Risk assessment of formaldehyde for the general population in Japan

Regulatory Toxicology and Pharmacology

Volumn 43, Issue 3, 2005, Pages 232-248

  Naya, Masato ^a   Nakanishi, Junko ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Cytotoxicity; Dose response; Formaldehyde; Human cancer risk; Risk assessment

Indexed keywords

FORMALDEHYDE;

ACUTE TOXICITY; AIR POLLUTION; CANCER RISK; CARCINOGENICITY; CHRONIC TOXICITY; CYTOTOXICITY; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGICAL DATA; EXPOSURE; EYE IRRITATION; GENOTOXICITY; HUMAN; IMMUNOTOXICITY; JAPAN; LEUKEMIA; LUNG TOXICITY; NONHUMAN; NOSE IRRITATION; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL; REPRODUCTIVE TOXICITY; REVIEW; RISK ASSESSMENT; SKIN IRRITATION; TOXICOKINETICS;

ANIMALIA;

EID: 27744475622     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2005.08.002     Document Type: Article

References (183)

1. D.O. Adams, T.A. Hamilton, L.D. Lauer, and J.H. Dean The effect of formaldehyde exposure upon the mononuclear phagocyte system of mice Toxicol. Appl. Pharmacol 88 1987 165 174
2. R. Alexandersson, and G. Hedenstierna Respiratory hazards associated with exposure to formaldehyde and solvents in acid-curing paints Arch. Environ. Health 43 1988 222 227
3. R. Alexandersson, and G. Hedenstierna Pulmonary function in wood workers exposed to formaldehyde: a prospective study Arch. Environ. Health 44 1989 5 11
4. M.O. Amdur The response of guinea pigs to inhalation of formaldehyde and formic acid alone and with a sodium chloride aerosol Int. J. Air Pollut. 3 1960 201 220
5. I. Andersen, and L. Molhave Controlled human studies with formaldehyde J.E. Gibson Formaldehyde Toxicity 1983 Hemisphere Washington, DC 155 165
6. K.E. Andersen, A. Boman, A. Volund, and J.E. Wahlberg Induction of formaldehyde contact sensitivity: dose-response relationship in the guinea-pig maximization test Act. dermato-venerol (Stockholm) 65 1985 472 478
7. D.A. Andjelkovich, D.B. Jansen, M.H. Brown, R.B. Richardson, and F.J. Miller Mortality of iron foundry workers. IV. Analysis of a subcohort exposed to formaldehyde J. Occup. Med. 36 1995 1301 1309
8. D.A. Andjelkovich, C.M. Shy, M.H. Brown, D.B. Jansen, and R.B. Richardson Mortality of iron foundry workers. III. Lung cancer case-control study J. Occup. Med. 36 1994 1301 1309
9. L.M. Appelman, R.A. Woutersen, A. Zwart, H.E. Falke, and V.J. Feron One-year inhalation toxicity study of formaldehyde in male rats with a damaged or undamaged nasal mucosa J. Appl. Toxicol. 8 1988 85 90
10. C. Ballarin, F. Sarto, L. Giacomelli, G.B. Bartolucci, and E. Clonfero Micronucleated cells in nasal mucosa of formaldehyde-exposed workers Mutat. Res. 280 1992 1 7
11. E.J. Bardana Jr., and A. Montanaro Formaldehyde: an analysis of its respiratory, cutaneous, and immunologic effects Ann. Allergy 66 1991 441 452
12. C.S. Barrow, W.H. Steinhagen, and J.F. Chang Formaldehyde sensory irritation J.E. Gibson Formaldehyde Toxicity 1983 Hemisphere Washington, DC 16 25
13. M. Bauchinger, and E. Schmid Cytogenetic effects in lymphocytes of formaldehyde workers of a paper factory Mutat. Res. 158 1985 195 199
14. Bertazzi, P.A., Pesatori, A., Guercilena, S., Consonni, D., Zocchetti, C., 1989. Cancer risk among workers producing formaldehyde-based resins: extension of follow-up. Medicina del Lavoro 80, 111-122 (in Italian) (cited in ICPS-CICAD, 2002).
