Diagnosis, treatment and control of Clostridium difficile infection;Diagnóstico, tratamiento y control de la infección causada por Clostridium difficile

Revista Espanola de Geriatria y Gerontologia

Volumn 40, Issue 5, 2005, Pages 310-319

  Gonzalez Garcia N ^a   Gomez Pavon J ^a   Martinez Porras J L ^a  

^a HOSPITAL CENTRAL DE LA CRUZ ROJA   (Spain)

Author keywords

Clostridium difficile; Elderly; Nosocomial infection

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; CEPHALOSPORIN DERIVATIVE; CHLORAMPHENICOL; CLINDAMYCIN; CLOSTRIDIUM DIFFICILE TOXIN A; CLOSTRIDIUM DIFFICILE TOXIN B; COLESTIPOL; COLESTYRAMINE; FUSIDIC ACID; IMMUNOGLOBULIN; MACROLIDE; METRONIDAZOLE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; SULFANILAMIDE; TEICOPLANIN; TETRACYCLINE; VANCOMYCIN;

AGED; AGING; ANTIBIOTIC THERAPY; BACTERIAL COLONIZATION; BACTERIUM DETECTION; CLINICAL FEATURE; CLINICAL PRACTICE; CLOSTRIDIUM DIFFICILE; COLON RESECTION; COMORBIDITY; DIARRHEA; DISEASE PREDISPOSITION; DRUG EFFICACY; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; GERIATRIC PATIENT; HEALTH CARE COST; HOSPITAL INFECTION; HUMAN; INTESTINE FLORA; LACTOBACILLUS; LATEX AGGLUTINATION TEST; LENGTH OF STAY; NAUSEA; NONHUMAN; POLYMERASE CHAIN REACTION; PRACTICE GUIDELINE; PSEUDOMEMBRANOUS COLITIS; REVIEW; SACCHAROMYCES BOULARDII; TASTE DISORDER; TOXIN ANALYSIS; TREATMENT INDICATION;

EID: 27444435430     PISSN: 0211139X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0211-139X(05)74875-7     Document Type: Review

References (72)

