Localization of quinolinic acid in the murine AIDS model of retrovirus-induced immunodeficiency: Implications for neurotoxicity and dendritic cell immunopathogenesis

AIDS

Volumn 10, Issue 2, 1996, Pages 151-158

  Espey, Michael G ^a   Tang, Yao ^b   Morse III, Herbert C ^b   Moffett, John R ^a   Namboodiri, M A Aryan ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

AIDS; AIDS dementia complex; Excitotoxicity; Immunohistochemistry; Interdigitating dendritic cell; Murine leukemia virus; Spleen

Indexed keywords

QUINOLINIC ACID;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; DISEASE COURSE; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IMMUNOREACTIVITY; LYMPHOID TISSUE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS;

EID: 0030022167     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199602000-00004     Document Type: Article

References (47)

1. Heyes MP, Brew BJ, Martin A, et al.: Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status. Ann Neurol 1991, 29:202-209.
2. Stone TW, Perkins MN: Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS. Eur J Pharmacol 1981, 72:411-412.
3. Schwarcz R, Whestsell WO, Mangano RM: Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in the rat brain. Science 1983, 219:316-318.
4. Weiss JH, Hartley DM, Koh J, Choi DW: The calcium channel blocker nefidipine attenuates slow excitatory amino acid neurotoxicity. Science 1990, 247:1474-1477.
5. Lu YM, Zhang JT, Zhao FQ, Qin YF: Effects of calcium antagonists on glutamate release and calcium influx in the hippocampus with in vivo intracerebral microdialysis. Br J Pharmacol 1991, 104:222-226.
6. Köhler C, Erikson LG, Okuno E, Schwarcz R: Localization of quinolinic acid metabolizing enzymes in the rat brain. Imimunohistochemical studies using antibodies to 3-hydroxyanthranillic acid oxygenase and quinolinic acid phosphoribosyltransrerase. Neuroscience 1988, 27:49-76.
7. Roberts RO, McCarthy KE, Du F, Okuno E, Schwarcz R: Immunocytochemical localization of the quinolinic acid synthesizing enzyme, 3-hydroxyanthranilic acid oxygenase in rat substantia-nigra. Brain Res 1994, 650:229-238.
8. During MJ, Heyes MP, Freese A, Markey SP, Martin JB, Roth RH: Quinolinic acid concentrations in striatal extracellular fluid reach potentially neurotoxic levels following systemic kynurenine loading. Brain Res 1989, 476:384-387.
9. Saito K, Crowley JS, Markey SP, Heyes MP: A mechanism for increased quinolinic acid formation following acute systemic immune stimulation. J Biol Chem 1993, 268:15496-15503.
10. Yasui H, Takai K, Yoshita R, Hayaishi O: Interferon enhances tryptophan metabolism by inducing indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients. Proc Natl Acad Sci USA 1986, 83:6622-6626.
11. Musso T, Gusella GL, Brooks A, Longo DL, Varesio L: Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes. Blood 1994, 83:1408-1411.
12. Thomas SR, Mohr D, Stocker R: Nitricoxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes. J Biol Chem 1994, 269:14457-14464.
13. Espey MG, Moffett JR, Namboodiri MAA: Temporal and spatial changes in quinolinic acid immunoreactivity in the immune system of lipopolysaccharide stimulated mice. J Leuk Biol 1994, 57:199-206.
14. Morse HC III, Chattopadhyay SK, Makino M, Fredrickson TN, Hügin AW, Hartley JW: Retrovirus-induced immunodeficiency in the mouse: MAIDS as a model for AIDS. AIDS 1992, 6:607-621.
15. Jolicoeur P: Murine immunodeficiency syndrome (MAIDS): an animal model to study the AIDS pathogenesis. FASEB J 1991, 5:2398-2405.
16. Klinken HP, Fredrickson TN, Hartley JW, Yetter RA, Morse HC III: Evolution of B cell lineage lymphomas in mice with a retrovirus-induced immunodeficiency syndrome, MAIDS. J Immunol 1988, 140:1123-1131.
17. Sei Y, Arora PR, Skolnick P, Paul IA: Spatial learning impairment in a murine model of AIDS. FASEB J 1992, 6:3008-3013.
18. + subset regulation in viral infection: preferential activation of Th2 cells during progression of retrovirus-induced immunodeficiency in mice. J Immunol 1992, 148:182-188.
19. Pitha PM, Biegel D, Yetter RA, Morse HC III: Abnormal regulation of IFN-α, -β, -γ expression in MAIDS, a murine retrovirus-induced immunodeficiency syndrome. J Immunol 1988, 141:3611-3616.
20. Rosenberg AS, Maniera TG, Morse HC III: In vivo immunological deficits in mice with murine acquired immunodeficiency syndrome and the effect of LP-BM5 infection on rejection of skin from infected mice. Transplantation Proc 1991, 23:167-169.
21. Cerny A, Izui S, Saurat JH, Waldvogel FA, Morse HC III, Hauser C: Epidermal and splenic antigen presenting cell function in a retrovirally induced murine deficiency syndrome (MAIDS). Arch Dermatol Res 1992, 284:189-192.
