P2X2 receptors are essential for [Ca2+]i increases in response to ATP in cultured rat myenteric neurons

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 289, Issue 5 52-5, 2005, Pages

  Ohta, Toshio ^a   Kubota, Akane ^a   Murakami, Matsuka ^a   Otsaguro, Ken Ichi ^a   Ito, Shigeo ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

Enteric neuron; Fura 2; Patch clamp; Purinoceptor

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATE; BENZOYLBENZOYL ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CYTIDINE TRIPHOSPHATE; FURA 2; IONOTROPIC RECEPTOR; MAGNESIUM ION; NICOTINE; POTASSIUM; PURINE P2X2 RECEPTOR; PURINE P2Y RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; SODIUM; UNCLASSIFIED DRUG; PURINE P2 RECEPTOR; RNA;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONCENTRATION RESPONSE; ELECTRIC CURRENT; ELECTRIC POTENTIAL; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MEMBRANE CURRENT; MYENTERIC PLEXUS; NERVE CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; NERVE CELL; PHYSIOLOGY; WISTAR RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CALCIUM SIGNALING; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION REGULATION; MALE; MYENTERIC PLEXUS; NEURONS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; RNA;

EID: 27444446871     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00017.2005     Document Type: Article

References (65)

1. Barajas-Lopez C, Huizinga JD, Collins SM, Gerzanich V, Espinosa-Luna R, and Peres AL. P2x-purinoceptors of myenteric neurones from the guinea-pig ileum and their unusual pharmacological properties. Br J Phamacol 119: 1541-1548, 1996.
2. Berridge MJ. Neuronal calcium signaling. Neuron 21: 13-26, 1998.
3. Bertrand PP. ATP and sensory transduction in the enteric nervous system. Neuroscientist 9: 243-260, 2003.
4. Bian X, Ren J, DeVries M, Schnegelsberg B, Cockayne DA, Ford AP, and Galligan JJ. Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit. J Physiol 551: 309-322, 2003.
5. Bianchi BR, Lynch KJ, Touma E, Niforatos W, Burgard EC, Alexander KM, Park HS, Yu H, Metzger R, Kowaluk E, Jarvis MF, and Van Biesen T. Pharmacological characterization of recombinant human and rat P2X receptor subtypes. Eur J Pharmacol 376: 127-138, 1999.
6. 2 receptor controlled by alternative splicing. FEBS Lett 404: 294-298, 1997.
7. Brookes SJ, Song ZM, Steele PA, and Costa M. Identification of motor neurons to the longitudinal muscle of the guinea pig ileum. Gastroenterology 103: 961-973, 1992.
8. Brookes SJ, Steele PA, and Costa M. Calretinin immunoreactivity in cholinergic motor neurones, interneurones and vasomotor neurones in the guinea-pig small intestine. Cell Tissue Res 263: 471-481, 1991.
9. Buell G, Lewis C, Collo G, North RA, and Surprenant A. An antagonist-insensitive P2X receptor expressed in epithelia and brain. EMBO J 15: 55-62, 1996.
10. Burnstock G and Williams M. P2 purinergic receptors: modulation of cell function and therapeutic potential. J Pharmacol Exp Ther 295: 862-869, 2000.
11. 2 receptors in the guinea-pig enteric nervous system. Histochem Cell Biol 117: 415-422, 2002.
12. Chen CC, Akopian AN, Sivilotti L, Colquhoun D, Burnstock G, and Wood JN. A P2X purinoceptor expressed by a subset of sensory neurons. Nature 377: 428-431, 1995.
13. Choi DW and Koh JY. Zinc and brain injury. Annu Rev Neurosci 21: 347-375, 1998.
14. 2 purinoceptors. Am J Physiol Gastrointest Liver Physiol 272: G463-G473, 1997.
