Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele

Molecular Brain Research

Volumn 139, Issue 1, 2005, Pages 163-168

  Oterino, Agustín ^a   Valle, Natalia ^a   Pascual, Julio ^a   Bravo, Yolanda ^a   Muñoz, Pedro ^b   Castillo, Jesús ^c   Ruiz Alegría, Carlos ^a   Sanchez Velasco, Pablo ^a   Leyva Cobián, Francisco ^a   Cid, Carmen ^a  

^a HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

^b Primary Care Management   (Spain)

^c Health Center of Camargo   (Spain)

Author keywords

Genetic association study; Methenyltetrahydrofolate cyclohydrolase formyltetrahydrofolate synthase; Methylenetetrahydrofolate reductase; Migraine; Thymidylate synthase

Indexed keywords

5',10' METHYLENETETRAHYDROFOLATE REDUCTASE; FORMATE TETRAHYDROFOLATE LIGASE; METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE; OXIDOREDUCTASE; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; FOLATE METABOLISM; GENE FREQUENCY; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIGRAINE; PATHOGENESIS; PRIORITY JOURNAL; RISK FACTOR; TANDEM REPEAT;

EID: 27744597687     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molbrainres.2005.05.015     Document Type: Article

References (32)

1. L.C. Brody, M. Conley, C. Cox, P.M. Kirke, M.P. McKeever, J.L. Mills, A.M. Molloy, V.O. O'Leary, A. Parle-McDermott, J.M. Scott, D.A. Swanson, A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group, Am. J. Hum. Genet. 71 (2002) 1207-1215.
2. L.H. Chen, M.L. Liu, H.Y. Hwang, L.S. Chen, J. Korenberg, B. Shane, Human methionine synthase. cDNA cloning, gene localization and expression, J. Biol. Chem. 272 (1997) 3628-3634.
3. J. Chen, M.J. Stampfer, J. Ma, J. Selhub, M.R. Malinow, C.H. Hennekens, D.J. Hunter, Influence of methionin synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction, Atherosclerosis 154 (2001) 667-672.
4. T. Dalsgaard-Nielsen, J. Trautmann, Prophylactic treatment of migraine with vitamin B12, Ugeskr. Laeg. 132 (1970) 339-341.
5. M.-T. Doolin, S. Barbaux, M. McDonnell, K. Hoess, A.S. Whitehead, L.E. Mitchell, Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida, Am. J. Hum. Genet. 71 (2002) 1222-1226.
6. S. Evers, H.G. Koch, I.W. Husstedt, Plasma homocysteine levels in primary headache, in: J. Olesen, L. Edvinsson (Eds.), Headache Pathogenesis: Monoamines, Neuropeptides, Purines and Nitric Oxide, Lippincott-Raven Publishers, Philadelphia, 1997, pp. 215-218.
7. P. Frosst, H.J. Blom, R. Milos, P. Goyette, C.A. Sheppard, R.G. Matthews, et al., A candidate genetic risk factor for vascular disease: a common mutation to methylenetetrahydrofolate reductase, Nat. Genet. 10 (1995) 111-113.
8. R. Hering-Hanit, N. Gadoth, A. Yavetz, S. Gavendo, B. Sela, Is blood homocysteine elevated in migraine? Headache 41 (2001) 779-781.
9. F.A. Hol, N.M.J. van der Put, M.P.A. Geurds, S.G. Heil, F.J.M. Trijbels, B.C.J. Hamel, E.C.M. Mariman, H.J. Blom, Molecular genetic analysis of the gene encoding the trifunctional enzyme MTHFD (methylenetetrahydrofolate- dehydrogenase, methenyltetrahydrofolate-cyclohydrolase, formyltetrahydrofolate synthase) in patients with neural tube defects. Clin. Genet. 53 (1998) 119-125.
10. N. Horie, K. Takeishi, Identification of functional elements in the promoter region of the human gene for thymidylate synthase and nuclear factors that regulate the expression of the gene, J. Biol. Chem. 272 (1997) 18375-18381.
11. I. Kara, A. Sazci, E. Ergul, G. Kaya, G. Kilic, Association of the C677T and A1298C polymorphisms in the 5,10 methylenetetrahydrofolate reductase gene in patients with migraine risk, Mol. Brain Res. 111 (2003) 84-90.
12. K. Kawakami, K. Amura, E. Kanehira, Y. Watanabe, Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers, Anticancer Res. 19 (1999) 3249-3252.
