Bertrand, E., Castanotto, D., Zhou, C., Carbonnelle, C., Lee, N.S., Good, P., Chatterjee, S., Grange, T., Pictet, R., Kohn, D., Engelke, D. and Rossi, J.J. (1997) RNA, 3, 75-88.
114. Good, P.D., Krikos, A.J., Li, S.X., Bertrand, E., Lee, N.S., Giver, L., Ellington, A., Zaia, J.A., Rossi, J.J. and Engelke, D.R. (1997) Gene Ther., 4, 45-54.
115. Kato, Y., Kuwabara, T., Warashina, M., Toda, H. and Taira, K. (2001) J. Biol. Chem., 276, 15378-15385.
116. Chang, Z., Westaway, S., Li, S., Zaia, J.A., Rossi, J.J. and Scherer, L.J. (2002) Mol. Ther., 6, 481-489.
117. Westaway, S.K., Larson, G.P., Li, S., Zaia, J.A. and Rossi, J.J. (1995) Nucleic Acids Symp. Ser., 33, 194-199.
118. Kuwabara, T., Warashina, M., Koseki, S., Sano, M., Ohkawa, J., Nakayama, K. and Taira, K. (2001) Nucleic Acids Res., 29, 2780-2788.
119. Ohta, Y., Kijima, H., Ohkawa, T., Kashani-Sabet, M. and Scanlon, K.J. (1996) Nucleic Acids Res., 24, 938-942.
120. Shaw, L.C., Skold, A., Wong, F., Petters, R., Hauswirth, W.W. and Lewin, A.S. (2001) Mol. Vis., 7, 6-13.
121. LaVail, M.M., Yasumura, D., Matthes, M.T., Drenser, K.A., Flannery, J.G., Lewin, A.S. and Hauswirth, W.W. (2000) Proc. Natl. Acad. Sci. U.S.A., 97, 11488-11493.
122. Lewin, A.S., Drenser, K.A., Hauswirth, W.W., Nishikawa, S., Yasumura, D., Flannery, J.G. and LaVail, M.M. (1998) Nat. Med., 4, 967-971.
123. Scanlon, K.J., Ishida, H. and Kashani-Sabet. M. (1994) Proc. Natl. Acad. Sci. U.S.A., 91, 11123-11127.
124. Thomas, M.K., Devon, O.N., Lee, J.H., Peter, A., Schlosser, D.A., Tenser, M.S. and Habener, J.F. (2001) J. Clin. Invest., 108, 310-329.
125. Tu, G., Kirchmaier, A.L., Liggitt, D., Liu, Y., Liu, S., Yu, W.H., Heath, T.D., Thor, A. and Debs, R.J. (2000) J. Biol. Chem., 275, 30408-30416.
126. Mathews, D.H., Sabina, J., Zuker, M. and Turner, D.H. (1999) J. Mol. Biol., 288, 911-940.
127. Takagi, Y., Suyama, E., Kawasaki, H., Miyagishi, M. and Taira, K. (2002) Biochem. Soc. Trans., 30, 1145-1149.
128. Tang, H., Gaietta, G.M., Fischer, W.H., Ellisman, M.H. and Wong-Staal, F. (1997) Science, 276, 1412-1415.
129. Warashina, M., Kuwabara, T., Kato, Y., Sano, M. and Taira, K. (2001) Proc. Natl. Acad. Sci. U.S.A., 98, 5572-5577.
130. Wadhwa, R., Ando, H., Kawasaki, H., Taira, K. and Kaul, S.C. (2003) EMBO Rep., 4, 595-601.
131. Suyama, E., Kawasaki, H., Nakajima, M. and Taira, K. (2003) Proc. Natl. Acad. Sci. U.S.A., 100, 5616-5621.
132. Kawasaki, H., Onuki, R., Suyama, E. and Taira, K. (2002) Nat. Biotechnol., 20, 376-380.
133. Kawasaki, H. and Taira, K. (2002) EMBO Rep., 3, 443-450.
134. Rossi, J.J. (1999) Curr. Opin. Mol. Ther., 1, 316-322.
135. Castanotto, D., Li, J.R., Michienzi, A., Langlois, M.A., Lee, N.S., Puymirat, J. and Rossi, J.J. (2001) Biochem. Soc. Trans., 30, 1140-1145.
