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Volumn 17, Issue 6, 2005, Pages 591-597

Recurrent miscarriage: Pathophysiology and outcome

Author keywords

Cytokines; Insulin resistance; Miscarriage; Natural killer cells; Preimplantation genetic diagnosis; Thrombophilias

Indexed keywords

ACETYLSALICYLIC ACID; BLOOD CLOTTING FACTOR 5 LEIDEN; CD56 ANTIGEN; ENOXAPARIN; FIBRINOGEN; HEPARIN; IMMUNOGLOBULIN; INSULIN SENSITIZING AGENT; LOW MOLECULAR WEIGHT HEPARIN; METFORMIN; PHOSPHOLIPID ANTIBODY; PLACENTA PROTEIN 14; SOMATOMEDIN BINDING PROTEIN; STEROID; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 27844555339     PISSN: 1040872X     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.gco.0000194112.86051.26     Document Type: Review
Times cited : (154)

References (84)
  • 1
    • 0030939856 scopus 로고    scopus 로고
    • Future pregnancy outcome in unexplained recurrent first trimester miscarriage
    • Clifford K, Rai R, Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Hum Reprod 1997; 12:387-389.
    • (1997) Hum Reprod , vol.12 , pp. 387-389
    • Clifford, K.1    Rai, R.2    Regan, L.3
  • 2
    • 1242284169 scopus 로고    scopus 로고
    • Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations
    • Sugiura-Ogasawara M, Ozaki Y, Sato T, Suzumori N, Suzumori K. Poor prognosis of recurrent aborters with either maternal or paternal reciprocal translocations. Fertil Steril 2004; 81:367-373. This study shows a poorer outcome for couples with reciprocal translocations compared with controls, and that the rate of unbalanced translocation in their offspring is 2.9%.
    • (2004) Fertil Steril , vol.81 , pp. 367-373
    • Sugiura-Ogasawara, M.1    Ozaki, Y.2    Sato, T.3    Suzumori, N.4    Suzumori, K.5
  • 3
    • 3242796599 scopus 로고    scopus 로고
    • Over a decade of experience with preimplantation genetic diagnosis: A multicenter report
    • Verlinsky Y, Cohen J, Munne S, et al. Over a decade of experience with preimplantation genetic diagnosis: a multicenter report. Fertil Steril 2004; 82:292-294. This large, long-term, multicentre study showed results of preimplantation genetic diagnosis for structural, single gene, and other genetic disorders.
    • (2004) Fertil Steril , vol.82 , pp. 292-294
    • Verlinsky, Y.1    Cohen, J.2    Munne, S.3
  • 4
    • 3242891085 scopus 로고    scopus 로고
    • ART in recurrent miscarriage: Preimplantation genetic diagnosis/screening or surrogacy?
    • Carp HJ, Dirnfeld M, Dor J, Grudzinskas JG. ART in recurrent miscarriage: preimplantation genetic diagnosis/screening or surrogacy? Hum Reprod 2004; 19:1502-1505. This article discusses the application of preimplantation genetic diagnosis and surrogacy for recurrent miscarriage of different causes.
    • (2004) Hum Reprod , vol.19 , pp. 1502-1505
    • Carp, H.J.1    Dirnfeld, M.2    Dor, J.3    Grudzinskas, J.G.4
  • 5
    • 0037248093 scopus 로고    scopus 로고
    • Chromosomal abnormalities and embryo development in recurrent miscarriage couples
    • Rubio C, Simon C, Vidal F, et al. Chromosomal abnormalities and embryo development in recurrent miscarriage couples. Hum Reprod 2003; 18:182-188.
    • (2003) Hum Reprod , vol.18 , pp. 182-188
    • Rubio, C.1    Simon, C.2    Vidal, F.3
  • 6
    • 1842584858 scopus 로고    scopus 로고
    • Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage
    • Goddijn M, Joosten JHK, Knegt AC, et al. Clinical relevance of diagnosing structural chromosome abnormalities in couples with repeated miscarriage. Hum Reprod 2004; 19:1013-1017. Unlike Sugiura-Ogasawara et al. [2] this smaller study group did not find any unbalanced offspring from couples carrying chromosomal abnormalities with recurrent misscarriage.
    • (2004) Hum Reprod , vol.19 , pp. 1013-1017
    • Goddijn, M.1    Joosten, J.H.K.2    Knegt, A.C.3
  • 7
    • 2342590663 scopus 로고    scopus 로고
    • Parental karyotype and subsequent live births in recurrent miscarriage
    • Carp HJA, Feldman B, Oelsner G, et al. Parental karyotype and subsequent live births in recurrent miscarriage. Fertil Steril 2004; 81:1296-1301. This is one of the studies showing that the subsequent live birth rate among couples with recurrent misscarriage and structural chromosomal abnormalities is similar to that in couples without abnormalities.
    • (2004) Fertil Steril , vol.81 , pp. 1296-1301
    • Carp, H.J.A.1    Feldman, B.2    Oelsner, G.3
  • 8
    • 0033957901 scopus 로고    scopus 로고
    • Embryonic karyotype of abortuses in relation to the number of previous miscarriages
    • Ogasawara M, Aoki K, Okada S, Suzumori K. Embryonic karyotype of abortuses in relation to the number of previous miscarriages. Fertil Steril 2000; 73:300-304.
