Increased sensitivity to the acute effects of MDMA ("ecstasy") in female rats

Physiology and Behavior

Volumn 86, Issue 4, 2005, Pages 546-553

  Palenicek, T ^a   Votava, M ^b   Bubenikova, V ^a   Horacek, J ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

Author keywords

3,4 Methylenedioxymethamphetamine; Activity cage; Behavior; Locomotion; MDMA; Open field; Rats; Sensitivity; Sex differences

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE;

ANIMAL EXPERIMENT; ANXIETY; ARTICLE; BEHAVIOR; CAGE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FEMALE; LOCOMOTION; MALE; MAZE TEST; NONHUMAN; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; RAT; RAT STRAIN; SENSITIVITY ANALYSIS; SEROTONINERGIC SYSTEM; SEX DIFFERENCE; STIMULATION; TASK PERFORMANCE;

EID: 27744527388     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2005.08.043     Document Type: Article

References (69)

1. M.J. Landry MDMA: a review of epidemiologic data J Psychoactive Drugs 34 2002 163 169
2. W. Slikker Jr., R.R. Holson, S.F. Ali, M.G. Kolta, M.G. Paule, and A.C. Scallet Behavioral and neurochemical effects of orally administered MDMA in the rodent and nonhuman primate Neurotoxicology 10 1989 529 542
3. G. Rudnick, and S.C. Wall The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release Proc Natl Acad Sci U S A 89 1992 1817 1821
4. J. Lyles, and J.L. Cadet Methylenedioxymethamphetamine (MDMA, ecstasy) neurotoxicity: cellular and molecular mechanisms Brain Res Brain Res Rev 42 2003 155 168
5. A.R. Green, A.J. Cross, and G.M. Goodwin Review of the pharmacology and clinical pharmacology of 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") Psychopharmacology (Berl) 119 1995 247 260
6. M.E. Liechti, A. Gamma, and F.X. Vollenweider Gender differences in the subjective effects of MDMA Psychopharmacology (Berl) 154 2001 161 168
7. M. Fišerová, and T. Páleníèek MDMA (3,4-methylendioxymetamfetamin)-"extáze" Adiktologie 2 2001 48 59
8. M.E. Carroll, W.J. Lynch, M.E. Roth, A.D. Morgan, and K.P. Cosgrove Sex and estrogen influence drug abuse Trends Pharmacol Sci 25 2004 273 279
9. V. Bubenikova, M. Votava, J. Horacek, and T. Palenicek Relation of sex and estrous phase to deficits in prepulse inhibition of the startle response induced by ecstasy (MDMA) Behav Pharmacol 16 2005 127 130
10. L. Reneman, J. Booij, K. De Bruin, J.B. Reitsma, F.A. de Wolff, and W.B. Gunning Effects of dose, sex, and long-term abstention from use on toxic effects of MDMA (ecstasy) on brain serotonin neurons Lancet 358 2001 1864 1869
11. U.D. McCann, A. Ridenour, Y. Shaham, and G.A. Ricaurte Serotonin neurotoxicity after (+/-)3,4-methylenedioxymethamphetamine (MDMA; "ecstasy"): a controlled study in humans Neuropsychopharmacology 10 1994 129 138
12. D. Bengel, D.L. Murphy, A.M. Andrews, C.H. Wichems, D. Feltner, and A. Heils Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("ecstasy") in serotonin transporter-deficient mice Mol Pharmacol 53 1998 649 655
13. A.C. McCreary, M.G. Bankson, and K.A. Cunningham Pharmacological studies of the acute and chronic effects of (+)-3, 4-methylenedioxymethamphetamine on locomotor activity: role of 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B/ 1D) receptors J Pharmacol Exp Ther 290 1999 965 973
14. A.A. Grace The tonic/phasic model of dopamine system regulation: its relevance for understanding how stimulant abuse can alter basal ganglia function Drug Alcohol Depend 37 1995 111 129
15. G.A. Ricaurte, J. Yuan, and U.D. McCann (+/-)3,4- Methylenedioxymethamphetamine ('ecstasy')-induced serotonin neurotoxicity: studies in animals Neuropsychobiology 42 2000 5 10
16. P. Boguszewski, and J. Zagrodzka Emotional changes related to age in rats-a behavioral analysis Behav Brain Res 133 2002 323 332
17. J. Tropp, and E.J. Markus Sex differences in the dynamics of cue utilization and exploratory behavior Behav Brain Res 119 2001 143 154
18. W.J. Lynch, M.E. Roth, and M.E. Carroll Biological basis of sex differences in drug abuse: preclinical and clinical studies Psychopharmacology (Berl) 164 2002 121 137
19. R.M. Craft, and J.A. Stratmann Discriminative stimulus effects of cocaine in female versus male rats Drug Alcohol Depend 42 1996 27 37
