The effects of anesthetics and ethanol on α2 adrenoceptor subtypes expressed with G protein-coupled inwardly rectifying potassium channels in Xenopus oocytes

Anesthesia and Analgesia

Volumn 101, Issue 5, 2005, Pages 1381-1388

  Hara, Koji ^a,b   Yamakura, Tomohiro ^c   Sata, Takeyoshi ^b   Harris, R Adron ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^c NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALFAXALONE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ANESTHETIC AGENT; BRIMONIDINE; COMPLEMENTARY DNA; COMPLEMENTARY RNA; GUANINE NUCLEOTIDE BINDING PROTEIN; HALOTHANE; INWARDLY RECTIFYING POTASSIUM CHANNEL; KETAMINE; PENTOBARBITAL; POTASSIUM CHANNEL; PROPOFOL; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT;

ANESTHESIA MECHANISM; ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

EID: 27444445655     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ANE.0000180190.05238.D5     Document Type: Article

References (24)

1. 2-adrenoceptor-subtype function. Trends Pharmacol Sci 1997;18:211-9.
2. 2-drenergic receptors. J Pharmacol Exp Ther 2000;293:1-7.
3. Lakhlani PP, MacMillan LB, Guo TZ, et al. Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc Natl Acad Sci USA 1997;94:9950-5.
4. North RA. Drug receptors and the inhibition of nerve cells. Br J Pharmacol 1989;98:13-28.
5. Williams JT, Henderson G, North RA. Characterization of alpha 2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones. Neuroscience 1985;14:95-101.
6. Yoshimura M, Polosa C, Nishi S. Slow IPSP and the noradrenaline-induced inhibition of the cat sympathetic preganglionic neuron in vitro. Brain Res 1987;419:383-6.
7. 2-agonists in locus coeruleus neurons. Brain Res 1986;371:390-4.
8. Blednov YA, Stoffel M, Alva H, Harris RA. A pervasive mechanism for analgesia: activation of GIRK2 channels. Proc Natl Acad Sci USA 2003;100:277-82.
9. + channels. J Biol Chem 1995;270:28660-7.
10. + channel mRNAs are differentially expressed in the adult rat brain. J Neurosci 1996;16:3559-70.
11. Yamakura T, Lewohl JM, Harris RA. Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels. Anesthesiology 2001;95:144-53.
12. Dildy-Mayfield JE, Harris RA. Comparison of ethanol sensitivity of rat brain kainate, DL-alpha-amino-3-hydroxy-5-methyl-4-isoxalone proprionic acid and N-methyl-D-aspartate receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 1992;262:487-94.
13. Kovoor A, Henry DJ, Chavkin C. Agonist-induced desensitization of the μ opioid receptor-coupled potassium channel (GIRK1). J Biol Chem 1995;270:589-95.
14. Franks NP, Lieb WR. Molecular and cellular mechanisms of general anaesthesia. Nature 1994;367:607-14.
15. Krasowski MD, Harrison NL. General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci 1999;55:1278-303.
16. Lewohl JM, Wilson WR, Mayfield RD, et al. G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. Nat Neurosci 1999;2:1084-90.
17. Durieux ME. Halothane inhibits signaling through m1 muscarinic receptors expressed in Xenopus oocytes. Anesthesiology 1995;82:174-82.
18. Durieux ME. Inhibition by ketamine of muscarinic acetylcholine receptor function. Anesth Analg 1995;1:57-62.
19. Minami K, Minami M, Harris RA. Inhibition of 5-hydroxytryptamine type 2A receptor-induced currents by n-alcohols and anesthetics. J Pharmacol Exp Ther 1997;281:1136-43.
20. Minami K, Gereau RW 4th, Minami M, et al. Effects of ethanol and anesthetics on type 1 and 5 metabotropic glutamate receptors expressed in Xenopus laevis oocytes. Mol Pharmacol 1998;53:148-56.
21. Mao L, Abdel-Rahman AA. Synergistic behavioral interaction between ethanol and clonidine in rats: role of alpha-2 adrenoceptors. J Pharmacol Exp Ther 1996;279:443-9.
22. Pentyala S, Moller D, Chowdhury A, et al. Effects of inhalational anesthetics on alpha2-adrenergic signaling in isolated platelets. Toxicol Lett 1998;23;100-1, 115-20.
23. Ikeda K, Kobayashi T, Kumanishi T, et al. Involvement of G-protein-activated inwardly rectifying K (GIRK) channels in opioid-induced analgesia. Neurosci Res 2000;38:113-6.
24. Krapivinsky G, Gordon EA, Wickman K, et al. The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K(+)-channel proteins. Nature 1995;374:135-41.