    • (2000) Fertil Steril , vol.73 , pp. 300-304
    • Ogasawara, M.1    Aoki, K.2    Okada, S.3    Suzumori, K.4
  • 10
    • 0037443934 scopus 로고    scopus 로고
    • Thrombophilic disorders and fetal loss: A meta-analysis
    • Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361:901-908.
    • (2003) Lancet , vol.361 , pp. 901-908
    • Rey, E.1    Kahn, S.R.2    David, M.3    Shrier, I.4
  • 11
    • 1242352044 scopus 로고    scopus 로고
    • Maternal thrombophilias are not associated with early pregnancy loss
    • Roque H, Paidas MJ, Funai EF, et al. Maternal thrombophilias are not associated with early pregnancy loss. Thromb Haemost 2004; 91:290-295. This study shows that maternal thrombophilia is only associated with pregnancy losses after 14 weeks (n = 491).
    • (2004) Thromb Haemost , vol.91 , pp. 290-295
    • Roque, H.1    Paidas, M.J.2    Funai, E.F.3
  • 12
    • 4444270353 scopus 로고    scopus 로고
    • High frequency of congenital thrombophilia in women with pathological pregnancies?
    • Rasmussen A, Ravn P. High frequency of congenital thrombophilia in women with pathological pregnancies? Acta Obstet Gynecol Scand 2004; 83: 808-817. This review did not find an association between maternal thrombophilia and early pregnancy loss.
    • (2004) Acta Obstet Gynecol Scand , vol.83 , pp. 808-817
    • Rasmussen, A.1    Ravn, P.2
  • 13
    • 4444343623 scopus 로고    scopus 로고
    • Thrombophilia and pregnancy complications
    • Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol 2004; 191:412-424. This systematic review found that thrombophilia is associated with increased risk for losses in all trimesters, although there is greater strength of association for second and third trimester loss than for first trimester loss.
    • (2004) Am J Obstet Gynecol , vol.191 , pp. 412-424
    • Kujovich, J.L.1
  • 14
    • 0036177333 scopus 로고    scopus 로고
    • Factor V Leiden and recurrent miscarriage: Prospective outcome of untreated pregnancies
    • Rai R, Backos M, Elgaddal S, et al. Factor V Leiden and recurrent miscarriage: prospective outcome of untreated pregnancies. Hum Reprod 2002; 17: 442-445.
    • (2002) Hum Reprod , vol.17 , pp. 442-445
    • Rai, R.1    Backos, M.2    Elgaddal, S.3
  • 15
    • 1842637313 scopus 로고    scopus 로고
    • The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: A meta-analysis
    • Dudding TE, Attia J. The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis. Thromb Haemost 2004; 91:700-711. This analysis shows that there is a stronger association between FVL mutation and second/third trimester losses than with first trimester losses.
    • (2004) Thromb Haemost , vol.91 , pp. 700-711
    • Dudding, T.E.1    Attia, J.2
  • 16
    • 0036547768 scopus 로고    scopus 로고
    • Placental pathology in early onset pre-eclampsia and intra-uterine growth restriction in women with and without thrombophilia
    • Sikkema JM, Franx A, Bruinse HW, et al. Placental pathology in early onset pre-eclampsia and intra-uterine growth restriction in women with and without thrombophilia. Placenta 2002; 23:337-342.
    • (2002) Placenta , vol.23 , pp. 337-342
    • Sikkema, J.M.1    Franx, A.2    Bruinse, H.W.3
  • 17
    • 27844442291 scopus 로고    scopus 로고
    • Thrombophilia is not associated with an increase in placental abnormalities in women with intrauterine fetal death
    • Morssink LP, Santema JG, Willemse F. Thrombophilia is not associated with an increase in placental abnormalities in women with intrauterine fetal death. Obstet Gynecol Surv 2004; 59:566-567. This study also looked at birthweight, gestational age at delivery and case-controlled placental abruption, and found no differences between the thrombophilic women and those without thrombophilias in these parameters.
    • (2004) Obstet Gynecol Surv , vol.59 , pp. 566-567
    • Morssink, L.P.1    Santema, J.G.2    Willemse, F.3
  • 18
    • 2342631905 scopus 로고    scopus 로고
    • Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - Yes
    • Brenner B. Antithrombotic prophylaxis for women with thrombophilia and pregnancy complications - yes. J Thromb Haemost 2003; 1:2070-2072.
    • (2003) J Thromb Haemost , vol.1 , pp. 2070-2072
    • Brenner, B.1
  • 19
    • 0141503825 scopus 로고    scopus 로고
    • Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia
    • Carp H, Dolitzky M, Inbal A. Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia. J Thromb Haemost 2003; 1:433-438. This study, performed in women with recurrent misscarriage, found significant benefit in primary aborters with LMWH when compared with untreated control women.
    • (2003) J Thromb Haemost , vol.1 , pp. 433-438
    • Carp, H.1    Dolitzky, M.2    Inbal, A.3
  • 20
    • 7044259698 scopus 로고    scopus 로고
    • Does heparin therapy improve pregnancy outcome in patients with thrombophilias?