15. D.K. Bhalla, V. Mahavni, T. Nguyen, and T. McClurem Effects of acute exposure to formaldehyde on surface morphology of nasal epithelia in rats J. Toxicol. Environ. Health 33 1991 171 188
16. H.S. Bhatt, S.B. Lober, and B. Combes Effect of glutathione depletion on aminopyrine and formaldehyde metabolism Biochem. Pharmacol. 37 1988 1581 1589
17. 2O) in mice Toxicologist 4 1984 29
18. 2 Am. Ind. Hyg. Assoc. J. 39 1978 129 138
19. A. Blair, and P.A. Stewart Comments on the Sterling and Weinkam analysis of data from the National Cancer Institute formaldehyde study Am. J. Ind. Med. 25 1994 603 606
20. A. Blair, P.A. Stewart, and R.N. Hoover Mortality from lung cancer among workers employed in formaldehyde industries Am. J. Indust. Med. 17 1990 683 699
21. A. Blair, R. Saracci, P.A. Stewart, R.B. Hayes, and C. Shy Epidemiologic evidence on the relationship between formaldehyde exposure and cancer Scand. J. Work Environ. Health 16 1990 381 393
22. A. Blair, PA. Stewart, R.N. Hoover, J.F. Fraumeni, J. Walrath, M. O'Berg, and W. Gaffey Cancers of the nasopharynx and oropharynx and formaldehyde exposure J. Nat. Cancer Inst. 78 1987 191 192
23. A. Blair, A. Linos, P.A. Stewart, L.F. Burmeister, R. Gibson, G. Everett, L. Schuman, and K.P. Cantor Evaluation of risks for non-Hodgkin's lymphoma by occupation and industry exposures from a case-control study Am. J. Ind. Med. 23 1993 301 312
24. A. Blair, P. Stewart, M. O'Berg, W. Gaffey, J. Walrath, J. Ward, R. Bales, S. Kaplan, and D. Cubit Mortality among industrial workers exposed to formaldehyde J. Natl. Cancer Inst. 76 1986 1071 1084
25. P. Boffetta, S.D. Stellman, and L. Garfinkel A case-control study of multiple myeloma nested in the American Cancer Society prospective study Int. J. Cancer 43 1989 554 559
26. G.G. Bond, G.H. Flores, R.J. Shellenberger, J.B. Cartmill, W.A. Fishbeck, and R.R. Cook Nested case-control study of lung cancer among chemical workers Am. J. Epidemiol. 124 1986 53 66
27. B.G. Bracamonte, F.J. Ortiz de Frutos, and L.I. Diez Occupational allergic contact dermatitis due to formaldehyde and textile finish resins Contact Dermatitis 33 1995 139 140
28. R.C. Brownson, M.C.R. Alavanja, and J.C. Chang Occupational risk factors for lung cancer among nonsmoking women: a case-control study in Missouri (United States) Cancer Causes Control 4 1993 449 454
29. P.W. Callas, H. Pastides, and D.W. Hosmer Lung cancer mortality among workers in formaldehyde industries J. Occup. Environ. Med. 38 1996 747 748
30. CANADA-EC/HC; Environment Canada, Health Canada, 2001. Canadian Environmental Protection Act. Priority Substances List assessment report-formaldehyde. Minister of Public Works and Government Services. Ottawa, Ont.
31. 14C]formaldehyde in Fischer-344 rats: effects of glutathione depletion Toxicol. Appl. Pharmacol. 89 1987 105 121
32. M. Casanova, H.d'A. Heck, J.I. Everitt, W.W. Harrington Jr., and J.A. Popp Formaldehyde concentrations in the blood of rhesus monkeys after inhalation exposure Food Chem. Toxicol. 26 1988 715 716
33. M. Casanova, K.T. Morgan, E.A. Gross, O.R. Moss, and H.d'A. Heck DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde Fundam. Appl. Toxicol. 23 1994 525 536
34. +-dependent dehydrogenases in rat nasal mucosal homogenates Biochem. Pharmacol. 33 1984 1137 1142
35. 3H]formaldehyde Toxicol. Appl. Pharmacol. 76 1984 26 44
36. F.R. Cassee, J.P. Grotenm, and V.J. Feronm Changes in the nasal epithelium of rats exposed by inhalation to mixtures of formaldehyde, acetaldehyde, and acrolein Fundam. Appl. Toxicol. 29 1996 208 218
37. CIIT; Chemical Industry Institute of Toxicology, 1999. Formaldehyde: hazard characterization and dose-response assessment for carcinogenicity by the route of inhalation, Rev. ed. Research Triangle Park, NC.
38. D. Coggan, E.C. Harris, J. Poole, and K.T. Palmer Extended follow-up a Cohort of British chemical workers exposed to formaldehyde J. Natl. Cancer Inst. 95 2003 1608 1615
39. P. Cole, and C. Axten Formaldehyde and leukemia: an improbable causal relationship Regul. Toxicol. Pharmacol. 40 2004 107 112
40. J.J. Collins, and G.A. Linker A review and meta-analysis of formaldehyde exposure and leukemia Regul. Toxicol. Pharmacol. 40 2004 81 91
41. J.J. Collins, J.F. Acquavella, and N.A. Esmen An updated meta-analysis of formaldehyde exposure and upper respiratory cancers J. Occup. Environ. Med. 39 1997 639 651
