Role of keratinocyte growth factor in the pathogenesis of autosomal dominant polycystic kidney disease

Nephrology Dialysis Transplantation

Volumn 20, Issue 11, 2005, Pages 2368-2375

  Mei, Changlin ^a   Mao, Zhiguo ^a   Shen, Xuefei ^a   Wang, Wenjing ^a   Dai, Bing ^a   Tang, Bing ^a   Wu, Yumei ^a   Cao, Yang ^a   Zhang, Shuzhong ^a   Zhao, Haidan ^a   Sun, Tianmei ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Autosomal dominant polycystic kidney disease (ADPKD); Cell cycle; Cyclin; Keratinocyte growth factor (KGF); Proliferation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR RECEPTOR; MESSENGER RNA;

ADULT; AGED; ARTICLE; CELL CYCLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; KIDNEY CYST; KIDNEY EPITHELIUM; KIDNEY INTERSTITIUM; KIDNEY PARENCHYMA; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE CELL; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; BLOTTING, WESTERN; CELL PROLIFERATION; CYCLIN D1; EPITHELIUM; FEMALE; FIBROBLAST GROWTH FACTOR 7; FLOW CYTOMETRY; FOLLOW-UP STUDIES; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY TUBULES, PROXIMAL; MALE; MIDDLE AGED; POLYCYSTIC KIDNEY, AUTOSOMAL DOMINANT; POLYMERASE CHAIN REACTION; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RETROSPECTIVE STUDIES; RNA, MESSENGER;

EID: 27644598624     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfi040     Document Type: Article

References (17)

1. Takayama H, Larochelle WJ, Sabnis SG et al. Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor. Lab Invest 1997; 77: 131-138
2. Mei C, Zhang W, Ge S et al. The difference of gene expression profile in polycystic kidney tissue detected by cDNA microarray. J Nephrol Dial Transplant 2002; 11: 307-22 [in Chinese]
3. Nguyen HQ, Danilenko DM, Bucay N et al. Expression of keratinocyte growth factor in embryonic liver of transgenic mice causes changes in epithelial growth and differentiation resulting in polycystic kidneys and other organ malformations. Oncogene 1996; 12: 2109-2119
4. Qiao J, Uzzo R, Obara-Ishihara T et al. FGF-7 modulates ureteric bud growth and nephron number in the developing kidney. Development 1999; 126: 547-554
5. Xu C, Mei C, Zhang L. Establishment and identification of ADPKD cyst-lining epithelial cell lines. J Nephrol Transplant 2000; 9: 142-145 [in Chinese]
6. Chen Y-M, Chien C-T, Hu-Tsai M-I et al. Pentoxifulline attenuates experimental mesangial proliferative glomerulonephritis. Kidney Int 1999; 56: 932-943
7. Rubin JS, Osada H, Finch PW et al. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 1989; 86: 802-806
8. Winkles JA, Alberts GF, Chedid M et al. Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries. J Cell Physiol 1997; 173: 380-386
9. Denizot F, Lang R. Rapid colorimetric assay for cell growth and survival. J Immunol Methods 1986; 89: 271-277
10. Ornitz DM, Itoch N. Fibroblast growth factors. Genome Biol 2001; 2: 3005.1-3005.12
11. Parrott JA, Mosher R, Kim G et al. Autocrine interactions of keratinocyte growth factor, hepatocyle growth factor and kit-ligand in the regulation of normal ovarian surface epithelial cells. Endocrinology 2000; 141: 2532-2539
12. Yamasaki MH, Miyake AM, Tagashira SZ et al. Structure and expression of the rat mRNA encoding a novel member of the fibroblast growth factor family. J Biochem 1996; 271: 15918-15921
13. Kaji H, Canaff L, Goltzman D et al. Cell cycle regulation of menin expression. Cancer Res 1999; 59: 5097-5101
14. Calbo J, Parreno M, Sotillo E et al. G1 cyclin/cyclin-dependent kinase-coordinated phosphorylation of endogenous pocket proteins differentially regulates their interactions with E2F4 and E2F1 and gene expression. J Biol Chem 2002; 277: 50263-50274
15. Lents NH, Keenan SM, Bellone C et al. Stimulation of the Raf/MEK/ERK cascade is necessary and sufficient for activation and Thr-160 phosphorylation of a nuclear-targeted CDK2. J Biol Chem 2002; 277: 47469-47475
16. 1 cell cycle arrest. Cancer Res 2003; 63: 3840-3844
17. Bhunia AK, Piontek K, Boletta A et al. PKD1 induces p21waf1 and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 2002; 109: 157-168