메뉴 건너뛰기




Volumn 153, Issue 4, 2005, Pages 613-625

Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resentive resistant human breast cancer cells to 40-H tamoxifen

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GONADORELIN AGONIST; GONADORELIN DERIVATIVE; GONADORELIN[6 DEXTRO LYSINE]; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P185; TRIPTORELIN; UNCLASSIFIED DRUG;

EID: 27644458748     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.1.01996     Document Type: Article
Times cited : (31)

References (51)
  • 1
    • 0024950999 scopus 로고
    • 6]-luteinizing hormone-releasing hormone, somatostatin, epidermal growth factor, and sex steroids in 500 biopsy samples of human breast cancer
    • 6]-luteinizing hormone-releasing hormone, somatostatin, epidermal growth factor, and sex steroids in 500 biopsy samples of human breast cancer. Journal of Clinical Laboratory Analysis 1989 3 137-147.
    • (1989) Journal of Clinical Laboratory Analysis , vol.3 , pp. 137-147
    • Fekete, M.1    Wittliff, J.L.2    Schally, A.V.3
  • 2
    • 0027532290 scopus 로고
    • Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters
    • Baumann KH, Kiesel L, Kaufmann M, Bastert G & Runnebaum B. Characterization of binding sites for a GnRH-agonist (buserelin) in human breast cancer biopsies and their distribution in relation to tumor parameters. Breast Cancer Research and Treatment 1993 25 37-46.
    • (1993) Breast Cancer Research and Treatment , vol.25 , pp. 37-46
    • Baumann, K.H.1    Kiesel, L.2    Kaufmann, M.3    Bastert, G.4    Runnebaum, B.5
  • 4
    • 0036726665 scopus 로고    scopus 로고
    • Gonadotropin releasing hormone receptor expression in primary breast cancer: Comparison of immunohistochemical, radioligand and Western blot analyses
    • Mangia A, Tommasi S, Reshkin SJ, Simone G, Stea B, Schittulli F & Paradiso A. Gonadotropin releasing hormone receptor expression in primary breast cancer: comparison of immunohistochemical, radioligand and Western blot analyses. Oncology Reports 2002 6 1127-1132.
    • (2002) Oncology Reports , vol.6 , pp. 1127-1132
    • Mangia, A.1    Tommasi, S.2    Reshkin, S.J.3    Simone, G.4    Stea, B.5    Schittulli, F.6    Paradiso, A.7
  • 5
    • 0021971578 scopus 로고
    • Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist
    • Miller WR, Scott WN, Morris R, Fraser HM & Sharpe RM. Growth of human breast cancer cells inhibited by a luteinizing hormone-releasing hormone agonist. Nature 1985 313 231-233.
    • (1985) Nature , vol.313 , pp. 231-233
    • Miller, W.R.1    Scott, W.N.2    Morris, R.3    Fraser, H.M.4    Sharpe, R.M.5
  • 6
    • 0022361230 scopus 로고
    • Direct inhibitory effect of a luteinizing hormone-releasing hormone agonist on MCF-7 human breast cancer cells
    • Blankenstein MA, Henkelmann MS & Klijn JG. Direct inhibitory effect of a luteinizing hormone-releasing hormone agonist on MCF-7 human breast cancer cells. European Journal of Cancer and Clinical Oncology 1985 21 1493-1499.
    • (1985) European Journal of Cancer and Clinical Oncology , vol.21 , pp. 1493-1499
    • Blankenstein, M.A.1    Henkelmann, M.S.2    Klijn, J.G.3
  • 8
    • 0023141072 scopus 로고
    • Gonadotropin releasing hormone (GnRH)-binding sites in human breast cancer cell lines and inhibitory effects of GnRH-agonists
    • Eidne KA, Flanagan CA, Harris NS & Millar RP. Gonadotropin releasing hormone (GnRH)-binding sites in human breast cancer cell lines and inhibitory effects of GnRH-agonists. Journal of Clinical Endocrinology and Metabolism 1987 64 425-432.
