No association between polymorphisms in the serotonin transporter gene and susceptibility to cocaine dependence among African-American individuals

Psychiatric Genetics

Volumn 12, Issue 3, 2002, Pages 161-164

  Patkar, Ashwin A ^a   Berrettini, Wade H ^a   Hoehe, Margret ^a   Hill, Kevin P ^a   Gottheil, Edward ^a   Thornton, Charles C ^a   Weinstein, Stephen P ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

African American; Cocaine dependence; Gene; Polymorphisms; Serotonin transporter; Variable number tandem repeat

Indexed keywords

COCAINE; GENOMIC DNA; SEROTONIN TRANSPORTER;

ADULT; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; DRUG DEPENDENCE; ETHNIC GROUP; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NEGRO; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; TANDEM REPEAT;

ADULT; AFRICAN AMERICANS; AFRICAN CONTINENTAL ANCESTRY GROUP; AGE OF ONSET; CARRIER PROTEINS; COCAINE-RELATED DISORDERS; GENOTYPE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PENNSYLVANIA; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; REFERENCE VALUES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 0036755405     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-200209000-00007     Document Type: Article

References (25)

1. Aronson SC, Black JE, McDougle CJ, Scanley BE, Jatlow P, Kosten TR, et al. (1995). Serotonergic mechanisms of cocaine effects in humans. Psychopharmacology (Berl) 119:179-185.
2. Bennett ST, Lucassen AM, Gough SCL, Powell EE, Undlien DE, Pritchard LE, et al. (1995). Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus. Nat Genet 9:284-291.
3. Bonnet-Brilhault F, Laurent C, Thibaut F, Campion D, Chavand O, Samolyk D, et al. (1997). Serotonin transporter gene polymorphism and schizophrenia: An association study. Biol Psychiatry 42:634-636.
4. Evans J, Battersby S, Ogilvie AD, Smith CA, Harmar AJ, Nutt DJ, et al. (1997). Association of short alleles of a VNTR of the serotonin transporter gene with anxiety symptoms in patients presenting after deliberate self harm. Neuropharmacology 56:439-443.
5. First MB, Spitzer RL, Gibbon M, Williams JBW (1997). Structured Clinical Interview for DSM-IV disorders (SCID-IV). Washington, DC: American Psychiatric Press.
6. Gelernter J, Pakstis AJ, Kidd KK (1995). Linkage mapping of serotonin transporter gene SLC6A4 on chromosome 17. Hum Genet 95:677-680.
7. Graham D, Langer SZ (1992). Advances in sodium-ion coupled biogenic amine transporters. Life Sci 51:631-645.
8. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. (1996). Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621-2624.
9. Hoehe MR, Wendel B, Grunewald I, Chiaroni P, Levy N, Morris-Rosendahl D, et al. (1998). Serotonin transporter (5-HTT) gene polymorphisms are not associated with susceptibility to mood disorders. Am J Med Genet (Neuropsychiatr Genet) 81:1-3.
10. Hranivolic D, Schwab SG, Jernej B, Knapp M, Lerer B, Albus M, et al. (2000). Serotonin transporter gene and schizophrenia: Evidence for association/linkage disequilibrium in families with affected siblings. Mol Psychiatry 5:91-95.
11. Jacobsen LK, Staley JK, Malison RT, Zoghbi SS, Seibyl JP, Kosten TR, et al. (2000). Elevated central serotonin transporter binding availabilty in acutely abstinent cocaine-dependent patients. Am J Psychiatry 157:1134-1140.
12. Kidd KK (1993). Associations of disease with genetic markers. Am J Med Genet 48:71-73.
13. Lesch K-P, Balling U, Gross J, Wolozin BL, Riederer P, Murphy DL (1994). Organization of the human serotonin transporter gene. J Neural Trans 95:157-162.
14. Little KY, McLaughlin DP, Zhang L, Livermore CS, Dalack GW, McFinton PR, et al. (1998). Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 155:207-213.
15. Mash DC, Staley JK, Izenwasser S, Basile M, Ruttenber AJ (2000). Serotonin transporters upregulate with chronic cocaine use. J Chem Neuroanat 20:271-280.
16. McLellan AT, Luborsky L, Cacciola J, Kushner H, Peters L, Smith I, et al. (1992). The fifth edition of the Addiction Severity Index: Cautions, additions and normative data. J Nerv Mental Dis 168:26-33.
17. Miller SA, Dykes D, Plessky HF (1988). A simple salting out procedure for extracting DNA from human nucleated cells [Miller]. Nucl Acids Res 16:1215.
18. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin G, et al. (1996). Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347:731-733.
19. Patkar AA, Berrettini WH, Hoehe M, Hill KP, Sterling RC, Gottheil E, Weinstein SP (2001). Serotonin transporter (5-HTT) gene polymorphisms and cocaine dependence among African-American individuals. Addiction Biol 6:335-345.
20. Sander T, Harms H, Dufeu P, Kuhn S, Hoehe M, Lesch K-P, et al. (1998). Serotonin transporter gene variants in alcohol dependent subjects with dissocial personality disorder. Biol Psychiatry 43:908-912.
21. Schloss P, Williams DC (1998). The serotonin transporter: A primary target for antidepressant drugs. J Psychopharmacol 12:115-121.
22. Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, et al. (1998). The MINI-international neuropsychiatric interview (M.I.N.I.): The development and validation of a structured diagnostic interview for DSM-IV and ICD-10. J Clin Psychiatry 59:22-33.
23. Sora I, Hall FS, Andrews AM, Itokawa M, Li XF, Wei HB, et al. (2001). Molecular mechanisms of cocaine reward: Combined dopamine and serotonin transporter knockouts eliminate cocaine place preference. Proce Natl Acad Sci USA 98:5300-5305.
24. Stober G, Heils A, Lesch KP (1996). Serotonin transporter gene polymorphism and affective disorder. Lancet 347:1340-1341.
25. Tan EC, Yeo BK, Ho BK, Tay AH, Tan CH (1999). Evidence for an association between heroin dependence and a VNTR polymorphism at the serotonin transporter. Mol Psychiatry 4:215-217.