Species differences in the elimination of a peroxisome proliferator- activated receptor agonist highlighted by oxidative metabolism of its acyl glucuronide

Drug Metabolism and Disposition

Volumn 33, Issue 12, 2005, Pages 1894-1904

  Kochansky, Christopher J ^a   Xia, Yuan Qing ^a   Wang, Sui ^a   Cato, Brian ^a   Creighton, Mellissa ^a   Vincent, Stella H ^a   Franklin, Ronald B ^a   Reed, James R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[5,7 DIPROPYL 3 (TRIFLUOROMETHYL) 1,2 BENZOISOXAZOL 6 YL]OXY] 2 METHYLPROPANOIC ACID; ACYLGLUCURONIDE; CARBON 14; CARBOXYLIC ACID; DRUG METABOLITE; GLUCURONIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SACCHAROLACTONE; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE GLUCURONIC ACID;

AEROBIC METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG BILE LEVEL; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; FEMALE; HUMAN; HUMAN CELL; LIVER CELL; LIVER MICROSOME; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; SPECIES COMPARISON;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOGS; GLUCURONIDES; HEPATOCYTES; HUMANS; ISOXAZOLES; MACACA MULATTA; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; OXIDATION-REDUCTION; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY;

ANIMALIA; CANIS FAMILIARIS;

EID: 28144444061     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.004010     Document Type: Article

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