    • Paidas M, Ku DH, Triche E, et al. Does heparin therapy improve pregnancy outcome in patients with thrombophilias? J Thromb Haemost 2004; 2:1194-1195. Outcomes of subsequent and previous pregnancies in the same women were compared.
    • (2004) J Thromb Haemost , vol.2 , pp. 1194-1195
    • Paidas, M.1    Ku, D.H.2    Triche, E.3
  • 21
    • 2342633147 scopus 로고    scopus 로고
    • Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder
    • Gris JC, Mercier E, Quere I, et al. Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood 2004; 103:3695-3699. This study compared the use of LMWH and LDA in women with inherited thrombophilias but the women had one previous loss only.
    • (2004) Blood , vol.103 , pp. 3695-3699
    • Gris, J.C.1    Mercier, E.2    Quere, I.3
  • 22
    • 0038761846 scopus 로고    scopus 로고
    • Thromboelastography, whole-blood haemostasis and recurrent miscarriage
    • Rai R, Tuddenham E, Backos M, et al. Thromboelastography, whole-blood haemostasis and recurrent miscarriage. Hum Reprod 2003; 18: 2540-2543.
    • (2003) Hum Reprod , vol.18 , pp. 2540-2543
    • Rai, R.1    Tuddenham, E.2    Backos, M.3
  • 23
    • 0032569480 scopus 로고    scopus 로고
    • Action of anticardiolipin and antibodies to beta2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death
    • Chamley LW, Duncalf AM, Mitchell MD, Johnson PM. Action of anticardiolipin and antibodies to beta2-glycoprotein-I on trophoblast proliferation as a mechanism for fetal death. Lancet 1998; 352:1037-1038.
    • (1998) Lancet , vol.352 , pp. 1037-1038
    • Chamley, L.W.1    Duncalf, A.M.2    Mitchell, M.D.3    Johnson, P.M.4
  • 24
    • 14144253793 scopus 로고    scopus 로고
    • Pathogenic role of anti-beta 2 glycoprotein I antibodies in antiphospholipid-associated fetal loss: Characterisation of beta 2 glycoprotein I binding to trophoblast cells and functional effects of anti-beta 2 glycoprotein I antibodies in vitro
    • 2-glycoprotein-I antibody binding to trophoblast cells is shown to down-regulate trophoblast human chorionic gonadotrophin synthesis and secretion. The authors suggest that this may be a mechanism of defective placentation in women with APS-related fetal loss.
    • (2005) Ann Rheum Dis , vol.64 , pp. 462-467
    • Di Simone, N.1    Raschi, E.2    Testoni, C.3
  • 25
    • 0032977127 scopus 로고    scopus 로고
    • Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome
    • Di Simone N, Caliandro D, Castellani R, et al. Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome. Hum Reprod 1999; 14:489-495.
    • (1999) Hum Reprod , vol.14 , pp. 489-495
    • Di Simone, N.1    Caliandro, D.2    Castellani, R.3
  • 26
    • 0029934389 scopus 로고    scopus 로고
    • Antiphospholipid antibody-associated recurrent pregnancy loss: Treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone
    • Kutteh WH. Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 1996; 174:1584-1589.
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 1584-1589
    • Kutteh, W.H.1
  • 27
    • 0031022366 scopus 로고    scopus 로고
    • Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)
    • Rai R, Cohen H, Dave M, Regan L. Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997; 314:253-257.
    • (1997) BMJ , vol.314 , pp. 253-257
    • Rai, R.1    Cohen, H.2    Dave, M.3    Regan, L.4
  • 28
    • 0036145638 scopus 로고    scopus 로고
    • Recurrent pregnancy loss with antiphospholipid antibody: A systematic review of therapeutic trials
    • Empson M, Lassere M, Craig JC, Scott JR. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynecol 2002; 99:135-144.
    • (2002) Obstet Gynecol , vol.99 , pp. 135-144
    • Empson, M.1    Lassere, M.2    Craig, J.C.3    Scott, J.R.4
  • 29
    • 0036711316 scopus 로고    scopus 로고
    • Antiphospholipid syndrome in pregnancy: A randomized, controlled trial of treatment
    • Farquharson RG, Quenby S, Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet Gynecol 2002; 100:408-413.
    • (2002) Obstet Gynecol , vol.100 , pp. 408-413
    • Farquharson, R.G.1    Quenby, S.2    Greaves, M.3
  • 30
    • 0036884788 scopus 로고    scopus 로고
    • Antiphospholipid syndrome in pregnancy: A randomized, controlled trial of treatment
    • Rai R, Regan L. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment [letter]. Obstet Gynecol 2002; 100:1354.
    • (2002) Obstet Gynecol , vol.100 , pp. 1354
    • Rai, R.1    Regan, L.2
  • 31
    • 0038301002 scopus 로고    scopus 로고
    • Antiphospholipid syndrome in pregnancy
    • author reply 1354-1356
    • Kutteh WH. Antiphospholipid syndrome in pregnancy [letter]. Obstet Gynecol 2002; 100:1354; author reply 1354-1356.
