Few but severe viral infections in children with cancer: A prospective RT-PCR and PCR-based 12-month study

Pediatric Blood and Cancer

Volumn 45, Issue 7, 2005, Pages 945-951

  Christensen, Merete Stubkjaer ^a   Nielsen, Lars Peter ^b   Hasle, Henrik ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Cancer; Febrile neutropenia; Immunocompromised hosts; Infections; PCR; Pediatric; Virus

Indexed keywords

ANTIBIOTIC AGENT;

ADENOVIRUS; ARTICLE; CHILDHOOD CANCER; ENTEROVIRUS INFECTION; FEMALE; FEVER; HERPES SIMPLEX VIRUS; HUMAN; HUMAN METAPNEUMOVIRUS; IMMUNE DEFICIENCY; INFLUENZA VIRUS A; INFLUENZA VIRUS B; MAJOR CLINICAL STUDY; MALE; PARAINFLUENZA VIRUS 3; PATIENT CARE; PNEUMOCYSTIS CARINII; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RESPIRATORY TRACT INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHINOVIRUS; VARICELLA ZOSTER VIRUS; VIRUS INFECTION; VIRUS PNEUMONIA;

CHILD; DNA, VIRAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; NEOPLASMS; PNEUMOCYSTIS INFECTIONS; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRUS DISEASES;

EID: 27644504060     PISSN: 15455009     EISSN: None     Source Type: Journal    
DOI: 10.1002/pbc.20469     Document Type: Article

References (43)