42. J.J. Collins, J.C. Caporossi, and H.M.D. Utidjian Formaldehyde exposure and nasopharyngeal cancer: re-examination of the National Cancer Institute study and an update of one plant J. National Cancer Instit. 80 1988 376 377
43. R.B. Conolly, J.S. Kimbell, D.B. Janszen, and F.J. Miller Dose response for formaldehyde-induced cytotoxicity in the human respiratory tract Regul. Toxicol. Pharmacol. 35 2002 32 43
44. R.B. Conolly, J.S. Kimbell, D. Janszen, P.M. Schlosser, D. Kalisak, J. Preston, and F.J. Miller Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat Toxicol. Sci. 75 2003 432 447
45. R.B. Conolly, J.S. Kimbell, D. Janszen, P.M. Schlosser, D. Kalisak, J. Preston, and F.J. Miller Human respiratory tract cancer risk of inhaled formaldehyde: Dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset Toxicol. Sci. 82 2004 279 296
46. W.E. Dalbey Formaldehyde and tumours in hamster respiratory tract Toxicology 24 1982 9 14
47. C.E. Dallas, M.J. Scott, J.B. Ward Jr., and J.C. Theiss Cytogenetic analysis of pulmonary lavage and bone marrow cells of rats after repeated formaldehyde inhalation J. Appl. Toxicol. 12 1992 199 203
48. J.H. Day, R.E.M. Lees, R.H. Clark, and P.L. Pattee Respiratory response to formaldehyde and off-gas of urea formaldehyde foam insulation Canad. Med. Assoc. J. 131 1984 1061 1065
49. J.H. Dean, L.D. Lauer, R.B. House, M.J. Murray, W.S. Stillman, R.D. Irons, W.H. Steinhagen, M.C. Phelps, and D.O. Adams Studies of immune function and host resistance in B6C3F1 mice exposed to formaldehyde Toxicol. Appl. Pharmacol. 72 1984 519 529
50. L. Dobias, L. Janca, I. Lochman, and A. Lochmanova Genotoxic action of formaldehyde in exposed children Mutat. Res. 216 1989 310
51. Dobias, L., Hanzl, J., Rossner, P., Janca, L., Ruliskova, H., Andelova, S., Klementova, H., 1988. Evaluation of the clastogenic effect of formaldehyde in children in preschool and school facilities. Ceskoslovenska Hygiena 33, 596-604 (in Czechoslovakian) (cited in ICPS-CICAD, 2002).
52. H. Ebner, and D. Kraft Formaldehyde-induced anaphylaxis after dental treatment? Contact Dermatitis 24 1991 307 309
53. C. Edling, B. Jarvholm, L. Andersson, and O. Axelson Mortality and cancer incidence among workers in an abrasive manufacturing industry Br. J. Ind. Med. 44 1987 57 59
54. F. El Sayed, D. Seite-Bellezza, B. Sans, P. Bayle-Lebey, M.C. Marguery, and J. Bazex Contact urticaria from formaldehyde in a root-canal dental paste Contact Dermatitis 33 1995 353
55. I. Fleig, N. Petri, W.G. Stocker, and A.M. Theiss Cytogenetic analysis of blood lymphocytes of workers exposed to formaldehyde in formaldehyde manufacturing and processing J. Occup. Med. 24 1982 1009 1012
56. M.-A. Flyvholm, and T. Menne Allergic contact dermatitis from formaldehyde Contact Dermatitis 27 1992 27 36
57. N. Fontignie-Houbrechts Genetic effects of formaldehyde in the mouse Mutat. Res. 88 1981 109 114
58. J.F. Fowler, S.M. Skinner, and D.V. Belsito Allergic contact dermatitis from formaldehyde resins in permanent press clothing: an underdiagnosed cause of generalized dermatitis J. Am. Acad. Dermatol. 27 1992 962 968
59. M.J. Gardner, B. Pannett, P.D. Winter, and A.M. Cruddas A cohort study of workers exposed to formaldehyde in the British chemical industry: an update Br. J. Ind. Med. 50 1993 827 834
60. M. Gerin, J. Siemiatycki, L. Nadon, R. Dewar, and D. Krewski Cancer risks due to occupational exposure to formaldehyde: results of a multi-site case-control study in Montreal Int. J. Cancer 44 1989 53 58
61. E. Gocke, M.-T. King, K. Eckhardt, and D. Wild Mutagenicity of cosmetics ingredients by the European Communities Mutat. Res. 90 1981 91 109
62. D.J. Green, L.R. Sauder, T.J. Kulle, and R. Bascom Acute response to 3.0 ppm formaldehyde in exercising healthy nonsmokers and asthmatics Am. Rev. Respir. Disease 135 1987 1261 1266
63. D.J. Green, R. Bascom, E.M. Healey, J.R. Hebel, L.R. Sauder, and T.J. Kulle Acute pulmonary response in healthy, nonsmoking adults to inhalation of formaldehyde and carbon J. Toxicol. Environ. Health 28 1989 261 275
64. J. Hansen, and J.H. Olsen Formaldehyde and cancer morbidity among male employees in Denmark Cancer Causes Control 6 1995 354 360
65. H. Harving, J. Korsgaard, O.F. Pedersen, L. Molhave, and R. Dahl Pulmonary function and bronchial reactivity in asthmatics during low-level formaldehyde exposure Lung 168 1990 15 21
66. M. Hauptman, J.H. Lubin, P.A. Stewart, and R.B. Hayes Mortality from lymphohematopoietic malignancies among workers in formaldehyde industries J. Natl. Cancer Inst. 95 2003 1615 1623
