Characterization of HIV-1 Gag-specific T cell responses in chronically infected Indian population

Clinical and Experimental Immunology

Volumn 142, Issue 2, 2005, Pages 388-397

  Kaushik, S ^a   Vajpayee, Madhu ^a   Wig, N ^a   Seth, P ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

CD4; CD8; Gag; HIV 1 specific; India

Indexed keywords

CYTOKINE; GAG PROTEIN; GAMMA INTERFERON; INTERLEUKIN 2; PROTEIN SUBUNIT; VIRUS PROTEIN;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CHRONIC PATIENT; CHRONICITY; CLINICAL ARTICLE; COMPARATIVE STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HAPLOTYPE; HLA SYSTEM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INDIAN; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; STAINING; T LYMPHOCYTE; VIRUS TYPING;

ADULT; AMINO ACID SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES, B-LYMPHOCYTE; FEMALE; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE COUNT; MALE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS;

EID: 27644522300     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02926.x     Document Type: Article

References (32)

1. World Health Organization. HIV/AIDS: meeting the challenge, 3rd edn. Geneva: World Health Organization 2004.
2. Lichterfeld M, Kaufmann DE, Yu XG et al. Loss of HIV-1-specific CD8+ T cell proliferation after acute HIV-1 infection and restoration by vaccine-induced HIV-1-specific CD4+ T cells. J Exp Med 2004; 200:701-12.
3. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB. Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary HIV-1 infection. J Virol 1994; 68:6103-10.
4. Schmitz JE, Kuroda MJ, Santra S et al. Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 1999; 283:857.
5. Jin X, Bauer DE, Tuttleton SE et al. Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques. J Exp Med 1999; 189:991.
6. Addo MM, Yu XG, Rathod A et al. Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load. J Virol 2003; 77:2081-92.
7. + T cell responses: relationship to viral load in untreated HIV infection. J Virol 2001; 73:11983-91.
8. Draenert R, Verrill CL, Tang Y et al. Persistent recognition of autologous-virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection. J Virol 2004; 78:630-41.
9. Kaufmann DE, Bailey PM, Sidney J et al. Comprehensive analysis of HIV-1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides. J Virol 2004; 78:4463-77.
10. McNeil AC, Shupert WL, Iyasure CA et al. High-level HIV-1 viremia suppresses viral antigen-specific CD4+ T cell proliferation. Proc Natl Acad Sci USA 2001; 98:13878-83.
11. Palmer BE, Boritz E, Blyveis N, Wilson CC. Discordance between frequency of HIV-1 -specific gamma interferon-producing CD4+ T cells and HIV-1-specific lymphoproliferation in HIV-1 infected subjects with active viral replication. J Virol 2002; 76:5925-36.
12. Rosenberg ES, Billingsley JM, Caliendo AM et al. Vigorous HIV-1-specific CD4+ T cell responses associated with control of viremia. Science 1997; 278:1447-50.
13. Shedlock DJ, Shen H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003; 300:337-9.
14. Sun JC, Bevan MJ. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 2003; 300:339-42.
15. Janssen EM, Lemmens EE, Wolfe T et al. CD4+ Tcells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 2003; 421:852-6.
16. Kaech SM, Ahmed R. CD8 T cells remember with a little help. Science 2003; 300:263-5.
17. Novitsky V, Rybak N, McLane MF et al. Identification of human immunodeficiency virus type 1 subtype C Gag-, Tat-, Rev-, and Nef-specific ELISPOT-based cytotoxic T-lymphocyte responses for AIDS vaccine design. J Virol 2001; 73:9210-28.
18. Masemola A, Mashishi T, Khoury G et al. Hierarchical targeting of Subtype C HIV-1 proteins by CD8+ T cells: correlation with viral load. J Virol 2004; 78:3233-43.
19. + T cell responses to the Gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma. J Virol 2002; 76:2298-305.
20. + t-cell determinations with CD45 gating for persons infected with human immunodeficiency virus. MMWR 2003;52:1-13.
21. Vithayasai V, Sirisanthana T, Sakonwasun C et al. Flow cytometric analysis of T lymphocyte subsets in adult Thais. Asian Pacific J Allergy Immunol 1997; 15:141-6.
22. Boaz MJ, Waters A, Murad S et al. CD4 responses to conserved HIV-1 T helper epitopes show both negative and positive associations with virus load in chronically infected subjects. Clin Exp Immunol 2003; 134:454-63.
23. Bitmansour AD, Douek DC, Maino VC, Picker LJ. Direct ex vivo analysis of human CD4+ memory T cell activation requirements at the single clonotype level. J Immunol 2002; 169:1207-18.
24. Ahmadzadeh M, Farber DL. Functional plasticity of an antigen-specific memeory CD4 T cell population. Proc Natl Acad Sci USA 2002; 99:11802-7.
25. Goulder PJ, Altfeld MA, Rosenberg ES et al. Substantial differences in specificity of HIV-specific cytotoxic T cells in acute and chronic HIV infection. J Exp Med 2001; 193:181-94.
26. Boritz E, Palmer BE, Wilson CC. Human immunodeficiency virus type (HIV-1 )-specific CD4+ T cells that proliferate in vitro detected in samples from most viremic subjects and inversely associated with plasma HIV-1 levels. J Virol 2004; 78:12638-46.
27. + T cells endowed with proliferative capacity. J Exp Med 2003; 198:1909-22.
28. + Cd4 T cell responses is associated with nonprogression in HIV-1 infection. J Immunol 2002; 169:6376-85.
29. The Newsletter on International AIDS. Vaccine research. IAVI Report December 2004-March 2005;9:1.
30. Wu CY, Kirman JR, Rotte MJ et al. Distinct lineages of Th 1 cells have differential capacities for memory cell generation in vivo. Nat Immunol 2002; 3:852-8.
31. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401:708-12.
32. Chun TW, Justement JS, Sanford C et al. Relationship between the frequency of HIV-specific CD8+ T cells and the level of CD38+CD8+ T cells in untreated HIV-infected individuals. Proc Natl Acad Sci USA 2004; 101:2464-9.