Involvement of G-protein-activated inwardly rectifying K+ (GIRK) channels in opioid-induced analgesia

Neuroscience Research

Volumn 38, Issue 1, 2000, Pages 113-116

  Ikeda, Kazutaka ^a   Kobayashi, Toru ^b   Kumanishi, Toshiro ^b   Niki, Hiroaki ^a   Yano, Ryoji ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^b Niigata University   (Japan)

Author keywords

GIRK channel; Intracellular signaling pathway; Opioid receptor; Opioid induced analgesia; Weaver mutant mouse

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; MORPHINE; OPIATE DERIVATIVE; POTASSIUM ION;

ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG EFFECT; HOT PLATE TEST; MOUSE; MOUSE MUTANT; NONHUMAN; POTASSIUM CHANNEL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TAIL FLICK TEST;

3,4-DICHLORO-N-METHYL-N-(2-(1-PYRROLIDINYL)-CYCLOHEXYL)-BENZENEACETAMIDE, (TRANS)-ISOMER; ANALGESIA; ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MICE, INBRED C3H; MICE, NEUROLOGIC MUTANTS; MORPHINE; PAIN MEASUREMENT; POTASSIUM CHANNELS; REACTION TIME; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; SUPPORT, NON-U.S. GOV'T;

EID: 0034282114     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(00)00144-9     Document Type: Article

References (21)

1. ATP channel. Nature. 370:1994;456-459.
2. + channel. J. Biol. Chem. 269:1994;7839-7842.
3. D'Amour F., Smith D. A method for determining loss of pain sensation. J. Pharmacol. Exp. Ther. 72:1941;74-79.
4. + channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochem. Biophys. Res. Commun. 212:1995;657-663.
5. Ikeda K., Ichikawa T., Kobayashi T., Kumanishi T., Oike S., Yano R. Unique behavioural phenotypes of recombinant-inbred CXBK mice: Partial deficiency of sensitivity to μ- and κ-agonists. Neurosci. Res. 34:1999;149-155.
6. + (GIRK) channels and functional couplings of the opioid receptors with the GIRK1 channel. Ann. New York Acad. Sci. 801:1996;95-109.
7. + channel. Biochem. Biophys. Res. Commun. 208:1995;302-308.
8. + (GIRK) channel. Brain Res. Mol. Brain Res. 45:1997;117-126.
9. + channel mRNAs are differentially expressed in the adult rat brain. J. Neurosci. 16:1996;3559-3570.
10. + channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain. Biochem. Biophys. Res. Commun. 208:1995;1166-1173.
11. + channels. Nat. Neurosci. 2:1999;1091-1097.
12. +-channel proteins. Nature. 374:1995;135-141.
13. Kubo Y., Reuveny E., Slesinger P.A., Jan Y.N., Jan L.Y. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature. 364:1993;802-806.
14. 2A-adrenergic receptor via 'hit and run' gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivo. Proc. Natl. Acad. Sci. USA. 94:1997;9950-9955.
15. + channels in the brain. FEBS Lett. 353:1994;37-42.
16. + channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons. Neuron. 19:1997;687-695.
17. Minami M., Satoh M. Molecular biology of the opioid receptors: structures, functions and distributions. Neurosci. Res. 23:1995;121-145.
18. + channels. Science. 272:1996;1950-1953.
19. North R.A. Drug receptors and the inhibition of nerve cells. Br. J. Pharmacol. 98:1989;13-28.
20. Patil N., Cox D.R., Bhat D., Faham M., Myers R.M., Peterson A.S. A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Nat. Genet. 11:1995;126-129.
21. Woolfe G., Macdonald A. The evaluation of the analgesic action of pethidine hydrochloride (demerol). J. Pharmacol. Exp. Ther. 80:1944;300-307.