Guanidine-thiourea bifunctional organocatalyst for the asymmetric Henry (nitroaldol) reaction

Advanced Synthesis and Catalysis

Volumn 347, Issue 11-13, 2005, Pages 1643-1648

  Sohtome, Yoshihiro ^b   Hashimoto, Yuichi ^b   Nagasawa, Kazuo ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bifunctional organocatalyst; Guanidines; Nitroaldol; Organic catalysis; Thioureas

Indexed keywords

EID: 27544433063     PISSN: 16154150     EISSN: None     Source Type: Journal    
DOI: 10.1002/adsc.200505148     Document Type: Article

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65. When the reaction was performed in the presence of triethylamine instead of KOH in toluene (homogeneous conditions), the yield of 11a was decreased to 13% (58% ee). In the case of the reaction under the base form of 1e in toluene (homogeneous conditions), the reaction did not proceed.