Weaning induces NOS-2 expression through NF-κB modulation in the lactating mammary gland: Importance of GSH

Biochemical Journal

Volumn 391, Issue 3, 2005, Pages 581-588

  Zaragozá, Rosa ^a   Miralles, Vicente J ^a   Rus, A Diana ^a   García, Concha ^a   Carmena, Rafael ^a   García Trevijano, Elena R ^a   Barber, Teresa ^a   Pallardó, Federico V ^a   Torres, Luís ^a   Viña, Juan R ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

Author keywords

GSH; Involution; Lactation; NF B; Nitric oxide

Indexed keywords

BIOSYNTHESIS; CELLS; PROTEINS; TISSUE;

GSH; INVOLUTION; LACTATION; NF-ΚB; NITRIC OXIDE;

BIOLOGICAL ORGANS;

GLUTATHIONE TRANSFERASE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE EXPRESSION; IMMUNOPRECIPITATION; LACTATION; MAMMARY GLAND FUNCTION; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; UPREGULATION; WEANING; WESTERN BLOTTING;

ANIMALS; DOWN-REGULATION; ENZYME INDUCTION; FEMALE; GENE EXPRESSION PROFILING; GLUTATHIONE; LACTATION; MAMMARY GLANDS, ANIMAL; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PROMOTER REGIONS (GENETICS); PROTEIN BINDING; PROTEIN TRANSPORT; RATS; RATS, WISTAR; UP-REGULATION; WEANING;

ANIMALIA;

EID: 27744551397     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050507     Document Type: Article

References (42)

