A dominant negative Gαs mutant that prevents thyroid-stimulating hormone receptor activation of cAMP production and inositol 1,4,5-trisphosphate turnover: Competition by different G proteins for activation by a common receptor

Journal of Biological Chemistry

Volumn 279, Issue 35, 2004, Pages 36601-36607

  Cleator, John H ^a   Ravenell, Roneka ^a   Kurtz, David T ^a   Hildebrandt, John D ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; CELLS; HORMONES; PROTEINS;

ISOFORMS; ISOTYPES; PHENOTYPE;

MUTAGENESIS;

ADENYLATE CYCLASE; ALPHA 1B ADRENERGIC RECEPTOR; ASPARAGINE; CYCLIC AMP; G(Q) PROTEIN; GLUTAMINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; INOSITOL 1,4,5 TRISPHOSPHATE; ISOENZYME; LEUCINE; PROTEIN SUBUNIT; SERINE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; INOSITOL PHOSPHATE; ISOPROTEIN;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STRAIN COS1; CELL STRAIN COS7; CONTROLLED STUDY; HORMONE ACTION; HUMAN; HUMAN CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; ANIMAL; BINDING COMPETITION; DIMERIZATION; DOMINANT GENE; DOSE RESPONSE; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; IMMUNOBLOTTING; METABOLISM; MUTATION;

ANIMALIA;

ADENYLATE CYCLASE; ANIMALS; BINDING, COMPETITIVE; CELL LINE; COS CELLS; CYCLIC AMP; DIMERIZATION; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, DOMINANT; GENETIC VECTORS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; IMMUNOBLOTTING; INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL PHOSPHATES; MUTATION; PHENOTYPE; PROTEIN ISOFORMS; RECEPTORS, THYROTROPIN; TRANSFECTION;

EID: 4344668165     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406232200     Document Type: Article

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