1. Fekety R. Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. Am J Gastroenterol. 1997;92:739-50.
2. Giannella RA. Diarrea asociada al uso de antibióticos y colitis por Clostridium difficile: una actualización. Rev Esp Enferm Dig. 2001;93:535-9.
3. Bartlett JG, Chang TW, Gurwith M, Gorbach SL, Onderdonk AB. Antibiotic-associated pseudomembranous colitis due to toxin-producing clostridium. N Engl J Med. 1978;298:531-4.
4. Knobel H, Salvado M, Pals E. Brote epidémico nosocomial de diarrea por Clostridium difficile. Estudio comparativo con la diarrea asociada al uso de antibioticos. Med Clin (Barc). 1994;102:165-8.
5. Guerrant RL, Hughes JM, Lima NL, Crane J. Diarrhea in develop and developing countries: Magnitude, special setting, and etiologies. Rev Infect Dis. 1990;12 Suppl 1:41-50.
6. McFarland LV. Epidemiology of infectious and iatrogenic nosocomial diarrhea in a cohort of general medecine patients. Am J Infect Control. 1995;23:295-305.
7. Kyne L, Farrell RJ, Kelly CP. Clostridium difficile. Gastroenterol Clin North Am. 2001;30:753-77.
8. Alonso R, Pelaez T, Bouza E. Diagnóstico, tratamiento y control de la infección causada por Clostridium difficile. En: Bouza E, Picazo JJ, editors, Infección 2003. Bilbao: Servisistem 2000; 2003. p. 199-221.
9. Bignardi GE. Risk factors for Clostridium difficile infection. J Hosp Infect. 1998;40:1-15.
10. Hirschhom LR, Trinka JR, Onderdonk A. Epidemiology of community-acquired Clostridium difficile diarrhea. J Infect Dis. 1994;169:127-33.
11. Kyne L, Warny M, Qamar A, Kelly CP. Asymtomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A. N Engl J Med. 2000;342:390-7.
12. McFarland LV, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med. 1998;320:204-10.
13. Samore MH, DeGirolami PC, Tlucko A, Lichtenberg DA, Melvin ZA, Karchmer AW. Clostridium difficile colonization and diarrhea at a tertiary care hospital. Clin Infect Dis. 1994;18:181-7.
14. Kim K, Fekety R, Batts DH, Brown D, Cudmore M, Silva J Jr, et al. Isolation of Clostridium difficile from the enviroment and contacts of patients with antibiotic-induced colitis. J Infect Dis. 1981;143:42-50.
15. McFarland L, Mulligan ME, Kwok RY, Stamm WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med. 1989;320:204-10.
16. Johson S, Clabots CR, Linn FV, Olson MM, Peterson LR, Gerding DN. Nosocomial Clostridium difficile colonization and disease. Lancet. 1990;336:97-100.
17. Johsonson S, Gerding D. Clostridium difficile associated Diarrhea. Clin Infect Dis. 1998;26:1027-36.
18. Cunningham R, Dale B, Undy B, Gaunt N. Proton pump inhibitors as a risk factor for Clostridium difficile diarrhea. J Hosp Infect. 2003;54:243-5.
19. Wilcox M. Cleaning up Clostridium difficile infection. Lancet. 1996; 348:767-8.
20. Karlström O, Fryklund B, Tullus K, Burman LG. The Swedish C. Difficile Study Group. A prospective nationwide study of Clostridium difficile associated diarrhea in Sweden. Clin Infect Dis. 1998;26:141-5.
21. Selva O'Callaghan A, Yuste M, Armadans L, Almirante B, San Jose A, Vilardell M. Factores de riesgo de infección por Clostridium difficile en pacientes ancianos. Estudio de casos y controles. Med Clin (Barc). 2002; 115:499-500.
22. Bennet RG, Greenough WB. Diarrhea in the elderly. En: Hazzard WR, Bias JP, Ettinger WH, Halter JB, Ouslander JG, editors. Principles of geriatric medicine and gerontology. New York: McGraw-Hill; 1998. p. 1507-17.
23. Ratnaike RN, Jones TE. Mechanisms of drugs induced diarrhea in the elderly. Drugs Aging. 1998;13:245-53.
24. Kelly CP, La Mont JT. Clostridium difficile infection. Ann Rev Med. 1998;49:375-90.
25. Pothoulakis C, Lamont JT. The integrated response of the intestine to Clostridium difficile toxins. Am J Physiol Gastrointest Liver Physiol. 2001;280: G178-83.
26. Bulusu M, Narayan S, Shetler K, Triadafilopoulos G. Leukocytosis as a harbinger and surrogate marker of Clostridium difficile infection in hospitalised patients with diarrhea. Am J Gastroenterol. 2000;95:3137-41.