67. M. Hauptman, J.H. Lubin, P.A. Stewart, R.B. Hayes, and A. Blair Mortality from solid cancers among workers in formaldehyde industries Am. J. Epidemiol. 159 2004 1117 1130
68. R.B. Hayes, A. Blair, P.A. Stewart, R.F. Herrick, and H. Mahar Mortality of U.S. embalmers and funeral directors Am. J. Ind. Med. 18 1990 641 652
69. H.d'A. Heck, and M. Casanova The implausibility of leukemia induction be formaldehyde: a critical review of the biological evidence on distant-site toxicity Regul. Toxicol. Pharmacol. 40 2004 92 106
70. H.d'A. Heck, T.Y. Chin, and M.C. Schmitz Distribution of [14C]formaldehyde in rats after inhalation exposure J.E. Gibson Formaldehyde toxicity 1983 Hemisphere Washington, DC 26 37
71. 2O under controlled conditions Am. Indust. Hygiene Assoc. J. 46 1985 1 3
72. E.F. Heineman, J.H. Olsen, L.M. Pottern, M. Gomez, E. Raffn, and A. Blair Occupational risk factors for multiple myeloma among Danish men Cancer Causes Control 3 1992 555 568
73. E.A. Holly, D.A. Aston, D.K. Ahn, and A.H. Smith Intraocular melanoma linked to occupations and chemical exposures Epidemiology 7 1996 55 61
74. M. Holmstrom, and B. Wilhelmsson Respiratory symptoms and pathophysiological effects of occupational exposure to formaldehyde and wood dust Scand. J. Work Environ. Health 14 1988 306 311
75. M. Holmstrom, B. Rynnel-Dagoo, and B. Wilhelmsson Antibody production in rats after long-term exposure to formaldehyde Toxicol. Appl. Pharmacol. 100 1989 328 333
76. M. Holmstrom, B. Wilhelmsson, H. Hellquist, and G. Rosen Histological changes in the nasal mucosa in persons occupationally exposed to formaldehyde alone and in combination with wood dust Acta Otolaryngol 107 1989 120 129
77. D.L. Holness, and J.R. Nethercott Health status of funeral service workers exposed to formaldehyde Arch. Environ. Health 44 1989 222 228
78. 3H mice J. Natl. Cancer Inst. 30 1963 31 43
79. E.P. Horvath Jr., H. Anderson Jr., W.E. Pierce, L. Hanrahan, and J.D. Wendlick Effects of formaldehyde on the mucous membranes and lungs. A study of an industrial population J. Am. Med. Assoc. 259 1988 701 707
80. IARC; Internatioal Agency of Research on Cancer, Press Release No. 153, 2004a. Available from: http://www.iarc.fr/pageroot/PRELEASES/pr153a.html.
81. IARC; Internatioal Agency of Research on Cancer, Formaldehyde (Group 1), 2004b. Available from: http://www-cie.iarc.fr/htdocs/monographs/vol88/formal. html.
82. ICPS-CICAD; International Programme on Chemical Safety, Concise International Chemical Assessment Document, Formaldehyde, 2002. Available from: http://www.inchem.org/documents/cicads/cicads/cicad40.htm.
83. IPCS-EHC; International Programme on Chemical Safety, Environmental Health Criteria 89, Formaldehyde, 1989. Available from: http://www.inchem.org/ documents/ehc/ehc/ehc89.htm.
84. F.R. Johannsen, G.J. Levinskas, and A.S. Tegeris Effects of formaldehyde in the rat and dog following oral exposure Toxicol. Lett. 30 1986 1 6
85. 14C]formaldehyde Toxicol. Appl. Pharmacol. 45 1978 565 575
86. E. Kamata, M. Nakadate, O. Uchida, Y. Ogawa, S. Suzuki, T. Kaneko, M. Saito, and Y. Kurokawa Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fischer-344 rats J. Toxicol. Sci. 22 1997 239 254
87. L.E. Kane, and Y. Alarie Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice Am. Ind. Hyg. Assoc. J. 28 1977 509 522
88. L.K. Keefer, A.J. Streeter, L.Y. Leung, W.C. Perry, H.S.-W Hu, and T.A. Baillie Pharmacokinetic and deuterium isotope effect studies on the metabolism of formaldehyde and formate to carbon dioxide in rats in vivo Drug Metabol. Dispos. 15 1987 300 304
89. W.D. Kerns, K.L. Pavkov, D.J. Donofrio, E.J. Gralla, and J.A. Swenberg Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure Cancer Res. 43 1983 4382 4392
90. K.H. Kilburn, R. Warshaw, C.T. Boylen, S.-J.S. Johnson, B. Seidman, R. Sinclair, and T. Takaro Jr. Pulmonary and neurobehavioral effects of formaldehyde exposure Arch. Environ. Health 40 1985 254 260
91. J.S. Kimbell, R.P. Subramaniam, E.A. Gross, P.M. Sclosser, and K.T. Morgan Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rats, monkey, and huma nasal passages Toxicol. Sci. 64 2001 100 110
92. Kitaeva, L.V., Kitaeva, E.M., Pimenova, M.N. 1990. Cytopathic and cytogenetic effects of chronic inhalation of formaldehyde on the female rat's germ and marrow cells. Tsitologiya 32, 1212-1216 (in Russian).
93. Kitaeva, L.V., Mikheeva, E.A., Shelomova, L.F., Shvartsman, P. Ya., 1996. Genotoxic effect of formaldehyde in somatic human cells in vivo. Genetika 32, 1287-1290 (in Russian).
