Locomotor response to MDMA is attenuated in knockout mice lacking the 5- HT(1B) receptor

Psychopharmacology

Volumn 141, Issue 2, 1999, Pages 154-161

  Scearce Levie, Kimberly ^a   Viswanathan, Sandya S ^a   Hen, René ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

3,4 Methylenedioxymethamphetamine (MDMA); 5 HT(1B) receptor; Drug abuse; Exploratory behavior; Knockout mice; Locomotion; Serotonin

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN; SEROTONIN 1B RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; EXPLORATORY BEHAVIOR; KNOCKOUT MOUSE; LOCOMOTION; MOUSE; NONHUMAN; OUTCOMES RESEARCH; PRIORITY JOURNAL; SEROTONIN RELEASE; STEREOTYPY;

ANIMALS; EXPLORATORY BEHAVIOR; HUMANS; MICE; MICE, KNOCKOUT; MOTOR ACTIVITY; N-METHYL-3,4-METHYLENEDIOXYAMPHETAMINE; RATS; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTORS, SEROTONIN; SEROTONIN AGENTS;

EID: 0032898984     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050819     Document Type: Article

References (34)

1. Battaglia G, Sharkey J, Kuhar MJ, de Souza EB (1991) Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4-methylenedioxymethamphetamine): assessment using quantitative autoradiography. Synapse 8:249-260
2. Berger UV, Gu XF, Azmitia EC (1992) The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-choroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine. Eur J Pharmacol 215:153-160
3. Callaway CW, Geyer MA (1992) Tolerance and cross-tolerance to the activating of 3,4-methylenedioxymethamphetamine and a 5-hydroxytryptamine1B agonist. J Pharmacol Exp Ther 263:318-326
4. Callaway CW, Nichols DE, Paulus MP, Geyer M (1991) Serotonin release is responsible for the locomotor hyperactivity in rats induced by derivatives of amphetamine releated to MDMA. In: Fozard JR, Saxena PR (eds) Serotonin: molecular biology, receptors, and functional effects. Birkhauser, Basel, pp 491-505
5. 1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine. Neuropsychopharmacology 7:113-127
6. Callaway CW, Wing LL, Geyer MA (1990) Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats. J Pharmacol Exp Ther 254:456-464
7. Castanon N, Lucas JJ, Scearce K, Hen R (1996) The 5-HT1B/1D antagonist GR 127935 decreases the effects of cocaine on c-fos expression and locomotion Society for Neuroscience 26th Annual Meeting, Washington, D.C.
8. Dulawa SC, Hen R, Scearce-Levie K, Geyer MA (1997) Serotonin1B receptor modulation of prepulse inhibition: recent findings in wild-type and 5-HT1B knockout mice. Serotonin Club Proceedings
9. Geyer MA, Callaway CW (1994) Behavioral pharmacology of ring-substituted amphetamine analogs. In: Cho AR, Segal OS (eds) Amphetamine and its analogs. Academic Press, New York, pp 177-201
10. Glennon RA, Young R (1984) Further investigation of the discriminative stimulus properties of MDA. Pharmacol Biochem Behav 20:501-505
11. Gold LH, Koob GF, Geyer MA (1988) Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and N-ethyl-3,4-methylenedioxyamphetamine in rats. J Pharmacol Exp Ther 247:547-555
12. Gudelsky GA, Nash JF (1996) Carrier-mediated release of serotonin by 3,4-methylenedioxymethamphetamine: implications for serotonin-dopamine interactions. J Neurochem 66:243-249
13. Hekmatpanah CR, Peroutka SJ (1990) 5-Hydroxytryptamine uptake blockers attenuate the 5-hydroxytryptamine-releasing effect of 3,4-methylenedioxymethamphetamine and related agents. Eur J Pharmacol 177:95-98
14. Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev 46:157-203
15. Li AA, Marek GJ, Vosmer G, Seiden LS (1989) Long-term central 5-HT depletions resulting from repeated administration of MDMA enhances the effects of single administration of MDMA on schedule-controlled behavior of rats. Pharmacol Biochem Behav 33:641-648
16. Lucas JJ, Segu L, Hen R (1997) 5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B/1D antagonist GR127935. Mol Pharmacol 51:755-763
17. McKenna DJ, Guan XM, Shulgin AT (1991) 3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine. Pharmacol Biochem Behav 38:505-512
18. Mittman SM, Geyer MA (1989) Effects of 5-HT1A agonists on locomotor and investigatory behaviors in rats differ from those of hallucinogens. Psychopharmacology 98:183-188
19. Paulus MP, Geyer MA (1992) The effects of MDMA and other methylenedioxy-substituted phenylalkylamines on the structure of rat locomotor activity. Neuropsychopharmacology 7:15-31
20. Paulus MP, Geyer MA, Gold LH, Mandell AJ (1990) Application of entropy measures derived from the ergodic theory of dynamical systems to rat locomotor behavior. Proc Natl Acad Sci USA 87:723-727
21. Pellow S, Johnston AL, File SE (1987) Selective agonists and antagonists for 5-hydroxytryptamine receptor subtypes, and interactions with yohimbine and FG 7142 using the elevated plus-maze test in the rat. J Pharm Pharmacol 39:917-928
22. Ramboz S, Oosting RS, Hen R (1997) Constituitive and inducible knockout of the 5-HT1A receptor 27th Annual Meeting, Society for Neuroscience. Society for Neuroscience, New Orleans, La., p 202.2
23. Rempel N, Callaway CW, Geyer MA (1993) The 5-HT1B receptor activation mimics behavioral effects of presynaptic serotonin release. Neuropsychopharmacology 8:201-212
24. Rocha BA, Scearce-Levie KS, Hiroi N, Lucas JJ, Castanon N, Crabbe JC, Nestler EJ, Hen R (1998) Increased vulnerability to cocaine in mice lacking the serotonin 1B receptor. Nature 393:175-178
25. Saudou F, Amara DA, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot MC, Hen R (1994) Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science 265:1875-1878
26. Scearce K, Kassir S, Lucas J, Castanon N, Segu L, Arango V, Hen R (1997) Dopaminergic compensations in knockout mice lacking the serotonin 1B receptor Society for Neuroscience, 27th Annual Meeting. Society for Neuroscience, New Orleans, La., p 202.2
27. Schechter MD (1988) Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy"). Pharmacol Biochem Behav 31:817-824
28. Schmidt CJ, Levin JA, Lovenberg W (1987) In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on striatal monoaminergic systems in the rat brain. Biochem Pharmacol 36:747-755
29. Skingle M, Skopes DIC, Feniuk W, Connor HE, Carter MC, Clitherow MC (1993) GR 127935: a potent orally active 5-HT1D receptor antagonist. Br J Pharmacol 110:9P
30. Tolliver BK, Carney JM (1994) Sensitization to stereotypy in DBA/2J but not C57BL/6J mice with repeated cocaine. Pharmacol Biochem Behav 48:169-173
31. White SR, Duffy P, Kalivas PW (1994) Methylenedioxymethamphetamine depresses glutamate-evoked neuronal firing and increases extracellular levels of dopamine and serotonin in the nucleus accumbens in vivo. Neuroscience 62:41-50
32. Wing LL, Tapson GS, Geyer MA (1990) 5-HT2 mediation of acute behavioral effects of hallucinogens in rats. Psychopharmacology 100:417-425
33. Wise R, Bozarth M (1987) A psychomotor theory of addiction. Psychol Rev 94:469-492
34. Yamamoto BK, Spanos LJ (1988) The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat. Eur J Pharmacol 148:195-203