Soybean germ oil inhibits oxidosqualene cyclase in 3T3 fibroblasts

European Journal of Lipid Science and Technology

Volumn 107, Issue 10, 2005, Pages 701-705

  Cravotto, Giancarlo ^a   Robaldo, Bruna ^a   Binello, Arianna ^a   Viola, Franca ^a   Oliaro Bosso, Simonetta ^a   Avogadro, Milvio ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b Oleificio Sabo   (Switzerland)

Author keywords

3t3 fibroblasts; Oil analysis; Oxidosqualene cyclase; Soybean germ oil

Indexed keywords

GLYCINE MAX; MURINAE;

EID: 27644581988     PISSN: 14387697     EISSN: None     Source Type: Journal    
DOI: 10.1002/ejlt.200401113     Document Type: Article

References (23)

1. Food and Drug Administration. Food labelling health claims. Soy protein and coronary heart disease. 21 CFR Part 101. FDA Docket No. 98P-0683, p 57-700. FDA Dockets Management Branch, Rockville, MD (USA) 1999.
2. R. L. Costa, M. A. Summa: Soy protein in the management of hyperlipidemia. Ann Pharmacother. 2000, 34, 931-935.
3. C. R. Sirtori, M. R. Lovati, C. Manzoni, E. Gianazza, A. Bondioli, B. Staels, J. Auwerx: Reduction of serum cholesterol by soy proteins: clinical experience and potential molecular mechanisms. Nutr Metab Card Dis. 1998, 8, 334-340.
4. J. W. Anderson, T. J. Stephenson: Soy protein decreases serum cholesterol: A meta-analysis of recent studies. J Nutr. 2002, 132, 611S-611S.
5. A. Faraj, T. Vasanthan: Soybean isoflavones: effects of processing and health benefits. Food Rev Int. 2004, 20, 51-75.
6. Y. Kawakami, W. Tsurugasaki, Y. Yoshida, Y. Igarashi, S. Nakamura, K. Osada: Regulative actions of dietary soy isoflavone on biological antioxidative system and lipid metabolism in rats. J Agr Food Chem. 2004, 52, 1764-1768.
7. P. Nestel: Isoflavones: their effects on cardiovascular risk and functions. Curr Opin Lipidol. 2003, 14, 3-8.
8. M. Ihara-Watanabe, H. Umekawa, T. Takahashi, Y. Furuichi: Comparative effects of safflower oil and perilla oil on serum and hepatic lipid levels, fatty acid compositions of serum and hepatic phospholipids, and hepatic mRNA expressions of 3-hydroxy-3-methylglutaryl CoA reductase, LDL receptor, and cholesterol 7alpha-hydroxylase in young and adult rats. Food Res Int. 2000, 33, 893-900.
9. T. A. Wilson, C. M. Meservey, R. J. Nicolosi: Soy lecithin reduces plasma lipoprotein cholesterol and early atherogenesis in hypercholesterolemic monkeys and hamsters: beyond linoleate. Atherosclerosis 1998, 140, 147-153.
10. Z. M. Xu, N. Hua, J. S. Godber: Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2′-azobis(2-methylpropionamidine) dihydrochloride. J Agr Food Chem. 2001, 49, 2077-2081.
11. R. E. Ostlund: Phytosterols and cholesterol metabolism. Curr Opin Lipidol. 2004, 15, 37-41.
12. T. Ishizaki, Y. Hara, K. Yamada, H. Sato, H. Tanimoto, O. Mori, E. Baba, I. Tashima: A comparison of plant sterols extracted from soy-bean germ oil and soy sterol on the cholesterol lowering effects in rats. Nipp Eiyo Shokuryo Gakkaishi 2005, 58, 11-16.
13. Y. Ozawa, H. Sato, A. Nakatani, O. Mori, Y. Hara, Y. Nakada, Y. Akiyama, Y. Morinaga: Chemical composition of soybean oil extracted from hypocotyl-enriched soybean raw material and its cholesterol lowering effects in rats. J Oleo Sci. 2001, 50, 217-223.
14. A. During, N. Combe, S. Mazette, B. Entressangles: Effects oil cholesterol balance and LDL cholesterol in the rat of a soft-ripened cheese containing vegetable oils. J Am Coll Nutr. 2000, 19, 458-466.
15. H. Sato, K. Ito, K. Sakai, Y. Morinaga, E. Sukegawa, H. Shimasaki, T. Kitamura, H. Itakura: Effects of soybean-germ oil on reducing serum cholesterol level. J Oleo Sci. 2001, 50, 649-656.
16. H. Sato, K. Ito, K. Sakai, Y. Morinaga, I. Tashima, E. Sukegawa, H. Shimasaki, H. Itakura: Effects of soybean-germ oil on reducing serum cholesterol levels in a double-blind controlled trial in healthy humans. J Oleo Sci. 2004, 53, 9-16.
17. www.ssog.it/italian/fattivi.htm, Norme Italiane Controllo Grassi e Derivati - N.G.D.
18. IUPAC: Standard Methods for the Analysis of Oil, Fats and Derivatives. 7th Edn. Blackwell, Oxford (UK) 1986.
19. H. J. Wang, P. A. Murphy: Isoflavone content in commercial soybean foods. J Agr Food Chem. 1994, 42, 1666-1673.
20. B. E. Chan, B. R. Knowles: A solvent system for delipidation of plasma or serum without protein precipitation. J Lipid Res. 1976, 17, 176-181.
21. N. Gerst, F. Schuber, F. Viola, L. Cattel: Inhibition of cholesterol biosynthesis in 3T3 fibroblasts by 2-aza-2,3-dihydrosqualene, a rationally designed 2,3-oxidosqualene cyclase inhibitor. Biochem Pharmacol. 1986, 35, 4243-4250.
22. F. Viola, P. Brusa, G. Balliano, M. Ceruti, O. Boutad, F. Schuber, L. Cattel: Inhibition of 2,3-oxidosqualene cyclase and sterol biosynthesis by 10- and 19-azasqualene derivatives. Biochem Pharmacol. 1995, 50, 787-796.
23. S. E. Saucier, A. A. Kandutsch, F. R. Taylor, T. A. Spencer, S. Phirwa, A. K Gayen: Identification of regulatory oxysterols, 24(S),25-epoxycholesterol and 25-hydroxycholesterol, in cultured fibroblasts. J Biol Chem. 1985, 20, 14571-14579.