94. A.D. Kligerman, M.C. Phelps, and G.L. Erexson Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation Toxicol. Lett. 21 1984 241 246
95. R. Kochhar, V. Nanda, B. Nagi, and S.K. Mehta Formaldehyde-induced corrosive gastric cicatrization: case report Human Toxicol. 5 1986 381 382
96. T.J. Kulle Acute odor and irritation response in healthy nonsmokers with formaldehyde exposure Inhal. Toxicol. 5 1993 323 332
97. Langecker, H., 1954. Distribution of hexamethylenetetramine in the phases of the blood fluid aqueous humour and pericardial fluid of the dog. Naunyn-Schmiedebergs Arch. Exp. Pathol. Pharmakol. 221, 166-170 (in German) (cited in IPCS-CICAD, 2002).
98. Lewis Sr., R.J., Tatken, R.L. 1980. Registry of Toxic Effects of Chemical Substances, vol. 1. National Institute for Occupational Safety and Health, Cincinnati, OH, p. 695 (cited in IPCS-EHC, 1989).
99. D. Luce, M. Gerin, A. Leclerc, J.-F. Morcet, J. Brugere, and M. Goldberg Sinonasal cancer and occupational exposure to formaldehyde and other substances Int. J. Cancer 53 1993 224 231
100. T. Malaka, and A.M. Kodama Respiratory health of plywood workers occupationally exposed to formaldehyde Arch. Environ. Health 45 1990 288 294
101. W.J. Martin A teratology study of inhaled formaldehyde in the rat Reprod. Toxicol. 4 1990 237 239
102. G.M. Marsh, and A.O. Youk Reevaluation of mortality risk from leukemia in the formaldehyde cohort study of the National Cancer Institute Regul. Toxicol. Pharmacol. 40 2004 113 124
103. G.M. Marsh, R.A. Stone, N.A. Esmen, V.L. Henderson, and K. Lee Mortality among chemical workers in a factory where formaldehyde was used Occup. Environ. Med. 53 1996 613 627
104. Matanoski, G.M., 1989. Risks of pathologists exposed to formaldehyde. Cincinnati, OH, National Institute for Occupational Safety and Health, 45 pp. (PB91-173682) (cited in IPCS-CICAD, 2002).
105. F. Maurice, J.-P. Rivory, P.H. Larsson, S.G.O. Johansson, and J. Bousquet Anaphylactic shock caused by formaldehyde in a patient undergoing long-term hemodialysis J. Allergy Clin. Immunol. 77 1986 594 597
106. F. Merletti, P. Boffetta, G. Ferro, P. Pisani, and B. Terracini Occupation and cancer of the oral cavity or oropharynx in Turin, Italy Scand. J. Work Environ. Health 17 1991 248 254
107. METI-Japan; Ministry of Economy, Trade and Industry, Japan, 2003. The survey of manufacture and import of chemical substances in FY 2001 (in Japanese). Available from: http://www.meti.go.jp/policy/chemical_management/ kasinhou/nekouhyouyouhyou_res.xls.
108. L. Migliore, L. Ventura, R. Barale, N. Loprieno, S. Castellino, and R. Pulci Micronuclei and nuclear anomalies induced in the gastro-intestinal epithelium of rats treated with formaldehyde Mutagenesis 4 1989 327 334
109. Ministry of Environment, Japan, 2004. Monitoring report of air pollutant in FY 2004 (in Japanese). Available from: http://www.env.go.jp/air/osen/ monitoring/mon_h15/index.html.
110. T.M. Monticello, and K.T. Morgan Cell proliferation and formaldehyde-induced respiratory carcinogenesis Risk Anal. 14 1994 313 319
111. T.M. Monticello, F.J. Miller, and K.T. Morgan Regional increases in rat nasal epithelial cell proliferation following acute and subchronic inhalation of formaldehyde Toxicol. Appl. Pharmacol. 111 1991 409 421
112. T.M. Monticello, K.T. Morgan, J.I. Everitt, and J.A. Popp Effects of formaldehyde gas on the respiratory tract of rhesus monkeys. Pathology and cell proliferation Am. J. Pathol. 134 1989 515 527
113. T.M. Monticello, J.A. Swenberg, E.A. Gross, J.R. Leininger, J.S. Kimbell, S. Seilkop, T.B. Starr, J.E. Gibson, and K.T. Morgan Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells Cancer Res. 56 1996 1012 1022
114. K.T. Morgan, E.A. Gross, and D.L. Patterson Distribution, progression, and recovery of acute formaldehyde-induced inhibition of nasal mucociliary function in F-344 rats Toxicol. Appl. Pharmacol. 86 1986 448 456
115. K.T. Morgan, D.L. Patterson, and E.A. Gross Responses of the nasal mucociliary apparatus of F-344 rats to formaldehyde gas Toxicol. Appl. Pharmacol. 82 1986 1 13
116. K.T. Morgan, X.-Z. Jiang, T.B. Starr, and W.D. Kerns More precise localization of nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gas Toxicol. Appl. Pharmacol. 82 1986 264 271
117. Nagorny, P.A., Sudakova, Z.H.A., Schabkenko, S.M. 1979. On the general toxic and allergic action of formaldehyde. Gig. Tr. Prof. Zabol. 7, 27-30 (in Russian) (cited in IPCS-EHC, 1989).