    • (2002) Obstet Gynecol , vol.100 , pp. 1354
    • Kutteh, W.H.1
  • 32
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004; 81:19-25. This is an informative article providing an update on the diagnostic criteria and management of PCOS.
    • (2004) Fertil Steril , vol.81 , pp. 19-25
  • 33
    • 0027230017 scopus 로고
    • Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin
    • Balen AH, Tan SL, MacDougall J, Jacobs HS. Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum Reprod 1993; 8:959-964.
    • (1993) Hum Reprod , vol.8 , pp. 959-964
    • Balen, A.H.1    Tan, S.L.2    MacDougall, J.3    Jacobs, H.S.4
  • 34
    • 0030014213 scopus 로고    scopus 로고
    • Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial
    • Clifford K, Rai R, Watson H, et al. Does suppressing luteinising hormone secretion reduce the miscarriage rate? Results of a randomised controlled trial. BMJ 1996; 312:1508-1511.
    • (1996) BMJ , vol.312 , pp. 1508-1511
    • Clifford, K.1    Rai, R.2    Watson, H.3
  • 35
    • 0030825938 scopus 로고    scopus 로고
    • Recurrent miscarriage: Screening for polycystic ovaries and subsequent pregnancy outcome
    • Liddell HS, Sowden K, Farquhar CM. Recurrent miscarriage: screening for polycystic ovaries and subsequent pregnancy outcome. Aust N Z J Obstet Gynaecol 1997; 37:402-406.
    • (1997) Aust N Z J Obstet Gynaecol , vol.37 , pp. 402-406
    • Liddell, H.S.1    Sowden, K.2    Farquhar, C.M.3
  • 36
    • 0036153292 scopus 로고    scopus 로고
    • High serum luteinizing hormone and testosterone concentrations do not predict pregnancy outcome in women with recurrent miscarriage
    • Nardo LG, Rai R, Backos M, et al. High serum luteinizing hormone and testosterone concentrations do not predict pregnancy outcome in women with recurrent miscarriage. Fertil Steril 2002; 77:348-352.
    • (2002) Fertil Steril , vol.77 , pp. 348-352
    • Nardo, L.G.1    Rai, R.2    Backos, M.3
  • 37
    • 0034008629 scopus 로고    scopus 로고
    • Polycystic ovaries and recurrent miscarriage: A reappraisal
    • Rai R, Backos M, Rushworth F, Regan L. Polycystic ovaries and recurrent miscarriage: a reappraisal. Hum Reprod 2000; 15:612-615.
    • (2000) Hum Reprod , vol.15 , pp. 612-615
    • Rai, R.1    Backos, M.2    Rushworth, F.3    Regan, L.4
  • 39
    • 0036732520 scopus 로고    scopus 로고
    • Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss
    • Craig LB, Ke RW, Kutteh WH. Increased prevalence of insulin resistance in women with a history of recurrent pregnancy loss. Fertil Steril 2002; 78:487-490.
    • (2002) Fertil Steril , vol.78 , pp. 487-490
    • Craig, L.B.1    Ke, R.W.2    Kutteh, W.H.3
  • 40
    • 0038281545 scopus 로고    scopus 로고
    • Is miscarriage a coagulopathy?
    • Rai R. Is miscarriage a coagulopathy? Curr Opin Obstet Gynecol 2003; 15:265-268.
    • (2003) Curr Opin Obstet Gynecol , vol.15 , pp. 265-268
    • Rai, R.1
  • 41
    • 0035044332 scopus 로고    scopus 로고
    • Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome
    • Jakubowicz DJ, Seppala M, Jakubowicz S, et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001; 86:1126-1133.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1126-1133
    • Jakubowicz, D.J.1    Seppala, M.2    Jakubowicz, S.3
  • 42
    • 0028908566 scopus 로고
    • Habitual abortion is accompanied by low serum levels of placental protein 14 in the luteal phase of the fertile cycle
    • Tulppala M, Julkunen M, Tiitinen A, et al. Habitual abortion is accompanied by low serum levels of placental protein 14 in the luteal phase of the fertile cycle. Fertil Steril 1995; 63:792-795.
    • (1995) Fertil Steril , vol.63 , pp. 792-795
    • Tulppala, M.1    Julkunen, M.2    Tiitinen, A.3
  • 43
    • 0028834645 scopus 로고
    • The measurement of CA 125 and placental protein 14 in uterine flushings in women with recurrent miscarriage; relation to endometrial morphology
    • Dalton CF, Laird SM, Serle E, et al. The measurement of CA 125 and placental protein 14 in uterine flushings in women with recurrent miscarriage; relation to endometrial morphology. Hum Reprod 1995; 10:2680-2684.
