Mapping of a novel susceptibility gene for rheumatoid arthritis in the telomeric MHC region

Cytokine

Volumn 32, Issue 2, 2005, Pages 71-75

  Kilding, Rachael ^a   Wilson, Anthony G ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Genetics; MHC; Polymorphism; Rheumatoid arthritis

Indexed keywords

ALLOGRAFT INFLAMMATORY FACTOR 1; HLA B ASSOCIATED TRANSCRIPT 1 PROTEIN; HLA B ASSOCIATED TRANSCRIPT 3 PROTEIN; HLA DQ ANTIGEN; HLA DR ANTIGEN; INHIBITORY OF KAPPA B PROTEIN; LEUCOCYTE SPECIFIC TRANSCRIPT 1 PROTEIN; LYMPHOTOXIN; LYMPHOTOXIN BETA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 3; PROTEIN; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SEQUENCE; CONFERENCE PAPER; CONFIDENCE INTERVAL; CROHN DISEASE; EPITOPE MAPPING; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETICS; HUMAN; IMMUNE RESPONSE; IMMUNOREGULATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; TELOMERE;

ARTHRITIS, RHEUMATOID; CHROMOSOMES, HUMAN, PAIR 6; EPITOPES; GENETIC PREDISPOSITION TO DISEASE; HLA-DR ANTIGENS; HUMANS; LINKAGE DISEQUILIBRIUM; MAJOR HISTOCOMPATIBILITY COMPLEX;

EID: 27644488704     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2005.07.015     Document Type: Conference Paper

References (46)

