The red wine polyphenol, resveratrol, exerts acute direct actions on guinea-pig ventricular myocytes

European Journal of Pharmacology

Volumn 519, Issue 1-2, 2005, Pages 1-8

  Liew, Reginald ^a   Stagg, Mark A ^b   MacLeod, Kenneth T ^a   Collins, Peter ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b HAREFIELD HOSPITAL   (United Kingdom)

Author keywords

Action potential; Ca2+ current; Cardiac myocyte; Cell contraction; Red wine

Indexed keywords

ANTIESTROGEN; CALCIUM; FULVESTRANT; POLYPHENOL; RESVERATROL; DRUG DERIVATIVE; ESTRADIOL; FLAVONOID; PHENOL DERIVATIVE; POLYPHENOLS; STILBENE DERIVATIVE; VASODILATOR AGENT;

ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DRUG MECHANISM; GUINEA PIG; HEART ELECTROPHYSIOLOGY; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART PROTECTION; MALE; MUSCLE FIBER CONTRACTION; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; RED WINE; ANIMAL; CELL MEMBRANE POTENTIAL; CELL SIZE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; HEART VENTRICLE; INTRACELLULAR SPACE; METABOLISM; PHYSIOLOGY; WINE;

ANIMALS; CALCIUM; CELL SIZE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN ANTAGONISTS; FLAVONOIDS; GUINEA PIGS; HEART VENTRICLES; INTRACELLULAR SPACE; MALE; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; PHENOLS; STILBENES; VASODILATOR AGENTS; WINE;

EID: 27744456142     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.06.017     Document Type: Article

References (34)

