New 7,8-ethylenedioxy-2,3-benzodiazepines as noncompetitive AMPA receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 1, 2006, Pages 167-170

  Zappalà, Maria ^a   Pellicanò, Alessia ^a   Micale, Nicola ^a   Menniti, Frank S ^b   Ferreri, Guido ^c   De Sarro, Giovambattista ^c   Grasso, Silvana ^a   De Micheli, Carlo ^d  

^a UNIVERSITY OF MESSINA   (Italy)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

3,5 Dihydro 7,8 ethylenedioxy 4H 2,3 benzodiazepin 4 ones; AMPA receptor antagonists; Anticonvulsant activity

Indexed keywords

1 (4 AMINO 2 CHLOROPHENYL) 2,3 BENZODIAZEPINE; 1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; AMPA RECEPTOR; AMPA RECEPTOR ANTAGONIST; BENZODIAZEPINE DERIVATIVE; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; AUDIOGENIC SEIZURE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; RAT;

ANIMALS; ANTICONVULSANTS; BENZODIAZEPINES; BINDING, COMPETITIVE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED DBA; MODELS, CHEMICAL; PROTEIN BINDING; RATS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 27744587095     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.09.029     Document Type: Article

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