1. Lund, L. R., Romer, J., Thomasset, N., Solberg, H., Pyke, C., Bissell, M. J., Dano, K. and Werb, Z. (1996) Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development 122, 181-193
2. Visvader, J. E. and Lindeman, G. J. (2003) Transcriptional regulators in mammary gland development and cancer. Int. J. Biochem. Cell Biol. 37, 1034-1051
3. Clarkson, R. W. E. and Watson, C. J. (2003) Microarray analysis of the involution switch. J. Mammary Gland Biol. Neoplasia 8, 309-319
4. Clarkson, R. W. E., Wayland, M. T., Lee, J., Freeman, T. and Watson, C. J. (2004) Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res. 6, R92-R109
5. Stein, T., Morris, J. S., Davies, C. R., Weber-Hall, S. J., Duffy, M.-A., Heath, V. J., Bell, A. K., Ferrier, R. K., Sandilands, G. P. and Gusterson, B. A. (2004) Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3. Breast Cancer Res. 6, R75-R91
6. Zaragozá, R., García, C., Rus, A. D., Pallardó, F. V., Barber, T., Torres, L., Miralles, V. J. and Vinã, J. R. (2003) Inhibition of liver trans-sulphuration pathway by propargylglycine mimics gene expression changes found in the mammary gland of weaned lactating rats: role of glutathione. Biochem. J. 373, 825-834
7. Barber, T., Triguero, A., Martinez-López, I., Torres, L., García, C., Miralles, V. J. and Viña, J. R. (1999) Elevated expression of liver gamma-cystathionase is required for the maintenance of lactation in rats. J. Nutr. 129, 928-933
8. Armstrong, J. S., Steinauer, K. K., Hornung, B., Irish, J. M., Lecane, P., Birrell, G. W., Peehl, D. M. and Knox, S. J. (2002) Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line. Cell Death Differ. 9, 252-263
9. Ghosh, S., May, M. J. and Kopp, E. B. (1998) NF-κB and REL proteins: Evolutionary conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260
10. Geymayer, S. and Doppler, W. (2000) Activation of NF-kappaB p50/p65 is regulated in the developing mammary gland and inhibits STAT5-mediated beta-casein gene expression. FASEB J. 14, 1159-1170
11. Cogswell, P. C., Cartridge, D. C., Funkhouser, W. K. and Baldwin, Jr, A. S. (2000) Selective activation of NF-kappa B subunits in human breast cancer: potential roles for NF-kappa B2/p52 and for Bcl-3. Oncogene 19, 1123-1131
12. Clarkson, R. W. E., Heeley, J. L., Chapman, R., Aillet, F., Hay, R. T., Wyllie, A. and Watson, C. J. (2000) NF-kB inhibits apoptosis in murine mammary epithelia. J. Biol. Chem. 275, 12737-12742
13. Brantley, D. M., Yull, F. E., Muraoka, R. S., Hicks, D. J., Cook, C. M. and Kerr, L. D. (2000) Dynamic expression and activity of NF-kappaB during post-natal mammary gland morphogenesis. Mech. Dev. 97, 149-155
14. Pahl, H. (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853-6866
15. Kleinert, H., Pautz, A., Linker, K. and Schwarz, P. M. (2004) Regulation of the expression of inducible nitric oxide synthase. Eur. J. Pharmacol. 500, 255-266
16. Palmer, R. M. J., Ferrige, A. G. and Moncada, S. (1987) Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature (London) 327, 524-526
17. Hemish, J., Nakaya, N., Mittel, V. and Enikolopov, G. (2003) Nitric oxide activates diverse signaling pathways to regulate gene expression. J. Biol. Chem. 278, 42321-42329
18. Wu, G. and Meininger, C. J. (2002) Regulation of nitric oxide synthesis by dietary factors. Annu. Rev. Nutr. 22, 61-86
19. Davis, K. L., Martin, E., Turko, I. V. and Murad, F. (2001) Novel effects of nitric oxide. Annu. Rev. Pharmacol. Toxicol. 41, 203-236
20. Brüne, B., Von Knethen, A. and Sandau, K. B. (1999) Nitric oxide (NO): an effector of apoptosis. Cell Death Differ. 10, 969-975
21. Iizuka, T., Sasaki, M., Oishi, K., Uemura, S. and Koike, M. (1998) The presence of nitric oxide synthase in the mammary glands of lactating rats. Pediatr. Res. 44, 197-200
22. Yabuki, M., Tsutsui, K., Horton, A. A., Yoshioka, T. and Utsumi, K. (2000) Caspase activation and cytochrome c release during HL-60 cell apoptosis induced by a nitric oxide donor. Free Radical Res. 32, 507-514
23. Brigelius, R., Muckel, C., Akerhoom, T. P. M. and Sies, H. (1983) Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide. Biochem. Pharmacol. 32, 2529-2534
24. Kalz, J., Wals, P. A. and Van de Velde, R. L. (1974) Lipogenesis by acini from mammary gland of lactating rats. J. Biol. Chem. 249, 7348-7357
25. Robinson, A. M. and Williamson, D. H. (1977) Comparison of glucose metabolism in the lactating mammary gland of the rat in vivo and in vitro. Effects of starvation, prolactin or insulin deficiency. Biochem. J. 164, 153-159
26. Borrás, E., Zaragozá, R., Morante, M., García, C., Gimeno, A., López-Rodas, G., Barber, T., Miralles, V. J., Viña, J. R. and Torres, L. (2003) In vivo studies of altered expression patterns of p53 and proliferative control genes in chronic vitamin A deficiency and hypervitaminosis. Eur. J. Biochem. 270, 1493-1501
27. Sandoval, J., Rodríguez, J. L., Tur, G., Serviddio, G., Pereda, J., Boukaba, A., Sastre, J., Torres, L., Franco, L. and López-Rodas, G. (2004) RNAPol-ChIP: a novel application of chromatin immunoprecipitation to the analysis of real-time gene transcription. Nucleic Acids Res. 32, e88
28. Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T. et al. (2000) Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat. Genet. 25, 25-29
29. Misko, T. P., Schilling, R. J, Salvemini, D., Moore, W. M. and Currie, M. G. (1993) A fluorometric assay for the measurement of nitrite in biological samples. Anal. Biochem. 214, 11-16
30. Agius, L., Robinson, A. M., Girard, J. R. and Williamson, D. H. (1979) Alterations in the rate of lipogenesis in vivo in maternal liver and adipose tissue on premature weaning of lactating rats: a possible regulatory role of prolactin. Biochem. J. 180, 689-692
31. Kolodziejski, P. J., Koo, J. S. and Eissa, N. T. (2004) Regulation of inducible nitric oxide synthase by rapid cellular turnover and cotranslational down-regulation by dimerization inhibitors. Proc. Natl. Acad. Sci. U.S.A. 101, 18141-18146
32. Cao, Y. and Karin, M. (2003) NF-kappaB in mammary gland development and breast cancer. J. Mammary Gland Biol. Neoplasia 8, 215-223
33. Shillingford, J. M. and Hennighausen, L. (2001) Experimental mouse genetics-answering fundamental questions about mammary gland biology. Trends Endocrinol. Metab. 12, 402-408
34. Wei, J., Quo, H., Gao, C. and Kuo, P. C. (2004) Peroxide-mediated chromatin remodelling of a nuclear factor κB site in the mouse inducible nitric oxide synthase promoter. Biochem. J. 377, 809-818
35. Thomsen, L. L., Miles, D. W., Happerfield, L., Bobrow, L. G., Knowles., R. G. and Moncada, S. (1995) Nitric oxide synthase activity in human breast cancer. Br. J. Cancer 72, 41-44
36. Lacasse, P., Farr, V. C., Davis, S. R. and Prosser, C. G. (1996) Local secretion of nitric oxide and the control of mammary blood flow. J. Dairy Sci. 79, 1369-1374
37. Onoda, M. and Inano, H. (1998) Localization of nitric oxide syntheses and nitric oxide production in the rat mammary gland. J. Histochem. Cytochem. 46, 1269-1278
38. Schwartz, D., Mendonca, M., Schwartz, I., Xia, Y., Satriano, J., Wilson, C. B. and Blantz, R. C. (1997) Inhibition of constitutive nitric oxide synthase (NOS) by nitric oxide generated by inducible NOS after lipopolysaccharide administration provokes renal dysfunction in rats. J. Clin. Invest. 100, 439-448
39. Lu, J. L., Schmiege, III, L. M., Kuo, L. and Liao, J. C. (1996) Downregulation of endothelial constitutive nitric oxide synthase expression by lipopolysaccharide. Biochem. Biophys. Res. Commun. 225, 1-5
40. Wang, X., Michael, D., de Murcia, G. and Oren, M. (2002) p53 activation by nitric oxide involves down-regulation of Mdm2. J. Biol. Chem. 277, 15697-15702
41. Ischiropoulos, H. (2003) Biological selectivity and functional aspects of protein tyrosine nitration. Biochem. Biophys. Res. Commun. 305, 776-783
42. Esteve, J. M., Mompó, J., Garcia de la Asunción, J., Sastre, J., Asensi, M., Boix, J., Viña, J. R., Viña, J. and Pallardó, F. V. (1999) Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro. FASEB J. 13, 1055-1064