Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway

Cancer Research

Volumn 65, Issue 21, 2005, Pages 9807-9816

  Ni, Jing ^a,b   Wen, Xingqiao ^a,b   Yao, Jorge ^b   Chang, Hong Chiang ^c   Yin, Yi ^a,b   Zhang, Min ^a,b   Xie, Shaozhen ^b   Chen, Ming ^a,b   Simons, Brenna ^a,b   Chang, Philip ^a,b   Di Sant'Agnese, Anthony ^b   Messing, Edward M ^a   Yeh, Shuyuan ^a,b  

^a UNIVERSITY OF ROCHESTER   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANDROGEN RECEPTOR; ASCORBIC ACID; BINDING PROTEIN; DELTA TOCOPHEROL; GAMMA TOCOPHEROL; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; PROTEIN P85; SMALL INTERFERING RNA; TOCOPHEROL ASSOCIATED PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; CELL CYCLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SUBUNIT; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; IN SITU HYBRIDIZATION; KNOCKOUT GENE; MALE; MITOSIS INHIBITION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; TUMOR SUPPRESSOR GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARRIER PROTEINS; CELL GROWTH PROCESSES; CELL LINE, TUMOR; GENE EXPRESSION; HUMANS; LIPOPROTEINS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS C-AKT; TRANS-ACTIVATORS; TRANSPLANTATION, HETEROLOGOUS; VITAMIN E;

EID: 27544490182     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-1334     Document Type: Article

References (53)

