The Pneumocystis carinii drug target S-adenosyl-L-methionine: Sterol C-24 methyl transferase has a unique substrate preference

Molecular Microbiology

Volumn 44, Issue 4, 2002, Pages 989-999

  Kaneshiro, Edna S ^a   Rosenfeld, Jill A ^a   Basselin Eiweida, Mireille ^a   Stringer, James R ^b   Keely, Scott P ^b   Smulian, A George ^b   Giner, José Luis ^c  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24 METHYLENELANOSTEROL; AMINO ACID; ANTIPROTOZOAL AGENT; COMPLEMENTARY DNA; CYCLOARTENOL; LANOSTEROL DERIVATIVE; METHYL GROUP; METHYLTRANSFERASE; PEPTIDE DERIVATIVE; PNEUMOCYSTEROL; S ADENOSYLMETHIONINE:STEROL C 24 METHYLTRANSFERASE; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CATALYSIS; CONTROLLED STUDY; DNA SEQUENCE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; EXPRESSED SEQUENCE TAG; FUNGUS; MAMMAL; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SEQUENCE HOMOLOGY;

ALKYLATION; ANTIFUNGAL AGENTS; BLOTTING, SOUTHERN; CHOLESTEROL; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; KINETICS; LANOSTEROL; MAGNETIC RESONANCE SPECTROSCOPY; METHYLTRANSFERASES; PHYTOSTEROLS; PNEUMOCYSTIS; RECOMBINANT PROTEINS; S-ADENOSYLMETHIONINE; STEROLS; SUBSTRATE SPECIFICITY; TEMPERATURE;

ESCHERICHIA COLI; FUNGI; MAMMALIA; PNEUMOCYSTIS CARINII; PROTOZOA;

EID: 0036090956     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02932.x     Document Type: Article

References (43)

1. Stereochemistry of yeast delta 24-sterol methyl transferase
2. Mechanism of inhibition of delta 24-sterol methyltransferase from Candida albicans and Candida tropicalis
3. Transport of aspartic acid, tyrosine, and arginine by the opportunistic protist Pneumocystis carini
4. A rapid method of total lipid extraction and purification
5. Identification of cDNAs encoding sterol methyl-transferases involved in the second methylation step of plant sterol biosynthesis
6. Two families of sterol methyltransferases are involved in the first and second methylation steps of plant sterol biosynthesis
7. Improved model of Pneumocystis carinii pneumonia: Induced laboratory infection in Pneumocystis-free animals
8. PCR-RFLP analysis of the DHPS gene for the study of resistance of Pneumocystis carinii to sulpha drugs in patients with co-infection PCP/HIV
9. Genetic stability and diversity of Pneumocystis carinii infecting rat colonies
10. Sterol methyltransferase 1 controls the level of cholesterol in plants
11. Occurrence of specific sterols in Pneumocystis carinii
12. Phytosterols are present in Pneumocystis carinii
13. Definitive structural identities of 42 sterol components in Pneumocystis carinii
14. Characterization of Zea mays endosperm C-24 sterol methyltransferase: One of two types of sterol methyltransferases in higher plants
15. Identification of 24-methylene-24,25-dihydrolanosterol as a precursor of ergosterol in the yeasts Schizosaccharomyces pombe and Schizosaccharomyces octosporus
16. Chemistry in the Annonaceae, XXIII. 24-methylene-lanosta-7,9(11)-dien-3beta-ol from Artabotrys adorotissimus stem bark
17. Lipid biochemistry of trypanosomatids
18. The lipid composition and permeability to azole of an azole-and polyene-resistant mutant of Candida albicans
19. Transformation of Saccharomyces cerevisiae with a cDNA encoding a sterol C-methyltransferase fromArabidopsis thaliana results in the synthesis of 24-ethyl sterol
20. Sequencing, disruption and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: Drug susceptibility studies in erg6 mutants
21. The lipids of Pneumocystis carinii
22. Pneumocystis carinii
23. 32 sterols in Pneumocystis, an opportunistic pathogen of immunocompromised mammals
24. Characterization of Pneumocystis carinii preparations developed for lipid analysis
25. Evidence for the presence of 'metabolic sterols' in Pneumocystis: Identification and initial characterization of Pneumocystis carinii sterols
26. The sterol composition of Pneumocystis carinii hominis organisms isolated from human lungs
27. Pneumocysterol [(24IZ)-ethylidenelanost-8-en-3β-ol], a rare sterol detected in the opportunistic pathogen Pneumocystis carinii f. sp. hominis: Structural identity and chemical synthesis
28. The effects of sterol biosynthesis inhibitors on the ATP content of Pneumocystis carinii
29. Pneumocystis carinii erg6 gene: Sequencing and expression of recombinant SAM: Sterol methyltransferase in heterologous systems
30. Protein measurement with the Folin phenol reagent
31. Pneumocystis carinii dihydropteroate synthase but not dihydrofolate reductase gene mutations correlate with prior trimethoprim-sulfamethoxazole or dapsone use
32. Sterol C-methyl transferase from Prototheca wickerhamii mechanism, sterol specificity and inhibition
33. Continuous axenic cultivation of Pneumocystis carinii
34. Sterol methyl transferase: Enzymology and inhibition
35. 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae
36. Synthesis and biological evaluation of fungal bioregulators of sterol biosynthesis
37. Identification and characterization of an S-adenosyl-L-methionine: Delta24-sterol-c-methyltransferase cDNA from soyabean
38. Pneumocystis carinii: What is it exactly?
39. 24(25)sterol methyltransferase block sterol synthesis and cell proliferation in Pneumocystis carinii
40. 24(25)-sterol methyl transferase from Saccharomyces cerevisiae
41. Sequence polymorphism in the Pneumocystis carinii cytochrome b gene and their association with atovaquone prophylaxis failure
42. Pneumocystis carinii
43. Fatty acids and sterols of Cronartium fusiforme basidiospores