    • (1995) Hum Reprod , vol.10 , pp. 2680-2684
    • Dalton, C.F.1    Laird, S.M.2    Serle, E.3
  • 44
    • 0027515722 scopus 로고
    • Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence
    • Jones JI, Gockerman A, Busby WH Jr, et al. Insulin-like growth factor binding protein 1 stimulates cell migration and binds to the alpha 5 beta 1 integrin by means of its Arg-Gly-Asp sequence. Proc Natl Acad Sci USA 1993; 90:10553-10557.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10553-10557
    • Jones, J.I.1    Gockerman, A.2    Busby Jr., W.H.3
  • 45
    • 0032142868 scopus 로고    scopus 로고
    • Paracrine actions of insulin-like growth factors and IGF binding protein-1 in non-pregnant human endometrium and at the decidual-trophoblast interface
    • Giudice LC, Mark SP, Irwin JC. Paracrine actions of insulin-like growth factors and IGF binding protein-1 in non-pregnant human endometrium and at the decidual-trophoblast interface. J Reprod Immunol 1998; 39:133-148.
    • (1998) J Reprod Immunol , vol.39 , pp. 133-148
    • Giudice, L.C.1    Mark, S.P.2    Irwin, J.C.3
  • 46
    • 0024559974 scopus 로고
    • Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease
    • Suikkari AM, Ruutiainen K, Erkkola R, Seppala M. Low levels of low molecular weight insulin-like growth factor-binding protein in patients with polycystic ovarian disease. Hum Reprod 1989; 4:136-139.
    • (1989) Hum Reprod , vol.4 , pp. 136-139
    • Suikkari, A.M.1    Ruutiainen, K.2    Erkkola, R.3    Seppala, M.4
  • 47
    • 3242735660 scopus 로고    scopus 로고
    • Insulin resistance and metformin in polycystic ovary syndrome
    • Ben-Haroush A, Yogev Y, Fisch B. Insulin resistance and metformin in polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol 2004; 115:125-133. This article gives a comprehensive update on the effects of insulin resistance on the reproductive system and evaluates the use of metformin in treating symptomatic women with PCOS.
    • (2004) Eur J Obstet Gynecol Reprod Biol , vol.115 , pp. 125-133
    • Ben-Haroush, A.1    Yogev, Y.2    Fisch, B.3
  • 48
    • 1442278770 scopus 로고    scopus 로고
    • Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy
    • Jakubowicz DJ, Essah PA, Seppala M, et al. Reduced serum glycodelin and insulin-like growth factor-binding protein-1 in women with polycystic ovary syndrome during first trimester of pregnancy. J Clin Endocrinol Metab 2004; 89:833-839. This study presents a possible mechanism for early miscarriage in PCOS.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 833-839
    • Jakubowicz, D.J.1    Essah, P.A.2    Seppala, M.3
  • 49
    • 0035044332 scopus 로고    scopus 로고
    • Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome
    • Jakubowicz DJ, Seppala M, Jakubowicz S, et al. Insulin reduction with metformin increases luteal phase serum glycodelin and insulin-like growth factor-binding protein 1 concentrations and enhances uterine vascularity and blood flow in the polycystic ovary syndrome. J Clin Endocrinol Metab 2001; 86:1126-1133.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 1126-1133
    • Jakubowicz, D.J.1    Seppala, M.2    Jakubowicz, S.3
  • 50
    • 8344258244 scopus 로고    scopus 로고
    • Impact of overweight and under-weight on assisted reproduction treatment
    • Epub ahead of print
    • Fedorcsak P, Dale PO, Storeng R, et al. Impact of overweight and under-weight on assisted reproduction treatment. Hum Reprod 2004 [Epub ahead of print]. This study leads to the conclusion that obesity has a negative impact on the live birth rate following assisted reproduction.
    • (2004) Hum Reprod
    • Fedorcsak, P.1    Dale, P.O.2    Storeng, R.3
  • 51
    • 0038639042 scopus 로고    scopus 로고
    • Obesity and the risk of spontaneous abortion after oocyte donation
    • Bellver J, Rossal LP, Bosch E, et al. Obesity and the risk of spontaneous abortion after oocyte donation. Fertil Steril 2003; 79:1136-1140.
    • (2003) Fertil Steril , vol.79 , pp. 1136-1140
    • Bellver, J.1    Rossal, L.P.2    Bosch, E.3
  • 52
    • 3242885070 scopus 로고    scopus 로고
    • Obesity is associated with increased risk of first trimester and recurrent miscarriage: Matched case-control study
    • Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod 2004; 19:1644-1646. This is a large case-control study showing a significant association between obesity and spontaneous miscarriage. Gestational diabetes was more prevalent in the obese subjects, suggesting a link between insulin resistance and spontaneous miscarriage.
    • (2004) Hum Reprod , vol.19 , pp. 1644-1646
    • Lashen, H.1    Fear, K.2    Sturdee, D.W.3
  • 53
    • 1642562579 scopus 로고    scopus 로고
    • Human uterine leukocytes and pregnancy
    • Trundley A, Moffett A. Human uterine leukocytes and pregnancy. Tissue Antigens 2004; 63:1-12. This review article covers immunological changes which occur at the site of implantation.
    • (2004) Tissue Antigens , vol.63 , pp. 1-12
    • Trundley, A.1    Moffett, A.2
  • 54
    • 0032727379 scopus 로고    scopus 로고
    • + natural killer cells in women with recurrent miscarriage: A histomorphometric study
    • + natural killer cells in women with recurrent miscarriage: a histomorphometric study. Hum Reprod 1999; 14:2727-2730.