27. Manabe YC, Vinetz JM, Moore RD, Merz C. Clostridium difficile colitis: an efficient clinical approach to diagnosis. Ann Intern Med. 1995;123:835-40.
28. Feldman RJ, Kallich M, Weinstein MP. Bacteremia due to Clostridium difficile: case report and review of extra intestinal C. difficile infections. Clin Infect Dis. 1995;20:1560-2.
29. Pron B, Merckx J, Touret P, Ferroni A, Poyart C, Berche P, Gaillard JL. Chronic septic artritis and osteomielitis in a prosthetic knee joint due to Clostridium difficile. Eur J Clin Microbiol Infect Dis. 1995;14:599-601.
30. Wolf LE, Gorbah SL, Granowitz EV. Extraintestinal Clostridium difficile: 10 years' experience at a tertiary-care hospital. Mayo Clin Proc. 1998;73: 943-7.
31. Kelly CP, Pothoulakis C, La Mont JT. Clostridium difficile colitis. N Engl J Med. 1994;330:257-62.
32. Laughon BE, Viscidi RP, Gdovin SL, Yolken RH, Bartleth JG. Enzyme inmunoassays for detection of Clostridium difficile toxins A and B in fecal specimens. J Infect Dis. 1984;149:781-8.
33. Lozniewski A, Rabaud C, Dotto E, Weber M, Mary F. Laboratory diagnosis of Clostridium difficile-associated diarrhea and colitis: usefulness of Premier Cytoclone A+B enzyme inmunoassays for combined detection of stool toxins and toxigenic C. difficile strains. J Clin Microbiol. 2001;39: 1996-8.
34. Jacobs J, Rudensky B, Dresner J, Berman A, Sonnenblick M, Van Dijk Y, et al. Comparison of four laboratory tets for diagnosis Clostridium difficile diarrhea. Eur J Clin Microbiol Infect Dis. 1996;5:561-6.
35. Mainick S, Zimhony O. Treatment of Clostridium difficile-associated diarrhea. Ann Pharmacol. 2002;36:1767-75.
36. Johal SS, Hammmond J, Solomon K, James PD, Mahida YR. Clostridium difficile associated diarrhoea in hospitalised patient onset in the community and hospital an role of flexible sigmoidoscopy. Gut. 2004;53:673-7.
37. Boland GW, Lee MJ, Cats AN, Mueller PR. Pseudomembranous colitis. Diagnostic sensitivy of the abdominal plain radiogrph. Clin Radiol. 1994;49:473-5.
38. Boland GW, Lee MJ, Cats AN, Ferraro MJ, Matthia AR, Mueller PR. Clostridium difficile colitis: correlation of CT findings with severity of clinical disease. Clin Radiol. 1995;50:153-6.
39. Spencer RC. The role of antimicrobial agents in the etiology of Clostridium difficile-associated disease. J Antimicrob Chemother. 1998;41 Suppl C:21-7.
40. Waley T, Milson D. Loperamide related toxic megacolon in Clostridium difficile colitis. Postgrad Med J. 1990;66:582.
41. Teasly DG, Gerding DN, Olson MM, Peterson LR, Gebhard RL, Schwartz MJ, et al. Prospective randomised trial of metronidazole versus vancomycin for Clostridium difficile-associated diarrhea and colitis. Lancet. 1983;2: 1043-6.
42. Wenisch C, Parschalk B, Hasenhundt M, Hirschl AM, Graninger W. Comparision of vancomycin, metronidazol and fusidic acid for the treatement for Clostridium difficile-associated diarrhea. Clin Infect Dis. 1996;22:813-8.
43. Bricker E, Garg R, Nelson R, Loza A, Novak T, Hansen J. Antibiotic treatment for Clostridium difficile-associated diarrea in adults. Cochrane Database Syst Rev. 2005;(1):CD004610.
44. Kelly CP, La Mont JT. Treatment Clostridium difficile diarrhea and colitis. En: Wolfe MM, editor. Therapy of digestive disorders. Philadelphia: WB Sounders; 2000. p. 513-22.
45. Olson MM, Shanholtzer CJ, Lee JT, Gerdin DN. Ten years of prospective Clostridium difficile-associated disease surveillance and treatment at Mineapolis VA Medical Center. Infect Control Hosp Epidemiol. 1994;15:371-81.
46. Mylonakis E, Ryan ET, Calderwood SB. Clostridium difficile associated diarrhea. Arch Intern Med. 2001;161:525-33.
47. Fekety R, Silva J, Kaulman C, Buggy B, Deery HG. Treatement of antibiotic-associated Clostridium difficile with oral vanconmycina: comparision of two dosage regimens. Am J Med. 1989;86:15-9.
48. Bartlett JG. Clinical practice. Antibiotic-associated diarrhea. N Engl J Med. 2002;31:346:334-9.
49. Jobe BA, Grasley A, Deveney KE, Deveney CW, Sheppard BC. Clostridium difficile colitis: an increasing hospital-acquired illness. Am J Surg. 1994;169:480-3.
