Monitoring of MRP-like activity in human erythrocytes: Inhibitory effect of isoflavones

Blood Cells, Molecules, and Diseases

Volumn 27, Issue 5, 2001, Pages 894-900

  Bobrowska Hägerstrand, Malgorzata ^a   Wróbel, Anna ^b   Rychlik, Blaej ^c   Bartosz, Grzegorz ^c   Söderström, Thomas ^a,d   Shirataki, Yoshiaki ^e   Motohashi, Noboru ^f   Molnár, Joseph ^g   Michalak, Krystyna ^h   Hägerstrand, Henry ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

^b WROCLAW UNIVERSITY OF TECHNOLOGY   (Poland)

^c UNIVERSITY OF LODZ   (Poland)

^d UNIVERSITY OF TURKU   (Finland)

^e JOSAI UNIVERSITY   (Japan)

^f MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

^g UNIVERSITY OF SZEGED   (Hungary)

^h WROCLAW MEDICAL UNIVERSITY   (Poland)

Author keywords

BCPCF; DIDS; Erythrocyte; Indomethacin; Isoflavonoid; Multidrug resistance; Probenecid

Indexed keywords

2',7' BIS(CARBOXYPROPYL) 5(6) CARBOXYFLUORESCEIN; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; CARBOXYFLUORESCEIN; DAIDZEIN; GENISTEIN; INDOMETACIN; ISOFLAVONE; ISOFLAVONE DERIVATIVE; LICOISOFLAVONE A; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN INHIBITOR; PROBENECID; SOPHORAISOFLAVONE A; UNCLASSIFIED DRUG; 2',7' BIS (CARBOXYPROPYL) 5(6) CARBOXYFLUORESCEIN; 2',7'-BIS-(CARBOXYPROPYL)-5(6)-CARBOXYFLUORESCEIN; DIAGNOSTIC AGENT; FLUORESCEIN DERIVATIVE; FLUORESCENT DYE; GLYCOPROTEIN P;

ARTICLE; CONCENTRATION RESPONSE; DRUG INHIBITION; DRUG MECHANISM; DRUG MONITORING; ENZYME SUBSTRATE; ERYTHROCYTE; FLUOROMETRY; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; MOLECULAR MODEL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN TRANSPORT; DOSE RESPONSE; DRUG EFFECT; HEMOLYSIS; KINETICS; METABOLISM;

4,4'-DIISOTHIOCYANOSTILBENE-2,2'-DISULFONIC ACID; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; FLUORESCEINS; FLUORESCENT DYES; HEMOLYSIS; HUMAN; INHIBITORY CONCENTRATION 50; ISOFLAVONES; KINETICS; P-GLYCOPROTEIN; SUPPORT, NON-U.S. GOV'T;

EID: 0035210534     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1006/bcmd.2001.0459     Document Type: Article

References (31)

1. Simultaneous activity of MRP1 and Pgp is correlated with in vitro resistance to daunorubicin and with in vivo resistance in adult acute myeloid leukemia
2. Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance
3. Identification of the multidrug-resistance protein (MRP) as the glutathione-Sconjugate export pump of erythrocytes
4. Transport of glutathione conjugates and glucorunides by the multidrug resistance proteins MRP1 and MRP2
5. Transbilayer movement of NBD-labeled phospholipids in red blood cell membranes: Outward-directed transport by the multidrug resistance protein 1 (MRP1)
6. Multidrug resistance protein 1 regulates lipid asymmetry in erythrocyte membranes
7. Transport of organic anions by multidrug resistance-associated protein in the erythrocytes
8. Cellular and biophysical evidence for interactions between adenosine triphosphate and P-glycoprotein substrates: Functional implications for adenosine triphosphate/drug cotransport in P-glycoprotein overexpressing tumor cells and in P-glycoprotein low-level expressing erythrocytes
9. Studies on the constituents of Sophora species. III
10. Sophoraflavanones H, I and J, flavonostilebenes from Sophora moorcroftiana
11. Studies on the constituents of Sophora species. XXII
12. Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes
13. ABC transporters in lipid transport
14. Transport properties of the multidrug resistance-associated protein (MRP) in human tumour cells
15. Evidence for a role of the multidrug resistance protein (MRP) in the outward translocation of NBD-phospholipids in the erythrocyte membrane
16. Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins
17. A family of drug transporters: The multidrug resistance-associated proteins
18. The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides
19. Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
20. pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells
21. Fluorescent molecular probes. III. 2′,7′-Bis-(3-carboxypropyl)-5-(and-6)-carboxyfluorescein (BCPCF): A new polar dual-excitation and dual-emission pH indicator with a pKA of 7.0
22. Indomethacin-mediated reversal of multidrug resistance and drug efflux in human and murine cell lines overexpressing MRP, but not P-glycoprotein
23. Active efflux of the free acid form of the fluorescent dye 2′,7′-bis(2-carboxyethyl)-5(6)-carboxyfluorescein in multidrug-resistance-protein-overexpressing murine and human leukemia cells
24. Genistein is a natural inhibitor of hexose and dehydroascorbic acid transport through the glucose transporter, GLUT1
25. Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein
26. Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells
27. The effect of glutathione on the ATPase activity of MRP1 in its natural membranes
28. Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds
29. Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells
30. Potent interaction of flavopiridol with MRP1
31. Effect of inhibitors on the transport of dinitrophenyl-S-glutathione in human erythrocytes