    • (1987) Journal of Clinical Endocrinology and Metabolism , vol.64 , pp. 425-432
    • Eidne, K.A.1    Flanagan, C.A.2    Harris, N.S.3    Millar, R.P.4
  • 9
    • 0025214532 scopus 로고
    • Compared effects of GnRH analogs and 4-hydroxytamoxifen on growth and steroid receptors in antiestrogen sensitive and resistant MCF-7 breast cancer sublines
    • Neri C, Berthois Y, Schatz B, Drieu K & Martin PM. Compared effects of GnRH analogs and 4-hydroxytamoxifen on growth and steroid receptors in antiestrogen sensitive and resistant MCF-7 breast cancer sublines. Breast Cancer Research and Treatment 1990 15 85-93.
    • (1990) Breast Cancer Research and Treatment , vol.15 , pp. 85-93
    • Neri, C.1    Berthois, Y.2    Schatz, B.3    Drieu, K.4    Martin, P.M.5
  • 10
    • 0026010356 scopus 로고
    • Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone
    • Scott WN, Mullen P & Miller WR. Factors influencing the response of MCF-7 cells to an agonist of luteinising hormone-releasing hormone. European Journal of Cancer 1991 27 1458-1461.
    • (1991) European Journal of Cancer , vol.27 , pp. 1458-1461
    • Scott, W.N.1    Mullen, P.2    Miller, W.R.3
  • 12
    • 0026772390 scopus 로고
    • Growth inhibition of estrogen independent MXT mouse mammary carcinomas in mice treated with an agonist or antagonist of LH-RH, an analog of somatostatin, or a combination
    • Szepeshazy K, Milovanovic S, Lapis K, Groot K & Schally AV. Growth inhibition of estrogen independent MXT mouse mammary carcinomas in mice treated with an agonist or antagonist of LH-RH, an analog of somatostatin, or a combination. Breast Cancer Research and Treatment 1992 21 181-192.
    • (1992) Breast Cancer Research and Treatment , vol.21 , pp. 181-192
    • Szepeshazy, K.1    Milovanovic, S.2    Lapis, K.3    Groot, K.4    Schally, A.V.5
  • 13
    • 0036173838 scopus 로고    scopus 로고
    • Two forms of gonadotropin-releasing hormone (GnRH) are expressed in human breast tissue and overexpressed in breast cancer: A putative mechanism for the antiproliferative effect of GnRH by down-regulation of acidic ribosomal phosphoproteins P1 and P2
    • Chen A, Kaganovsky E, Rahimipour S, Ben-Aroya N, Okon E & Koch Y. Two forms of gonadotropin-releasing hormone (GnRH) are expressed in human breast tissue and overexpressed in breast cancer: a putative mechanism for the antiproliferative effect of GnRH by down-regulation of acidic ribosomal phosphoproteins P1 and P2. Cancer Research 2002 62 1036-1044.
    • (2002) Cancer Research , vol.62 , pp. 1036-1044
    • Chen, A.1    Kaganovsky, E.2    Rahimipour, S.3    Ben-Aroya, N.4    Okon, E.5    Koch, Y.6
  • 14
    • 0033842808 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone agonist triptorelin and antagonist cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers
    • Gründker C, Völker P, Schulz KD & Emons G. Luteinizing hormone-releasing hormone agonist triptorelin and antagonist cetrorelix inhibit EGF-induced c-fos expression in human gynecological cancers. Gynecologic Oncology 2000 78 194-202.
    • (2000) Gynecologic Oncology , vol.78 , pp. 194-202
    • Gründker, C.1    Völker, P.2    Schulz, K.D.3    Emons, G.4
  • 15
    • 0029803245 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines
    • Emons G, Müller V, Ortmann O, Grossmann G, Trautner U, v Stuckrad B, Schulz KD & Schally AV. Luteinizing hormone-releasing hormone agonist triptorelin antagonizes signal transduction and mitogenic activity of epidermal growth factor in human ovarian and endometrial cancer cell lines. International Journal of Oncology 1996 9 1129-1137.