1. R.J. Allcock, F.T. Christiansen, and P. Price The central MHC gene IKBL carries a structural polymorphism that is associated with HLA-A3,B7,DR15 Immunogenetics 49 1999 660 665
2. R.J. Allcock, P. Price, S. Gaudieri, C. Leelayuwat, C.S. Witt, and R.L. Dawkins Characterisation of the human central MHC gene, BAT1: genomic structure and expression Exp Clin Immunogenet 16 1999 98 106
3. R.J. Allcock, J.H. Williams, and P. Price The central MHC gene, BAT1, may encode a protein that down-regulates cytokine production Genes Cells 6 2001 487 494
4. B.M. Brinkman, T.W. Huizinga, S.S. Kurban, E.A. van der Velde, G.M. Schreuder, and J.M. Hazes Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 36 1997 516 521
5. F. Castro, E. Acevedo, E. Ciusani, J.A. Angulo, F.A. Wollheim, and M. Sandberg-Wollheim Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1* and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis Ann Rheum Dis 60 2001 791 795
6. Y. Date, N. Seki, S. Kamizono, T. Higuchi, T. Hirata, and K. Miyata Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5′-flanking region of the TNFalpha gene and HLA genes Arthritis Rheum 42 1999 2577 2582
7. E.G. de la Concha, M. Fernandez-Arquero, G. Lopez-Nava, E. Martin, R.J. Allcock, and L. Conejero Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL Gastroenterology 119 2000 1491 1495
8. N. de Vries, C. van Elderen, H. Tijssen, P.L. van Riel, and L.B. van de Putte No support for HLA-DQ encoded susceptibility in rheumatoid arthritis Arthritis Rheum 42 1999 1621 1627
9. P. Emery, M. Salmon, H. Bradley, P. Wordsworth, E. Tunn, and P.A. Bacon Genetically determined factors as predictors of radiological change in patients with early symmetrical arthritis Bmj 305 1992 1387 1389
10. S. Gonzalez, J. Martinez-Borra, J.C. Torre-Alonso, S. Gonzalez-Roces, J. Sanchez del Rio, and A. Rodriguez Perez The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis Arthritis Rheum 42 1999 1010 1016
11. P.K. Gregersen, J. Silver, and R.J. Winchester The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis Arthritis Rheum 30 1987 1205 1213
12. A.H. Hajeer, A. Dababneh, R.F. Makki, W. Thomson, K. Poulton, and M.A. Gonzalez-Gay Different gene loci within the HLA-DR and TNF regions are independently associated with susceptibility and severity in Spanish rheumatoid arthritis patients Tissue Antigens 55 2000 319 325
13. R. Heller, M. Schena, A. Chai, D. Shalon, T. Bedilion, and J. Gilmore Discovery and analysis of inflammatory disease-related genes using cDNA microarrays Proc Natl Acad Sci U S A 94 1997 2150 2155
14. I. Holzinger, A. de Baey, G. Messer, G. Kick, H. Zwierzina, and E.H. Weiss Cloning and genomic characterization of LST1: a new gene in the human TNF region Immunogenetics 42 1995 315 322
15. J.P. Hugot, M. Chamaillard, H. Zouali, S. Lesage, J.P. Cezard, and Belaiche Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 2001 599 603
16. D. Jawaheer, M.F. Seldin, C.I. Amos, W.V. Chen, R. Shigeta, and J. Monteiro A genomewide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases Am J Hum Genet 68 2001 927 936
17. R. Kilding, M.M. Iles, J.M. Timms, J. Worthington, and A.G. Wilson Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus Arthritis Rheum 50 2004 763 769
18. K. Koss, J. Satsangi, G.C. Fanning, K.I. Welsh, and D.P. Jewell Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies Genes Immun 1 2000 185 190
19. R.C. Lawrence, C.G. Helmick, F.C. Arnett, R.A. Deyo, D.T. Felson, and Giannini Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States Arthritis Rheum 41 1998 778 799
20. A.S. Low, M.A. Gonzalez-Gay, M. Akil, R.S. Amos, D.E. Bax, and C. Cannings TNF +489 polymorphism does not contribute to susceptibility to rheumatoid arthritis Clin Exp Rheumatol 20 2002 829 832
21. A. Martinez, M. Fernandez-Arquero, A. Balsa, A. Rubio, H. Alves, and D. Pascual-Salcedo Primary association of a MICA allele with protection against rheumatoid arthritis Arthritis Rheum 44 2001 1261 1265
22. A. Martinez, M. Fernandez-Arquero, D. Pascual-Salcedo, L. Conejero, H. Alves, and A. Balsa Primary association of tumor necrosis factor-region genetic markers with susceptibility to rheumatoid arthritis Arthritis Rheum 43 2000 1366 1370
23. A. Martinez, M. Pascual, D. Pascual-Salcedo, A. Balsa, J. Martin, and E.G. de la Concha Genetic polymorphisms in Spanish rheumatoid arthritis patients: an association and linkage study Genes Immun 4 2003 117 121
24. D.L. Mattey, A.B. Hassell, P.T. Dawes, W.E. Ollier, and A. Hajeer Interaction between tumor necrosis factor microsatellite polymorphisms and the HLA-DRB1 shared epitope in rheumatoid arthritis: influence on disease outcome Arthritis Rheum 42 1999 2698 2704
25. J.E. McDonagh, A. Dunn, W.E. Ollier, and D.J. Walker Compound heterozygosity for the shared epitope and the risk and severity of rheumatoid arthritis in extended pedigrees Br J Rheumatol 36 1997 322 327
26. N. Mizuki, M. Ota, M. Kimura, S. Ohno, H. Ando, and Y. Katsuyama Triplet repeat polymorphism in the transmembrane region of the MICA gene: a strong association of six GCT repetitions with Behcet disease Proc Natl Acad Sci U S A 94 1997 1298 1303
27. B. Mulcahy, F. Waldron-Lynch, M.F. McDermott, C. Adams, C.I. Amos, and D.K. Zhu Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis Am J Hum Genet 59 1996 676 683
28. G.T. Nepom, C.E. Seyfried, S.L. Holbeck, K.R. Wilske, and B.S. Nepom Identification of HLA-Dw14 genes in DR4+ rheumatoid arthritis Lancet 2 1986 1002 1005
29. M.J. Neville, and R.D. Campbell A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC J Immunol 162 1999 4745 4754
30. J. Newton, M.A. Brown, A. Milicic, H. Ackerman, C. Darke, and J.N. Wilson The effect of HLA-DR on susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor necrosis factor haplotype Arthritis Rheum 48 2003 90 96
31. J.R. O'Dell, B.S. Nepom, C. Haire, V.H. Gersuk, L. Gaur, and G.F. Moore HLA-DRB1 typing in rheumatoid arthritis: predicting response to specific treatments Ann Rheum Dis 57 1998 209 213
32. K. Okamoto, S. Makino, Y. Yoshikawa, A. Takaki, Y. Nagatsuka, and M. Ota Identification of I kappa BL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis Am J Hum Genet 72 2003 303 312
33. M. Ota, Y. Katsuyama, A. Kimura, K. Tsuchiya, M. Kondo, and T. Naruse A second susceptibility gene for developing rheumatoid arthritis in the human MHC is localized within a 70-kb interval telomeric of the TNF genes in the HLA class III region Genomics 71 2001 263 270
34. V. Ramensky, P. Bork, and S. Sunyaev Human non-synonymous SNPs: server and survey Nucleic Acids Research 30 2002 3894 3900
35. I. Rollinger-Holzinger, B. Eibl, M. Pauly, U. Griesser, F. Hentges, and B. Auer LST1: a gene with extensive alternative splicing and immunomodulatory function J Immunol 164 2000 3169 3176
36. R.S. Spielman, R.E. McGinnis, and W.J. Ewens Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM) Am J Hum Genet 52 1993 506 516
37. P. Stastny Association of the B-cell alloantigen DRw4 with rheumatoid arthritis N Engl J Med 298 1978 869 871
38. E. Thorsby Invited anniversary review: HLA associated diseases Hum Immunol 53 1997 1 11
39. M.V. van Krugten, T.W. Huizinga, E.L. Kaijzel, E. Zanelli, K.W. Drossaers-Bakker, and P. van de Linde Association of the TNF +489 polymorphism with susceptibility and radiographic damage in rheumatoid arthritis Genes Immun 1 1999 91 96
40. D. van Zeben, J.M. Hazes, A.H. Zwinderman, A. Cats, G.M. Schreuder, and J. D'Amaro Association of HLA-DR4 with a more progressive disease course in patients with rheumatoid arthritis. Results of a followup study Arthritis Rheum 34 1991 822 830
41. G.R. Wallace, D.H. Verity, L.J. Delamaine, S. Ohno, H. Inoko, and M. Ota MIC-A allele profiles and HLA class I associations in Behcet's disease Immunogenetics 49 1999 613 617
42. C.M. Weyand, and J.J. Goronzy Inherited and noninherited risk factors in rheumatoid arthritis Curr Opin Rheumatol 7 1995 206 213
43. C.M. Weyand, and J.J. Goronzy HLA polymorphisms and T cells in rheumatoid arthritis Int Rev Immunol 18 1999 37 59
44. C.M. Weyand, C. Xie, and J.J. Goronzy Homozygosity for the HLA-DRB1 allele selects for extraarticular manifestations in rheumatoid arthritis J Clin Invest 89 1992 2033 2039
45. E. Zanelli, M.A. Gonzalez-Gay, and C.S. David Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immunol Today 16 1995 274 278
46. E. Zanelli, G. Jones, M. Pascual, P. Eerligh, A.R. van der Slik, and A.H. Zwinderman The telomeric part of the HLA region predisposes to rheumatoid arthritis independently of the class II loci Hum Immunol 62 2001 75 84