136. Sarver, N., Cantin, E.M., Chang, P.S., Zaia, J.A., Ladne, P.A., Stephens, D.A. and Rossi, J.J. (1990) Science, 247, 1222-1225.
137. Rossi, J.J. (2000) Adv. Drug Deliv. Rev., 44, 71-78.
138. Ojwang, J.O., Hampel, A., Looney, D.J., Wong-Staal, F. and Rappaport, J. (1992) Proc. Natl. Acad. Sci. U.S.A., 89, 10802-10806.
139. Li, X., Gervaix, A., Kang, D., Law, P., Spector, S.A., Ho, A.D. and Wong-Staal, F. (1998) Gene Ther., 5, 233-239.
140. Wang, L., Witherington, C., King, A., Gerlach, W.L., Carr, A., Penny, R., Cooper, D., Symonds, G. and Sun, L.Q. (1998) Hum. Gene Ther., 9, 1283-1291.
141. Rigden, J.E., Ely, J.A., Macpherson, J.L., Gerlach, W.L., Sun, L.Q. and Symonds, G.P. (2000) Curr. Issues Mol. Biol., 2, 61-69.
142. Yu, M., Ojwang, J., Yamada, O., Hampel, A., Rapapport, J., Looney, D., Wong-Staal, F. (1993) Proc. Natl. Acad. Sci. U.S.A., 90, 6340-6344.
143. Feng, Y., Leavitt, M., Tritz, R., Duarte, E., Kang, D., Mamounas, M., Gilles, P., Wong-Staal, F., Kennedy, S., Merson, J., Yu, M. and Barber, J.R. (2000) Virology, 276, 271-278.
144. Welch, P.J., Tritz, R., Yei, S., Barber, J. and Yu, M. (1997) Gene Ther., 4, 736-743.
145. Wang, C.H, Tsai, L.J., Tsao, Y.P., Hsieh, J.T., Chien, W.W., Liao, C.L., Wang, H.W., Liu, H.S. and Chen, S.L. (2002) Biochem. Biophys. Res. Commu., 298, 805-814.
146. Tone, T., Kashani-Sabet, M., Funato, T., Shitara, T., Yoshida, E., Kashfian, B.I., Horng, M., Fodstadt, O. and Scanlon K.J. (1993) In Vivo, 7, 471-476.
147. Kashani-Sabet, M., Funato, T., Tone, T., Jiao, L., Wang, W., Yoshida, E., Kashfinn, B.I., Shitara, T., Wu, A.M., Moreno, J.G., Traweek, S.T., Ahlering, T.E. and Scanlon, K.J. (1992) Antisense Res. Dev., 2, 3-15.
148. Ohta, Y., Kijima, H., Kashani-Sabet, M. and Scanlon, K.J. (1996) J. Invest. Dermatol., 106, 275-280.
149. Zhang, Y.A., Nemunaitis, J., Scanlon, K.J. and Tong A.W. (2000) Gene Ther., 7, 2041-2050.
150. Tsuchida, T., Kijima, H., Oshika, Y., Tokunaga, T., Abe, Y., Yamazaki, H., Tamaoki, N., Ueyama, Y., Scanlon, K.J. and Nakamura, M. (1998) Biochem. Biophys. Res. Commun., 253, 368-373.
151. Gibson, S.A., Pellenz, C., Hutchison, R.E., Davey, F.R. and Shillitoe, E.J. (2000) Clin. Cancer Res., 6, 213-222.
152. Reed, J. C. (1997) Semin. Hematol., 34, 9-19.
153. Luzi, E., Papucci, L., Schiavone, N., Donnini, M., Lapucci, A., Tempestini, A., Witort, E., Nicolin, A. and Capaccioli, S. (2003) Cancer Gene Ther., 10, 201-208.
154. Ludwig, A., Saretzki, G., Holm, P.S., Tiemann, F., Lorenz, M., Emrich, T., Harley, C.B. and von Zglinicki, T. (2001) Cancer Res., 61, 3053-3061.