15. Costa M, Furness JB, Pompolo S, Brookes SJ, Bornstein JC, Bredt DS, and Snyder SH. Projections and chemical coding of neurons with immunoreactivity for nitric oxide synthase in the guinea-pig small intestine. Neurosci Lett 148: 121-125, 1992.
16. Crist JR, He XD, and Goyal RK. Both ATP and the peptide VIP are inhibitory neurotransmitters in guinea-pig ileum circular muscle. J Physiol 447: 119-131, 1992.
17. Dunn PM, Zhong Y, and Burnstock G. P2X receptors in peripheral neurons. Prog Neurobiol 65: 107-134, 2001.
18. Ekblad E, Aim P, and Sundler F. Distribution, origin and projections of nitric oxide synthase-containing neurons in gut and pancreas. Neuroscience 63: 233-248, 1994.
19. Evans RJ, Lewis C, Virginio C, Lundstrom K, Buell G, Surprenant A, and North RA. Ionic permeability of, and divalent cation effects on, two ATP-gated cation channels (P2X receptors) expressed in mammalian cells. J Physiol 497: 413-422, 1996.
20. Furness JB. Types of neurons in the enteric nervous system. J Auton Nerv Syst 81: 87-96, 2000.
21. Galligan JJ and Bertrand PP. ATP mediates fast synaptic potentials in enteric neurons. J Neurosci 14: 7563-7571, 1994.
22. Galligan JJ and North RA. Pharmacology and function of nicotinic acetylcholine and P2X receptors in the enteric nervous system. Neurogastroenterol Motil, Suppl 1: 64-70, 2004.
23. 4 receptor reveals pharmacological differences to the rat homologue. Mol Pharmacol 51: 109-118, 1997.
24. Glushakov AV, Glushakova UY, and Skok VI. Two types of P2X-purinoceptors in neurons of the guinea-pig ileum submucous plexus. Neurophysiology (Moscow) 28: 77-85, 1998.
25. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 260: 3440-3450, 1985.
26. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391: 85-100, 1981.
27. Hanani M, Francke M, Hartig W, Grosche J, Reichenbach A, and Pannicke T. Patch-clamp study of neurons and glial cells in isolated myenteric ganglia. Am J Physiol Gastrointest Liver Physiol 278: G644-G651, 2000.
28. Hanani M and Reichenbach A. Morphology of horseradish peroxidase (HRP)-injected glial cells in the myenteric plexus of the guinea-pig. Cell Tissue Res 278: 153-160, 1994.
29. 2+ concentration in cultured rat myenteric neurones. Neurogastroenterol Motil 14: 133-143, 2002.
30. 7 receptors in the enteric nervous system of guinea-pig small intestine. J Comp Neurol 440: 299-310, 2001.
31. Hu HZ, Gao N, Zhu MX, Liu S, Ren J, Gao C, Xia Y, and Wood JD. Slow excitatory synaptic transmission mediated by P2Y1 receptors in the guinea-pig enteric nervous system. J Physiol 550: 463-504, 2003.
32. Kennedy C. The discovery and development of P2 receptor subtypes. J Auton Nerv Syst 81: 158-163, 2000.
33. Kennedy MB. Regulation of neuronal function by calcium. Trends Neurosci 12: 417-420, 1989.
34. Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Seguela P, Voigt M, and Humphrey PP. International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53: 107-118, 2001.
35. Kimball BC and Mulholland MW. Neuroligands evoke calcium signaling in cultured myenteric neurons. Surgery 118: 162-169, 1995.
36. 2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism. Am J Physiol Gastrointest Liver Physiol 270: G587-G593, 1996.
37. 2+ stores in cultured guinea pig myenteric neurons. Am J Physiol Gastrointest Liver Physiol 270: G594-G603, 1996.
38. Kirchgessner AL and Liu MT. Immunohistochemical localization of nicotinic acetylcholine receptors in the guinea pig bowel and pancreas. J Comp Neurol 390: 497-514, 1998.
