How to find new antibiotics. Metagenomics could be the way to mine the soil beneath our feet

Scientist

Volumn 19, Issue 19, 2005, Pages 20-21

  Handelsman, Jo ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 27644471074     PISSN: 08903670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (7)

1. http://www.cdc.gov/nchs/fastats/deaths.htm
2. S.J. Projan, "Why is Big Pharma getting out of antibacterial drug discovery?" Curr Opin Microbiol, 6:427-30, 2003.
3. J.L. Stein et al., "Characterization of uncultivated prokaryotes: Isolation and analysis of a 40-kilobase-pair genome fragment from a planktonic marine archaeon," J Bacteriol, 178:591-9, 1996.
4. M.R. Rondon et al., "Cloning the soil metagenome: A strategy for accessing the genetic and functional diversity of uncultured microorganisms," Appl Environ Microbiol, 66:2541-7, 2000.
5. D.E. Gillespie et al., "Isolation of antibiotics turbomycin A and B from a metagenomic library of soil microbial DNA," Appl Environ Microbiol, 68:4301-6, 2002.
6. G.Y. Wang et al., "Novel natural products from soil DNA libraries in a streptomycete host," Organic Letters, 2:2401-4, 2000.
7. T. Uchiyama, et al., "Substrate-induced gene-expression screening of environmental metagenome libraries for isolation of catabolic genes," Nat Biotechnol, 23:88-93, 2005.