    • (1996) International Journal of Oncology , vol.9 , pp. 1129-1137
    • Emons, G.1    Müller, V.2    Ortmann, O.3    Grossmann, G.4    Trautner, U.5    v Stuckrad, B.6    Schulz, K.D.7    Schally, A.V.8
  • 16
    • 0035020249 scopus 로고    scopus 로고
    • I-mediated activation of phosphotyrosine phosphatase
    • I-mediated activation of phosphotyrosine phosphatase. Endocrinology 2001 142 2369-2380.
    • (2001) Endocrinology , vol.142 , pp. 2369-2380
    • Gründker, C.1    Völker, P.2    Emons, G.3
  • 18
    • 9444256957 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells
    • Gründker C, Günthert AR, Hellriegel M & Emons G. Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells. European Journal of Endocrinology 2004 151 619-628.
    • (2004) European Journal of Endocrinology , vol.151 , pp. 619-628
    • Gründker, C.1    Günthert, A.R.2    Hellriegel, M.3    Emons, G.4
  • 19
    • 0033756722 scopus 로고    scopus 로고
    • Luteinizing hormone-releasing hormone induces nuclear factor κB-activation and inhibits apoptosis in ovarian cancer cells
    • Gründker C, Schulz K, Günthert AR & Emons G. Luteinizing hormone-releasing hormone induces nuclear factor κB-activation and inhibits apoptosis in ovarian cancer cells. Journal of Clinical Endocrinology and Metabolism 2000 10 3815-3820.
    • (2000) Journal of Clinical Endocrinology and Metabolism , vol.10 , pp. 3815-3820
    • Gründker, C.1    Schulz, K.2    Günthert, A.R.3    Emons, G.4
  • 21
    • 0001888382 scopus 로고    scopus 로고
    • Coordinated evolution of GnRHs and their receptors
    • Eds PS Parhar & Y Sakuma. Tokyo: Brain Shuppan Publishers
    • King JA & Millar RP. Coordinated evolution of GnRHs and their receptors. In GnRH Neurones: Gene to Behavior, pp 51-77. Eds PS Parhar & Y Sakuma. Tokyo: Brain Shuppan Publishers, 1997.
    • (1997) GnRH Neurones: Gene to Behavior , pp. 51-77
    • King, J.A.1    Millar, R.P.2
  • 22
    • 0027499820 scopus 로고
    • Origin of mammalian gonadotropin-releasing hormones
    • Sherwood NM, Lovejoy DA & Coe IR. Origin of mammalian gonadotropin-releasing hormones. Endocrine Reviews 1993 14 241-254.
    • (1993) Endocrine Reviews , vol.14 , pp. 241-254
    • Sherwood, N.M.1    Lovejoy, D.A.2    Coe, I.R.3
  • 23
    • 0030937284 scopus 로고    scopus 로고
    • Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor
    • Sealfon SC, Weinstein H & Millar RP. Molecular mechanisms of ligand interaction with the gonadotropin-releasing hormone receptor. Endocrine Reviews 1997 18 180-205.
    • (1997) Endocrine Reviews , vol.18 , pp. 180-205
    • Sealfon, S.C.1    Weinstein, H.2    Millar, R.P.3
  • 24
    • 0036965115 scopus 로고    scopus 로고
    • Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation
    • Gründker C, Günthert AR, Millar RP & Emons G. Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation. Journal of Clinical Endocrinology and Metabolism 2002 87 1427-1430.
    • (2002) Journal of Clinical Endocrinology and Metabolism , vol.87 , pp. 1427-1430
    • Gründker, C.1    Günthert, A.R.2    Millar, R.P.3    Emons, G.4
  • 25
    • 4344633012 scopus 로고    scopus 로고
    • The antiproliferative effects of GnRH antagonist Cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I (GnRH-I) receptor
    • Gründker C, Schlotawa L, Viereck V, Eicke N, Horst A, Kairies B & Emons G. The antiproliferative effects of GnRH antagonist Cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I (GnRH-I) receptor. European Journal of Endocrinology 2004 152 141-149.