39. Kunze WA, Bornstein JC, and Furness JB. Identification of sensory nerve cells in a peripheral organ (the intestine) of a mammal. Neuroscience 66: 1-4, 1995.
40. 2+ channel subtypes in cultured astrocytes. Glia 41: 347-353, 2003.
41. 2+ increase induced by ATP in PC12 cells. Brain Res 1013: 40-50, 2004.
42. Nishi R and Willard AL. Neurons dissociated from rat myenteric plexus retain differentiated properties when grown in cell culture. I. Morphological properties and immunocytochemical localization of transmitter candidates. Neuroscience 16: 187-199, 1985.
43. North RA. Molecular physiology of P2X receptors. Physiol Rev 82: 1013-1067, 2002.
44. North RA and Surprenant A. Pharmacology of cloned P2X receptors. Annu Rev Pharmacol Toxicol 40: 563-580, 2000.
45. Nurgali K, Furness JB, and Stebbing MJ. Analysis of purinergic and cholinergic fast synaptic transmission to identified myenteric neurons. Neuroscience 116: 335-347, 2003.
46. + current and exocytosis in responses to caffeine and muscarine in voltage-clamped guinea-pig adrenal chromaffin cells. J Neurochem 78: 1243-1255, 2001.
47. 2 ATP receptor from the guinea pig organ of Corti. Hear Res 121: 62-70, 1998.
48. 3 purine receptor subunits in the guinea pig enteric nervous system. Auton Neurosci 101: 39-47, 2002.
49. Ralevic V and Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 50: 413-492, 1998.
50. Ramirez AN and Kunze DL. P2X purinergic receptor channel expression and function in bovine aortic endothelium. Am J Physiol Heart Circ Physiol 282: H2106-H2116, 2002.
51. 2 subunits contribute to fast synaptic excitation in myenteric neurons of the mouse small intestine. J Physiol 552: 809-821, 2003.
52. 2 receptors. Neuropharmacology 36: 1181-1187, 1997.
53. Schäfer KH, Saffrey MJ, and Burnstock G. Trophic actions of 2-chloroadenosine and bFGF on cultured myenteric neurons. Neuroreport 6: 937-941, 1995.
54. Schäfer KH, Saffrey MJ, Burnstock G, and Mestres-Ventura P. A new method for the isolation of myenteric plexus from the newborn rat gastrointestinal tract. Brain Res Protocols 1: 109-113, 1997.
55. 2 receptor. Mol Pharmacol 52: 237-248, 1997.
56. 2+ signaling in cultured myenteric neurons. Am J Physiol Gastrointest Liver Physiol 278: G905-G914, 2000.
57. Von Kügelgen I and Wetter A. Molecular pharmacology of P2Y-receptors. Naunyn-Schmiedeberg's Arch Pharmacol 362: 310-323, 2000.
58. Vulchanova L, Arvidsson U, Riedl M, Wang J, Buell G, Surprenant A, North RA, and Elde R. Differential distribution of two ATP-gated channels (P2X receptors) determined by immunocytochemistry. Proc Natl Acad Sci USA 93: 8063-8067, 1996.
59. 3 receptor subunits in rat and monkey sensory neurons and their central terminals. "Neuropharmacology 36: 1229-1242, 1997.
60. Wood JD. Physiology of the enteric nervous system. In: Physiology of the Gastrointestinal Tract (3rd ed.), edited by Johnson LR. New York: Raven 1994, p. 423-482.
61. 3 purinoceptors in the rat enteric nervous system. Histochem Cell Biol 121: 169-179, 2004.
62. 4 receptor function. J Neurophysiol 81: 2088-2094, 1999.
63. Zhong Y, Dunn PM, and Burnstock G. Pharmacological comparison of P2X recetptors on rat celiac, mouse celiac and mouse pelvic ganglion neurons. Neuropharmacology 39: 172-180, 2000.
64. Zhou X and Galligan JJ. P2X purinoceptors in cultured myenteric neurons of guinea-pig small intestine. J Physiol 496: 719-729, 1996.
65. Zhou X, Ren J, Brown E, Schneider D, Caraballo-Lopez Y, and Galligan JJ. Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons. J Pharmacol Exp Ther 302: 889-897, 2002.