1. Margrave DR, Hann IM, Richards SM, et al. Progressive reduction in treatment-related deaths in Medical Research Council childhood lymphoblastic leukaemia trials from 1980 to 1997 (UKALL VIII, X and XI). Br J Haematol 2001;112:293-299.
2. Innes HE, Smith DB, O'Reilly SM, et al. Oral antibiotics with early hospital discharge compared with in-patient intravenous antibiotics for low-risk febrile neutropenia in patients with cancer: A prospective randomised controlled single centre study. Br J Cancer 2003;89:43-49.
3. Klaassen RJ, Allen U, Doyle JJ. Randomized placebo-controlled trial of oral antibiotics in pediatric oncology patients at low-risk with fever and neutropenia. J Pediatr Hematol Oncol 2000;22:405-411.
4. Juven T, Mertsola J, Waris M, et al. Etiology of community-acquired pneumonia in 254 hospitalized children. Pediatr Infect Dis J 2000;19:293-298.
5. Glezen WP, Greenberg SB, Atmar RL, et al. Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA 2000;283:499-505.
6. Grondahl B, Puppe W, Hoppe A, et al. Rapid identification of nine microorganisms causing acute respiratory tract infections by single-tube multiplex reverse transcription-PCR: Feasibility study. J Clin Microbiol 1999;37:1-7.
7. Arola M, Ruuskanen O, Ziegler T, et al. Respiratory virus infections during anticancer treatment in children. Pediatr Infect Dis J 1995;14:690-694.
8. Mottonen M, Uhari M, Lanning M, et al. Prospective controlled survey of viral infections in children with acute lymphoblastic leukemia during chemotherapy. Cancer 1995;75:1712-1717.
9. Maltezou HC, Kafetzis DA, Abisaid D, et al. Viral infections in children undergoing hematopoietic stem cell transplant. Pediatr Infect Dis J 2000;19:307-312.
10. Cole PD, Suh JS, Onel K, et al. Benign outcome of RSV infection in children with cancer. Med Pediatr Oncol 2001;37:24-29.
11. Hall CB, Powell KR, MacDonald NE, et al. Respiratory syncytial viral infection in children with compromised immune function. N Engl J Med 1986;315:77-81.
12. Shaw PJ. Suspected infection in children with cancer. J Antimicrob Chemother 2002;49Suppl 1:63-67.
13. Uys R, Cotton MF, Wessels G, et al. Viral isolates during febrile neutropaenia in children with cancer. J Trop Pediatr 2000;46:21-24.
14. Gonzalez Y, Martino R, Badell I, et al. Pulmonary enterovirus infections in stem cell transplant recipients. Bone Marrow Transplant 1999;23:511-513.
15. Jartti T, van den HB, Garofalo RP, et al. Metapneumovirus and acute wheezing in children. Lancet 2002;360:1393-1394.
16. Boivin G, De Serres G, Cote S, et al. Human metapneumovirus infections in hospitalized children. Emerg Infect Dis 2003;9:634-640.
17. Pelletier G, Dery P, Abed Y, et al. Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child. Emerg Infect Dis 2002;8:976-978.
18. Cane PA, van den Hoogen BG, Chakrabarti S, et al. Human metapneumovirus in a haematopoietic stem cell transplant recipient with fatal lower respiratory tract disease. Bone Marrow Transplant 2003;31:309-310.
19. Munch M, Nielsen LP, Handberg KJ, et al. Detection and subtyping (H5 and H7) of avian type A influenza virus by reverse transcription-PCR and PCR-ELISA. Arch Virol 2001;146:87-97.
20. Musher DM. How contagious are common respiratory tract infections? N Engl J Med 2003;348:1256-1266.
21. Helweg-Larsen J, Jensen JS, Lundgren B. Non-invasive diagnosis of Pneumocystis carinii pneumonia in haematological patients using PCR on oral washes. J Eukaryot Microbiol 1997;44:59S.
22. Helweg-Larsen J, Jensen JS, Benfield T, et al. Diagnostic use of PCR for detection of Pneumocystis carinii in oral wash samples. J Clin Microbiol 1998;36:2068-2072.
23. Fischer S, Gill VJ, Kovacs J, et al. The use of oral washes to diagnose Pneumocystis carinii pneumonia: A blinded prospective study using a polymerase chain reaction-based detection system. J Infect Dis 2001;184:1485-1488.
24. Corsaro D, Valassina M, Venditti D, et al. Multiplex PCR for rapid and differential diagnosis of Mycoplasma pneumoniae and Chlamydia pneumoniae in respiratory infections. Diagn Microbiol Infect Dis 1999;35:105-108.
25. Weir SC, Fischer SH, Stock F, et al. Detection of Legionella by PCR in respiratory specimens using a commercially available kit. Am J Clin Pathol 1998;110:295-300.
26. Schalasta G, Arents A, Schmid M, et al. Fast and type-specific analysis of herpes simplex virus types 1 and 2 by rapid PCR and fluorescence melting-curve-analysis. Infection 2000;28:85-91.
27. Croci L, De Medici D, Scalfaro C, et al. The survival of hepatitis A virus in fresh produce. Int J Food Microbiol 2002;73:29-34.
28. Bogosian G, Sammons LE, Morris PJ, et al. Death of the Escherichia coli K-12 strain W3110 in soil and water. Appl Environ Microbiol 1996;62:4114-4120.
29. Chan GCF, Peiris JSM, Ho PL, et al. Respiratory viral infection in children with neutropenic fever: Implication on the traditional therapeutic approach. J Pediatr Hematol Oncol 2001;23:2A, abstract 1225.
30. Ong GM, Wyatt DE, O'Neill HJ, et al. A comparison of nested polymerase chain reaction and immunofluorescence for the diagnosis of respiratory infections in children with bronchiolitis, and the implications for a cohorting strategy. J Hosp Infect 2001;49:122-128.
31. Coyle PV, Ong GM, O'Neill HJ, et al. A touchdown nucleic acid amplification protocol as an alternative to culture backup for immunofluorescence in the routine diagnosis of acute viral respiratory tract infections. BMC Microbiol 2004;4:41.
32. Kaiser L, Wat C, Mills T, et al. Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations. Arch Intern Med 2003;163:1667-1672.
33. Maeda M, Fukunaga Y, Asano T, et al. Zanamivir is an effective treatment for influenza in children undergoing therapy for acute lymphoblastic leukemia. Scand J Infect Dis 2002;34:632-633.
34. Rotbart HA, Webster AD. Treatment of potential Iy life-threatening enterovirus infections with pleconaril. Clin Infect Dis 2001;32:228-235.
35. Schmiegelow K. Prognostic significance of methotrexate and 6-mercaptopurine dosage during maintenance chemotherapy for childhood acute lymphoblastic leukemia. Pediatr Hematol Oncol 1991;8:301-312.
36. Relling MV, Hancock ML, Boyett JM, Pui CH, and Evans WE. Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia. Blood 1999;93:2817-2823.
37. Carrega G, Castagnola E, Canessa A, et al. Herpes simplex virus and oral mucositis in children with cancer. Support Care Cancer 1994;2:266-269.
38. Bustamante CI, Wade JC. Herpes simplex virus infection in the immunocompromised cancer patient. J Clin Oncol 1991;9:1903-1915.
39. Bergmann OJ, Mogensen SC, Ellermann-Eriksen S, et al. Acyclovir prophylaxis and fever during remission-induction therapy of patients with acute myeloid leukemia: A randomized, double-blind, placebo-controlled trial. J Clin Oncol 1997;15:2269-2274.
40. Virkki R, Juven T, Rikalainen H, et al. Differentiation of bacterial and viral pneumonia in children. Thorax 2002;57:438-441.
41. Schroder H, Lassen BT, Andersen ST, et al. [Bacteremia in children with acute lymphoblastic leukemia]. Ugeskr Laeger 1998;160:5487-5490.
42. Toikka P, Irjala K, Juven T, et al. Serum procalcitonin, C-reactive protein and interleukin-6 for distinguishing bacterial and viral pneumonia in children. Pediatr Infect Dis J 2000;19:598-602.
43. Lala SG, Madhi SA, Pettifor JM. The discriminative value of C-reactive protein levels in distinguishing between community-acquired bacteraemic and respiratory virus-associated lower respiratory tract infections in HIV-1-infected and -uninfected children. Ann Trop Paediatr 2002;22:271-279.