155. Tekur, S. and Ho, S.M. (2002) Mol. Carcinog., 33, 44-55.
156. Kiehntopf, M., Brach, M.A., Licht, T., Petschauer, S., Karawajew, L., Kirschning, C. and Herrmann, F. (1994) EMBO J., 13, 4645-4652.
157. Matsushita, H., Kizaki, M., Kobayashi, H., Ueno, H., Muto, A., Takayama, N., Awaya, N., Kinjo, K., Hattori, Y. and Ikeda, Y. (1998) Blood, 91, 2452-2458.
158. Wang, F.S., Kobayashi, H., Liang, K.W., Holland, J.F. and Ohnuma, T. (1999) Hum. Gene Ther., 10, 1185-1195.
159. Nagata, J., Kijima, H., Hatanaka, H., Asai, S., Miyachi, H., Abe, Y., Yamazaki, H., Nakamura, M., Watanabe, N., Mine, T., Kondo, T., Scanlon, K.J. and Ueyama, Y. (2002) Int. J. Oncol., 21, 1021-1026.
160. Kobayashi, H., Takemura, Y. and Miyachi, H. (2001) Hum. Cell, 14, 172-184.
161. Nagata, J., Kijima, H., Hatanaka, H., Asai, S., Miyachi, H., Takagi, A., Miwa, T., Mine, T., Yamazaki, H., Nakamura, M., Kondo, T., Scanlon, K.J. and Ueyama, Y. (2001) Biochem. Biophys. Res. Commun., 286, 406-413.
162. Pennati, M., Colella, G., Folini, M., Citti, L., Daidone, M.G. and Zaffaroni, N. (2002) J. Clin. Invest, 109, 285-286.
163. Pennati, M., Binda, M., Colella, G., Folini, M., Citti, L., Villa, R., Daidone, M.G. and Zaffaroni, N. (2003) J. Invest. Dermatol., 120, 648-654.
164. Choi, K.S., Lee, T.H. and Jung, M.H. (2003) Cancer Gene Ther. 10, 87-95.
165. Orlandi, L., Binda, M., Folini, M., Bearzatto, A., Villa, R., Daidone, M.G. and Zaffaroni, N. (2003) Prostate, 54, 133-143.
166. Leirdal, M. and Sioud, M. (1999) Br. J. Cancer, 80, 1558-1564.
167. Funato, T., Yoshida, E., Jiao, L., Tone, T., Kashani-Sabet, M. and Scanlon, K.J. (1992) Adv. Enzyme Regul., 32, 195-209.
168. Funato, T., Ishii, T., Kanbe, M., Scanlon, K.J. and Sasaki, T. (1997) In Vivo, 11, 217-220.
169. Aigner, A., Renneberg, H., Bojunga, J., Apel, J., Nelson, P.S. and Czubayko, F. (2002) Oncogene, 21, 5733-5742.
170. Czubayko, F., Liaudet-Coopman, E.D., Aigner, A., Tuveson, A.T., Berchem, G.J. and Wellstein, A. (1997) Nat. Med., 3, 1137-1140.
171. Czubayko, F., Riegel, A.T. and Wellstein, A. (1994) J. Biol. Chem., 269, 21358-21363.
172. Czubayko, F., Schulte, A.M., Berchem, G.J. and Wellstein, A. (1996) Proc. Natl. Acad. Sci. U.S.A., 93, 14753-14758.
173. Weber, D., Klomp, H.J., Czubayko, F., Wellstein, A. and Juhl, H. (2000) Cancer Res., 60, 5284-5288.
174. Powers, C., Aigner, A., Stoica, G.E., McDonnell, K. and Wellstein, A. (2002) J. Biol. Chem., 277, 14153-14158.
175. Maelandsmo, G.M., Hovig, E., Skrede, M., Engebraaten, O., Florenes, V.A., Myklebost, O., Grigorian, M., Lukanidin, E., Scanlon, K.J. and Fodstad, O. (1996) Cancer Res., 56, 5490-5498.
