Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 139 B, Issue 1, 2005, Pages 106-108

  Dahl, John P ^a   Weller, Andrew E ^a   Kampman, Kyle M ^a   Oslin, David W ^a   Lohoff, Falk W ^a   Ferraro, Thomas N ^a   O'Brien, Charles P ^a   Berrettini, Wade H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cocaine dependence; Genetic association; Prodynorphin

Indexed keywords

ALCOHOL; COCAINE; DNA; DYNORPHIN; KAPPA OPIATE RECEPTOR; LEUMORPHIN; NEOENDORPHIN; OPIATE PEPTIDE; PRODYNORPHIN; UNCLASSIFIED DRUG;

ADULT; ALCOHOLISM; ALLELE; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; VARIABLE NUMBER OF TANDEM REPEAT;

ADULT; AFRICAN AMERICANS; COCAINE-RELATED DISORDERS; ENKEPHALINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROTEIN PRECURSORS;

EID: 27644433919     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30238     Document Type: Article

References (18)

1. Adams DH, Hanson GR, Keefe KA. 2003. Distinct effects of methamphetamine and cocaine on preprodynorphin messenger RNA in rat striatal patch and matrix. J Neurochem 84(1):87-93.
2. Berrettini WH, Hoehe MR, Ferraro TN, DeMaria PA, Gottheil E. 1997. Human mu opioid receptor gene polymorphisms and vulnerability to substance abuse. Addict Biol 2:303-308.
3. Chen AC, LaForge KS, Ho A, McHugh PF, Kellogg S, Bell K, Schluger RP, Leal SM, Kreek MJ. 2002. Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse. Am J Med Genet 114(4):429-435.
4. Fagergren P, Smith HR, Daunais JB, Nader MA, Porrino LJ, Kurd YL. 2003. Temporal upregulation of prodynorphin mRNA in the primate striatum after cocaine self-administration. Eur J Neurosci 17(10):2212-2218.
5. Freimer M, Kranzler H, Satel S, Lacobelle J, Skipsey K, Charney D, Gelernter J. 1996. No association between D3 dopamine receptor (DRD3) alleles and cocaine dependence. Addict Biol 1(3):281-287.
6. Kakidani H, Furutani Y, Takahashi H, Noda M, Morimoto Y, Hirose T, Asai M, Inayama S, Nakanishi S, Numa S. 1982. Cloning and sequence analysis of cDNA for porcine beta-neo-endorphin/dynorphin precursor. Nature 298(5871):245-249.
7. Kalivas PW. 2004. Glutamate systems in cocaine addiction. Curr Opin Pharmacol 4(1):23-29.
8. Kendler KS, Prescott CA. 1998. Cocaine use, abuse and dependence in a population-based sample of female twins. Br J Psychiatry 173:345-350.
9. Kendler KS, Karkowski LM, Neale MC, Prescott CA. 2000. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch Gen Psychiatry 57(3):261-269.
10. Kreek MJ, Schluger J, Borg L, Gunduz M, Ho A. 1999. Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: Gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. J Pharmacol Exp Ther 288(1):260-269.
11. Manzanares J, Wagner EJ, LaVigne SD, Lookingland KJ, Moore KE. 1992. Sexual differences in kappa opioid receptor-mediated regulation of tuberoinfundibular dopaminergic neurons. Neuroendocrinology 55(3):301-307.
12. McLaughlin JP, Marton-Popovici M, Chavkin C. 2003. Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses. J Neurosci 23(13):5674-5683.
13. Noble EP. 2003. D2 dopamine receptor gene in psychiatric and neurologic disorders and its phenotypes. Am J Med Genet B Neuropsychiatr Genet 116(1):103-125.
14. Patkar AA, Berrettini WH, Hoehe M, Hill KP, Gottheil E, Thornton CC, Weinstein SP. 2002. No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals. Psychiatr Genet 12(3):161-164.
15. Schlussman SD, Zhang Y, Yuferov V, LaForge KS, Ho A, Kreek MJ. 2003. Acute 'binge' cocaine administration elevates dynorphin mRNA in the caudate putamen of C57BL/6J but not 129/J mice. Brain Res 974(1-2):249-253.
16. Sershen H, Hashim A, Lajtha A. 1998. Gender differences in kappa-opioid modulation of cocaine-induced behavior and NMDA-evoked dopamine release. Brain Res 801(1-2):67-71.
17. Yuferov V, Zhou Y, LaForge KS, Spangler R, Ho A, Kreek MJ. 2001. Elevation of guinea pig brain preprodynorphin mRNA expression and hypothalamic-pituitary-adrenal axis activity by "binge" pattern cocaine administration. Brain Res Bull 55(1):65-70.
18. Zimprich A, Kraus J, Woltje M, Mayer P, Rauch E, Hollt V. 2000. An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression. J Neurochem 74(2):472-477.