20. S.L. Sell, J.M. Scalzitti, M.L. Thomas, and K.A. Cunningham Influence of ovarian hormones and estrous cycle on the behavioral response to cocaine in female rats J Pharmacol Exp Ther 293 2000 879 886
21. T. Stohr, W.D. Schulte, I. Weiner, and J. Feldon Rat strain differences in open-field behavior and the locomotor stimulating and rewarding effects of amphetamine Pharmacol Biochem Behav 59 1998 813 818
22. M.L. Forgie, and J. Stewart Six differences in the locomotor-activating effects of amphetamine: role of circulating testosterone in adulthood Physiol Behav 55 1994 639 644
23. A.H. Tseng, and R.M. Craft Sex differences in antinociceptive and motoric effects of cannabinoids Eur J Pharmacol 430 2001 41 47
24. D. Honack, and W. Loscher Sex differences in NMDA receptor mediated responses in rats Brain Res 620 1993 167 170
25. S.A. Castner, L. Xiao, and J.B. Becker Sex differences in striatal dopamine: in vivo microdialysis and behavioral studies Brain Res 610 1993 127 134
26. S.A. Castner, and J.B. Becker Sex differences in the effect of amphetamine on immediate early gene expression in the rat dorsal striatum Brain Res 712 1996 245 257
27. B.K. Yamamoto, and L.J. Spanos The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat Eur J Pharmacol 148 1988 195 203
28. M.G. Bankson, and K.A. Cunningham 3,4-Methylenedioxymethamphetamine (MDMA) as a unique model of serotonin receptor function and serotonin-dopamine interactions J Pharmacol Exp Ther 297 2001 846 852
29. E.D. O'Loinsigh, G. Boland, J.P. Kelly, and K.M. O'Boyle Behavioural, hyperthermic and neurotoxic effects of 3,4-methylenedioxymethamphetamine analogues in the Wistar rat Prog Neuropsychopharmacol Biol Psychiatry 25 2001 621 638
30. L.J. Spanos, and B.K. Yamamoto Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat Pharmacol Biochem Behav 32 1989 835 840
31. 1B receptor activation mimics behavioral effects of presynaptic serotonin release Neuropsychopharmacology 8 1993 201 211
32. Y.J. Ho, C.R. Pawlak, L. Guo, and R.K. Schwarting Acute and long-term consequences of single MDMA administration in relation to individual anxiety levels in the rat Behav Brain Res 149 2004 135 144
33. 1A agonists Mol Pharmacol 37 1990 231 237
34. R. De La Garza, and K.A. Cunningham The effects of the 5-hydroxytryptamine(1A) agonist 8-hydroxy-2-(di-n-propylamino)tetralin on spontaneous activity, cocaine-induced hyperactivity and behavioral sensitization: a microanalysis of locomotor activity J Pharmacol Exp Ther 292 2000 610 617
35. V. Hillegaart, M.L. Wadenberg, and S. Ahlenius Effects of 8-OH-DPAT on motor activity in the rat Pharmacol Biochem Behav 32 1989 797 800
36. 1B receptor Psychopharmacology (Berl) 141 1999 154 161
37. 2A receptor antagonist MDL 100,907 on MDMA-induced locomotor stimulation in rats Neuropsychopharmacology 15 1996 116 124
38. D. Crespi, T. Mennini, and M. Gobbi Carrier-dependent and Ca(2+)-dependent 5-HT and dopamine release induced by (+)-amphetamine, 3,4-methylendioxymethamphetamine, p-chloroamphetamine and (+)-fenfluramine Br J Pharmacol 121 1997 1735 1743
39. C.W. Callaway, L.L. Wing, and M.A. Geyer Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats J Pharmacol Exp Ther 254 1990 456 464
40. 1 agonist C-APB in mice Psychopharmacology (Berl) 145 1999 237 250
41. E.A. Jackson, and P.H. Kelly Role of nigral dopamine in amphetamine-induced locomotor activity Brain Res 278 1983 366 369
42. R. Ventura, A. Alcaro, S. Cabib, D. Conversi, L. Mandolesi, and S. Puglisi-Allegra Dopamine in the medial prefrontal cortex controls genotype-dependent effects of amphetamine on mesoaccumbens dopamine release and locomotion Neuropsychopharmacology 29 2004 72 80
43. 2C receptor subtypes in the control of in vivo dopamine outflow in the rat striatum J Neurochem 74 2000 693 701
44. 2 receptors J Neurosci Res 55 1999 600 607
45. 2-like receptor antagonists on the hypermotive and discriminative stimulus effects of (+)-MDMA Psychopharmacology (Berl) 173 2004 326 336
46. K.T. Ball, D. Budreau, and G.V. Rebec Acute effects of 3,4-methylenedioxymethamphetamine on striatal single-unit activity and behavior in freely moving rats: differential involvement of dopamine D(1) and D(2) receptors Brain Res 994 2003 203 215