118. A.T. Natarajan, F. Darroudi, C.J.M. Bussman, van Kesteren-van, and A.C. Leeuwen Evaluation of the mutagenicity of formaldehyde in mammalian cytogenetic assays in vivo and vitro Mutat. Res. 122 1983 355 360
119. K. Nishi, M. Yamada, and C. Wakasugi Formaldehyde poisoning: report of an autopsy case Nippon Hoigaku Zasshi 42 1988 85 89
120. L.A. Norton Common and uncommon reactions to formaldehyde-containing nail hardeners Seminars Dermatol. 10 1991 29 33
121. NTP; National Toxicology Programme, Formaldehyde (Gas), CAS No. 50-00-0, 2005. Available from: http://ntp.niehs.nih.gov/ntp/roc/eleventh/profiles/ s089form.pdf.
122. NRC; National Research Council, Formaldehyde, 1980: an assessment of its health effects, Washington, DC (report NAS/ACT/P-881A).
123. A.J. Nunn, A.A. Craigen, J.H. Darbyshire, K.M. Venables, Newman, and A.J. Taylor Six year follow up of lung function in men occupationally exposed to formaldehyde Br. J. Ind. Med. 47 1990 747 752
124. OECD; Organisation for Economic Co-operation and Development, Screening Information Data Sets, 2002. Formaldehyde. Available from: http://www.chem.unep. ch/irptc/sids/oecdsids/FORMALDEHYDE.pdf.
125. J.H. Olsen, and S. Asnaes Formaldehyde and the risk of squamous cell carcinoma of the sinonasal cavities Br. J. Ind. Med. 43 1986 769 774
126. K. Pazdrak, P. Gorski, A. Krakowiak, and U. Ruta Changes in nasal lavage fluid due to formaldehyde inhalation Int. Arch. Occup. Environ. Health 64 1993 515 519
127. T. Partanen Formaldehyde exposure and respiratory cancer- a meta-analysis of the epidemiologic evidence Scand. J. Work Environ. Health 19 1993 8 15
128. D.L. Patterson, E.A. Gross, M.S. Bogdanffy, and K.T. Morgan Retention of formaldehyde gas by the nasal passages of F-344 rats Toxicologist 6 1986 55
129. L.E. Pinkerton, M.J. Hein, and L.T. Stayner Mortality among a cohort of garment workers ezposed to formaldehyde: an update Occup. Environ. Med. 61 2004 193 200
130. L.M. Pottern, E.F. Heineman, J.H. Olsen, E. Raffn, and A. Blair Multiple myeloma among Danish women: employment history and workplace exposures Cancer Causes Control 3 1992 427 432
131. F. Riedel, E. Hasenauer, P.J. Barth, A. Koziorowski, and C.H.L. Rieger Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig Allergy 51 1996 94 96
132. P.G.J. Reuzel, J.W.G.M. Wilmer, R.A. Woutersen, A. Zwart, P.J.A. Rombout, and V.J. Feron Interactive effects of ozone and formaldehyde on the nasal respiratory lining epithelium in rats J. Toxicol. Environ. Health 29 1990 279 292
133. I.M. Ritchie, and R.G. Lehnen Formaldehyde-related health complaints of residents living in mobile and conventional homes Am. J. Public Health 77 1987 323 328
134. J.S. Ross, J.G. Rycroft, and E. Cronin Melamine-formaldehyde contact dermatitis in orthopaedic practice Contact Dermatitis 26 1992 203 204
135. G.C. Roush, J. Walrath, L.T. Stayner, S.A. Kaplan, J.T. Flannery, and A. Blair Nasopharyngeal cancer, sinonasal cancer, and occupations related to formaldehyde: a case-control study J. Natl. Cancer Inst. 79 1987 1221 1224
136. G.M. Rusch, H.F. Bolte, and W.E. Rinehart A 26-week inhalation toxicity study with formaldehyde in the monkey, rat and hamster J.E. Gibson Formaldehyde Toxicity 1983 Hemisphere Washington, DC 98 110
137. A.M. Saillenfait, P. Bonnet, and J. de Ceaurriz The effects of maternally inhaled formaldehyde on embryonal and foetal development in rats Food Chem. Toxicol. 8 1989 545 548
138. L.R. Sauder, M.D. Chatham, D.J. Green, and T.J. Kulle Acute pulmonary response to formaldehyde exposure in healthy nonsmokers J. Occup. Med. 28 1986 420 424
139. L.R. Sauder, D.J. Green, M.D. Chatham, and T.J. Kulle Acute pulmonary response of asthmatics to 3.0 ppm formaldehyde Toxicol. Ind. Health 3 1987 569 578
140. E.N. Schachter, T.J. Witek Jr., T. Tosun, B.P. Leaderer, and G.J. Beck A study of respiratory effects from exposure to 2 ppm formaldehyde in healthy subjects Arch. Environ. Health 41 1986 229 239