    • (1999) Hum Reprod , vol.14 , pp. 2727-2730
    • Clifford, K.1    Flanagan, A.M.2    Regan, L.3
  • 55
    • 0032873588 scopus 로고    scopus 로고
    • Pre-implantation endometrial leukocytes in women with recurrent miscarriage
    • Quenby S, Bates M, Doig T, et al. Pre-implantation endometrial leukocytes in women with recurrent miscarriage. Hum Reprod 1999; 14:2386-2391.
    • (1999) Hum Reprod , vol.14 , pp. 2386-2391
    • Quenby, S.1    Bates, M.2    Doig, T.3
  • 56
    • 0029870464 scopus 로고    scopus 로고
    • Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome
    • 56_ Lachapelle MH, Miron P, Hemmings R, Roy DC. Endometrial T, B, and NK cells in patients with recurrent spontaneous abortion. Altered profile and pregnancy outcome. J Immunol 1996; 156:4027-4034.
    • (1996) J Immunol , vol.156 , pp. 4027-4034
    • Lachapelle, M.H.1    Miron, P.2    Hemmings, R.3    Roy, D.C.4
  • 57
    • 1342283262 scopus 로고    scopus 로고
    • + dendritic cells in the decidua of women with recurrent miscarriage and normal pregnancy
    • + dendritic cells in the decidua of women with recurrent miscarriage and normal pregnancy. Placenta 2004; 25:140-145. In this study, the dendritic cell density of the uterine decidua is shown to be significantly increased in some cases of early recurrent miscarriage.
    • (2004) Placenta , vol.25 , pp. 140-145
    • Askelund, K.1    Liddell, H.S.2    Zanderigo, A.M.3
  • 58
    • 0029004576 scopus 로고
    • Preconceptional natural-killer-cell activity as a predictor of miscarriage
    • Aoki K, Kajiura S, Matsumoto Y, et al. Preconceptional natural-killer-cell activity as a predictor of miscarriage. Lancet 1995; 345:1340-1342.
    • (1995) Lancet , vol.345 , pp. 1340-1342
    • Aoki, K.1    Kajiura, S.2    Matsumoto, Y.3
  • 59
    • 0030010390 scopus 로고    scopus 로고
    • Elevated peripheral blood natural killer cells are effectively downregulated by immunoglobulin G infusion in women with recurrent spontaneous abortions
    • Kwak JY, Kwak FM, Ainbinder SW, et al. Elevated peripheral blood natural killer cells are effectively downregulated by immunoglobulin G infusion in women with recurrent spontaneous abortions. Am J Reprod Immunol 1996; 35:363-369.
    • (1996) Am J Reprod Immunol , vol.35 , pp. 363-369
    • Kwak, J.Y.1    Kwak, F.M.2    Ainbinder, S.W.3
  • 60
    • 0029876279 scopus 로고    scopus 로고
    • Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles
    • Beer AE, Kwak JY, Ruiz JE. Immunophenotypic profiles of peripheral blood lymphocytes in women with recurrent pregnancy losses and in infertile women with multiple failed in vitro fertilization cycles. Am J Reprod Immunol 1996; 35:376-382.
    • (1996) Am J Reprod Immunol , vol.35 , pp. 376-382
    • Beer, A.E.1    Kwak, J.Y.2    Ruiz, J.E.3
  • 61
    • 0034055556 scopus 로고    scopus 로고
    • Peripheral natural killer cytotoxicity and CD56(pos)CD16(pos) cells increase during early pregnancy in women with a history of recurrent spontaneous abortion
    • Emmer PM, Nelen WL, Steegers EA, et al. Peripheral natural killer cytotoxicity and CD56(pos)CD16(pos) cells increase during early pregnancy in women with a history of recurrent spontaneous abortion. Hum Reprod 2000; 15:1163-1169.
    • (2000) Hum Reprod , vol.15 , pp. 1163-1169
    • Emmer, P.M.1    Nelen, W.L.2    Steegers, E.A.3
  • 62
    • 0035004533 scopus 로고    scopus 로고
    • Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology
    • Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, et al. Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 2001; 16:855-861.
    • (2001) Hum Reprod , vol.16 , pp. 855-861
    • Ntrivalas, E.I.1    Kwak-Kim, J.Y.2    Gilman-Sachs, A.3
  • 64
    • 0141682192 scopus 로고    scopus 로고
    • Pre-conceptional natural killer cell activity and percentage as predictors of biochemical pregnancy and spontaneous abortion with normal chromosome karyotype
    • Yamada H, Morikawa M, Kato EH, et al. Pre-conceptional natural killer cell activity and percentage as predictors of biochemical pregnancy and spontaneous abortion with normal chromosome karyotype. Am J Reprod Immunol 2003; 50:351-354.
    • (2003) Am J Reprod Immunol , vol.50 , pp. 351-354
    • Yamada, H.1    Morikawa, M.2    Kato, E.H.3
  • 65
    • 0043066767 scopus 로고    scopus 로고
    • Differences in number and activity of peripheral natural killer cells in primary versus secondary recurrent miscarriage
    • Shakhar K, Ben-Eliyahu S, Loewenthal R, et al. Differences in number and activity of peripheral natural killer cells in primary versus secondary recurrent miscarriage. Fertil Steril 2003; 80:368-375.
