Neurokinin 1 receptor signaling affects the local innate immune defense against genital herpes virus infection

Journal of Immunology

Volumn 175, Issue 10, 2005, Pages 6802-6811

  Svensson, Alexandra ^a   Kaim, Joanna ^b   Mallard, Carina ^b   Olsson, Annika ^c   Brodin, Ernst ^c   Hökfelt, Tomas ^c   Eriksson, Kristina ^a,b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; NEUROKININ 1 RECEPTOR; SUBSTANCE P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; IMMUNOHISTOCHEMISTRY; INFECTION RESISTANCE; INNATE IMMUNITY; MOUSE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; PRIORITY JOURNAL; RADIOIMMUNOASSAY; TH1 CELL; VACCINATION; VIRUS REPLICATION;

EID: 27744547160     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.10.6802     Document Type: Article

References (57)

1. Kinghorn, G. R. 1994. Epidemiology of genital herpes. J. Intern. Med. Res. 22: 14A-23A.
2. Hökfelt, T., B. Pernow, and J. Wahren. 2001. Substance P: a pioneer amongst neuropeptides. J. Intern. Med. 249: 27-40.
3. Alm, P., J. Alumets, E. Brodin, R. Hakanson, G. Nilsson, N. O. Sjoberg, and F. Sundler. 1978. Peptidergic (substance P) nerves in the genito-urinary tract. Neuroscience 3: 419-425.
4. Mitchell, B. S., and E. Ahmed. 1992. An immunohistochemical study of the catecholamine synthesizing enzymes and neuropeptides in the female guinea-pig uterus and vagina. Histochem. J. 24: 361-367.
5. Papka, R. E., J. P. Cotton, and H. H. Traurig. 1985. Comparative distribution of neuropeptide tyrosine-, vasoactive intestinal polypeptide-, substance P-immunoreactive, acetylcholinesterase-positive, and noradrenergic nerves in the reproductive tract of the female rat. Cell Tissue Res. 242: 475-490.
6. Lambrecht, B. N., P. R. Germonpre, E. G. Everaert, I. Carro-Muino, M. de Veerman, D. de Filipe, S. P. Hunt, K. Thielmans, G. F. Joos, and R. A. Pauwels. 1999. Endogenously produced substance P contributes to lymphocyte proliferation induced by dendritic cells and direct TCR ligation. Eur. J. Immunol. 29: 3815-3825.
7. Ho, W.-Z., J. P. Lai, X. H. Zhu, M. Uvaydova, and S. D. Douglas. 1997. Human monocytes and macrophages express substance P and neurokinin-1 receptor. J. Immunol. 159: 5654-5660.
8. de Giorgio, R., P. L. Tazzari, G. Barbara, V. Stanghellini, and R. Corinaldesi. 1998. Detection of substance P immunoreactivity in human peripheral leucocytes. J. Neuroimmunol. 82: 175-181.
9. Lotz, M., J. H. Vaughan, and D. A. Carson. 1988. Effect of neuropeptides on production of inflammatory cytokines. Science 241: 1218-1221.
10. Kincy-Cain, T., and K. L. Bost. 1997. Substance P-induced IL-12 production by murine macrophages. J. Immunol. 158: 2334-2339.
11. Laurenzi, M. A., M. A. Persson, C. J. Dalsgaard, and A. Haegerstrand. 1990. The neuropeptide substance P stimulates production of interleukin-1 in human blood monocytes: activated cells are preferentially influenced by the neuropeptide. Scand. J. Immunol. 31: 529-533.
12. Ho, W.-Z., D. Kaufman, M. Uvaydova, and S. D. Douglas. 1996. Substance P augments interleukin-10 and tumor necrosis factor-α release by human cord blood monocytes and macrophages. J. Neuroimmunol. 71: 73-80.
13. Levite, M. 1998. Neuropeptides, by direct interaction with T cells, induce cytokine secretion and break the commitment to a distinct T helper phenotype. Proc. Natl. Acad. Sci. USA 95: 12544-12549.
14. Lang, K., T. L. Drell, B. Niggemann, K. S. Zanker, and F. Entschladen. 2003. Neurotransmitters regulate the migration and cytotoxicity in natural killer cells. Immunol. Lett. 90: 165-172.
15. Flageole, H., M. Senterman, and J. L. Trudel. 1992. Substance P increases in vitro lymphokine-activated-killer (LAK) cell cytotoxicity against fresh colorectal cancer cells. J. Surg. Res. 53: 445-449.
16. Croitoru, K., P. B. Ernst, J. Bienenstock, I. Padol, and A. M. Stanisz. 1990. Selective modulation of the natural killer activity of murine intestinal intraepithetial leucocytes by the neuropeptide substance P. Immunology 71: 196-201.