141. E.N. Schachter, T.J. Witek Jr., D.J. Brody, T. Tosun, G.J. Beck, and B.P. Leaderer A study of respiratory effects from exposure to 2.0 ppm formaldehyde in occupationally exposed workers Environ. Res. 44 1987 188 205
142. A.R. Sellakumar, C.A. Snyder, J.J. Solomon, and R.E. Albert Carcinogenicity of formaldehyde and hydrogen chloride in rats Toxicol. Appl. Pharmacol. 81 1985 401 406
143. E. Skog A toxicological investigation of lower aliphatic aldehydes. I Acta Pharmacol. 6 1950 99 318 (cited in IPCS-EHC, 1989)
144. H.F. Smyth Jr., J. Seaton, and L. Fishcer The single dose toxicity of some glycols and derivatives J. Ind. Hyg. Toxicol. 23 1941 259 268 (cited in IPCS-EHC, 1989)
145. M. Soffritti, C. Maltoni, F. Maffei, and R. Biagi Formaldehyde: an experimental multipotential carcinogen Toxicol. Indl. Health 5 1989 699 730
146. L.T. Stayner, L. Elliott, L. Blade, R. Keenlyside, and W. Halperin A retrospective cohort mortality study of workers exposed to formaldehyde in the garment industry Am. J. Ind. Med. 13 1988 667 681
147. S.C. Stenton, and D.J. Hendrick Formaldehyde Immunol. Allergy Clin. North Am. 14 1994 635 657
148. N.E. Stroup, A. Blair, and G.E. Erikson Brain cancer and other causes of death in anatomists J. Natl. Cancer Inst. 77 1986 1217 1224
149. A. Suruda, P. Schulte, M. Boeniger, R.B. Hayes, G.K. Livingston, K. Steenland, P. Stewart, R. Herrick, D. Douthit, and M.A. Fingerhut Cytogenetic effects of formaldehyde exposure in students of mortuary science Cancer Epidemiol. Biomarkers Prevent. 2 1993 453 460
150. I.I. Suskov, and L.A. Sazonova Cytogenetic effects of epoxy, phenolform aldehyde and polyvinylchloride resins in man Mutat. Res. 104 1982 137 140
151. J.A. Swenberg, E.A. Gross, J. Martin, and J.A. Popp Mechanisms of formaldehyde toxicity J.E. Gibson Formaldehyde Toxicity 1983 Hemisphere Washington, DC 132 147
152. J.A. Swenberg, E.A. Gross, J. Martin, and H.A. Randall Localization and quantitation of cell proliferation following exposure to nasal irritants C.S. Barrow Toxicology of the Nasal Passages 1986 Hemisphere Washington, DC 291 300
153. M. Tarkowski, and P. Gorski Increased IgE antiovalbumin level in mice exposed to formaldehyde Int. Arch. Allergy Immunol. 106 1995 422 424
154. E.J. Thomson, S. Shackleton, and J.M. Harrington Chromosome aberrations and sister-chromatid exchange frequencies in pathology staff occupationally exposed to formaldehyde Mutat. Res. 141 1984 89 93
155. H.P. Til, R.A. Woutersen, and V.J. Feron Evaluation of the oral toxicity of acetaldehyde and formaldehyde in a 4-week drinking water study in rats Food Chem. Toxicol. 26 1988 447 452
156. H.P. Til, R.A. Woutersen, V.J. Feron, V.H.M. Hollanders, and H.E. Falke Two-year drinking-water study of formaldehyde in rats Food Chem. Toxicol. 27 1989 77 87
157. N. Titenko-Holland, A.J. Levine, M.T. Smith, P.J.E. Quintana, M. Boeniger, R. Hayes, A. Suruda, and P. Schulte Quantification of epithelial cell micronuclei by fluorescence in situ hybridization (FISH) in mortuary science students exposed to formaldehyde Mutat. Res. 371 1996 237 248
158. M. Tobe, K. Naito, and Y. Kurokawa Chronic toxicity study on formaldehyde administered orally to rats Toxicology 56 1989 79 86
159. Tobe, M., Kaneko, T., Uchida, Y., Kamata, E., Ogawa, Y., Ikeda, Y., Saito, M., 1985. Studies on the inhalation toxicity of formaldehyde. Tokyo, National Sanitary and Medical Laboratory Service, Toxicity, 43 pp. (TR-85-0236).
160. K. Tsuchiya, Y. Hayashi, M. Onodera, and T. Hasegawa Toxicity of formaldehyde in experimental animals-concentrations of the chemical in the elution from dishes of formaldehyde resin in some vegetables Keio J. Med. 24 1975 19 37
161. R.K. Upreti, M.Y.H. Farooqui, A.E. Ahmed, and G.A.S. Ansari Toxicokinetics and molecular interaction of [14C]-formaldehyde in rats Arch. Environ. Contamin. Toxicol. 16 1987 263 273
162. US-DHHD-ATSDR; Agency for Toxic Substances and Disease Registry, U.S. Dep. Health Human Services, Toxicological Profile for Formaldehyde, 1999. Available from: http://www.atsdr.cdc.gov/toxprofiles/tp111.html.