47. B.K. Yamamoto, and L.J. Spanos The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat Eur J Pharmacol 148 1988 195 203
48. M. Carlsson, K. Svensson, E. Eriksson, and A. Carlsson Rat brain serotonin: biochemical and functional evidence for a sex difference J Neural Transm 63 1985 297 313
49. M. Hyyppa, and U.K. Rinne Hypothalamic monoamines after the neonatal androgenization, castration or reserpine treatment of the rat Acta Endocrinol (Copenh) 66 1971 317 324
50. D.C. Blanchard, J.K. Shepherd, R.J. Rodgers, and R.J. Blanchard Evidence for differential effects of 8-OH-DPAT on male and female rats in the anxiety/defense test battery Psychopharmacology (Berl) 106 1992 531 539
51. T.E. Robinson, J.B. Becker, and V.D. Ramirez Sex differences in amphetamine-elicited rotational behavior and the lateralization of striatal dopamine in rats Brain Res Bull 5 1980 539 545
52. R.E. Hruska, and K.T. Pitman Hypophysectomy reduces the haloperidol-induced changes in striatal dopamine receptor density Eur J Pharmacol 85 1982 201 205
53. W. Zhou, K.A. Cunningham, and M.L. Thomas Estrogen regulation of gene expression in the brain: a possible mechanism altering the response to psychostimulants in female rats Brain Res Mol Brain Res 100 2002 75 83
54. 2 dopamine receptor binding Brain Res 637 1994 163 172
55. B.E. Summer, and G. Fink Estrogen increases the density of 5-hydroxytryptamine(2A) receptors in cerebral cortex and nucleus accumbens in the female rat J Steroid Biochem Mol Biol 54 1995 15 20
56. G. Attali, A. Weizman, I. Gil-Ad, and M. Rehavi Opposite modulatory effects of ovarian hormones on rat brain dopamine and serotonin transporters Brain Res 756 1997 153 159
57. R. Bosse, R. Rivest, and T. Di Paolo Ovariectomy and estradiol treatment affect the dopamine transporter and its gene expression in the rat brain Brain Res Mol Brain Res 46 1997 343 346
58. J.K. McQueen, H. Wilson, and G. Fink Estradiol-17 beta increases serotonin transporter (SERT) mRNA levels and the density of SERT-binding sites in female rat brain Brain Res Mol Brain Res 45 1997 13 23
59. J.B. Becker Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis Neurosci Lett 118 1990 169 171
60. L. Xiao, and J.B. Becker Hormonal activation of the striatum and the nucleus accumbens modulates paced mating behavior in the female rat Horm Behav 32 1997 114 124
61. J.B. Becker, and V.D. Ramirez Sex differences in the amphetamine stimulated release of catecholamines from rat striatal tissue in vitro Brain Res 204 1981 361 372
62. J.B. Becker, and V.D. Ramirez Experimental studies on the development of sex differences in the release of dopamine from striatal tissue fragments in vitro Neuroendocrinology 32 1981 168 173
63. J.B. Becker, and C.N. Rudick Rapid effects of estrogen or progesterone on the amphetamine-induced increase in striatal dopamine are enhanced by estrogen priming: a microdialysis study Pharmacol Biochem Behav 64 1999 53 57
64. T. Di Paolo, C. Rouillard, and P. Bedard 17beta-Estradiol at a physiological dose acutely increases dopamine turnover in rat brain Eur J Pharmacol 117 1985 197 203
65. T. Chu, Y. Kumagai, E.W. DiStefano, and A.K. Cho Disposition of methylenedioxymethamphetamine and three metabolites in the brains of different rat strains and their possible roles in acute serotonin depletion Biochem Pharmacol 51 1996 789 796
66. S.Y. Yeh, and F.L. Hsu The neurochemical and stimulatory effects of putative metabolites of 3,4-methylenedioxyamphetamine and 3,4- methylenedioxymethamphetamine in rats Pharmacol Biochem Behav 39 1991 787 790
67. W.M. Davis, and R.F. Borne Pharmacologic investigation of compounds related to 3,4-methylenedioxyamphetamine (MDA) Subst Alcohol Actions Misuse 5 1984 105 110
68. A.C. Parrott Is ecstasy MDMA? A review of the proportion of ecstasy tablets containing MDMA, their dosage levels, and the changing perceptions of purity Psychopharmacology (Berl) 173 2004 234 241
69. R.M. Milani, A.C. Parrott, J.J. Turner, and H.C. Fox Gender differences in self-reported anxiety, depression, and somatization among ecstasy/MDMA polydrug users, alcohol/tobacco users, and nondrug users Addict Behav 29 2004 965 971