17. Elsawa, S. F., W. Taylor, C. C. Petty, I. Marriott, J. V. Weinstock, and K. L. Bost. 2003. Reduced CTL response and increased viral burden in substance P receptor-deficient mice infected with murine γ-herpesvirus 68. J. Immunol. 170: 2605-2612.
18. Ho, W. Z., J. P. Lai, Y. Li, and S. D. Douglas. 2002. HIV enhances substance P expression in human immune cells. FASEB J. 16: 616-618.
19. Li, Y., S. D. Douglas, L. Song, S. Sun, and W.-Z. Ho. 2001. Substance P enhances HIV-1 replication in latently infected human immune cells. J. Neuroimmunol. 121: 67-75.
20. Tripp, R. A., D. Moore, J. Winter, and L. J. Anderson. 2000. Respiratory syncytial virus infection and G and/or SH protein expression contribute to substance P, which mediates inflammation and enhanced pulmonary disease in BALB/c mice. J. Virol. 74: 1614-1622.
21. Piedimonte, G., M. M. Rodriguez, K. A. King, S. McLean, and X. Jiang. 1999. Respiratory syncytial virus upregulates expression of the substance P receptor in rat lungs. Am. J. Physiol. 277: L831-L840.
22. Tripp, R. A., A. Barskey, L. Goss, and L. J. Anderson. 2002. Substance P receptor expression on lymphocytes is associated with the immune response to respiratory syncytial virus infection. J. Neuroimmunol 129: 141-153.
23. McDermott, M. R., J. R. Smiley, L. J. Brais, H. E. Rudzroga, and J. Bienenstock. 1984. Immunity in the female genital tract after intravaginal vaccination of mice with an attenuated strain of herpes simplex virus type 2. J. Virol 51: 747-753.
24. Parr, M. B., L. Kepple, M. McDermott, M. D. Drew, J. J. Bozzola, and E. L. Parr. 1994. A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2. Lab. Invest. 70: 369-380.
25. + T-cells in innate and adaptive immune control of genital HSV-2 infection in mice. J. Gen. Virol. 82: 845-853.
26. Harandi, A. M., B. Svennerholm, J. Holmgren, and K. Eriksson. 2001. Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired γ interferon-mediated protective immunity. J. Virol. 75: 6705-6709.
27. Bozic, C. R., B. Lu, U. E. Höpken, C. Gerard, and N. P. Gerard. 1996. Neurogenic amplification of immune complex formation. Science 273: 1722-1725.
28. Andrei, G., R. Snoeck, and E. De Clerq. 1997. Differential susceptibility of several drug-resistant strains of herpes simplex virus type 2 to various antiviral compounds. Antivir. Chem. Chemother. 8: 457-461.
29. Seth, P., W. E. Rawls, R. Duff, F. Rap, E. Adam, and J. L. Melnick. 1974. Antigenic differences between isolates of herpesvirus type 2. Intervirology 3: 1-14.
30. Streit, W. J. 1990. An improved staining method for rat microglial cells using the lectin from Griffonia simplicifolia (GSA I-B4). J. Histochem. Cytochem. 38: 1683-1686.
31. Brodin, E., A. Rosen, E. Theodorsson, A. Jonczyk, B. E. Sandberg, and K. Brodin. 1994. Multiple molecular forms of tachykinins in rat spinal cord: a study comparing different extraction methods. Regul. Pept. 52: 97-110.
32. Brodin, E., N. Lindefors, C. J. Dalsgaard, E. Theodorsson-Norheim, and S. Rosell. 1986. Tachykinin multiplicity in rat central nervous system as studied using antisera raised against substance P and neurokinin A. Regul. Pept. 13: 253-272.
33. Adams, J. C. 1992. Biotin amplification of biotin and horseradish peroxidase signals in histochemical stains. J. Histochem. Cytochem. 40: 1457-1463.
34. Christensson-Nylander, I., M. Herrera-Marschitz, W. Staines, T. Hokfelt, L. Terenius, U. Ungerstedt, C. Cuello, W. H. Oertel, and M. Goldstein. 1986. Striato-nigral dynorphin and substance P pathways in the rat. I. Biochemical and immunohistochemical studies. Exp. Brain Res. 64: 169-192.
35. Harandi, A. M., B. Svennerholm, J. Holmgren, and K. Eriksson. 2001. Protection against genital HSV-2 infection in mice is associated with a rapid induction of local IFN-γ-dependent RANTES production following a vaginal viral challenge. Am. J. Reprod. Immunol. 46: 420-424.