163. US-EPA, 2003. Benchmark Dose Software (BMDS Version 1.3.2). Available from: http://cfpub1.epa.gov/ncea/cfm/bnchmrk/dwnldu.cfm?ActType=default.
164. US-EPA-IRIS; Integrated Risk Information System, U.S. Environmental Protection Agency, Formaldehyde (CASRN 50-00-0). Available from: http://www.epa.gov/IRIS/subst/0419.htm.
165. M. Vargova, J. Wagnerova, A. Liskova, J. Jakubovsky, M. Gajdova, E. Stolcova, J. Kubova, J. Tulinska, and R. Stenclova Subacute immunotoxicity study of formaldehyde in male rats Drug Chem. Toxicol. 16 1993 255 275
166. N. Vasudeva, and C. Anand Cytogenetic evaluation of medical students exposed to formaldehyde vapor in the gross anatomy dissection laboratory J. Am. Coll. Health 44 1996 177 179
167. T.L. Vaughan, C. Strader, S. Davis, and J.R. Daling Formaldehyde and cancers of the pharynx, sinus and nasal cavity: I. Occupational exposures Int. J. Cancer 38 1986 677 683
168. T.L. Vaughan, C. Strader, S. Davis, and J.R. Daling Formaldehyde and cancers of the pharynx, sinus and nasal cavity: II. Residential exposures Int. J. Cancer 38 1986 685 688
169. C. Vincenzi, L. Guerra, A.M. Peluso, and V. Zucchelli Allergic contact dermatitis due to phenol-formaldehyde resins in a knee-guard Contact Dermatitis 27 1992 54
170. F. Wantke, W. Hemmer, T. Haglmuller, M. Gotz, and R. Jarisch Anaphylaxis after dental treatment with a formaldehyde-containing tooth filling material Allergy 50 1995 274 276
171. S. West, A. Hildesheim, and M. Dosemeci Non-viral risk factors for nasopharyngeal carcinoma in the Philippines: results from a case-control study Int. J. Cancer 55 1993 722 727
172. WHO: World Health Organization, Guidelines for drinking-water quality, Vol. 2, 1996. Health criteria and other supporting information. Geneva, World Health Organization, International Programme on Chemical Safety, 973 pp.
173. WHO-ROE: World Health Organization, Regional Office for Europe, Air quality guidelines for Europe, 2nd Ed., Regional Office for Europe, Copenhagen, 2000. WHO Regional Publications, European Series, No. 91. 2001. Available from: http://www.who.dk/document/e71922.pdf.
174. J.W.G.M. Wilmer, R.A. Woutersen, L.M. Appelman, W.R. Leeman, and V.J. Feron Subacute (4-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposures J. Appl. Toxicol. 7 1987 15 16
175. J.W.G.M. Wilmer, R.A Woutersen, L.M. Appelman, W.R. Leeman, and V.J. Feron Subchronic (13-week) inhalation toxicity study of formaldehyde in male rats: 8-hour intermittent versus 8-hour continuous exposures Toxicol. Lett. 47 1989 287 293
176. T.J. Witek Jr., E.N. Schachter, T. Tosun, G.J. Beck, and B.P. Leaderer An evaluation of respiratory effects following exposure to 2.0 ppm formaldehyde in asthmatics: lung function, symptoms, and airway reactivity Arch. Environ. Health 42 1987 230 237
177. P. Wortley, T.L. Vaughan, S. Davis, M.S. Morgan, and D.B. Thomas A case-control study of occupational risk factors for laryngeal cancer Br. J. Ind. Med. 49 1992 837 844
178. R.A. Woutersen, L.M. Appelman, J.W.G.M. Wilmer, H.E. Falke, and V.J. Feron Subchronic (13-week) inhalation toxicity study of formaldehyde in rats J. Appl. Toxicol. 7 1987 43 49
179. R.A. Woutersen, A. van Garderen-Hoetmer, J.P. Bruijntjes, A. Zwart, and V.J. Feron Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehyde J. Appl. Toxicol. 9 1989 39 46
180. J.W. Yager, K.L. Cohn, R.C. Spear, J.M. Fisher, and L. Morse Sister-chromatid exchanges in lymphocytes of anatomy students exposed to formaldehyde-embalming solution Mutat. Res. 174 1986 135 139
181. C.-J. Ying, W.-S. Yan, M.-Y. Zhao, X.-L. Ye, H. Xie, S.-Y. Yin, and X.-S. Zhu Micronuclei in nasal mucosa, oral mucosa and lymphocytes in students exposed to formaldehyde vapor in anatomy class Biomed. Environ. Sci. 10 1997 451 455
182. A. Zhitkovich, A. Lukanova, T. Popov, E. Taioli, H. Cohen, M. Costa, and P. Toniolo DNA-protein crosslinks in peripheral lymphocytes of individuals exposed to hexavalent chromium compounds Biomarkers 1 1996 86 93
183. A. Zwart, R.A. Woutersen, J.W.G.M. Wilmer, B.J. Spit, and V.J. Feron Cytotoxic and adaptive effects in rat nasal epithelium after 3-day and 13-week exposure to low concentrations of formaldehyde vapour Toxicology 51 1988 87 99