    • (2003) Fertil Steril , vol.80 , pp. 368-375
    • Shakhar, K.1    Ben-Eliyahu, S.2    Loewenthal, R.3
  • 66
    • 0141628381 scopus 로고    scopus 로고
    • - cells in total natural killer cells as an indication of fertility and infertility
    • - cells in total natural killer cells as an indication of fertility and infertility. Fertil Steril 2003; 80 (suppl 2):691-697.
    • (2003) Fertil Steril , vol.80 , Issue.SUPPL. 2 , pp. 691-697
    • Michou, V.I.1    Kanavaros, P.2    Athanassiou, V.3
  • 67
    • 0033051383 scopus 로고    scopus 로고
    • Natural killer (NK) cell subsets and NK cell cytotoxicity in women with histories of recurrent spontaneous abortions
    • Gilman-Sachs A, DuChateau BK, Aslakson CJ, et al. Natural killer (NK) cell subsets and NK cell cytotoxicity in women with histories of recurrent spontaneous abortions. Am J Reprod Immunol 1999; 41:99-105.
    • (1999) Am J Reprod Immunol , vol.41 , pp. 99-105
    • Gilman-Sachs, A.1    Duchateau, B.K.2    Aslakson, C.J.3
  • 68
    • 6444235737 scopus 로고    scopus 로고
    • + NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome
    • + NK cells in the peripheral blood is associated with a poorer IVF treatment and pregnancy outcome. Hum Reprod 2004; 19:2395-2400. This is a prospective study of women undergoing IVF treatment. Those with peripherally elevated CD56dimCD16+CD69+ natural killer cells had a significantly lower embryo implantation rate and higher miscarriage rate than women with lower counts.
    • (2004) Hum Reprod , vol.19 , pp. 2395-2400
    • Thum, M.Y.1    Bhaskaran, S.2    Abdalla, H.I.3
  • 69
    • 0035024521 scopus 로고    scopus 로고
    • The effects of sex, menstrual cycle, and oral contraceptives on the number and activity of natural killer cells
    • Yovel G, Shakhar K, Ben-Eliyahu S. The effects of sex, menstrual cycle, and oral contraceptives on the number and activity of natural killer cells. Gynecol Oncol 2001; 81:254-262.
    • (2001) Gynecol Oncol , vol.81 , pp. 254-262
    • Yovel, G.1    Shakhar, K.2    Ben-Eliyahu, S.3
  • 70
    • 0347407873 scopus 로고    scopus 로고
    • Successful pregnancy outcome following 19 consecutive miscarriages: Case report
    • Quenby S, Farquharson R, Young M, Vince G. Successful pregnancy outcome following 19 consecutive miscarriages: case report. Hum Reprod 2003; 18:2562-2564.
    • (2003) Hum Reprod , vol.18 , pp. 2562-2564
    • Quenby, S.1    Farquharson, R.2    Young, M.3    Vince, G.4
  • 71
    • 0030746019 scopus 로고    scopus 로고
    • Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss
    • Laskin CA, Bombardier C, Hannah ME, et al. Prednisone and aspirin in women with autoantibodies and unexplained recurrent fetal loss. N Engl J Med 1997; 337:148-153.
    • (1997) N Engl J Med , vol.337 , pp. 148-153
    • Laskin, C.A.1    Bombardier, C.2    Hannah, M.E.3
  • 72
    • 0026585838 scopus 로고
    • Repeated fetal losses associated with antiphospholipid antibodies: A collaborative randomized trial comparing prednisone with low-dose heparin treatment
    • Cowchock FS, Reece EA, Balaban D, et al. Repeated fetal losses associated with antiphospholipid antibodies: a collaborative randomized trial comparing prednisone with low-dose heparin treatment. Am J Obstet Gynecol 1992; 166:1318-1323.
    • (1992) Am J Obstet Gynecol , vol.166 , pp. 1318-1323
    • Cowchock, F.S.1    Reece, E.A.2    Balaban, D.3
  • 73
    • 3042767577 scopus 로고    scopus 로고
    • 'Actively acquired tolerance' of foreign cells. 1953
    • Billingham RE, Brent L, Medawar PB. 'Actively acquired tolerance' of foreign cells. 1953. Transplantation 2003; 76:1409-1412.
    • (2003) Transplantation , vol.76 , pp. 1409-1412
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 74
    • 0027207375 scopus 로고
    • Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a TH2 phenomenon?
    • Wegmann TG, Lin H, Guilbert L, Mosmann TR. Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon? Immunol Today 1993; 14:353-356.
    • (1993) Immunol Today , vol.14 , pp. 353-356
    • Wegmann, T.G.1    Lin, H.2    Guilbert, L.3    Mosmann, T.R.4
  • 75
    • 0029759714 scopus 로고    scopus 로고
    • Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy
    • Marzi M, Vigano A, Trabattoni D, et al. Characterization of type 1 and type 2 cytokine production profile in physiologic and pathologic human pregnancy. Clin Exp Immunol 1996; 106:127-133.