36. Nandi, D., and J. P. Allison. 1993. Characterization of neutrophils and T lymphocytes associated with the murine vaginal epithelium. Reg. Immunol. 5: 332-338.
37. Parr, M. B., and E. L. Parr. 1991. Langerhans cells and T lymphocyte subsets in the murine vagina and cervix. Biol. Reprod. 44: 491-498.
38. Blaney, J. E., Jr., E. Nobusawa, M. A. Brehm, R. H. Bonneau, L. M. Mylin, T. M. Fu, Y. Kawaoka, and S. S. Tevethia. 1998. Immunization with a single major histocompatibility complex class I-restricted cytotoxic T-lymphocyte recognition epitope of herpes simplex virus type 2 confers protective immunity. J. Virol. 72; 9567-9574.
39. Traurig, H., A. Sana, and F. Lembeck. 1984. Substance P in primary afferent neurons of the female rat reproductive system. Naunyn Schmiedebergs Arch. Pharmacol. 326: 343-346.
40. Israel, B. A., K. T. Schultz, and C. J. Murphy. 1998. Lack of detectable interaction between HSV-1 and integrins or tachykinins. Intervirology 41: 132-134.
41. Schroeder, C. 1986. Substance P, a neuropeptide, inhibits measles virus replication in cell culture. Acta Virol. 30: 432-435.
42. Yasin, B., W. Wang, M. Pang, N. Cheshenko, T. Hong, A. J. Waring, B. C. Herold, E. A. Wagar, and R. I. Lehrer. 2004. 32 θ Defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry. J. Virol. 78: 5147-5156.
43. Jenssen, H., J. H. Andersen, D. Mantzilas, and T. J. Gutteberg. 2004. A wide range of medium-sized, highly cationic, α-helical peptides show antiviral activity against herpes simplex virus. Antiviral Res. 64: 119-126.
44. Ashkar, A. A., and K. L. Rosenthal. 2003. Interleukin-15 and natural killer and NKT cells play a critical role in innate protection against genital herpes simplex virus type 2 infection. J. Virol. 77: 10168-10171.
45. - cells. J. Immunol. 160: 4738-4746.
46. Wolf, S. F., P. A. Temple, M. Kobayashi, D. Young, M. Dicig, L. Lowe, R. Dzialo, L. Fitz, C. Ferenz, R. M. Hewick, et al. 1991. Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J. Immunol. 146: 3074-3081.
47. Moser, B., and P. Loetscher. 2001. Lymphocyte traffic control by chemokines. Nat. Immunol. 2: 123-128.
48. Menten, P., A. Wuyts, and S. Van Damme. 2002. Macrophage inflammatory protein-1. Cytokine Growth Factor Rev. 13: 455-481.
49. Salazar-Mather, T. P., and K. L. Hokeness. 2003. Calling in the troops: regulation of inflammatory cell trafficking through innate cytokine/chemokine networks. Viral Immunol. 16: 291-306.
50. Lambrecht, B. N. 2001. Immunologists getting nervous: neuropeptides, dendritic cells, and T cell activation. Respir. Res. 2: 133-138.
51. Milligan, G. N., and D. I. Bernstein. 1995. Analysis of herpes simplex virus-specific T cells in the murine female genital react following genital infection with herpes simplex virus type. Virology 212: 481-489.
52. Milligan, G. N., and D. I. Bernstein. 1997. Interferon-γ enhances resolution of herpes simplex virus type 2 infection of the murine genital tract. Virology 229: 259-268.
53. Milligan, G. N., D. I. Bernstein, and N. Bourne. 1998. T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2. J. Immunol. 160: 6093-6100.
54. + T-cell responses to herpes simplex virus type 2 (HSV-2) glycoprotein G are type-specific and differ in symptomatic and asymptomatic HSV-2 infected individuals. J. Gen. Virol 85: 2139-2147.
55. Singh, R., A. Kumar, W. D. Creery, M. Ruben, A. Giulivi, and F. Diaz-Mitoma. 2003. Dysregulated expression of IFN-γ and 1L-10 and impaired IFN-γ-mediated responses at different stages in patients with genital herpes simplex virus-2 infection. Clin. Exp. Immunol 133: 97-107.
56. Almeida, T. A., J. Rojo, P. M. Nieto, F. M. Pinto, M. Hernandez, J. D. Martin, and M. L. Candenas. 2004. Tachykinins and tachykinin receptors: structure and activity relationships. Curr. Med. Chem. 11: 2045-2081.
57. van Hagen, P. M., L. J. Hofland, A. M. ten Bokum, E. G. Lichtenauer-Kaligis, D. J. Kwekkeboom, D. Ferone, and S. W. Lamberts. 1999. Neuropeptides and their receptors in the immune system. Ann. Med. 31(Suppl.) 2: 15-22.