    • (2004) European Journal of Endocrinology , vol.152 , pp. 141-149
    • Gründker, C.1    Schlotawa, L.2    Viereck, V.3    Eicke, N.4    Horst, A.5    Kairies, B.6    Emons, G.7
  • 26
    • 0034667395 scopus 로고    scopus 로고
    • Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells
    • Kurokawa H, Lenferink AE, Simpson JF, Pisacane PI, Sliwkowski MX, Forbes JT & Arteaga CL. Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells. Cancer Research 2000 60 5887-5894.
    • (2000) Cancer Research , vol.60 , pp. 5887-5894
    • Kurokawa, H.1    Lenferink, A.E.2    Simpson, J.F.3    Pisacane, P.I.4    Sliwkowski, M.X.5    Forbes, J.T.6    Arteaga, C.L.7
  • 27
    • 0037373326 scopus 로고    scopus 로고
    • Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells
    • Knowlden JM, Hutcheson IR, Jones HE, Madden T, Gee JM, Harper ME, Barrow D, Wakeling AE & Nicholson RI. Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cells. Endocrinology 2003 144 1032-1044.
    • (2003) Endocrinology , vol.144 , pp. 1032-1044
    • Knowlden, J.M.1    Hutcheson, I.R.2    Jones, H.E.3    Madden, T.4    Gee, J.M.5    Harper, M.E.6    Barrow, D.7    Wakeling, A.E.8    Nicholson, R.I.9
  • 28
    • 0037109014 scopus 로고    scopus 로고
    • ZD1839 (Iressa): An orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy
    • Wakeling AE, Guy SP, Woodburn JR, Ashton SE, Curry BJ, Baker AJ & Gibson KH. ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy. Cancer Research 2002 62 5749-5753.
    • (2002) Cancer Research , vol.62 , pp. 5749-5753
    • Wakeling, A.E.1    Guy, S.P.2    Woodburn, J.R.3    Ashton, S.E.4    Curry, B.J.5    Baker, A.J.6    Gibson, K.H.7
  • 29
    • 0036182849 scopus 로고    scopus 로고
    • Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: Frequency, autoregulation, and correlation with direct antiproliferative activity of luteinizing hormone-releasing hormone analogues
    • Völker P, Gründker C, Schmidt O, Schulz KD & Emons G. Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: frequency, autoregulation, and correlation with direct antiproliferative activity of luteinizing hormone-releasing hormone analogues. American Journal of Obstetrics and Gynecology 2002 186 171-179.
    • (2002) American Journal of Obstetrics and Gynecology , vol.186 , pp. 171-179
    • Völker, P.1    Gründker, C.2    Schmidt, O.3    Schulz, K.D.4    Emons, G.5
  • 34
    • 85047684264 scopus 로고    scopus 로고
    • GnRH and GnRH receptor genes in the human genome
    • Neill JD. GnRH and GnRH receptor genes in the human genome. Endocrinology 2002 143 737-743.
    • (2002) Endocrinology , vol.143 , pp. 737-743
    • Neill, J.D.1
  • 37
    • 0037320294 scopus 로고    scopus 로고
    • A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12
    • Morgan K, Conklin D, Pawson AJ, Sellar R, Ott TR & Millar RP. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology 2003 144 423-436.
    • (2003) Endocrinology , vol.144 , pp. 423-436
    • Morgan, K.1    Conklin, D.2    Pawson, A.J.3    Sellar, R.4    Ott, T.R.5    Millar, R.P.6
  • 39
    • 4344598882 scopus 로고    scopus 로고
    • Human type II GnRH receptor mediates effects of GnRH on cell proliferation
    • Enomoto M, Endo D, Kawashima S & Park MK. Human type II GnRH receptor mediates effects of GnRH on cell proliferation. Zoological Science 2004 21 763-770.