13. T.L. Kopjas, The use of folic acid in vascular headache of the migraine type, Headache 8 (1969) 167-170.
14. H. Kowa, K. Yasui, T. Takeshima, et al., The homozygous C677T mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for migraine, Am. J. Med. Genet, Part B Neuropsychiatr. Genet. 96 (2000) 762-764.
15. R. Lea, M. Ovcaric, J. Sundholm, J. McMillan, L.R. Griffiths, The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine aura, BMC Med. 2 (2004) 3 (available on http://www.biomedcentral. com/1741-7015/2/3).
16. D. Leclerc, E. Campeau, P. Goyette, et al., Human methionin synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders, Hum. Mol. Genet. 5 (1996) 1867-1874.
17. J. Ma, M.J. Stampfer, B. Christensen, et al., A polymorphism of the methionin synthase gene: association with plasma folate, vitamin B12, homocysteine, and colorectal cancer risk, Cancer Epidemiol., Biomarkers Prev. 8 (1999) 825-829.
18. S. Marsh, M.M. Ameyaw, J. Githang'a, A. Indalo, D. Ofori-Adjei, H.L. McLeod, Novel thymidylate synthase enhancer region alleles in African populations, Hum. Mutat. 16 (2000 Dec.) 528.
19. S. Marsh, E.S. Collie-Duguid, T. Li, X. Liu, H.L. McLeod, Ethnic variation in the thymidylate synthase enhancer region polymorphism among Caucasians and Asian populations, Genomics 58 (1999) 310-312.
20. K. Matsuo, R. Suzuki, N. Hamajima, M. Ogura, Y. Kagami, H. Taji, E. Kondoh, S. Maeda, S. Asakura, S. Kaba, et al., Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma, Blood 97 (2001) 3205-3209.
21. A. Oterino, N. Valle, Y. Bravo, P. Muñoz, P. Sanchez-Velasco, C. Ruiz-Alegria, et al., MTHFR T667 homozygosis influences the presence of aura in migraineurs, Cephalalgia 24 (2004) 491-494.
22. C.L. Relton, C.S. Wilding, M.S. Pearce, A.J. Laffling, P.A. Jonas, S.A. Lynch, E.J. Tawn, J. Burn, Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population, J. Med. Genet. 41 (2004) 256-260.
23. J. Schoenen, M. Lenaerts, E. Bastings, High-dose riboflavin as a prophylactic treatment of migraine: results of an open pilot study, Cephalalgia 14 (1994) 328-329.
24. J. Schoenen, J. Jacquy, M. Lenaerts, Effectiveness of high-dose riboflavine in migraine prophylaxis: a randomized controlled trial, Neurology 50 (1998) 466-470.
25. J. Selhub, Homocysteine metabolism, Annu. Rev. Nutr. 19 (1999) 217-246.
26. C.F. Skibola, M.T. Smith, A. Hubbard, B. Shane, A.C. Roberts, G.R. Law, S. Rollinson, E. Roman, R.A. Cartwright, G.J. Morgan, Polymorphisms in the thymidylate synthase and serine hydroxymehtyltransferase genes and risk of adult acute lymphocytic leukemia, Blood 99 (2002) 3786-3791.
27. K. Snell, U. Baumann, P.C. Byrne, et al., The genetic organization and protein crystallographic structure of human serine hydroximethyltransferase, Adv. Enzyme Regul. 40 (2000) 353-403.
28. B.N. Trinh, Ch.-N. Ong, G.A. Coetzee, M.C. Yu, P.W. Laird, Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels, Hum. Genet. 111 (2002) 299-302.
29. C.M. Ulrich, J. Bigler, R. Bostick, L. Fosdick, J.D. Potter, Thymidylate synthase promoter polymorphism, interaction with folate intake and risk of colorectal adenomas, Cancer Res. 62 (2002) 3361-3364.
30. P.H. Van der Kuy, F.W. Merkus, J.J. Lohman, J.W. ter Berg, P.M. Hooymans, Hydroxicobalamin, a nitric oxide scavenger, in the prophylaxis of migraine: an open, pilot study, Cephalalgia 22 (2002) 513-519.
31. X.I. Wang, N. Duarte, H. Cai, et al., Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population, Atherosclerosis 146 (1999) 133-140.
32. I. Weisberg, P. Tran, B. Christensen, S. Sibani, R. Rozen, A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity, Mol. Genet. Metab. 64 (1998) 169-172.