A study of the in vitro interaction between lidocaine and premeditations using human liver microsomes

Journal of Clinical Pharmacy and Therapeutics

Volumn 30, Issue 2, 2005, Pages 185-188

  Nagashima, A ^a   Tanaka, Einosuke ^a   Inomata, S ^a   Honda, K ^a   Misawa, S ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Cytochrome P450; Drug interaction; Hepatic enzyme activity; Human liver microsomes; In vitro metabolism; Lidocaine

Indexed keywords

CIMETIDINE; CLONIDINE; DEETHYLLIDOCAINE; DIAZEPAM; LIDOCAINE; MIDAZOLAM; PANCURONIUM; PENTOBARBITAL; SUXAMETHONIUM; THIAMYLAL; VECURONIUM;

ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; DRUG METABOLISM; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER MICROSOME; PREMEDICATION; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; CIMETIDINE; CLONIDINE; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG INTERACTIONS; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; KETOCONAZOLE; LIDOCAINE; MICROSOMES, LIVER; MIDAZOLAM; NEUROMUSCULAR DEPOLARIZING AGENTS; PENTOBARBITAL; PHARMACOGENETICS; PREMEDICATION; RATS; THEOPHYLLINE; THIAMYLAL;

EID: 27744484150     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2004.00617.x     Document Type: Article

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