    • (2004) Zoological Science , vol.21 , pp. 763-770
    • Enomoto, M.1    Endo, D.2    Kawashima, S.3    Park, M.K.4
  • 41
    • 15944401007 scopus 로고    scopus 로고
    • Extracellular signal-regulated protein kinase, but not c-jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation
    • Kim KY, Choi KC, Park SH, Auersperg N & Leung PC. Extracellular signal-regulated protein kinase, but not c-jun N-terminal kinase, is activated by type II gonadotropin-releasing hormone involved in the inhibition of ovarian cancer cell proliferation. Journal of Clinical Endocrinology and Metabolism 2005 90 1670-1677.
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , pp. 1670-1677
    • Kim, K.Y.1    Choi, K.C.2    Park, S.H.3    Auersperg, N.4    Leung, P.C.5
  • 43
    • 0029877913 scopus 로고    scopus 로고
    • Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation
    • Bunone G, Briand PA, Miksicek RJ & Picard D. Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO Journal 1996 15 2174-2183.
    • (1996) EMBO Journal , vol.15 , pp. 2174-2183
    • Bunone, G.1    Briand, P.A.2    Miksicek, R.J.3    Picard, D.4
  • 44
    • 0030998328 scopus 로고    scopus 로고
    • The partial agonist activity of antagonist-occupied steroids receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT
    • Jackson TA, Richer JK, Bain DL, Takimoto GS, Tung L & Horwitz KB. The partial agonist activity of antagonist-occupied steroids receptors is controlled by a novel hinge domain-binding coactivator L7/SPA and the corepressors N-CoR or SMRT. Molecular Endocrinology 1997 11 693-705.
    • (1997) Molecular Endocrinology , vol.11 , pp. 693-705
    • Jackson, T.A.1    Richer, J.K.2    Bain, D.L.3    Takimoto, G.S.4    Tung, L.5    Horwitz, K.B.6
  • 45
    • 0031936410 scopus 로고    scopus 로고
    • Specificity within the EGF family/ErbB receptor family signaling network
    • Riese DJ 2nd & Stern DF. Specificity within the EGF family/ErbB receptor family signaling network. Bioassays 1998 20 41-48.
    • (1998) Bioassays , vol.20 , pp. 41-48
    • Riese II, D.J.1    Stern, D.F.2
  • 47
    • 0026786658 scopus 로고
    • Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-71 human breast cancer cells
    • van Agthoven T, van Agthoven TL, Portengen H, Foekens JA & Dorssers LC. Ectopic expression of epidermal growth factor receptors induces hormone independence in ZR-75-71 human breast cancer cells. Cancer Research 1992 52 5082-5088.
    • (1992) Cancer Research , vol.52 , pp. 5082-5088
    • van Agthoven, T.1    van Agthoven, T.L.2    Portengen, H.3    Foekens, J.A.4    Dorssers, L.C.5
  • 50
    • 18244391514 scopus 로고    scopus 로고
    • Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients
    • Perez-Tenorio G & Stal O. Activation of AKT/PKB in breast cancer predicts a worse outcome among endocrine treated patients. British Journal of Cancer 2002 86 540-545.
    • (2002) British Journal of Cancer , vol.86 , pp. 540-545
    • Perez-Tenorio, G.1    Stal, O.2
  • 51
    • 4143145476 scopus 로고    scopus 로고
    • Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: Role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways
    • Kraus S, Levy G, Hanoch T, Naor Z & Seger R. Gonadotropin-releasing hormone induces apoptosis of prostate cancer cells: role of c-Jun NH2-terminal kinase, protein kinase B, and extracellular signal-regulated kinase pathways. Cancer Research 2004 64 5736-5744.
    • (2004) Cancer Research , vol.64 , pp. 5736-5744
    • Kraus, S.1    Levy, G.2    Hanoch, T.3    Naor, Z.4    Seger, R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.