50. Kyne L, Merry C, O'Connell B, Kelly A, Keane C, O'Neill D. Factors associated with prolonged symptoms and severe disease due to Clostridium difficile. Age Ageing. 1999;28:107-13.
51. Bolton RP, Culshaw MA. Faecal metronidazole concentrations during oral and intravenous therapy for antibiotic associated colitis due to Clostridium difficile. Gut. 1986;27:1169-72.
52. Buggy BP, Fekety R, Silva J. Therapy of relapsing Clostridium difficile associated diarrhea and colitis with combination of vancomycine and rifampin. J Clin Gastroenterol. 1987;9:155-9.
53. Fekety R, O'Connor R, Silva J. Rifampin and pseudomenbranous colitis. Rev Infect Dis. 1983;5 Suppl 3:8254-8.
54. Tedesco FJ, Gordon D. Approach to patients with mutiple relapses of antibiotic-associated pseudomembranous colitis. Am J Gastroenterol. 1985;80:867-8.
55. Tedesco FJ. Treatment of recurrent antibiotic-associated pseudomembranous colitis. Am J Gastroenterol. 1982;77:220-1.
56. Surawicz CM, Elmer GW, Sperlman P, McFarland LV, Chinn J, Van Belle G. Prevenction of antibiotic-associated diarrhea by Saccharomyces boulardii: a prospective study. Gastroenterology. 1989;96:981-8.
57. Fisher A, Morley JE. Antiaging Medicine: the good, the bad and the ugly. J Gerontol Med Sci. 2002;57A 10:M636-9.
58. McFarland LV, Surawicz CM, Greenberg RN, Bowen KE, Melcher SA, Mulligan ME. A randomised placebo-controlled trial of Saccharomyces boulardii in combination with standard antibiotics for Clostridium difficile disease. JAMA. 1994;271:1913-8.
59. Surawicz CM, McFarland LV, Greenberg RN, Rubin M, Fekety R, Mulligan ME, et al. The search for a better treatment for reccurrent Clostridium difficile disease: use of high dose vancomycin combined with Saccaromyces boulardii. Clin Infect Dis. 2000;31:1012-7.
60. Pochapin M. The effect of probiotics on Clostridium difficile diarrhea. Am J Gastroenterol. 2000;95 Suppl:S11-3.
61. Lipsett RA, Samantaray DK, Tam ML, Bartlett JG, Lillemoe KD. Pseudomembranous colitis: a surgical disease? Surgery. 1994;116:535-9.
62. Synnott K, Mealy K, Merry C, Kyne L, Keane C, Quill R. Timing of surgery for fulmination pseudomembranous colitis. Br J Surg. 1998;85:229-31.
63. Bradbury AW, Barrett S. Surgical aspects of Clostridium difficile colitis. Br J Surg. 1997;84:150-9.
64. Morris JB, Zollinger RM, Stellato TA. Role of surgery in antibiotic-induced pseudomembranous colitis. Am J Surg. 1990;160:535-9.
65. McFarland LV, Surawicz CM, Greenberg RN. Recurrent Clostridium difficile diarrhea: characteristics of and risk factors for patients enrolled in a prospective, randomised, double-blinded trial. Clin Infect Dis. 1997;24: 324-33.
66. McFarland LV, Surawicz CM, Rubin M, FeKety R, Elmer GW, Greenberg RN. Recurrent Clostridium difficile disease: epidemiology and clinical characteristics. Infect Control Hosp Epidemiol. 1999;20:43-50.
67. Mogg GA, Arabi A, Younes D, Johnson M, Bentley S, Burdon DW, et al. Therapeutic trials of antibiotic associated colitis. Scand J Infect Dis Suppl. 1980;Suppl 22:41-5.
68. Nath SK, Thornley JH, Kelly M, Kucera B. A sustained outbreak of C. difficile in a general hospital: persistence of a toxigenic clone in four unit. Infect Control Hosp Epidemiol. 1994;15:382-9.
69. Kyne L, Wany M, Qamar A, Kelly CP. Association between antibody response to toxina A and protection against recurrent Clostridium difficile diarrhea. Lancet. 2001;357:89-93.
70. Bettin K, Clabots C, Mathie P, Gerding DN. Effectiveness of liquid soap vs chlorhexidina gluconato for removal of C. difficile from bare hands and gloved hands. Infect Control Hosp Epidemiol. 1994;15:697-702.
71. Brooks SE, Veal RO, Kramer M, Dore L, Schupf N. Reduction of incidence of C. difficile associated diarrhea in an acute care hospital and skilled nursing facility following replacement of electronic thermometers with single-used disposables. Infect Control Hosp Epidemiol. 1992;13:98-103.
72. Marienela MA, Pierson C, Chenoweth C. The stethoscospe. A potencial source of nosocomial infection? Arch Intern Med. 1997;157:786-90.