Synthesis of some novel D-dihomo-aza- and D-dihomo-oxa-steroid derivatives in the estrone series

Synlett

Volumn , Issue 18, 2005, Pages 2814-2816

  Frank, Éva ^a   Schneider, Gyula ^a   Messinger, Josef ^b   Thole, Hubert ^b   Wölfling, János ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b Solvay Pharmaceuticals GmbH   (Germany)

Author keywords

Condensation; Cyclization; D dihomoestrone derivatives; Lactams; Michael addition

Indexed keywords

ESTRONE DERIVATIVE; STEROID;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CHEMICAL REACTION KINETICS; CYCLIZATION; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RING CLOSING METATHESIS;

EID: 27844535784     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-918940     Document Type: Article

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22. 2), 112.9 (C-2), 114.4 (C-4), 127.8 (C-1), 133.6 (C-10), 138.7 (C-5), 159.0 (C-3), 187.4 (C-17).
23. 2), 3.68 (s, 3
24. 2 and C-16a′), 54.8 (3-OMe), 111.6 (C-2), 113.0 (C-4), 115.8 (C-16a), 126.3 (C-1), 131.7 (C-10), 137.3 (C-5), 140.4 (C-16), 157.0 (C-3), 179.4 (C-17).
25. 2, C-16a and C-16a′), 54.8 (3-OMe), 111.4 (C-2), 112.7 (C-4), 125.8 (C-1), 132.6 (C-10), 137.4 (C-5), 157.1 (C-3), 177.2 (C-17).
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29. 3): δ = 15.6 (C-18), 26.1, 26.5, 29.9, 37.0, 38.8, 40.2, 42.3, 43.3, 47.8 (C-13), 55.1 (3-OMe), 72.2 (C-16a′), 111.6 (C-2), 113.3 (C-4), 120.2 (C-16a), 126.2 (C-1), 131.9 (C-10), 137.4 (C-5), 141.8 (C-16), 157.6 (C-3), 181.2 (C-17).
30. 3): δ = 15.2 (C-18), 16.5 (C-16a), 25.5, 26.0, 29.3, 31.9, 36.5, 43.0 (C-13), 43.7, 51.4, 55.2 (3-OMe), 85.5 (C-15), 111.7 (C-2), 113.8 (C-4), 118.7 (C-16a′), 126.3(C-1), 131.0 (C-10), 137.2 (C-5), 141.7 (C-16), 157.7 (C-3), 180.1 (C-17). The compounds give correct elemental analyses.