Porcine endogenous retrovirus in xenotransplantation

Current Opinion in Organ Transplantation

Volumn 10, Issue 4, 2005, Pages 334-337

  Patience, Clive ^a  

^a BIOGEN   (United States)

Author keywords

Porcine; Porcine endogenous retrovirus; Safety; Xenotransplantation

Indexed keywords

ANIMAL HUSBANDRY; GENE LOCATION; GENETIC ENGINEERING; GERM LINE; GRAFT INFECTION; INFECTION RISK; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NONHUMAN; PATIENT MONITORING; RETROVIRUS; REVIEW; SWINE; TRANSGENIC ANIMAL; VIRUS RECOMBINATION; XENOGRAFT; XENOTRANSPLANTATION;

EID: 28044471982     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/01.mot.0000184015.08703.b2     Document Type: Review

References (25)

1. Niebert M, Tonjes RR. Evolutionary spread and recombination of porcine endogenous retroviruses in the suiformes. J Virol 2005; 79:649-654.
2. Scobie L, Taylor S, Logan NA, et al. Characterization of germline porcine endogenous retroviruses from Large White pig. J Gen Virol 2004; 85:2421-2428.
3. Scobie L, Taylor S, Wood JC, et al. Absence of replication-competent human-tropic porcine endogenous retroviruses in the germ line DNA of inbred miniature Swine. J Virol 2004; 78:2502-2509.
4. Lu Q, Han H, Lian Z, et al. The screening and identification of endogenous retrovirus free CEMPs. Sci China C Life Sci 2004; 47:562-566. Once the identification of pigs that lack all PERV has been substantiated, these animals would represent a major advance for xenotransplantation from a safety perspective. Further analysis is needed, and is keenly awaited.
5. Oldmixon BA, Wood JC, Ericsson TA, et al. Porcine endogenous retrovirus transmission characteristics of an inbred herd of miniature swine. J Virol 2002; 76:3045-3048.
6. Harrison I, Takeuchi Y, Bartosch B, et al. Determinants of high titer in recombinant porcine endogenous retroviruses. J Virol 2004; 78:13871-13879. The precise delineation of the determinants of high titer growth in human cells has confirmed PERV-C as a critical factor. By selecting animals lacking PERV-C expression, one will minimize the potential of generating the recombinant PERV, which is probably the greatest microbiological safety concern for xenotransplantation.
7. Bartosch B, Stefandis D, Myers R, et al. Evidence and consequence of porcine endogenous retrovirus recombination. J Virol 2004; 78:13880-13890. This is a similar manuscript to Harrison et al., which also concludes safety advantages of using PERV-C negative donor pigs.
8. Klymiuk N, Aigner B. Reliable classification and recombination analysis of porcine endogenous retroviruses. Virus Genes 2005; 30:357-362.
9. Lavillette D, Kabat D. Porcine endogenous retroviruses infect cells lacking cognate receptors by an alternative pathway: implications for retrovirus evolution and xenotransplantation. J Virol 2004; 78:8868-8877.
10. Watanabe R, Miyazawa T, Matsuura Y. Cell-binding properties of the envelope proteins of porcine endogenous retroviruses. Microbes Infect 2005; 7:658-665.
11. Karlas A, Kurth R, Denner J. Inhibition of porcine endogenous retroviruses by RNA interference: increasing the safety of xenotransplantation. Virology 2004; 325:18-23.
12. Lai L, Kolber-Simonds D, Park KW, et al. Production of alpha-1,3-galactosyl-transferase knockout pigs by nuclear transfer cloning. Science 2002; 295:1089-1092.
13. Phelps CJ, Koike C, Vaught TD, et al. Production of alpha 1,3-galactosyltransferase-deficient pigs. Science 2003; 299:411-414.
14. Kuwaki K, Tseng YL, Dor FJ, et al. Heart transplantation in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat Med 2005; 11:29-31.
15. Yamada K, Yazawa K, Shimizu A, et al. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med 2005; 11:32-34.
16. Quinn G, Wood JC, Ryan DJ, et al. Porcine endogenous retrovirus transmission characteristics of galactose alpha1-3 galactose-deficient pig cells. J Virol 2004; 78:5805-5811.
17. Ramachandran S, Jaramillo A, Xu XC, et al. Human immune responses to porcine endogenous retrovirus-derived peptides presented naturally in the context of porcine and human major histocompatibility complex class I molecules: implications in xenotransplantation of porcine organs. Transplantation 2004; 77:1580-1588.
18. Binette TM, Seeberger KL, Lyon JG, et al. Porcine endogenous retroviral nucleic acid in peripheral tissues is associated with migration of porcine cells post islet transplant. Am J Transplant 2004; 4:1051-1060.
19. Goto M, Maeda A, Elfman L, et al. No transmission of porcine endogenous retrovirus after transplantation of adult porcine islets into diabetic nude mice and immunosuppressed rats. Xenotransplantation 2004; 11:340-346.
20. Kuddus RH, Metes DM, Nalesnik MA, et al. Porcine cell microchimerism but lack of productive porcine endogenous retrovirus (PERV) infection in naive and humanized SCID-beige mice treated with porcine peripheral blood mononuclear cells. Transpl Immunol 2004; 13:15-24.
21. Irgang M, Karlas A, Laue C, et al. Porcine endogenous retroviruses PERV-A and PERV-B infect neither mouse cells in vitro nor SCID mice in vivo. Intervirology 2005; 48:167-173.
22. Moscoso I, Hermida-Prieto M, Manez R, et al. Lack of cross-species transmission of porcine endogenous retrovirus in pig-to-baboon xenotransplantation with sustained depletion of anti-alphagal antibodies. Transplantation 2005; 79:777-782.
23. Winkler ME, Winkler M, Burian R, et al. Analysis of pig-to-human porcine endogenous retrovirus transmission in a triple-species kidney xenotransplantation model. Transpl Int 2005; 17:848-858.
24. Yang YG, Wood JC, Lan P, et al. Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice. J Clin Invest 2004; 114:695-700. This study highlights the limitations to certain mouse models of PERV infection. More stringent models of PERV infectivity in vivo are required to generate a representative analysis of the factors that might influence PERV transmission in the clinic.
25. Martina Y, Kurian S, Cherqui S, et al. Pseudotyping of porcine endogenous retrovirus by xenotropic murine leukemia virus in a pig islet xenotransplantation model. Am J Transplant 2005; 5:1837-1847. The further delineation of the role of murine viruses in PERV infectivity in vivo will allow for the improvement of safety studies in murine models.