    • (1996) Clin Exp Immunol , vol.106 , pp. 127-133
    • Marzi, M.1    Vigano, A.2    Trabattoni, D.3
  • 76
    • 0034008633 scopus 로고    scopus 로고
    • Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion
    • Raghupathy R, Makhseed M, Azizieh F, et al. Cytokine production by maternal lymphocytes during normal human pregnancy and in unexplained recurrent spontaneous abortion. Hum Reprod 2000; 15:713-718.
    • (2000) Hum Reprod , vol.15 , pp. 713-718
    • Raghupathy, R.1    Makhseed, M.2    Azizieh, F.3
  • 77
    • 0034794829 scopus 로고    scopus 로고
    • Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions
    • Makhseed M, Raghupathy R, Azizieh F, et al. Th1 and Th2 cytokine profiles in recurrent aborters with successful pregnancy and with subsequent abortions. Hum Reprod 2001; 16:2219-2226.
    • (2001) Hum Reprod , vol.16 , pp. 2219-2226
    • Makhseed, M.1    Raghupathy, R.2    Azizieh, F.3
  • 78
    • 3042543912 scopus 로고    scopus 로고
    • Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage
    • Wilson R, Jenkins C, Miller H, et al. Abnormal cytokine levels in non-pregnant women with a history of recurrent miscarriage. Eur J Obstet Gynecol Reprod Biol 2004; 115:51-54. Prepregnant interferon-γ and interleukin-12 levels were found to be higher and interleukin-18 lower in women with at least three miscarriages compared with women with no such history. A subsequent miscarriage was associated with a higher interleukin-18 in the prepregnant state.
    • (2004) Eur J Obstet Gynecol Reprod Biol , vol.115 , pp. 51-54
    • Wilson, R.1    Jenkins, C.2    Miller, H.3
  • 79
    • 0242522108 scopus 로고    scopus 로고
    • Prospective, serial investigations of in-vitro lymphocyte cytokine production, CD62L expression and proliferative response to microbial antigens in women with recurrent miscarriage
    • Kruse C, Varming K, Christiansen OB. Prospective, serial investigations of in-vitro lymphocyte cytokine production, CD62L expression and proliferative response to microbial antigens in women with recurrent miscarriage. Hum Reprod 2003; 18:2465-2472.
    • (2003) Hum Reprod , vol.18 , pp. 2465-2472
    • Kruse, C.1    Varming, K.2    Christiansen, O.B.3
  • 80
    • 0141793971 scopus 로고    scopus 로고
    • No difference in natural-killer-T cell population, but Th2/Tc2 predominance in peripheral blood of recurrent aborters
    • Shimada S, Iwabuchi K, Kato EH, et al. No difference in natural-killer-T cell population, but Th2/Tc2 predominance in peripheral blood of recurrent aborters. Am J Reprod Immunol 2003; 50:334-339.
    • (2003) Am J Reprod Immunol , vol.50 , pp. 334-339
    • Shimada, S.1    Iwabuchi, K.2    Kato, E.H.3
  • 81
    • 0037339109 scopus 로고    scopus 로고
    • Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: An intracellular flow cytometric analysis of peripheral blood mononuclear cells
    • Sacks GP, Redman CW, Sargent IL. Monocytes are primed to produce the Th1 type cytokine IL-12 in normal human pregnancy: an intracellular flow cytometric analysis of peripheral blood mononuclear cells. Clin Exp Immunol 2003; 131:490-497.
    • (2003) Clin Exp Immunol , vol.131 , pp. 490-497
    • Sacks, G.P.1    Redman, C.W.2    Sargent, I.L.3
  • 82
    • 1842815073 scopus 로고    scopus 로고
    • Reproductive immunology 2003: Reassessing the Th1/Th2 paradigm?
    • Chaouat G, Ledee-Bataille N, Dubanchet S, et al. Reproductive immunology 2003: reassessing the Th1/Th2 paradigm? Immunol Lett 2004; 92:207-214.
    • (2004) Immunol Lett , vol.92 , pp. 207-214
    • Chaouat, G.1    Ledee-Bataille, N.2    Dubanchet, S.3
  • 83
    • 1842584796 scopus 로고    scopus 로고
    • Maternal C-reactive protein levels are raised at 4 weeks gestation
    • Sacks GP, Seyani L, Lavery S, Trew G. Maternal C-reactive protein levels are raised at 4 weeks gestation. Hum Reprod 2004; 19:1025-1030. This study suggests that activation of innate immunity occurs or is required during the earliest phases of embryo implantation.
    • (2004) Hum Reprod , vol.19 , pp. 1025-1030
    • Sacks, G.P.1    Seyani, L.2    Lavery, S.3    Trew, G.4
  • 84
    • 4344667265 scopus 로고    scopus 로고
    • The assessment of LIF in uterine flushing: A possible new diagnostic tool in states of impaired fertility
    • Mikolajczyk M, Skrzypczak J, Szymanowski K, Wirstlein P. The assessment of LIF in uterine flushing: a possible new diagnostic tool in states of impaired fertility. Reprod Biol 2003; 3:259-270.
    • (2003) Reprod Biol , vol.3 , pp. 259-270
    • Mikolajczyk, M.1    Skrzypczak, J.2    Szymanowski, K.3    Wirstlein, P.4


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