176. Herynk, M.H., Stoeltzing, O., Reinmuth, N., Parikh, N.U., Abounader, R., Laterra, J., Radinsky, R., Ellis, L.M. and Gallick, G.E. (2003) Cancer Res., 63, 2990-2996.
177. Kashani-Sabet, M., Liu, Y., Fong, S., Desprez, P.Y., Liu, S., Tu, G., Nosrati, M., Handumrongkul, C., Liggitt, D., Thor, A.D. and Debs, R.J. (2002) Proc. Natl. Acad. Sci. U.S.A., 99, 3878-3883.
178. Hua, J. and Muschel, R.J. (1996) Cancer Res., 56, 5279-5284.
179. Sehgal, G., Hua, J., Bernhard, E.J., Sehgal, I., Thompson, T.C. and Muschel, R.J. (1998) Am.J. Pathol., 152, 591-596.
180. Bauer, G.I., Valdez, P., Kearns, K., Bahner, I., Wen, S.F., Zaia, J.A. and Kohn, D.B. (1997) Blood, 89, 2259-2267.
181. Wong-Staal, F., Poeschla, E.M. and Looney, D.J. (1998) Hum. Gene Ther., 9, 2407-2425.
182. Amado, R.G., Mitsuyasu, R.T., Symonds, G., Rosenblatt, J.D., Zack, J., Sun, L.Q., Miller, M., Ely, J. and Gerlach, W. (1999) Hum. Gene Ther., 10, 2255-2270.
183. Usman, N. and Blatt, L.M. (2000) J. Clin. Invest., 106, 1197-1202.
184. Pavco, P.A., Bouhana, K.S., Gallegos, A.M., Agrawal, A., Blanchard, K.S., Grimm, S.L., Jensen, K.L., Andrews, L.E., Wincott, F.E., Pitot, P.A., Tressler, R.J., Cushman, C., Reynolds, M.A. and Parry, T.J. (2000) Clin. Cancer Res., 6, 2094-2103.
185. Morrissey, D.V., Lee, P.A., Johnson, D.A., Overly, S.L., McSwiggen, J.A., Beigelman, L., Mokler, V.R., Maloney, L., Vargeese, C., Bowman, K., O'Brien, J.T., Shaffer, C.S., Conrad A., Schmid P., Morrey, J.D., Macejak, D.G., Pavco, P.A. and Blatt, L.M. (2002) J. Viral Hepat., 9, 411-418.
186. Lee, P.A., Blatt, L.M., Blanchard, K.S., Bouhana, K.S., Pavco, P.A., Bellon, L. and Sandberg, J.A. (2000) Hepatology, 32, 640-646.
187. Lui, V.W., He, Y., Goyal, K. and Huang, L. (2001) Mol. Ther., 3, 169-177.
188. Suzuki, T., Anderegg, B., Ohkawa, T., Irie, A., Engebraaten, O., Halks-Miller, M., Holm, P.S., Curiel, D.T., Kashani-Sabet, M. and Scanlon, K.J. (2000) Gene Ther., 7, 241-248.
189. Thybusch-Bernhardt, A., Aigner, A., Beckmann, S., Czubayko, F. and Juhl, H. (2001) Eur. J. Cance., 37, 1688-1694.
190. Macejak, D.G., Jensen, K.L., Pavco, P.A., Phipps, K.M., Heinz, B.A., Colacino, J.M. and Blatt, L.M. (2001) J. Viral Hepat., 8, 400-405.
191. Karayiannis, P. (2003) J. Antimicrob. Chemother., 51, 761-785.
192. Kilpatrick, M.W. and Phylactou, L.A. (1998) Mol. Med. Today, 4, 376-381.
193. Phylactou, L.A., Tsipouras, P. and Kilpatrick, M.W. (1998) Biochem. Biophys. Res. Commun., 249, 804-810.
194. Kilpatrick, M.W., Phylactou, L.A., Godfrey, M., Wu, C.H., Wu, G.Y. and Tsipouras, P. (1996) Hum. Mol. Genet, 5, 1939-1944.