1. Zimmer S, Stocker A, Sarbolouki MN, et al. A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. J Biol Chem 2000;275: 25672-80.
2. Ford ES, Sowell A. Serum α-tocopherol status in the U.S. population: findings from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 1999;150:290-300.
3. Shibata N, Arita M, Misaki Y, et al. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Proc Natl Acad Sci USA 2001;98:2244-9.
4. Panagabko C, Morley S, Hernandez M, et al. Ligand specificity in the CRAL-TRIO protein family. Biochemistry 2003;42:6467-74.
5. Stocker A, Tomizaki T, Schulze-Briese C, Baumann U. Crystal structure of the human supernatant protein factor. Structure (Camb) 2002;10:1533-40.
6. Kasamon KM, Dawson NA. Update on hormone-refractory prostate cancer. Curr Opin Urol 2004;14: 185-93.
7. The effect of vitamin E and β carotene on the incidence of lung cancer and other cancers in male smokers. The α-Tocopherol, β-Carotene Cancer Prevention Study Group. N Engl J Med 1994;330:1029-35.
8. Israel K, Sanders BG, Kline K. RRR-α-tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways. Nutr Cancer 1995;24:161-9.
9. Zhang Y, Ni J, Messing EM, et al. Vitamin E succinate inhibits the function of androgen receptor and the expression of prostate-specific antigen in prostate cancer cells. Proc Natl Acad Sci U S A 2002; 99:7408-13.
10. Ni J, Chen M, Zhang Y, et al. Vitamin E succinate inhibits human prostate cancer cell growth via modulating cell cycle regulatory machinery. Biochem Biophys Res Commun 2003;300:357-63.
11. Venkateswaran V, Fleshner NE, Klotz LH. Modulation of cell proliferation and cell cycle regulators by vitamin E in human prostate carcinoma cell lines. J Urol 2002; 168:1578-82.
12. Gunawardena K, Murray DK, Meikle AW. Vitamin E and other antioxidants inhibit human prostate cancer cells through apoptosis. Prostate 2000;44:287-95.
13. Israel K, Yu W, Sanders BG, Kline K. Vitamin E succinate induces apoptosis in human prostate cancer cells: role for Fas in vitamin E succinate-triggered apoptosis. Nutr Cancer 2000;36:90-100.
14. Zu K, Ip C. Synergy between selenium and vitamin E in apoptosis induction is associated with activation of distinctive initiator caspases in human prostate cancer cells. Cancer Res 2003;63:6988-95.
15. Zhang M, Altuwaijri S, Yeh S. RRR-α-tocopheryl succinate inhibits human prostate cancer cell invasiveness. Oncogene 2004;23:3080-8.
16. Lin HK, Yeh S, Kang HY, Chang C. Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. Proc Natl Acad Sci U S A 2001;98;7200-5.
17. Fariss MW, Merson MH, O'Hara TM. α-Tocopheryl succinate protects hepatocytes from chemical-induced toxicity under physiological calcium conditions. Toxicol Lett 1989;47:61-75.
18. Plymate SR, Haugk KH, Sprenger CC, et al. Increased manganese superoxide dismutase (SOD-2) is part of the mechanism for prostate tumor suppression by Mac25/insulin-like growth factor binding-protein-related protein-1. Oncogene 2003;22:1024-34.
19. Rasiah KK, Stricker PD, Haynes AM, et al. Prognostic significance of Gleason pattern in patients with Gleason score 7 prostate carcinoma. Cancer 2003;98:2560-5.
20. Huang J, Yao JL, Zhang L, et al. Differential expression of interleukin-8 and its receptors in the neuroendocrine and non-neuroendocrine compartments of prostate cancer. Am J Pathol 2005;166:1807-15.
21. Uitenbroek DG. SISA Fisher exact at http://home, clara.net/sisa/fisher. htm.
22. Santti R, Newbold RR, Makela S, Pylkkanen L, McLachlan JA. Developmental estrogenization and prostatic neoplasia. Prostate 1994;24:67-78.
23. Yeh S, Tsai MY, Xu Q, et al. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci USA 2002;99:13498-503.
24. Linja MJ, Savinainen KJ, Tammela TL, Isola JJ, Visakorpi T. Expression of ERα and ERβ in prostate cancer. Prostate 2003;55:180-6.
25. Lau KM, LaSpina M, Long J, Ho SM. Expression of estrogen receptor (ER)-α and ER-β in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation. Cancer Res 2000;60:3175-82.
26. Heinlein CA, Chang C. Androgen receptor in prostate cancer. Endocr Rev 2004;25:276-308.
27. Yeh S, Miyamoto H, Chang C. Hydroxyflutamide may not always be a pure antiandrogen. Lancet 1997;349: 852-3.
28. Maroni PD, Koul S, Meacham RB, Koul HK. Mitogen activated protein kinase signal transduction pathways in the prostate. Cell Commun Signal 2004;2:5.
29. Huang HF, Murphy TF, Shu P, Barton AB, Barton BE. Stable expression of constitutively-activated STAT3 in benign prostatic epithelial cells changes their phenotype to that resembling malignant cells. Mol Cancer 2005;4:2.
30. Ni Z, Lou W, Leman ES, Gao AC. Inhibition of constitutively activated Stat3 signaling pathway suppresses growth of prostate cancer cells. Cancer Res 2000; 60:1225-8.
31. Carson JP, Kulik G, Weber MJ. Antiapoptotic signaling in LNCaP prostate cancer cells: a survival signaling pathway independent of phosphatidylinositol 3′-kinase and Akt/protein kinase B. Cancer Res 1999;59: 1449-53.
32. Fresno Vara JA, Casado E, de Castro J, et al. P13K/Akt signalling pathway and cancer. Cancer Treat Rev 2004; 30:193-204.
33. Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-7.
34. Xie S, Lin HK, Ni J, et al. Regulation of interleukin-6-mediated P13K activation and neuroendocrine differentiation by androgen signaling in prostate cancer LNCaP cells. Prostate 2004;60:61-7.
35. Lin J, Adam RM, Santiestevan E, Freeman MR. The phosphatidylinositol 3′-kinase pathway is a dominant growth factor-activated cell survival pathway in LNCaP human prostate carcinoma cells. Cancer Res 1999;59: 2891-7.
36. Simon R, Mirlacher M, Sauter G. Tissue microarrays. Methods Mol Med 2004;97:377-90.
37. Song MS, Song SJ, Ayad NG, et al. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol 2004;6:129-37.
38. Kuzmin I, Gillespie JW, Protopopov A, et al. The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells. Cancer Res 2002;62:3498-502.
39. Wang ZG, Delva L, Gaboli M, et al. Role of PML in cell growth and the retinoic acid pathway. Science 1998;279: 1547-51.
40. Gurrieri C, Capodieci P, Bernardi R, et al. Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J Natl Cancer Inst 2004;96:269-79,
41. He D, Mu ZM, Le X, et al. Adenovirus-mediated expression of PML suppresses growth and tumorigenicity of prostate cancer cells. Cancer Res 1997;57:1868-72.
42. Bomar JM, Benke PJ, Slattery EL, et al. Mutations in a novel gene encoding a CRAL-TRIO domain cause human Cayman ataxia and ataxia/dystonia in the jittery mouse. Nat Genet 2003;35:264-9.
43. Maw MA, Kennedy B, Knight A, et al. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa. Nat Genet 1997;17:198-200.
44. Yokota T, Uchihara T, Kumagai J, et al. Postmortem study of ataxia with retinitis pigmentosa by mutation of the α-tocopherol gene. J Neurol Neurosurg Psychiatry 2000;68:521-5.
45. Knudson AG. Cancer genetics. Am J Med Genet 2002; 111:96-102.
46. Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
47. Arita M, Nomura K, Arai H, Inoue K. α-Tocopherol transfer protein stimulates the secretion of α-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Proc Natl Acad Sci U S A 1997;94: 12437-41.
48. Kempna P, Zingg JM, Ricciarelli R, et al. Cloning of novel human SEC14p-like proteins: ligand binding and functional properties. Free Radic Biol Med 2003;34: 1458-72.
49. Stocker A, Baumann U. Supernatant protein factor in complex with RHR-α-tocopherylquinone: a link between oxidized vitamin E and cholesterol biosynthesis. J Mol Biol 2003;332:759-65.
50. Wilson MJ, Kaye D, Smith WE, et al. Effect of vitamin E deficiency on the growth and secretory function of the rat prostatic complex. Exp Mol Pathol 2003;74:267-75.
51. Nakamura N, Ramaswamy S, Vazquez F, et al. Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol Cell Biol 2000;20:8969-82.
52. Yamauchi J, Iwamoto T, Kida S, et al. Tocopherol-associated protein is a ligand-dependent transcriptional activator. Biochem Biophys Res Commun 2001;285:295-9.
53. Manor D, Shmidt EN, Budhu A, et al. Mammary carcinoma suppression by cellular retinoic acid binding protein-II. Cancer Res 2003;63:4426-33.