22. Masuda A, Burton GF, Fuchs BA, Szakal AK, Tew JG: Destruction of follicular dendritic cells in murine acquired immunodeficiency syndrome (MAIDS). Adv Exp Med Biol 1993, 329:411-416.
23. Masuda A, Burton GF, Fuchs BA, et al.: Follicular dendritic cell function and murine AIDS. Immunology 1994, 81:41-46.
24. Sei Y, Paul IA, Saito K, et al.: Quinolinic acid levels in a murine retrovirus-induced immunodeficiency syndrome. J Neurochem 1996 (in press).
25. Laterjet R, Duplan JF: Experiments and discussion on leukemogenesis by cell-free extracts of radiation-induced leukemia in mice. Int J Radiat Biol 1962, 5:339-344.
26. Moiser DE, Yetter RA, Morse HC III: Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice. J Exp Med 1985, 161:766-784.
27. Chattopadhyay SK, Morse HC III, Makino M, Ruscetti SK, Hartley JW: A defective virus is associated with induction of retrovirus-induced immunodeficiency syndrome, MAIDS. Proc Natl Acad Sci USA 1989, 86:3862-3866.
28. Moffett JR, Espey MG, Namboodiri MAA: Antibodies to quinolinic acid and the determination of its cellular distribution within the rat immune system. Cell Tissue Res 1994, 278:461-469.
29. Veerman AJP: On the interdigitating cells in the thymus-dependent area of the rat spleen: a relation between the mononuclear phagocyte system and T lymphocytes. Cell Tissue Res 1973, 148:247-257.
30. Breel M, Mebius RE, Kraal G: The interaction of interdigitating cells and lymphocytes in vitro and in vivo. Immunology 1988, 17:331-337.
31. Swartzendruber DC, Congdon CC: Electron microscopic observations on tingible macrophages in mouse spleen. J Cell Biol 1963, 19:641-646.
32. Fliedner TM: On the origin of tingible bodies in germinal centers. In Germinal Centers in Immune Responses. Edited by Cottier H, Odartchenko D, Schindler R, Congdon CC. New York: Springer-Verlag; 1967:218-221.
33. Smith JP, Lister AM, Tew JG, Szakal AK: Kinetics of the tingible body macrophage response in mouse germinal center development and its depression with age. Anat Rec 1991, 229:511-520.
34. Rademakers LHPM, De Weger RA, Roholl PJM: Identification of alkaline phosphatase positive cells in human germinal centers as follicular dendritic cells. Adv Exp Med Biol 1988, 237:165-169.
35. Ennas MG, Chilosi M, Scarpa A, Lantini MS, Cadeddu G, Fiore-Donati L: Isolation of multicellular complexes of follicular dendritic cells and lymphocytes: immunphenotypical characterization, electron microscopy and culture studies. Cell Tissue Res 1989, 257:9-15.
36. Rausch DM, Heyes MP, Murray EA, et al.: Cytopathologic and neurochemical correlate of progression to motor/cognitive impairment in SIV-infected rhesus monkeys. J Neuropathol Exp Neurol 1994, 53:165-175.
37. Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith QR: Blood brain barrier transport of kynurenines: implications for brain synthesis and metabolism. J Neurochem 1991, 56:2007-2017.
38. Popovich PG, Horner PJ, Mullin BB, Wei P, Stokes BT: A quantitative spatial analysis of blood-brain barrier permeability after spinal contusion injury. Society for Neuroscience. Miami, November 1994 [abstract 85.7].
39. Nagra RM, Burrola PG, Wiley CA: Development of spongiform encephalopathy in retroviral infected mice. Lab Invest 1992, 66:292-302.
40. Hurwitz AA, Berman JW, Lyman WD: The role of the blood-brain barrier in HIV infection of the central nervous system. Adv Neuroimmunol 1994, 4:249-256.
41. Werner-Felmayer G, Werner ER, Fuchs D, Hausen A, Reibnegger G, Watcher H: Tumor necrosis factor-α and lipopolysaccharide enhance interferon induced tryplophan degradation and pleridine synthesis in human cells. Biol Chem Hoppe-Seyler 1989, 370:1063-1069.
42. Heyes MP, Saito K, Markey SP: Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid. Biochem J 1992, 283:633-635.
43. Fuchs D, Forsman A, Hagberg L, et al.: Immune activation and decreased tryptophan in patients with HIV1 infection. J Interferon Res 1990, 10:599-603.
44. Hortin GL, Landt M, Powderly WG: Changes in plasma amino acid concentrations in response to HIV-1 infection. Clin Chem 1994, 40:785-789.
45. Yoshida R, Nukiwa T, Watanabe Y, Fujiwara M, Hirata F, Hayaishi O: Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and epididymis of mice. Arch Biochem Biophys 1980, 203:343-351.
46. Rapoport MI, Beisel WR, Hornick RB: Tryptophan metabolism during infectious illness in man. J Infect Dis 1970, 122:159-169.
47. Takikawa O, Yoshida R, Kido R, Hayaishi O: Tryptophan degradation in mice initiated by indoleamine dioxygenase. J Biol Chem 1986, 261:3648-3653.