Extracellular ATP mediates Ca2+ signaling in cultured myenteric neurons via a PLC-dependent mechanism

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 270, Issue 4 33-4, 1996, Pages

  Kimball, Beth C ^a   Yule, David I ^a   Mulholland, Michael W ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Acetoxymethyl ester; Enteric nervous system; Fura 2; Signal transduction

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 CHLOROADENOSINE 5' TRIPHOSPHATE; 2 METHYLTHIOADENOSINE TRIPHOSPHATE; ADENOSINE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM ION; CYCLOPIAZONIC ACID; NIFEDIPINE; PERTUSSIS TOXIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOLIPASE C; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; ENZYME ACTIVATION; ENZYME MECHANISM; GUINEA PIG; MYENTERIC PLEXUS; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELLS, CULTURED; ENZYME ACTIVATION; EXTRACELLULAR SPACE; GUINEA PIGS; INOSITOL 1,4,5-TRISPHOSPHATE; MYENTERIC PLEXUS; NEURONS; NIFEDIPINE; PERTUSSIS TOXIN; PHOSPHOLIPASE C; RECEPTORS, PURINERGIC; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; VIRULENCE FACTORS, BORDETELLA;

EID: 0029881941     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.1996.270.4.g587     Document Type: Article

References (33)

1. Baluk, R, K. R. Jessen, M. J. Saffrey, and G. Burnstock. The enteric nervous system in tissue culture. II. Ultrastructural studies of cell types and their relationships. Brain Res. 262: 37-47, 1983.
2. Bean, B. P. Pharmacology and electrophysiology of ATP-activatedion channels. Trends Pharmacol. Sci. 13: 87-90, 1992.
3. 2+-permeable channel activated by ATP in smooth muscle. Nature Land. 328: 275-278, 1987.
4. 2+ channels in neuronal cells. Annu. Rev. Pharmacol. Toxicol. 32: 399-421, 1992.
5. Bleasdale, J. E., and S. K. Fisher. Use of U-73122 as an inhibitor of phospholipase C-dependent processes. Neuroprotocols 3: 125-133, 1993.
6. Born, G. V. R., and M. A. A. Kratzer. Source and concentration of extracellular adenosine triphosphate during haemostasis in rats, rabbits, and man. J. Physiol. Land. 354: 419-429, 1984.
7. Broussard, D. L., P. G. C. Banner-man, C.-M. Tang, M. Hardy, and D. Pleasure. Electrophysiologic and molecular properties of cultured enteric glia. J. Neuro. Res 34: 24-31, 1993.
8. Brown, H. A., E. R. Lazarowski, R, C. Boucher, and T. K. Harden. Evidence that UTP and ATP regulate phospholipase C through a common extracellular 5′-nucleotide receptor in human airway epithelial cells. Mol. Pharmacol. 40: 648-655, 1991.
9. Burnstock, G. A basis for distinguishing two types of purinergic receptor. In: Cell Membrane Receptors for Drugs, and Hormones: A Multidisciplinary Approach, edited by R. W. Straub and L. Bolis. New York: Raven, 1978, p. 107-118.
10. Burnstock, G. Neurotransmitters, and trophic factors in the autonomie nervous system J. Physiol. Land. 313: 1-35, 1981.
11. 2+ stores and activates an influx pathway for divalent cations in HL-60 cells. J. Biol. Chem. 267: 2318-2324, 1992.
12. 2-purinergic receptors for extracellular ATP. Am. J. Respir. Cell Mol. Biol. 4: 295-300, 1991.
13. 2-purinoceptor antagonist in the mouse vas deferens. Br. J. Pharmacol. 93: 243-245, 1988.
14. Edwards, F. A., and A. J. Gibb. ATP - a fast neurotransmitter. FEES Lett. 325: 86-89, 1993.
15. Ehrlich, Y. H., R. M. Snider, E. Kornecki, M. G. Garfield, and R. H. Lenox. Modulation of neuronal signal transduction systems by extracellular ATP. J. Neurochem. 50: 295-301, 1988.
16. 2y purinergic receptor that couples to phospholipase C. Mol. Pharmacol. 46: 8-14, 1994.
17. Galligan, J. J., and P. P. Bertrand. ATP mediates fast synaptic potentials in enteric neurons. J. Neurosci. 14: 7563-7571, 1994.
18. Gordon, J. L. Extracellular ATP: effects, sources, and fate. Biochem. J. 233: 309-319, 1986.
19. 2+ indicators with greatly improved fluorescent properties. J. Biol. Chem. 260: 3440-3450, 1985.
20. 2+ currents in cultured myenteric neurons by neuropeptide Y: evidence for direct receptor/channel coupling. Brain Res. 532: 120-130, 1990.
21. Illes, P., and W. Nörenberg. Neuronal ATP receptors and their mechanism of action. Trends Pharmacol. Sci. 14: 50-54, 1993.
22. 2 receptor in the neuronal cell line, N1E-115. Br. J. Pharmacol. 107: 1083-1087, 1992.
23. Jessen, K. R., M. J. Saffrey, and G. Burnstock. The enteric neurons in tissue culture. I. Cell types and their interactions in explants of the myenteric and submucous plexuses from guinea pig, rabbit, and rat. Brain Res. 262: 17-35, 1983.
24. Katayama, Y., and K. Morita. Adenosine 5′ -triphosphate modulated membrane potassium conductance in guinea-pig myenterie neurones. J. Physiol Land. 408: 373-390, 1989.
25. Lustig, K. D., A. K. Shiau, A. J. Brake, and D. Julius. Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc. Natl. Acad. Sci. USA 90: 5113-5117, 1993.
26. Mulholland, M. W., and S. Jaffer. Stimulation of acetylcholine release in myenterie plexus by calcitonin gene-related peptide. Am. J. Physiol. 259 (Gastrointest. Liver Physiol. 22): G934-G939, 1990.
27. 2+ homeostasis. Trends Neurosci. 11: 444-448, 1988.
28. O'Connor, S. E., I. Dainty, and P. Leff. Further subclassification of ATP receptors based on agonist studies. Trends Physiol. Sci. 12: 137-141, 1991.
29. 2purinergic receptors are coupled to two signal transduction systems leading to inhibition of cAMP generation and to production of inositol trisphosphate in rat hepatocytes. J. Biol. Chem. 262: 13483-13490, 1987.
30. Saffrey, M. J., D. J. Bailey, and G. Burnstock. Growth of enteric neurones from isolated myenterie ganglia in dissociated cell culture. Cell Tissue Res. 265: 527-534, 1991
31. 2+ concentration in guinea-pig myenteric neurons by using fura-2. Brain Res. 451: 371-375, 1988.
32. Webb, T. E., J. Simon, B. J. Krishek, A. N. Bateson, T. G. Smart, B. F. King, G. Burnstock, and E. A. Barnard. Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett. 324: 219-225, 1993.
33. White, T. D., and R. A. Leslie. Depolarization-induced release of adenosine 5′-triphosphate from isolated varicosities derived from the myenterie plexus of the guinea pig small intestine. J. Neurosci. 2: 206-215, 1982.