CD8αα homodimer expression and role in CD8 T cell memory generation during influenza virus A infection in mice

European Journal of Immunology

Volumn 35, Issue 11, 2005, Pages 3103-3110

  Zhong, Weimin ^a   Reinherz, Ellis L ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

CD8 coreceptor; Influenza A virus; T cell memory; Thymic leukemia antigen

Indexed keywords

CD8ALPHA ANTIGEN; INTERLEUKIN 7 RECEPTOR; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; CELL MATURATION; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION REGULATION; IN VIVO STUDY; INFLUENZA; INFLUENZA VIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION;

ANIMALS; ANTIGENS, CD8; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; DIMERIZATION; ENHANCER ELEMENTS (GENETICS); FEMALE; IMMUNOLOGIC MEMORY; INFLUENZA A VIRUS; MICE; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; UP-REGULATION;

EID: 27944487059     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535162     Document Type: Article

References (23)

1. Littman, D. R., Thomas, Y., Maddon, P. J., Chess, L. and Axel, R., The isolation and sequence of the gene encoding T8: A molecule defining functional classes of T lymphocytes. Cell 1985. 40: 237-246.
2. Potter, T. A., Rajan, T. V., Dick, R. F., 2nd and Bluestone, J. A., Substitution at residue 227 of H-2 class I molecules abrogates recognition by CD8-dependent, but not CD8-independent, cytotoxic T lymphocytes. Nature 1989. 337: 73-75.
3. Salter, R. D., Benjamin, R. J., Wesley, P. K., Buxton, S. E., Garrett, T. P., Clayberger, C., Krensky, A. M. et al., A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Nature 1990. 345: 41-46.
4. Veillette, A., Bookman, M. A., Horak, E. M. and Bolen, J. B., The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell 1988. 55: 301-308.
5. Kern, P. S., Teng, M. K., Smolyar, A., Liu, J. H., Liu, J., Hussey, R. E., Spoerl, R. et al., Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity 1998. 9: 519-530.
6. Hayday, A., Theodoridis, E., Ramsburg, E. and Shires, J., Intraepithelial lymphocytes: Exploring the Third Way in immunology. Nat. Immunol. 2001. 2: 997-1003.
7. Renard, V., Romero, P., Vivier, E., Malissen, B. and Luescher, I. F., CD8 beta increases CD8 coreceptor function and participation in TCR-ligand binding. J. Exp. Med. 1996. 184: 2439-2444.
8. Witte, T., Spoerl, R. and Chang, H. C., The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers. Cell. Immunol. 1999. 191: 90-96.
9. Garcia, K. C., Scott, C. A., Brunmark, A., Carbone, F. R., Peterson, P. A., Wilson, I. A. and Teyton, L., CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature 1996. 384: 577-581.
10. Leishman, A. J., Naidenko, O. V., Attinger, A., Koning, F., Lena, C. J., Xiong, Y., Chang, H. C. et al., T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. Science 2001. 294: 1936-1939.
11. Weber, D. A., Attinger, A., Kemball, C. C., Wigal, J. L., Pohl, J., Xiong, Y., Reinherz, E. L. et al., Peptide-independent folding and CD8 alpha alpha binding by the nonclassical class I molecule, thymic leukemia antigen. J. Immunol. 2002. 169: 5708-5714.
12. Liu, Y., Xiong, Y., Naidenko, O. V., Liu, J., Zhang, R., Joachimiak, A., Kronenberg, M. et al., The Crystal Structure of a TL/CD8alphaalpha complex at 2.1 A resolution. Implications for modulation of T cell activation and memory. Immunity 2003. 18: 205-215.
13. Madakamutil, L. T., Christen, U., Lena, C. J., Wang-Zhu, Y., Attinger, A., Sundarrajan, M., Ellmeier, W. et al., CD8alphaalpha-mediated survival and differentiation of CD8 memory T cell precursors. Science 2004. 304: 590-593.
14. Zhong, W., Reche, P. A., Lai, C. C., Reinhold, B. and Reinherz, E. L., Genome-wide characterization of a viral cytotoxic T lymphocyte epitope repertoire. J. Biol. Chem. 2003. 278: 45135-45144.
15. Schluns, K. S. and Lefrancois, L., Cytokine control of memory T-cell development and survival. Nat. Rev. Immunol. 2003. 3: 269-279.
16. Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D. and Ahmed, R., Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 2003. 4: 1191-1198.
17. Sallusto, F., Lenig, D., Forster, R., Lipp, M. and Lanzavecchia, A., Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999. 401: 708-712.
18. Wherry, E. J., Teichgraber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H. and Ahmed, R., Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 2003. 4: 225-234.
19. + T cells persist in the lungs following recovery from respiratory virus infections. J. Immunol. 2001. 166: 1813-1822.
20. Ellmeier, W., Sunshine, M. J., Losos, K. and Littman, D. R., Multiple developmental stage-specific enhaners regulate CD8 expression in developing thymocytes and in thymus-independent T cells. Immunity 1998. 9: 485-496.
21. Cawthon, A. G., Lu, H. and Alexander-Miller, M. A., Peptide requirement for CTL activation reflects the sensitivity to CD3 engagement: Correlation with CD8alphabeta versus CD8alphaalpha expression. J. Immunol. 2001. 167: 2577-2584.
22. Zhong, W. and Reinherz, E. L., In vivo selection of a TCR V beta repertoire directed against an immunodominant influenza virus CTL epitope. Int. Immunol. 2004. 16: 1549-1559.
23. Chandele, A. and Kaech, S. M., Memory CD8 T cell maturation occurs independently of CD8αα. J. Immunol. 2005, in press.