Effect and mechanisms of FR167653, a dual inhibitor of TNF-α and IL-1, on BCG plus LPS induced-liver injury

Inflammation Research

Volumn 54, Issue 11, 2005, Pages 471-477

  Yao, H W ^a   Yue, L ^b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b ANHUI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

FR167653; Hepatocyte injury; Interleukin 1; Kupffer cells; Tumor necrosis factor

Indexed keywords

1 [7 (4 FLUOROPHENYL) 1,2,3,4 TETRAHYDRO 8 (4 PYRIDYL)PYRAZOLO[5,1 C][1,2,4]TRIAZIN 2 YL] 2 PHENYLETHANEDIONE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BCG VACCINE; GELATINASE A; INTERLEUKIN 1; INTERLEUKIN 1 ANTIBODY; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; LIPOPOLYSACCHARIDE; PRONASE; PROTEIN INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR INHIBITOR; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVATION; CELL DEATH; CELL INFILTRATION; CELL ISOLATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DENSITY GRADIENT CENTRIFUGATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATORY CELL; KUPFFER CELL; LIVER; LIVER CELL; LIVER INJURY; MALE; MOUSE; NONHUMAN; PROTEIN CONTENT; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPECTROPHOTOMETRY; STATISTICAL SIGNIFICANCE; TAIL; VEIN;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS, TOXIC; INTERLEUKIN-1; KUPFFER CELLS; LIPOPOLYSACCHARIDES; LIVER; LIVER FUNCTION TESTS; MALE; MICE; MYCOBACTERIUM BOVIS; PYRAZOLES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUBERCULOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 28044456308     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-005-1381-6     Document Type: Article

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