1. D.M. Bers Cardiac excitation-contraction coupling Nature 415 2002 198 205
2. A.A. Bertelli, L. Giovannini, R. Stradi, A. Bertelli, and J.P. Tillement Plasma, urine and tissue levels of trans- and cis-resveratrol (3,4′,5-trihydroxystilbene) after short-term or prolonged administration of red wine to rats Int. J. Tissue React. 18 1996 67 71
3. A.A. Bertelli, L. Giovannini, R. Stradi, S. Urien, J.P. Tillement, and A. Bertelli Evaluation of kinetic parameters of natural phytoalexin in resveratrol orally administered in wine to rats Drugs Exp. Clin. Res. 24 1998 51 55
4. K.P.L. Bhat, J.W. Kosmeder, and J.M. Pezzuto Biological effects of resveratrol Antioxid. Redox Signal 3 2001 1041 1064
5. J.L. Bowers, V.V. Tyulmenkov, S.C. Jernigan, and C.M. Klinge Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta Endocrinology 141 2000 3657 3667
6. Z. Cao, and Y. Li Potent induction of cellular antioxidants and phase 2 enzymes by resveratrol in cardiomyocytes: protection against oxidative and electrophilic injury Eur. J. Pharmacol. 489 2004 39 48
7. J.P. Chamunorwa, and S.C. O'Neill Regional differences in rest decay and recoveries of contraction and the calcium transient in rabbit ventricular muscle Pflugers Arch. 430 1995 195 204
8. C.K. Chen, and C.R. Pace-Asciak Vasorelaxing activity of resveratrol and quercetin in isolated rat aorta Gen. Pharmacol. 27 1996 363 366
9. R.S. Danziger, M. Sakai, M.C. Capogrossi, H.A. Spurgeon, R.G. Hansford, and E.G. Lakatta Ethanol acutely and reversibly suppresses excitation- contraction coupling in cardiac myocytes Circ. Res. 68 1991 1660 1668
10. L.M. Delbridge, P.J. Connell, P.J. Harris, and T.O. Morgan Ethanol effects on cardiomyocyte contractility Clin. Sci. (Lond) 98 2000 401 407
11. A.M. El Mowafy, and R.E. White Resveratrol inhibits MAPK activity and nuclear translocation in coronary artery smooth muscle: reversal of endothelin-1 stimulatory effects FEBS Lett. 451 1999 63 67
12. B.D. Gehm, J.M. McAndrews, P.Y. Chien, and J.L. Jameson Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor Proc. Natl. Acad. Sci. U. S. A. 94 1997 14138 14143
13. C. Grohe, S. Kahlert, K. Lobbert, M. Stimpel, R.H. Karas, H. Vetter, and L. Neyses Cardiac myocytes and fibroblasts contain functional estrogen receptors FEBS Lett. 416 1997 107 112
14. 2+ in guinea-pig isolated cardiac myocytes Br. J. Pharmacol. 106 1992 739 745
15. N.Q. Khan, D.M. Lees, J.A. Douthwaite, M.J. Carrier, and R. Corder Comparison of red wine extract and polyphenol constituents on endothelin-1 synthesis by cultured endothelial cells Clin. Sci.(Lond) 103 Suppl 48 2002 72S 75S
16. P. Kopp Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the "French paradox"? Eur. J. Endocrinol. 138 1998 619 620
17. + current in vascular endothelial cells Cardiovasc. Res. 45 2000 1035 1045
18. R. Liew, M.A. Stagg, K.T. MacLeod, and P. Collins Raloxifene acutely suppresses ventricular myocyte contractility through inhibition of the L-type calcium current Br. J. Pharmacol. 142 2004 89 96
19. R. Liew, K.T. MacLeod, and P. Collins Novel stimulatory actions of the phytoestrogen genistein: effects on the gain of cardiac excitation-contraction coupling FASEB J. 17 2003 1307 1309
20. 2+ in isolated mammalian ventricular myocytes J. Physiol. 444 1991 481 498
21. K. Mizutani, K. Ikeda, and Y. Yamori Resveratrol inhibits AGEs-induced proliferation and collagen synthesis activity in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats Biochem. Biophys. Res. Commun. 274 2000 61 67
22. K.J. Mukamal, K.M. Conigrave, M.A. Mittleman, C.A. Camargo Jr., M.J. Stampfer, W.C. Willett, and E.B. Rimm Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men N. Engl. J. Med. 348 2003 109 118
23. E.K. Naderali, P.J. Doyle, and G. Williams Resveratrol induces vasorelaxation of mesenteric and uterine arteries from female guinea-pigs Clin. Sci. (Lond) 98 2000 537 543
24. C.R. Pace-Asciak, S. Hahn, E.P. Diamandis, G. Soleas, and D.M. Goldberg The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease Clin. Chim. Acta 235 1995 207 219
25. T.C. Pappas, B. Gametchu, and C.S. Watson Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding FASEB J. 9 1995 404 410
26. S. Renaud, and M. de Lorgeril Wine, alcohol, platelets, and the French paradox for coronary heart disease Lancet 339 1992 1523 1526
27. E.B. Rimm, A. Klatsky, D. Grobbee, and M.J. Stampfer Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits BMJ 312 1996 731 736
28. 2+, contraction, and potential in cardiac myocytes Am. J. Physiol. 258 1990 H574 H586
29. H.A. Spurgeon, W.H. duBell, M.D. Stern, S.J. Sollott, B.D. Ziman, H.S. Silverman, M.C. Capogrossi, A. Talo, and E.G. Lakatta Cytosolic calcium and myofilaments in single rat cardiac myocytes achieve a dynamic equilibrium during twitch relaxation J. Physiol. 447 1992 83 102
30. 2+ extrusion mechanisms to relaxation in guinea-pig ventricular myocytes J. Physiol. 500 1997 557 570
31. H. Tunstall-Pedoe, K. Kuulasmaa, M. Mahonen, H. Tolonen, E. Ruokokoski, and P. Amouyel Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease Lancet 353 1999 1547 1557
32. T. Wallerath, G. Deckert, T. Ternes, H. Anderson, H. Li, K. Witte, and U. Forstermann Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase Circulation 106 2002 1652 1658
33. S.D. Wollin, and P.J.H. Jones Alcohol, red wine and cardiovascular disease J. Nutr. 131 2001 1401 1404
34. J.M. Wu, Z.R. Wang, T.C. Hsieh, J.L. Bruder, J.G. Zou, and Y.Z. Huang Mechanism of cardioprotection by resveratrol, a phenolic antioxidant present in red wine (Review) Int. J. Mol. Med. 8 2001 3 17