195. Phylactou, L.A., Darrah, C. and Wood, M.J. (1998) Nat. Genet., 18, 378-381.
196. Lan, N., Howrey, R.P., Lee, S.W., Smith, C.A. and Sullenger, B.A. (1998) Science, 280, 1593-1596.
197. Rogers, C.S., Vanoye, C.G., Sullenger, B.A. and George, A.L. Jr. (2002) J. Clin. Invest., 110, 1783-1789.
198. Watanabe, T. and Sullenger, B.A. (2000) Adv. Drug Deliv. Rev., 44, 109-118.
199. Puttaraju, M., DiPasquale, J., Baker, C.C., Mitchell, L.G. and Garcia-Blanco, M.A. (2001) Mol. Ther., 4, 105-114.
200. Puttaraju, M., Jamison, S.F., Mansfield, S.G., Garcia-Blanco, M.A. and Mitchell, L.G. (1999) Nat. Biotechnol., 17, 246-252.
201. Dallinger, G., Puttaraju, M., Mitchell, L.G., Yancey, K.B., Hintner, H. and Bauer, J.W. (2000) J. Invest. Dermatol., 115, 332.
202. Liu, X., Jiang, Q., Mansfield, S.G., Puttaraju, M., Zhang, Y., Zhou, W., Cohn, J.A., Garcia-Blanco, M.A., Mitchell, L.G. and Engelhardt, J.F. (2002) Nat. Biotechnol., 20, 47-52.
203. Mansfield, S.G., Kole, J., Puttaraju, M., Yang, C.C., Garcia-Blanco, M.A., Cohn, J.A. and Mitchell, L.G. (2000) Gene Ther., 7, 1885-1895.
204. Chao, H., Mansfield, S.G., Bartel, R.C., Hiriyanna, S., Mitchell, L.G., Garcia-Blanco, M.A., and Walsh, C.E. (2003) Nat. Med., 9, 1015-1019.
205. Dolzhanskaya, N., Conti, J., Merz, G., and Denman, R.B. (2000) Mol. Cell Biol. Res. Commun., 4, 239-247.
206. Denman, R.B., Smedman, M., Ju, W., Rubenstein, R., Potempska, A. and Miller, D.L. (1994) Nucleic Acids Res., 22, 2375-2382.
207. Denman, R.B., Rosenzcwaig, R. and Miller, D.L. (1993) Biochem. Biophys. Res. Commun., 192, 96-103.
208. Denman, R.B. and Miller, D.L. (1993) Arch. Biochem. Biophys., 305, 392-400.
209. Qi, X., Lewin, A.S., Hauswirth, W.W., and Guy, J. (2003) Invest. Ophthalmol. Vis. Sci., 44, 1088-1096.
210. Flory, C.M., Pavco, P.A., Jarvis, T.C., Lesch, M.E., Wincott, F.E., Beigelman, L., Hunt, S.W. 3rd and Schrier, D.J. (1996) Proc. Natl. Acad. Sci. U.S.A., 93, 754-758.
211. Jarvis, T.C., Bouhana, K.S., Lesch, M.E., Brown, S.A., Parry, T.J., Schrier, D.J., Hunt, S.W. 3rd, Pavco, P.A. and Flory, C.M. (2000) J. Immunol., 165, 493-498.
212. Turck, J., Pollock, A.S., Lee, L.K., Marti, H.P. and Lovett, D. H. (1996) J. Biol. Chem., 271, 15074-15083.
213. Tsukioka, K., Suzuki, J., Fujimori, M., Wada, Y., Yamaura, K., Ito, K., Morishita, R., Kaneda, Y., Isobe, M. and Amano, J. (2002) J. Cardiovasc. Res., 56, 472-478.
214. Afzal, A., Shaw, L.C., Caballero, S., Spoerri, P.E., Lewin, A.S., Zeng, D., Belardinelli, L. and Grant, M.B. (2003) Circ. Res., 93, 500-506.
215. Shaw, L.C., Afzal, A., Lewin, A.S., Timmers, A.M., Spoerri, P.E. and Grant, M.B. (2003) Invest. Ophthalmol. Vis. Sci., 44, 4105-4113.