Antiproliferative effects of the GnRH antagonist cetrorelix and GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor

European Journal of Endocrinology

Volumn 151, Issue 1, 2004, Pages 141-149

  Gründker, Carsten ^a   Schlotawa, Lars ^a   Viereck, Volker ^a   Eicke, Nicola ^a   Horst, Anika ^a   Kairies, Britta ^a   Emons, Günter ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CETRORELIX; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; GONADORELIN DERIVATIVE; GONADORELIN RECEPTOR; TRIPTORELIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; HORMONAL REGULATION; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS, HORMONAL; CELL DIVISION; CELL LINE, TUMOR; ENDOMETRIAL NEOPLASMS; FEMALE; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; MUTAGENESIS; OVARIAN NEOPLASMS; RECEPTORS, LHRH; TRIPTORELIN;

EID: 4344633012     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/eje.0.1510141     Document Type: Article

References (17)

1. Gründker C, Günthert AR, Westphalen S & Emons G. Biology of the gonadotropin-releasing hormone (GnRH) system in gynecological cancers. European Journal of Endocrinology 2002 146 1-14.
2. Emons G, Ortmann O, Becker M, Irmer G, Springer B, Laun R, Holzel F, Schulz KD & Schally AV. High affinity binding and direct antiproliferative effects of LHRH analogues in human ovarian cancer cell lines. Cancer Research 1993 54 5439-5446.
3. Emons G, Schröder B, Ortmann O, Westphalen S, Schulz KD & Schally AV. High affinity binding and direct antiproliferative effects of luteinizing hormone-releasing hormone analogs in human endometrial cancer cell lines. Journal of Clinical Endocrinology and Metabolism 1993 77 1458-1464.
4. Irmer G, Bürger C, Müller R, Ortmann O, Peter U, Kakar SS, Neill JD, Schulz KD & Emons G. Expression of the messenger RNAs for luteinizing hormone-releasing hormone (LHRH) and its receptor in human ovarian epithelial carcinoma. Cancer Research 1995 55 817-822.
5. Emons G, Ortmann O, Schulz KD & Schally AV. Growth-inhibitory actions of luteinizing hormone releasing hormone on tumor cells. Trends in Endocrinology and Metabolism 1997 8 355-362.
6. Gründker C, Günthert AR, Millar RP & Emons G. Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation. Journal of Clinical Endocrinology and Metabolism 2002 87 1427-1430.
7. Völker P, Gründker C, Schmidt O, Schulz KD & Emons G. Expression of receptors for luteinizing hormone-releasing hormone in human ovarian and endometrial cancers: frequency, autoregulation and correlation with direct antiproliferative activity of LHRH analogues. American Journal of Obstetrics and Gynecology 2002 186 171-179.
8. Choi KC, Auersperg N & Leung PCK. Expression and anti-proliferative effect of a second form of gonadotropin-releasing hormone in normal and neoplastic ovarian surface epithelial cells. Journal of Clinical Endocrinology and Metabolism 2001 86 5075-5078.
9. Millar R, Lowe S, Conklin D, Pawson A, Maudsley S, Troskie B, Ott T, Millar M, Lincoln G, Sellar R, Faurholm B, Scobie G, Kuestner R, Terasawa E & Katz A. A novel mammalian receptor for the evolutionarily conserved type II GnRH. PNAS 2001 98 9636-9641.
10. Millar RP, Conklin D, Lofton-Day C, Hutchinson E, Troskie B, Illing N, Sealfon SC & Hapgood J. A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript. Journal of Endocrinology 1999 162 117-126.
11. Neill JD, Duck LW, Sellers JC & Musgrove LC. A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates. Biochemical and Biophysical Research Communications 2001 282 1012-1018.
12. Neill JD. GnRH and GnRH receptor genes in the human genome. Endocrinology 2002 143 737-743.
13. Millar RP. GnRH II and type II GnRH receptors. Trends in Endocrinology and Metabolism 2003 14 35-43.
14. Morgan K, Conklin D, Pawson AJ, Sellar R, Ott TR & Millar RP. A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12. Endocrinology 2003 144 423-436.
15. Emons G, Weiß S, Ortmann O, Gründker C & Schutz KD. Luteinizing hormone releasing hormone (LHRH) acts as a negative autocrine regulator of proliferation of human ovarian cancer. European Journal of Endocrinology 2000 142 665-670.
16. Gründker C, Völker P & Emons G. Antiproliferative signaling of LHRH in human endometrial and ovarian cancer cells through G-protein αi-mediated activation of phosphotyrosine phosphatase. Endocrinology 2001 142 2369-2380.
17. Gründker C, Schulz K, Günthert AR & Emons G. Luteinizing hormone-releasing hormone induces nuclear factor κB-activation and inhibits apoptosis in ovarian cancer cells. Journal of Clinical Endocrinology and Metabolism 2000 85 3815-3820.