Lack of cross-species transmission of porcine endogenous retrovirus in pig-to-baboon xenotransplantation with sustained depletion of anti-αGal antibodies

Transplantation

Volumn 79, Issue 7, 2005, Pages 777-782

  Moscoso, Isabel ^a   Hermida Prieto, Manuel ^b   Mañez, Rafael ^a,c   Lopez Pelaez, Eduardo ^a   Centeno, Alberto ^a   Diaz, Tomas M ^a   Domenech, Nieves ^a  

^a HOSPITAL JUAN CANALEJO   (Spain)

^b UNIVERSITY OF A CORUÑA   (Spain)

^c HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Anti Gal 1 3Gal antibodies; Porcine endogenous retrovirus (PERV); Xenotransplantation

Indexed keywords

ANTI ALPHA GAL ANTIBODIES; ANTIBODY; MITOCHONDRIAL DNA; UNCLASSIFIED DRUG;

ARTICLE; BABOON; CHIMERA; DEPLETION; DNA SEQUENCE; ENTEROVIRUS; HEART GRAFT; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT; LYMPH NODE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; SWINE; VIRUS TRANSMISSION; XENOTRANSPLANTATION;

ANIMALS; ANTIBODIES; CELL LINE; CHIMERA; ENDOGENOUS RETROVIRUSES; GALACTOSE; HEART TRANSPLANTATION; HUMANS; KIDNEY TRANSPLANTATION; PAPIO; POLYMERASE CHAIN REACTION; RETROVIRIDAE INFECTIONS; RNA, MESSENGER; SPECIES SPECIFICITY; SWINE; TRANSPLANTATION, HETEROLOGOUS; TRISACCHARIDES;

EID: 17444431233     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.TP.0000152662.55720.83     Document Type: Article

References (22)

1. Kuwaki K, Knosalla C, Dor FJM, et al. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD 154 mb-based regimen. Am J Transplant 2004; 4: 363.
2. Onions D, Cooper DKC, Alexander TJL, et al. An approach to the control of disease transmission in pig-to-human xenotransplantation. Xenotransplantation 2000; 7: 143.
3. Patience C, Takeuchi Y, Weiss RA. Infection of human cells by an endogenous retrovirus of pigs. Nat Med 1997; 3: 282.
4. Van der Laan LJW, Lockey C, Griffeth BC, et al. Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice. Nature 2000; 407: 90.
5. Paradis K, Langford G, Long Z, et al. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science 1999; 285: 1236.
6. Blusch JH, Patience C, Martin U. Pig endogenous retroviruses and xenotransplantation. Xenotransplantation 2002; 9: 242.
7. Rother RP, Fodor WL, Springhorn JP, et al. A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibodies. J Exp Med 1995; 182: 1345.
8. Weiss RA. Transgenic pigs and virus adaptation. Nature 1998; 391: 327.
9. Specke V, Rubant S, Denner J. Productive infection of human primary cells and cell lines with porcine endogenous retroviruses. Virology 2001; 285: 177.
10. Katopodis AG, Warner RG, Duthaler RO, et al. Removal of anti-Galalpha1,3Gal xenoantibodies with an injectable polymer. J Clin Invest 2002; 110(12): 1869.
11. Blusch JH, Patience C, Takeuchi Y, et al. Infection of nonhuman primate cells by pig endogenous retrovirus. J Virol 2000; 74: 7687.
12. Ritzhaupt A, Van Der Laan LJ, Salomon DR, et al. Porcine endogenous retrovirus infects but does not replicate in nonhuman primate primary cells and cell lines. J Virol 2002; 76: 11312.
13. Martin U, Tacke SJ, Simon AR, et al. Absence of PERV specific humoral immune response in baboons after transplantation of porcine cells or organs. Transpl Int 2002; 15: 361.
14. Manez R, Blanco FJ, Diaz I, et al. Removal of bowel aerobic gram-negative bacteria is more effective than immunosuppression with cyclophosphamide and steroids to decrease natural alpha-galactosyl IgG antibodies. Xenotransplantation 2001; 8: 15.
15. Matthews AL, Brown J, Switzer W, et al. Development and validation of a western immunoblot assay for detection of antibodies to porcine endogenous retrovirus. Transplantation 1999; 67: 939.
16. Martin U, Winkler ME, Id M, et al. Productive infection of primary human endothelial cells by pig endogenous retrovirus (PERV). Xenotransplantation 2000; 7: 138.
17. Switzer WM, Michler RE, Shanmugam V, et al. Lack of cross-species transmission of porcine endogenous retrovirus infection to nonhuman primate recipients of porcine cells, tissues, or organs. Transplantation 2001; 71: 959.
18. Loss M, Arends H, Winkler M, et al. Analysis of potential porcine endogenous retrovirus (PERV) transmission in a whole-organ xenotransplantation model without interfering microchimerism. Transpl Int 2001; 14: 31.
19. McKane W, Lee J, Preston R, et al. Polymorphism in the human anti-pig natural antibody repertoire. Transplantation 1998; 66: 626.
20. Lin SS, Hanaway MJ, Gonzalez-Stawinski GV, et al. The role of anti-Gal alpha 1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. Transplantation 2000; 70: 1667.
21. Manez R, Domenech N, Diaz T, et al. Acute humoral rejection of hDAF pig organs transplanted in baboons may be caused by non anti-alpha-Gal elicited antibodies. Transplantation 2002; 74 (suppl): 357.
22. Simon AR, Schroder C, Martin U, et al. Induction of long-term peripheral microchimerism in non-human primates in a model of xenogeneic peripheral tolerance induction. Ann Transplant 2002; 7: 40.